Alistair Jan Gunn

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. pmc LPS and TNF alpha modulate AMPA/NMDA receptor subunit expression and induce PGE2 and glutamate release in preterm fetal ovine mixed glial cultures
    Luke Weaver-Mikaere
    The Liggins Institute, The University of Auckland, 85 Park Rd, Grafton, Private Bag 92019, Auckland 1142, New Zealand
    J Neuroinflammation 10:153. 2013
  2. pmc Synergistic white matter protection with acute-on-chronic endotoxin and subsequent asphyxia in preterm fetal sheep
    Lotte G van den Heuij
    Department of Physiology, University of Auckland, Park Road, Grafton, Auckland 1023, New Zealand
    J Neuroinflammation 11:89. 2014
  3. pmc Maturation of the mitochondrial redox response to profound asphyxia in fetal sheep
    Paul P Drury
    Fetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand
    PLoS ONE 7:e39273. 2012
  4. pmc Pre-existing hypoxia is associated with greater EEG suppression and early onset of evolving seizure activity during brief repeated asphyxia in near-term fetal sheep
    Guido Wassink
    Department of Physiology, University of Auckland, Auckland, New Zealand
    PLoS ONE 8:e73895. 2013
  5. ncbi Ontogeny and control of the heart rate power spectrum in the last third of gestation in fetal sheep
    Miriam E Koome
    A J Gunn Fetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Exp Physiol 99:80-8. 2014
  6. ncbi A key role for connexin hemichannels in spreading ischemic brain injury
    Joanne O Davidson
    Department of Physiology, The University of Auckland, Auckland, New Zealand
    Curr Drug Targets 14:36-46. 2013
  7. ncbi Nonadditive neuroprotection with early glutamate receptor blockade and delayed hypothermia after asphyxia in preterm fetal sheep
    Sherly A George
    Department of Physiology, The University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    Stroke 43:3114-7. 2012
  8. ncbi Subclinical exposure to low-dose endotoxin impairs EEG maturation in preterm fetal sheep
    Michael J Keogh
    Department of Physiology, University of Auckland, New Zealand
    Am J Physiol Regul Integr Comp Physiol 303:R270-8. 2012
  9. ncbi Therapeutic hypothermia: from lab to NICU
    Alistair Jan Gunn
    University of Auckland, Auckland, New Zealand
    J Perinat Med 33:340-6. 2005
  10. pmc Fetal hypoxia insults and patterns of brain injury: insights from animal models
    Alistair Jan Gunn
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, 85 Park Road, Grafton, Auckland 1023, New Zealand
    Clin Perinatol 36:579-93. 2009

