Jacqueline I Keenan

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. doi request reprint Using food to reduce H. pylori-associated inflammation
    Jacqueline I Keenan
    Department of Surgery, University of Otago Christchurch, Christchurch, New Zealand
    Phytother Res 26:1620-5. 2012
  2. ncbi request reprint Helicobacter species in the human colon
    J I Keenan
    Department of Surgery, University of Otago, Christchurch, New Zealand
    Colorectal Dis 12:48-53. 2010
  3. doi request reprint Individual and combined effects of foods on Helicobacter pylori growth
    Jacqueline I Keenan
    Department of Surgery, University of Otago Christchurch, Christchurch, New Zealand
    Phytother Res 24:1229-33. 2010
  4. doi request reprint Alterations in Helicobacter pylori outer membrane and outer membrane vesicle-associated lipopolysaccharides under iron-limiting growth conditions
    Jacqueline I Keenan
    Department of Surgery, University of Otago, Christchurch, New Zealand
    Innate Immun 14:279-90. 2008
  5. ncbi request reprint Interactions between gastric and enteric infections: clues to the pathogenesis of inflammatory bowel disease?
    Jacqueline I Keenan
    Department of Surgery, University of Otago, Christchurch, New Zealand
    N Z Med J 124:62-7. 2011
  6. doi request reprint Composition and function of Helicobacter pylori outer membrane vesicles
    Heather Parker
    Department of Pathology, University of Otago, PO Box 4345, Christchurch, New Zealand
    Microbes Infect 14:9-16. 2012
  7. pmc Uptake of Helicobacter pylori outer membrane vesicles by gastric epithelial cells
    Heather Parker
    Department of Surgery, University of Otago, Christchurch, New Zealand
    Infect Immun 78:5054-61. 2010
  8. pmc The action of bismuth against Helicobacter pylori mimics but is not caused by intracellular iron deprivation
    Michael V Bland
    School of Biological Scienes, University of Canterbury, Christchurch, New Zealand
    Antimicrob Agents Chemother 48:1983-8. 2004
  9. pmc Helicobacter pylori outer membrane vesicles modulate proliferation and interleukin-8 production by gastric epithelial cells
    Salim Ismail
    Department of Surgery, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Infect Immun 71:5670-5. 2003
  10. doi request reprint Human lactoferrin increases Helicobacter pylori internalisation into AGS cells
    Dorien S Coray
    School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    World J Microbiol Biotechnol 28:1871-80. 2012

