Paul Leslie Hofman

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. pmc Needle with a novel attachment versus conventional screw-thread needles: a preference and ease-of-use test among children and adolescents with diabetes
    Paul Hofman
    Liggins Institute, University of Auckland, Auckland, New Zealand
    J Diabetes Sci Technol 5:1480-7. 2011
  2. ncbi request reprint Antenatal exercise in overweight and obese women and its effects on offspring and maternal health: design and rationale of the IMPROVE (Improving Maternal and Progeny Obesity Via Exercise) randomised controlled trial
    Sumudu N Seneviratne
    Liggins Institute, University of Auckland, Auckland, New Zealand
    BMC Pregnancy Childbirth 14:148. 2014
  3. pmc Increased adiposity in adults born preterm and their children
    Sarah Mathai
    Liggins Institute, University of Auckland, Auckland, New Zealand Gravida National Centre for Growth and Development, Auckland, New Zealand
    PLoS ONE 8:e81840. 2013
  4. ncbi request reprint Systolic and diastolic abnormalities reduce the cardiac response to exercise in adolescents with type 2 diabetes
    Teresa E Pinto
    Corresponding author Paul L Hofman
    Diabetes Care 37:1439-46. 2014
  5. doi request reprint Neurodevelopmental and body composition outcomes in children with congenital hypothyroidism treated with high-dose initial replacement and close monitoring
    Benjamin B Albert
    Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, 1023 Auckland, New Zealand
    J Clin Endocrinol Metab 98:3663-70. 2013
  6. pmc Insulin sensitivity and β-cell function in adults born preterm and their children
    Sarah Mathai
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Diabetes 61:2479-83. 2012
  7. doi request reprint Etiology of increasing incidence of congenital hypothyroidism in New Zealand from 1993-2010
    Benjamin B Albert
    Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Clin Endocrinol Metab 97:3155-60. 2012
  8. pmc Design and testing of an MRI-compatible cycle ergometer for non-invasive cardiac assessments during exercise
    Silmara Gusso
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Biomed Eng Online 11:13. 2012
  9. ncbi request reprint The metabolic consequences of prematurity
    P L Hofman
    Liggins Institute, University of Auckland, 2 6 Park Avenue, Auckland, New Zealand
    Growth Horm IGF Res 14:S136-9. 2004
  10. ncbi request reprint Premature birth and later insulin resistance
    Paul L Hofman
    Liggins Institute, Faculty of Medicine and Health Science, University of Auckland, Auckland, New Zealand
    N Engl J Med 351:2179-86. 2004