Collaborators

Detail Information

Publications73

  1. pmc LPS and TNF alpha modulate AMPA/NMDA receptor subunit expression and induce PGE2 and glutamate release in preterm fetal ovine mixed glial cultures
    Luke Weaver-Mikaere
    The Liggins Institute, The University of Auckland, 85 Park Rd, Grafton, Private Bag 92019, Auckland 1142, New Zealand
    J Neuroinflammation 10:153. 2013
    ..The current study explores the therapeutic potential of glutamate receptor blockade or cyclooxygenase-2 (COX-2) inhibition for inflammatory WMI...
  2. pmc Synergistic white matter protection with acute-on-chronic endotoxin and subsequent asphyxia in preterm fetal sheep
    Lotte G van den Heuij
    Department of Physiology, University of Auckland, Park Road, Grafton, Auckland 1023, New Zealand
    J Neuroinflammation 11:89. 2014
    ..In this study we tested the hypothesis that acute-on-chronic exposure to lipopolysaccharide (LPS) would exacerbate white matter injury after subsequent asphyxia in preterm fetal sheep...
  3. pmc Maturation of the mitochondrial redox response to profound asphyxia in fetal sheep
    Paul P Drury
    Fetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand
    PLoS ONE 7:e39273. 2012
    ..This study examined the hypothesis that this is associated with impaired mitochondrial adaptation, as measured by more rapid oxidation of cytochrome oxidase (CytOx) during profound asphyxia...
  4. pmc Pre-existing hypoxia is associated with greater EEG suppression and early onset of evolving seizure activity during brief repeated asphyxia in near-term fetal sheep
    Guido Wassink
    Department of Physiology, University of Auckland, Auckland, New Zealand
    PLoS ONE 8:e73895. 2013
    ....
  5. ncbi Ontogeny and control of the heart rate power spectrum in the last third of gestation in fetal sheep
    Miriam E Koome
    A J Gunn Fetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Exp Physiol 99:80-8. 2014
    ..This study does not support substantial, consistent differences between the frequencies of sympathetic and parasympathetic activity in late-gestation fetal sheep. ..
  6. ncbi A key role for connexin hemichannels in spreading ischemic brain injury
    Joanne O Davidson
    Department of Physiology, The University of Auckland, Auckland, New Zealand
    Curr Drug Targets 14:36-46. 2013
    ....
  7. ncbi Nonadditive neuroprotection with early glutamate receptor blockade and delayed hypothermia after asphyxia in preterm fetal sheep
    Sherly A George
    Department of Physiology, The University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    Stroke 43:3114-7. 2012
    ..7 weeks gestation (equivalent to 28-32 weeks in humans)...
  8. ncbi Subclinical exposure to low-dose endotoxin impairs EEG maturation in preterm fetal sheep
    Michael J Keogh
    Department of Physiology, University of Auckland, New Zealand
    Am J Physiol Regul Integr Comp Physiol 303:R270-8. 2012
    ..These data suggest that low-dose endotoxin exposure can impair EEG maturation in preterm fetal sheep in association with neural inflammation but without hemodynamic disturbances or cortical injury...
  9. ncbi Therapeutic hypothermia: from lab to NICU
    Alistair Jan Gunn
    University of Auckland, Auckland, New Zealand
    J Perinat Med 33:340-6. 2005
    ..Both long-term followup studies and further large studies of whole body cooling are in progress...
  10. pmc Fetal hypoxia insults and patterns of brain injury: insights from animal models
    Alistair Jan Gunn
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, 85 Park Road, Grafton, Auckland 1023, New Zealand
    Clin Perinatol 36:579-93. 2009
    ....
  11. ncbi Brain cooling for preterm infants
    Alistair Jan Gunn
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Clin Perinatol 35:735-48, vi-vii. 2008
    ..Induced hypothermia likely has potential to significantly reduce disability. Cautious, systematic trials are essential before hypothermia can be used in these vulnerable infants...
  12. ncbi Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy
    Alistair J Gunn
    Department of Physiology, University of Auckland, Auckland, New Zealand
    J Pediatr 152:55-8, 58.e1. 2008
    ..To evaluate whether therapeutic hypothermia alters the prognostic value of clinical grading of neonatal encephalopathy...
  13. ncbi Head cooling for neonatal encephalopathy: the state of the art
    Alistair Jan Gunn
    Department of Physiology, The University of Auckland, Auckland, New Zealand
    Clin Obstet Gynecol 50:636-51. 2007
    ..The key remaining issues are to finding better ways of identifying babies who are most likely to benefit, to define the optimal mode and conditions of hypothermia and to find ways to further improve the effectiveness of treatment...
  14. pmc Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs
    A J Gunn
    Research Centre for Developmental Medicine and Biology, Department of Paediatrics, School of Medicine, University of Auckland, New Zealand
    J Clin Invest 99:248-56. 1997
    ..g., 40 vs. 99% in the parasagittal cortex, P < 0.001). Selective head cooling, maintained throughout the secondary phase of injury, is noninvasive and safe and shows potential for improving neonatal outcome after perinatal asphyxia...
  15. pmc Hypothermic neuroprotection
    A J Gunn
    Dept of Physiology, The University of Auckland, New Zealand
    NeuroRx 3:154-69. 2006