Collaborators

Detail Information

Publications17

  1. doi request reprint Using food to reduce H. pylori-associated inflammation
    Jacqueline I Keenan
    Department of Surgery, University of Otago Christchurch, Christchurch, New Zealand
    Phytother Res 26:1620-5. 2012
    ..The results suggest that in the future certain foods may find increased clinical use as a non-antimicrobial approach for reducing the inflammation that is a major risk factor for H. pylori-associated disease, notably gastric cancer...
  2. ncbi request reprint Helicobacter species in the human colon
    J I Keenan
    Department of Surgery, University of Otago, Christchurch, New Zealand
    Colorectal Dis 12:48-53. 2010
    ..To determine the prevalence, frequency and colonization patterns of Helicobacter species throughout the colon...
  3. doi request reprint Individual and combined effects of foods on Helicobacter pylori growth
    Jacqueline I Keenan
    Department of Surgery, University of Otago Christchurch, Christchurch, New Zealand
    Phytother Res 24:1229-33. 2010
    ..The results suggest that food synergy should be considered in any nutraceutical approach to H. pylori infection...
  4. doi request reprint Alterations in Helicobacter pylori outer membrane and outer membrane vesicle-associated lipopolysaccharides under iron-limiting growth conditions
    Jacqueline I Keenan
    Department of Surgery, University of Otago, Christchurch, New Zealand
    Innate Immun 14:279-90. 2008
    ..These differences were linked to bacterial ATP levels. Since iron availability affects the extent and nature of LPS expressed by H. pylori, host iron status may contribute to H. pylori pathogenesis...
  5. ncbi request reprint Interactions between gastric and enteric infections: clues to the pathogenesis of inflammatory bowel disease?
    Jacqueline I Keenan
    Department of Surgery, University of Otago, Christchurch, New Zealand
    N Z Med J 124:62-7. 2011
    ..Understanding the interactions between these antigenically-related bacteria may provide us with clues that ultimately help unravel the complex aetiology of CD...
  6. doi request reprint Composition and function of Helicobacter pylori outer membrane vesicles
    Heather Parker
    Department of Pathology, University of Otago, PO Box 4345, Christchurch, New Zealand
    Microbes Infect 14:9-16. 2012
    ..Here we review current knowledge on the composition of H. pylori OMV and discuss evidence for their potential roles in bacterial survival and pathogenesis...
  7. pmc Uptake of Helicobacter pylori outer membrane vesicles by gastric epithelial cells
    Heather Parker
    Department of Surgery, University of Otago, Christchurch, New Zealand
    Infect Immun 78:5054-61. 2010
    ..We conclude that VacA toxin enhances the association of H. pylori OMV with cells and that the presence of the toxin may allow vesicles to exploit more than one pathway of internalization...
  8. pmc The action of bismuth against Helicobacter pylori mimics but is not caused by intracellular iron deprivation
    Michael V Bland
    School of Biological Scienes, University of Canterbury, Christchurch, New Zealand
    Antimicrob Agents Chemother 48:1983-8. 2004
    ..Thus, the antimicrobial effect of bismuth and of iron limitation on H. pylori may be similar. However, the respective mechanisms of intracellular action would appear to be mediated by different pathways within the cell...
  9. pmc Helicobacter pylori outer membrane vesicles modulate proliferation and interleukin-8 production by gastric epithelial cells
    Salim Ismail
    Department of Surgery, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Infect Immun 71:5670-5. 2003
    ..In summary, we suggest that constitutively shed OMV play a role in promoting the low-grade gastritis associated with H. pylori infection...
  10. doi request reprint Human lactoferrin increases Helicobacter pylori internalisation into AGS cells
    Dorien S Coray
    School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    World J Microbiol Biotechnol 28:1871-80. 2012
    ..pylori's ability to persistence in the human stomach, an observation that potentially has implications for the risk of H. pylori-associated disease...
  11. doi request reprint Outer membrane vesicles enhance the carcinogenic potential of Helicobacter pylori
    Kenny Chitcholtan
    Department of Surgery, University of Otago Christchurch, Christchurch, New Zealand
    Carcinogenesis 29:2400-5. 2008
    ..In conclusion, OMV-mediated delivery of VacA to the gastric epithelium may constitute a new mechanism for H.pylori-induced gastric carcinogenesis...
  12. ncbi request reprint NADPH oxidase involvement in the pathology of Helicobacter pylori infection
    Jacqueline I Keenan
    Department of Surgery, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Free Radic Biol Med 38:1188-96. 2005
    ..This is exacerbated by the absence of a functional NADPH oxidase, and is consistent with this enzyme complex having an important role in dampening the inflammatory response...
  13. pmc Uptake and persistence of Mycobacterium avium subsp. paratuberculosis in human monocytes
    Dayle A Keown
    Department of Surgery, University of Otago Christchurch, Christchurch, New Zealand
    Infect Immun 80:3768-75. 2012
    ..avium subsp. paratuberculosis persistence in human cells, but there was no evidence that internalized M. avium subsp. paratuberculosis also affects the survival of bacteria taken up during a secondary phagocytic event...
  14. ncbi request reprint Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury
    Jarkko Piuhola
    Christchurch Cardioendocrine Research Group, University of Otago, Christchurch, New Zealand
    Clin Sci (Lond) 114:293-304. 2008
    ..Thus EPO directly enhances cardiac contractility and BNP secretion and alleviates ischemia/reperfusion injury via ET-1-dependent and -independent mechanisms respectively...
  15. ncbi request reprint Probiotic-mediated modulation of host inflammation
    Andrew S Day
    Department of Paediatrics, University of Otago, Christchurch, Riccarton Avenue, Christchurch, 8140, New Zealand
    Expert Rev Gastroenterol Hepatol 5:319-21. 2011
    ..The article under evaluation provides important new information on the mechanisms by which specific probiotic organisms may be able to be attenuate gut inflammation in individuals with IBD...
  16. ncbi request reprint Counterstaining improves visualization of the myenteric plexus in immunolabelled whole-mount preparations
    Parkash Mandhan
    Children s Developmental Genetic Research Group, Department of Surgery, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    J Fluoresc 16:655-8. 2006
    ..Furthermore, this technique allows the detailed qualitative and quantitative study of myenteric plexuses in whole-mount preparations...
  17. ncbi request reprint Differences in immunogenicity and protection in mice and guinea pigs following intranasal immunization with Helicobacter pylori outer membrane antigens
    Jacqueline I Keenan
    Department of Surgery, Christchurch School of Medicine and Health Sciences, P O Box 4345, Christchurch, New Zealand
    FEMS Immunol Med Microbiol 36:199-205. 2003
    ..These antibodies did not, however, correlate with protection in these animals, which suggests that vaccine formulation is as important as choice of antigen in the development of an H. pylori vaccine...