Collaborators

Detail Information

Publications35

  1. pmc Needle with a novel attachment versus conventional screw-thread needles: a preference and ease-of-use test among children and adolescents with diabetes
    Paul Hofman
    Liggins Institute, University of Auckland, Auckland, New Zealand
    J Diabetes Sci Technol 5:1480-7. 2011
    ..This usability test investigated the overall preference and usability of the novel NovoTwist® insulin pen needle versus conventional screw-thread needles, when used with Next Generation FlexPen®, in children and adolescents with diabetes...
  2. ncbi request reprint Antenatal exercise in overweight and obese women and its effects on offspring and maternal health: design and rationale of the IMPROVE (Improving Maternal and Progeny Obesity Via Exercise) randomised controlled trial
    Sumudu N Seneviratne
    Liggins Institute, University of Auckland, Auckland, New Zealand
    BMC Pregnancy Childbirth 14:148. 2014
    ....
  3. pmc Increased adiposity in adults born preterm and their children
    Sarah Mathai
    Liggins Institute, University of Auckland, Auckland, New Zealand Gravida National Centre for Growth and Development, Auckland, New Zealand
    PLoS ONE 8:e81840. 2013
    ..We therefore aimed to examine body composition and cardiovascular risk factors in adults born preterm and their children...
  4. ncbi request reprint Systolic and diastolic abnormalities reduce the cardiac response to exercise in adolescents with type 2 diabetes
    Teresa E Pinto
    Corresponding author Paul L Hofman
    Diabetes Care 37:1439-46. 2014
    ....
  5. doi request reprint Neurodevelopmental and body composition outcomes in children with congenital hypothyroidism treated with high-dose initial replacement and close monitoring
    Benjamin B Albert
    Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, 1023 Auckland, New Zealand
    J Clin Endocrinol Metab 98:3663-70. 2013
    ..Subsequently, frequent monitoring and dose alterations are performed for 2 years. We aimed to assess whether the Auckland treatment strategy prevents impairment of intellectual and motor development...
  6. pmc Insulin sensitivity and β-cell function in adults born preterm and their children
    Sarah Mathai
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Diabetes 61:2479-83. 2012
    ..In conclusion, adults born preterm have insulin resistance in midadulthood, but this was not associated with insulin resistance in their children...
  7. doi request reprint Etiology of increasing incidence of congenital hypothyroidism in New Zealand from 1993-2010
    Benjamin B Albert
    Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Clin Endocrinol Metab 97:3155-60. 2012
    ..We aimed to determine whether the incidence of CHT in New Zealand has changed and whether ethnic-specific rates and the rates of CHT subtypes have also changed...
  8. pmc Design and testing of an MRI-compatible cycle ergometer for non-invasive cardiac assessments during exercise
    Silmara Gusso
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Biomed Eng Online 11:13. 2012
    ..Magnetic resonance imaging (MRI) is an important tool for cardiac research, and it is frequently used for resting cardiac assessments. However, research into non-pharmacological stress cardiac evaluation is limited...
  9. ncbi request reprint The metabolic consequences of prematurity
    P L Hofman
    Liggins Institute, University of Auckland, 2 6 Park Avenue, Auckland, New Zealand
    Growth Horm IGF Res 14:S136-9. 2004
    ....
  10. ncbi request reprint Premature birth and later insulin resistance
    Paul L Hofman
    Liggins Institute, Faculty of Medicine and Health Science, University of Auckland, Auckland, New Zealand
    N Engl J Med 351:2179-86. 2004
    ....
  11. pmc Defining the ideal injection techniques when using 5-mm needles in children and adults
    Paul Leslie Hofman
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Diabetes Care 33:1940-4. 2010
    ..We aimed to establish the ideal injection techniques using 5-mm needles to reliably inject insulin into the subcutaneous fat in both children and adults and to quantify the associated pain and leakage of the test medium...
  12. ncbi request reprint Prematurity--another example of perinatal metabolic programming?
    P L Hofman
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Horm Res 66:33-9. 2006
    ..We present data demonstrating that premature infants also have metabolic abnormalities similar to those observed in term, SGA children and that these occur irrespective of whether they are SGA or appropriate for gestational age (AGA)...
  13. ncbi request reprint Insulin sensitivity in people born pre-term, with low or very low birth weight and small for gestational age
    P L Hofman
    Liggins Institute, University of Auckland, Auckland, New Zealand
    J Endocrinol Invest 29:2-8. 2006
    ....
  14. ncbi request reprint Combination therapy with acipimox enhances the effect of growth hormone treatment on linear body growth in the normal and small-for-gestational-age rat
    M H Vickers
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Am J Physiol Endocrinol Metab 291:E1212-9. 2006
    ....
  15. ncbi request reprint Neonatal leptin treatment reverses developmental programming
    M H Vickers
    Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland 1020, New Zealand
    Endocrinology 146:4211-6. 2005
    ..The complete normalization of the programmed phenotype by neonatal leptin treatment implies that leptin has effects that reverse the prenatal adaptations resulting from relative fetal undernutrition...
  16. doi request reprint Effect of reduced total blood volume on left ventricular volumes and kinetics in type 2 diabetes
    S Lalande
    Department of Sport and Exercise Science, University of Auckland, Auckland, New Zealand
    Acta Physiol (Oxf) 199:23-30. 2010
    ..The purpose of this study was to examine the influence of LV function and LV loading conditions on stroke volume in men with type 2 diabetes...
  17. ncbi request reprint Evaluation of the buserelin stimulation test in diagnosing gonadotropin deficiency in males with delayed puberty
    Dyanne A Wilson
    Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    J Pediatr 148:89-94. 2006
    ..To assess the efficacy of the gonadotropin-releasing hormone (GnRH) agonist buserelin in a stimulated gonadotropin test for the investigation of delayed puberty in males...
  18. ncbi request reprint An angled insertion technique using 6-mm needles markedly reduces the risk of intramuscular injections in children and adolescents
    P L Hofman
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Diabet Med 24:1400-5. 2007
    ....
  19. ncbi request reprint Massive hepatic hemangioendothelioma and consumptive hypothyroidism
    Frances Mouat
    The Liggins Institute, The University ofAuckland, New Zealand
    J Pediatr Endocrinol Metab 21:701-3. 2008
