A A Mercer

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. ncbi request reprint A novel strategy for determining protective antigens of the parapoxvirus, orf virus
    A A Mercer
    Virus Research Unit, University of Otago, Dunedin, New Zealand
    Virology 229:193-200. 1997
  2. ncbi request reprint Vascular endothelial growth factors encoded by Orf virus show surprising sequence variation but have a conserved, functionally relevant structure
    A A Mercer
    Department of Microbiology, University of Otago, PO Box 56, Dunedin, New Zealand
    J Gen Virol 83:2845-55. 2002
  3. ncbi request reprint Comparative analysis of genome sequences of three isolates of Orf virus reveals unexpected sequence variation
    Andrew A Mercer
    Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
    Virus Res 116:146-58. 2006
  4. ncbi request reprint F-box-like domains are present in most poxvirus ankyrin repeat proteins
    Andrew A Mercer
    Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin, New Zealand
    Virus Genes 31:127-33. 2005
  5. pmc A homolog of interleukin-10 is encoded by the poxvirus orf virus
    S B Fleming
    Health Research Council Virus Research Unit and University of Otago Centre for Gene Research, University of Otago, Dunedin, New Zealand
    J Virol 71:4857-61. 1997
  6. doi request reprint Delivery of Echinococcus granulosus antigen EG95 to mice and sheep using recombinant vaccinia virus
    S Dutton
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    Parasite Immunol 34:312-7. 2012
  7. ncbi request reprint Construction of a recombinant orf virus that expresses an Echinococcus granulosus vaccine antigen from a novel genomic insertion site
    B J Marsland
    Virus Research Unit, Department of Microbiology, University of Otago, Dunedin, New Zealand
    Arch Virol 148:555-62. 2003
  8. ncbi request reprint Gene homology between orf virus and smallpox variola virus
    A A Mercer
    Health Research Council Virus Research Unit, University of Otago, Dunedin, New Zealand
    Virus Genes 13:175-8. 1996
  9. ncbi request reprint Parapoxvirus of red deer: evidence for its inclusion as a new member in the genus parapoxvirus
    A J Robinson
    Health Research Council Virus Research Unit, University of Otago, Dunedin, New Zealand
    Virology 208:812-5. 1995
  10. ncbi request reprint Viral vascular endothelial growth factors vary extensively in amino acid sequence, receptor-binding specificities, and the ability to induce vascular permeability yet are uniformly active mitogens
    Lyn M Wise
    Virus Research Unit, Department of Microbiology, University of Otago, P O Box 56, Dunedin, New Zealand
    J Biol Chem 278:38004-14. 2003

