Fiona J McDonald

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. ncbi request reprint Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel
    Fiona J McDonald
    Department of Physiology, University of Otago, Dunedin 9100, New Zealand
    Am J Physiol Renal Physiol 283:F431-6. 2002
  2. doi request reprint Regulation of the delta and alpha epithelial sodium channel (ENaC) by ubiquitination and Nedd8
    Kevin L Y
    Department of Physiology, University of Otago, Dunedin, New Zealand
    J Cell Physiol 228:2190-201. 2013
  3. doi request reprint COMMD1 downregulates the epithelial sodium channel through Nedd4-2
    Ying Ke
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Am J Physiol Renal Physiol 298:F1445-56. 2010
  4. doi request reprint Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel
    Yong feng Liu
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Am J Physiol Renal Physiol 305:F80-9. 2013
  5. pmc Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation
    Dominik Wiemuth
    Department of Physiology, University of Otago, Dunedin, New Zealand
    PLoS ONE 5:e12163. 2010
  6. ncbi request reprint COMMD1 regulates the delta epithelial sodium channel (δENaC) through trafficking and ubiquitination
    Tina Chang
    Department of Physiology, University of Otago, PO Box 913, Dunedin 9054, New Zealand
    Biochem Biophys Res Commun 411:506-11. 2011
  7. pmc Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface
    Dominik Wiemuth
    Department of Physiology, University of Otago, PO Box 913, Dunedin 9054, New Zealand
    Biochem J 405:147-55. 2007
  8. ncbi request reprint Identification of Murr1 as a regulator of the human delta epithelial sodium channel
    Wolfgang Biasio
    Department of Physiology, University of Otago, Dunedin 9001, New Zealand
    J Biol Chem 279:5429-34. 2004
  9. ncbi request reprint Lithium-induced reduction in urinary concentrating ability and urinary aquaporin 2 (AQP2) excretion in healthy volunteers
    Robert J Walker
    Department of Medical and Surgical Sciences, University of Otago, Dunedin, New Zealand
    Kidney Int 67:291-4. 2005
  10. pmc Lithium-induced nephrogenic diabetes insipidus: renal effects of amiloride
    Jennifer J Bedford
    Department of Medical and Surgical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand
    Clin J Am Soc Nephrol 3:1324-31. 2008

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel
    Fiona J McDonald
    Department of Physiology, University of Otago, Dunedin 9100, New Zealand
    Am J Physiol Renal Physiol 283:F431-6. 2002
    ..Thus expression, binding, and functional data all suggest that WWP2 is a candidate to regulate ENaC-mediated Na(+) transport in epithelia...
  2. doi request reprint Regulation of the delta and alpha epithelial sodium channel (ENaC) by ubiquitination and Nedd8
    Kevin L Y
    Department of Physiology, University of Otago, Dunedin, New Zealand
    J Cell Physiol 228:2190-201. 2013
    ..Therefore δ- and α - βγENaC channel function may be influenced by RING-domain E3 ubiquitin ligases...
  3. doi request reprint COMMD1 downregulates the epithelial sodium channel through Nedd4-2
    Ying Ke
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Am J Physiol Renal Physiol 298:F1445-56. 2010
    ..These data suggest that COMMD1 modulates Na(+) transport in epithelial cells through regulation of ENaC cell surface expression and this effect is likely mediated via Nedd4-2...
  4. doi request reprint Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel
    Yong feng Liu
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Am J Physiol Renal Physiol 305:F80-9. 2013
    ..These data suggest that COMMD3 and COMMD9 may be endogenous regulators of ENaC to regulate Na⁺ transport through altering ENaC cell surface expression...
  5. pmc Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation
    Dominik Wiemuth
    Department of Physiology, University of Otago, Dunedin, New Zealand
    PLoS ONE 5:e12163. 2010
    ..WW-domains in Nedd4-like proteins bind PY-motifs (PPXY) present in ENaC subunits, and SGK also has a PY-motif...
  6. ncbi request reprint COMMD1 regulates the delta epithelial sodium channel (δENaC) through trafficking and ubiquitination
    Tina Chang
    Department of Physiology, University of Otago, PO Box 913, Dunedin 9054, New Zealand
    Biochem Biophys Res Commun 411:506-11. 2011
    ..These results suggest that COMMD1 downregulates δENaC activity by reducing δENaC surface expression through promoting internalization of surface δENaC to an intracellular recycling pool, possibly via enhanced ubiquitination...
  7. pmc Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface
    Dominik Wiemuth
    Department of Physiology, University of Otago, PO Box 913, Dunedin 9054, New Zealand
    Biochem J 405:147-55. 2007
    ....
  8. ncbi request reprint Identification of Murr1 as a regulator of the human delta epithelial sodium channel
    Wolfgang Biasio
    Department of Physiology, University of Otago, Dunedin 9001, New Zealand
    J Biol Chem 279:5429-34. 2004
    ..Murr1 also bound to the beta- and gammaENaC subunits and inhibited alphabetagammaENaC sodium current. Therefore, these results suggest that Murr1 is a novel regulator of ENaC...
  9. ncbi request reprint Lithium-induced reduction in urinary concentrating ability and urinary aquaporin 2 (AQP2) excretion in healthy volunteers
    Robert J Walker
    Department of Medical and Surgical Sciences, University of Otago, Dunedin, New Zealand
    Kidney Int 67:291-4. 2005
    ..This study examined the effects of four weeks of lithium therapy on desmopressin (dDAVP)-stimulated urinary concentrating ability in healthy volunteers...
  10. pmc Lithium-induced nephrogenic diabetes insipidus: renal effects of amiloride
    Jennifer J Bedford
    Department of Medical and Surgical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand
    Clin J Am Soc Nephrol 3:1324-31. 2008
    ..Polyuria, polydipsia, and nephrogenic diabetes insipidus have been associated with use of psychotropic medications, especially lithium...
  11. pmc A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel
    J Shaun Lott
    School of Biological Sciences, University of Auckland, Private Bag 92 019, Auckland, New Zealand
    Biochem J 361:481-8. 2002
    ..Differential binding propensities between the various WW domains and Na(+) channel subunit peptides are explained on the basis of quantitative structural modelling of the complexes and their isolated components...
  12. ncbi request reprint Mu and delta opioid receptor immunoreactivity and mu receptor regulation in brainstem cells cultured from late fetal and early postnatal rats
    Bronwyn M Kivell
    School of Biological Sciences, Victoria University, P O Box 600, Wellington, New Zealand
    Brain Res Dev Brain Res 149:9-19. 2004
    ..It was concluded that many brainstem neurons express functional MOR or DOR or coexpress both receptors, although intracellular distributions of the receptors are unique for each receptor type...