    ..Large doses of thyroxine were initially required to normalise TSH. Thyroxine was tapered as the tumor regressed and was discontinued at 16 months old. Thyroid function remains normal without treatment...
  20. doi request reprint The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy
    Mark H Vickers
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Endocrinology 149:1906-13. 2008
    ..These data further reinforce the importance of leptin in determining long-term energy homeostasis, and suggest that leptin's effects are modulated by gender and both prenatal and postnatal nutritional status...
  21. ncbi request reprint The endocrine consequences for very low birth weight premature infants
    Wayne S Cutfield
    Department of Paediatrics, Faculty of Medicine and Health Sciences, Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Growth Horm IGF Res 14:S130-5. 2004
    ..Conversely, term SGA children have elevated plasma IGF-I and IGFBP-3 levels. When combined, premature birth plays a more dominant role than SGA on the IGF-IGF binding protein axis...
  22. ncbi request reprint Insulin resistance is not due to persistently elevated serum tumor necrosis-alpha levels in small for gestational age, premature, or twin children
    Craig A Jefferies
    Department of Paediatrics and Liggins Institute, University of Auckland, Auckland, New Zealand
    Pediatr Diabetes 5:20-5. 2004
    ..We hypothesized that an adverse fetal or early neonatal environment for SGA, twin, and premature children leads to persistently elevated TNF-alpha levels that induce insulin resistance in each of these groups...
  23. ncbi request reprint Insulin sensitivity in the offspring of women with type 1 and type 2 diabetes
    Wendy A Hunter
    Liggins Institute, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand
    Diabetes Care 27:1148-52. 2004
    ..To determine if insulin sensitivity is altered in prepubertal offspring exposed to a diabetic intrauterine environment...
  24. ncbi request reprint Insulin resistance in healthy prepubertal twins
    Craig A Jefferies
    Liggins Institute, Health Research Council Biostatistics Unit, Department of Community Health, University of Auckland, Auckland, New Zealand
    J Pediatr 144:608-13. 2004
    ..To evaluate insulin sensitivity (S(I)) in prepubertal twins and to examine the relation to reduced birth weight, prematurity, and peroxisome proliferator-activated receptor-gamma (PPAR gamma) polymorphism...
  25. ncbi request reprint Fetal origins of adult disease: a paediatric perspective
    Harriet L Miles
    Liggins Institute, University of Auckland, Private Bag 92019, New Zealand
    Rev Endocr Metab Disord 6:261-8. 2005
    ..Future research in this field is likely to focus on the mechanisms through which environmental changes lead to these programmed effects...
  26. ncbi request reprint Simple fasting methods to assess insulin sensitivity in childhood
    Wayne S Cutfield
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Horm Res 64:25-31. 2005
    ..However, if the study groups are small or longitudinal changes in insulin sensitivity are sought, more precise techniques such as the clamp or minimal model should be used...
  27. ncbi request reprint IGFs and binding proteins in short children with intrauterine growth retardation
    Wayne S Cutfield
    Department of Pediatrics, University of Auckland, Auckland 92019, New Zealand
    J Clin Endocrinol Metab 87:235-9. 2002
    ..We speculate that hyperinsulinism secondary to insulin resistance may have led to these changes to the IGF-IGFBP axis in the IUGR group...
  28. ncbi request reprint Reduced insulin sensitivity during growth hormone therapy for short children born small for gestational age
    Wayne S Cutfield
    Department of Paediatrics, the Liggins Institue for Medical Research, University of Auckland, Auckland, New Zealand
    J Pediatr 142:113-6. 2003
    ..To examine the influence of recombinant human growth hormone (rhGH) therapy on insulin sensitivity in short children born small for gestational age (SGA)...
  29. ncbi request reprint The impact of early nutrition in premature infants on later childhood insulin sensitivity and growth
    Fiona M Regan
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Pediatrics 118:1943-9. 2006
    ..The etiology of this insulin resistance is unknown. The aim of this study was to evaluate infant nutrition and its influence on insulin sensitivity and postnatal growth in children born < or = 32 weeks' gestation...
  30. ncbi request reprint Could epigenetics play a role in the developmental origins of health and disease?
    Wayne S Cutfield
    Liggins Institute, National Research Centre for Growth and Development, University of Auckland, Department of Pediatrics, New Zealand
    Pediatr Res 61:68R-75R. 2007
    ..The relevance of these animal studies to IVF, SGA, and very premature children are discussed as are potential candidate genes that may have undergone epigenetic modification to alter growth and metabolism...
  31. ncbi request reprint Evaluation of HOMA and QUICKI as measures of insulin sensitivity in prepubertal children
    Wayne S Cutfield
    Department of Paediatrics and the Health Research Council Biostatistics Unit, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Pediatr Diabetes 4:119-25. 2003
    ..The aim of this study was to compare HOMA and QUICKI to the minimal model as measures of SI in prepubertal children...
  32. ncbi request reprint Increased nocturnal blood pressure in healthy prepubertal twins
    Craig A Jefferies
    Department of Paediatrics and Liggins Institute, University of Auckland, New Zealand
    J Hypertens 21:1319-24. 2003
    ..To compare ambulatory blood pressure monitoring (ABPM) in twin children to a published singleton population, and to examine the influence of birthweight and fasting plasma cortisol on blood pressure...
  33. ncbi request reprint In vitro fertilization improves childhood growth and metabolism
    Harriet L Miles
    The National Research Centre for Growth and Development and Liggins Institute, University of Auckland, Auckland 1010, New Zealand
    J Clin Endocrinol Metab 92:3441-5. 2007
    ..There is limited information regarding the long-term outcome of children born after in vitro fertilization (IVF), although an increase in rare imprinted gene disorders such as Beckwith-Wiedemann syndrome has been reported...
  34. doi request reprint Reduced leg blood flow during submaximal exercise in type 2 diabetes
    Sophie Lalande
    Department of Sport and Exercise Science, University of Auckland, Auckland, New Zealand
    Med Sci Sports Exerc 40:612-7. 2008
    ..It is unclear whether impaired cardiac and/or vascular function contribute to exercise intolerance in patients with type 2 diabetes...
  35. ncbi request reprint Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statement
    Craig Munns
    The Children s Hospital at Westmead, Sydney, NSW, Australia
    Med J Aust 185:268-72. 2006
    ..High-dose bolus therapy (300,000-500,000 IU) should be considered for children over 12 months of age if compliance or absorption issues are suspected...