Collaborators

Detail Information

Publications28

  1. ncbi request reprint A novel strategy for determining protective antigens of the parapoxvirus, orf virus
    A A Mercer
    Virus Research Unit, University of Otago, Dunedin, New Zealand
    Virology 229:193-200. 1997
    ..Vaccination of OV-naive sheep with the recombinant library provided protection against a subsequent challenge with virulent OV. These data confirm the feasibility of the proposed strategy...
  2. ncbi request reprint Vascular endothelial growth factors encoded by Orf virus show surprising sequence variation but have a conserved, functionally relevant structure
    A A Mercer
    Department of Microbiology, University of Otago, PO Box 56, Dunedin, New Zealand
    J Gen Virol 83:2845-55. 2002
    ..Structural modelling also revealed that a groove seen in the VEGF-A homodimer and believed to play a role in its binding to VEGFR-1 is blocked in the viral VEGFs. This may contribute to the inability of the viral VEGFs to bind VEGFR-1...
  3. ncbi request reprint Comparative analysis of genome sequences of three isolates of Orf virus reveals unexpected sequence variation
    Andrew A Mercer
    Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
    Virus Res 116:146-58. 2006
    ..The availability of genomic sequences of three orf virus isolates allowed us to more accurately assess likely coding regions and thereby revise published data for 24 genes and to predict two previously unrecognized genes...
  4. ncbi request reprint F-box-like domains are present in most poxvirus ankyrin repeat proteins
    Andrew A Mercer
    Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin, New Zealand
    Virus Genes 31:127-33. 2005
    ..The large number of different poxviral ANK-F-box proteins suggests a wide range of cellular proteins might be subjected to ubiquitin-mediated degradation, thereby modulating diverse cellular responses to viral infection...
  5. pmc A homolog of interleukin-10 is encoded by the poxvirus orf virus
    S B Fleming
    Health Research Council Virus Research Unit and University of Otago Centre for Gene Research, University of Otago, Dunedin, New Zealand
    J Virol 71:4857-61. 1997
    ..OV IL-10 is likely to be important in immune evasion by OV, since IL-10 is a multifunctional cytokine that has inhibitory effects on nonspecific immunity and Th1 effector function...
  6. doi request reprint Delivery of Echinococcus granulosus antigen EG95 to mice and sheep using recombinant vaccinia virus
    S Dutton
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    Parasite Immunol 34:312-7. 2012
    ..Sheep antibody responses to the recombinant vector or to EG95 protein mirrored those in mice...
  7. ncbi request reprint Construction of a recombinant orf virus that expresses an Echinococcus granulosus vaccine antigen from a novel genomic insertion site
    B J Marsland
    Virus Research Unit, Department of Microbiology, University of Otago, Dunedin, New Zealand
    Arch Virol 148:555-62. 2003
    ..This recombinant will be a valuable tool with which to assess the potential of recombinant orf viruses to deliver vaccine antigens to sheep...
  8. ncbi request reprint Gene homology between orf virus and smallpox variola virus
    A A Mercer
    Health Research Council Virus Research Unit, University of Otago, Dunedin, New Zealand
    Virus Genes 13:175-8. 1996
    ..The parapoxvirus and orthopoxvirus correlates have about 20% amino acid sequence resemblance to African swine fever virus DNA binding protein p10, suggesting an ancestral relation of genes...
  9. ncbi request reprint Parapoxvirus of red deer: evidence for its inclusion as a new member in the genus parapoxvirus
    A J Robinson
    Health Research Council Virus Research Unit, University of Otago, Dunedin, New Zealand
    Virology 208:812-5. 1995
    ..These results indicate that the genome of DPV is as different from the genomes of the three accepted members of the genus as the latter are from each other and argue for the inclusion of DPV as a new member of the parapoxvirus genus...
  10. ncbi request reprint Viral vascular endothelial growth factors vary extensively in amino acid sequence, receptor-binding specificities, and the ability to induce vascular permeability yet are uniformly active mitogens
    Lyn M Wise
    Virus Research Unit, Department of Microbiology, University of Otago, P O Box 56, Dunedin, New Zealand
    J Biol Chem 278:38004-14. 2003
    ..We propose that the extensive sequence divergence seen in the viral VEGFs was generated primarily by selection against VEGFR-1 binding...
  11. pmc Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes
    Stephanie Sonnberg
    Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9016, New Zealand
    Proc Natl Acad Sci U S A 105:10955-60. 2008
    ..We propose that poxviruses use these unique ANK/F-box proteins to dictate target specificity to SCF1 ubiquitin ligases and thereby exploit the cell's ubiquitin-proteasome machinery...
  12. doi request reprint Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR
    Stéphanie Cébe-Suarez
    Paul Scherrer Institut, Laboratory of Biomolecular Research, Molecular Cell Biology, 5232 Villigen PSI Switzerland
    FASEB J 22:3078-86. 2008
    ..Functional studies showed that stable coreceptor assembly by VEGF correlated with its ability to promote vessel formation in an embryoid body angiogenesis assay...
  13. ncbi request reprint The C-terminus of viral vascular endothelial growth factor-E partially blocks binding to VEGF receptor-1
    Marie K Inder
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    FEBS J 275:207-17. 2008
    ....
