Tony R Merriman


Affiliation: University of Otago
Country: New Zealand


  1. Major T, Topless R, Dalbeth N, Merriman T. Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts. BMJ. 2018;363:k3951 pubmed publisher
    ..9% of variance in serum urate levels was explained by common, genome wide single nucleotide variation. In contrast with genetic contributions, diet explains very little variation in serum urate levels in the general population. ..
  2. Fatima T, McKinney C, Major T, Stamp L, Dalbeth N, Iverson C, et al. The relationship between ferritin and urate levels and risk of gout. Arthritis Res Ther. 2018;20:179 pubmed publisher
    ..These data replicate the association of ferritin with serum urate. Increased ferritin levels associated with gout and flare frequency. There was evidence of a causal effect of iron and ferritin on urate. ..
  3. Major T, Dalbeth N, Stahl E, Merriman T. An update on the genetics of hyperuricaemia and gout. Nat Rev Rheumatol. 2018;14:341-353 pubmed publisher
  4. Krishnan M, Major T, Topless R, Dewes O, Yu L, Thompson J, et al. Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand. Diabetologia. 2018;61:1603-1613 pubmed publisher
  5. Fatima T, Altaf S, Phipps Green A, Topless R, Flynn T, Stamp L, et al. Association analysis of the beta-3 adrenergic receptor Trp64Arg (rs4994) polymorphism with urate and gout. Rheumatol Int. 2016;36:255-61 pubmed publisher
    ..This association provides an etiological link between metabolic syndrome components and urate homeostasis. ..
  6. Merriman T. Genomic Influences on Hyperuricemia and Gout. Rheum Dis Clin North Am. 2017;43:389-399 pubmed publisher
    ..However identification of causal genes at other urate loci is challenging. Finally, relatively little is known about the genetic control of progression from hyperuricemia to gout. Only 4 small GWAS have been published for gout. ..
  7. Merriman T. Population heterogeneity in the genetic control of serum urate. Semin Nephrol. 2011;31:420-5 pubmed publisher
    ..A more complete picture will be revealed by very large meta-analyses of genome-wide association scans in Caucasian and in other populations with less genetic heterogeneity than Caucasians. ..
  8. Rasheed H, Phipps Green A, Topless R, Smith M, Hill C, Lester S, et al. Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout. Rheumatology (Oxford). 2016;55:1421-30 pubmed publisher
    ..10). Our data, replicating a previous study, supports the hypothesis that the apolipoprotein A1-C3-A4 gene cluster plays a causal role in gout. ..
  9. Dalbeth N, Phipps Green A, House M, Gamble G, Horne A, Stamp L, et al. Body mass index modulates the relationship of sugar-sweetened beverage intake with serum urate concentrations and gout. Arthritis Res Ther. 2015;17:263 pubmed publisher
    ..Australian Clinical Trials Registry ACTRN12610001036000 . Registered 24 November 2010. ..

More Information


  1. Rasheed H, Hughes K, Flynn T, Merriman T. Mendelian randomization provides no evidence for a causal role of serum urate in increasing serum triglyceride levels. Circ Cardiovasc Genet. 2014;7:830-7 pubmed publisher
    ..018). These data provide no evidence for a causal role for SU in raising triglyceride levels, consistent with a previous Mendelian randomization report of no association between SU and ischemic heart disease. ..
  2. McKinney C, Stamp L, Dalbeth N, Topless R, Day R, Kannangara D, et al. Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout. Arthritis Res Ther. 2015;17:288 pubmed publisher
  3. Merriman T, Choi H, Dalbeth N. The genetic basis of gout. Rheum Dis Clin North Am. 2014;40:279-90 pubmed publisher
    ..Extending knowledge in this area depends on recruitment of large, clinically ascertained gout sample sets suitable for GWAS. ..
  4. Cadzow M, Merriman T, Dalbeth N. Performance of gout definitions for genetic epidemiological studies: analysis of UK Biobank. Arthritis Res Ther. 2017;19:181 pubmed publisher
    ..236). Of the limited items available in multipurpose cohorts, the case definition of self-report of gout or ULT use has high sensitivity and precision for detecting association in genetic epidemiological studies of gout. ..
  5. Rasheed H, Stamp L, Dalbeth N, Merriman T. Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout. Arthritis Res Ther. 2017;19:161 pubmed publisher
    ..These data support the hypothesis that alcohol influences the risk of gout via glucose and apolipoprotein metabolism. In the absence of alcohol exposure, genetic variants in the GCKR and A1CF genes have a stronger role in gout. ..
  6. He W, Phipps Green A, Stamp L, Merriman T, Dalbeth N. Population-specific association between ABCG2 variants and tophaceous disease in people with gout. Arthritis Res Ther. 2017;19:43 pubmed publisher
    ..Variation in ABCG2 function may play a role in the development of tophaceous disease in some populations with high prevalence of severe gout. ..
  7. Merriman T. An update on the genetic architecture of hyperuricemia and gout. Arthritis Res Ther. 2015;17:98 pubmed publisher
    ..In such a study, use of asymptomatic hyperurcemic controls would be expected to increase the ability to detect genetic associations with gout. ..
  8. Dalbeth N, House M, Gamble G, Pool B, Horne A, Purvis L, et al. Influence of the ABCG2 gout risk 141 K allele on urate metabolism during a fructose challenge. Arthritis Res Ther. 2014;16:R34 pubmed publisher
    ..This study aimed to test the hypothesis that the ABCG2 gout risk allele 141 K promotes the hyperuricaemic response to fructose loading...
  9. Flynn T, Phipps Green A, Hollis Moffatt J, Merriman M, Topless R, Montgomery G, et al. Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects. Arthritis Res Ther. 2013;15:R220 pubmed
    ..Further fine mapping of the association signal is needed using trans-ancestral re-sequence data. ..
  10. Hollis Moffatt J, Gow P, Harrison A, Highton J, Jones P, Stamp L, et al. The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity. Arthritis Res Ther. 2011;13:R85 pubmed publisher
    ..Our results also suggest that the effect of this variant is population-specific, further confirming population heterogeneity regarding the association of SLC2A9 with gout. ..
  11. Hollis Moffatt J, Phipps Green A, Chapman B, Jones G, Van Rij A, Gow P, et al. The renal urate transporter SLC17A1 locus: confirmation of association with gout. Arthritis Res Ther. 2012;14:R92 pubmed publisher
    ..70, P = 3.0 × 10-8). Haplotype analysis suggested the presence of a common protective haplotype. We confirm the SLC17A1 locus as the third associated with gout at a genome-wide level of significance. ..