  14. pmc The structure of a putative scaffolding protein of immature poxvirus particles as determined by electron microscopy suggests similarity with capsid proteins of large icosahedral DNA viruses
    Jae Kyung Hyun
    School of Biological Sciences, University of Auckland, Thomas Building, 3A Symonds Street, Auckland, New Zealand
    J Virol 81:11075-83. 2007
    ....
  15. ncbi request reprint Infection with recombinant orf viruses demonstrates that the viral interleukin-10 is a virulence factor
    Stephen B Fleming
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    J Gen Virol 88:1922-7. 2007
    ..Removal of any one of these genes would be expected to have only a partial effect on virulence, which is what was observed in this study with vorfIL-10...
  16. ncbi request reprint Major amino acid sequence variants of viral vascular endothelial growth factor are functionally equivalent during Orf virus infection of sheep skin
    Lyn M Wise
    Virus Research Unit, Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
    Virus Res 128:115-25. 2007
    ....
  17. ncbi request reprint Orf virus interleukin-10 inhibits cytokine synthesis in activated human THP-1 monocytes, but only partially impairs their proliferation
    Lyn Wise
    Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin, New Zealand
    J Gen Virol 88:1677-82. 2007
    ..These findings suggest that the partial ability of ORFV IL-10 to inhibit THP-1 monocyte proliferation may be due to the absence of critical residues that mediate the interaction with human IL-10R2...
  18. pmc A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus
    Dana Westphal
    Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
    J Virol 81:7178-88. 2007
    ..ORFV125 is the first parapoxvirus apoptosis inhibitor to be identified, and we propose that it is a new antiapoptotic member of the Bcl-2 family...
  19. ncbi request reprint Pseudocowpox virus encodes a homolog of vascular endothelial growth factor
    Norihito Ueda
    Virus Research Unit, Department of Microbiology, University of Otago, Dunedin, New Zealand
    Virology 305:298-309. 2003
    ..It seems likely that the biological activities of PCPV(VR634)VEGF contribute to the proliferative and highly vascularized nature of PCPV lesions...
  20. ncbi request reprint Bovine papular stomatitis virus encodes a functionally distinct VEGF that binds both VEGFR-1 and VEGFR-2
    Marie K Inder
    Virus Research Unit, Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin, New Zealand
    J Gen Virol 88:781-91. 2007
    ..These data suggest that BPSVV660VEGF is an evolutionary and functional intermediate between VEGF-A and the other parapoxviral VEGFs...
  21. ncbi request reprint Parapoxvirus of red deer in New Zealand encodes a variant of viral vascular endothelial growth factor
    Norihito Ueda
    Virus Research Unit, Department of Microbiology and Immunology, University of Otago, P O Box 56, Dunedin, New Zealand
    Virus Res 124:50-8. 2007
    ..Our data also reveal that all members of the genus encode a VEGF and that an extraordinary degree of inter-species sequence variation is a general feature of the parapoxvirus VEGFs...
  22. ncbi request reprint The Orf virus E3L homologue is able to complement deletion of the vaccinia virus E3L gene in vitro but not in vivo
    Sangeetha Vijaysri
    Department of Microbiology, Arizona State University, Tempe, AZ 85287 2701, USA
    Virology 314:305-14. 2003
    ..Domain swap experiments demonstrate that the difference in pathogenesis maps to the C-terminal domain of these proteins. This domain has been shown to be required for the dsRNA binding function of the VV E3L...
  23. ncbi request reprint Recent isolates of parapoxvirus of Finnish reindeer (Rangifer tarandus tarandus) are closely related to bovine pseudocowpox virus
    Maria K Tikkanen
    National Veterinary and Food Research Institute, Department of Virology, PO Box 45, Hämeentie 57, FIN 00581 Helsinki, Finland
    J Gen Virol 85:1413-8. 2004
    ....
  24. pmc Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: intra-nasal vaccination
    Sangeetha Vijaysri
    Graduate Program in Microbiology, Arizona State University, Tempe, AZ 85287 5401, USA
    Vaccine 26:664-76. 2008
    ..These recombinant VACV constructs may be promising vector candidates for use in vaccination strategies against smallpox and other pathogens...
  25. ncbi request reprint Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2
    Stephanie Dillon
    Virus Research Unit, Dept Microbiology and Immunology, University of Otago, PO Box 56, Dunedin, New Zealand
    J Gen Virol 88:803-13. 2007
    ....
  26. ncbi request reprint A comparison of the anti-inflammatory and immuno-stimulatory activities of orf virus and ovine interleukin-10
    David M Haig
    The Moredun Research Institute, International Research Center, Pentlands Science Park, Bush Loan, EH26 0PZ, Penicuik
    Virus Res 90:303-16. 2002
    ..Finally, ovine keratinocytes do not express ovIL-10. This might explain why orf virus has evolved a viral IL-10...
  27. ncbi request reprint Orf virus-encoded interleukin-10 stimulates the proliferation of murine mast cells and inhibits cytokine synthesis in murine peritoneal macrophages
    Wendy Imlach
    Virus Research Unit and Centre for Gene Research, Department of Microbiology, University of Otago, PO Box 56, Dunedin, New Zealand
    J Gen Virol 83:1049-58. 2002
    ....
  28. ncbi request reprint Maturation and function of human dendritic cells are inhibited by orf virus-encoded interleukin-10
    Anna Chan
    Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin, New Zealand
    J Gen Virol 87:3177-81. 2006
    ..These findings suggest that ORFV IL-10 may influence the development of acquired immunity in humans by impairing DC function...