    ..These studies, however, show that only a subset of babies seemed to benefit. The challenge for the future is to find ways of improving the effectiveness of treatment...
  16. ncbi The premature fetus: not as defenseless as we thought, but still paradoxically vulnerable?
    A J Gunn
    Liggins Institute and Department of Pediatrics, University of Auckland, New Zealand
    Dev Neurosci 23:175-9. 2001
    ....
  17. ncbi The 'pharmacology' of neuronal rescue with cerebral hypothermia
    A J Gunn
    Department of Paediatrics, Research Centre for Developmental Medicine and Biology, University of Auckland, New Zealand
    Early Hum Dev 53:19-35. 1998
    ..These encouraging results must be balanced against the adverse systemic effects of hypothermia. Randomised clinical trials are in progress to establish the safety and efficacy of prolonged cerebral hypothermia...
  18. ncbi Is temperature important in delivery room resuscitation?
    A J Gunn
    Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, Auckland, New Zealand
    Semin Neonatol 6:241-9. 2001
    ....
  19. ncbi Bibliometric analysis of HRC-supported biomedical publications, 1990 to 1994
    A J Gunn
    Department of Paediatrics, University of Auckland
    N Z Med J 112:351-4. 1999
    ....
  20. ncbi Does early hospital discharge with home support of families with preterm infants affect breastfeeding success? A randomized trial
    T R Gunn
    Department of Paediatrics, University of Auckland, New Zealand
    Acta Paediatr 89:1358-63. 2000
    ..8% vs 11.9% at 6 wk, p = 0.37)...
  21. pmc Antenatal dexamethasone after asphyxia increases neural injury in preterm fetal sheep
    Miriam E Koome
    Department of Physiology, The University of Auckland, Auckland New Zealand
    PLoS ONE 8:e77480. 2013
    ..We investigated the effect of maternal glucocorticoid exposure after acute asphyxia on injury in the preterm brain...
  22. ncbi Window of opportunity of cerebral hypothermia for postischemic white matter injury in the near-term fetal sheep
    Vincent Roelfsema
    The Liggins Institute, University of Auckland, Auckland, New Zealand
    J Cereb Blood Flow Metab 24:877-86. 2004
    ..Protection was closely associated with reduced expression of both activated caspase-3 and of reactive microglia...
  23. ncbi Dopamine infusion for postresuscitation blood pressure support after profound asphyxia in near-term fetal sheep
    Paul P Drury
    Departments of Physiology and Paediatrics, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    Exp Physiol 98:699-709. 2013
    ..05]. In conclusion, dopamine infusion delayed but did not prevent terminal hypotension after severe asphyxia...
  24. ncbi The ontogeny of hemodynamic responses to prolonged umbilical cord occlusion in fetal sheep
    Guido Wassink
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Appl Physiol 103:1311-7. 2007
    ....
  25. ncbi Regulation of cytochrome oxidase redox state during umbilical cord occlusion in preterm fetal sheep
    Laura Bennet
    Department of Physiology, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Am J Physiol Regul Integr Comp Physiol 292:R1569-76. 2007
    ..In conclusion, these data strongly suggest active regulation of cerebral metabolism during the initial response to severe hypoxia, which may help to protect the immature brain from injury...
  26. pmc The effect of cerebral hypothermia on white and grey matter injury induced by severe hypoxia in preterm fetal sheep
    L Bennet
    Department of Physiology and Paediatrics, University of Auckland, Auckland, New Zealand
    J Physiol 578:491-506. 2007
    ..Further studies are required to evaluate the long-term impact of cooling on brain growth and maturation...
  27. ncbi Induced cerebral hypothermia reduces post-hypoxic loss of phenotypic striatal neurons in preterm fetal sheep
    S George
    Department of Physiology, Faculty of Medicine and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Exp Neurol 203:137-47. 2007
    ..These findings suggest that head cooling may help reduce basal ganglia injury in some premature babies...
  28. ncbi Effect of cerebral hypothermia and asphyxia on the subventricular zone and white matter tracts in preterm fetal sheep
    Robert Daniel Barrett
    Department of Physiology, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    Brain Res 1469:35-42. 2012
    ..Although white matter protection with cerebral hypothermia was associated with reduced proliferation in the white matter tracts, it did not impair proliferation in the SVZ...
  29. ncbi Differential effects of hypothermia on early and late epileptiform events after severe hypoxia in preterm fetal sheep
    L Bennet
    Department of Physiology, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Neurophysiol 97:572-8. 2007
    ....
  30. pmc Partial neuroprotection by nNOS inhibition during profound asphyxia in preterm fetal sheep
    Paul P Drury
    Department of Physiology, University of Auckland, Auckland, New Zealand Electronic address
    Exp Neurol 250:282-92. 2013
    ....
  31. ncbi Destruction and reconstruction: hypoxia and the developing brain
    Robert D Barrett
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Birth Defects Res C Embryo Today 81:163-76. 2007
    ..Based on these concepts the impact of proposed interventions such as induced hypothermia and endogenous growth factors are likely to be complex, but potentially offer focused ways of improving the outcomes of premature birth...
  32. ncbi Does head cooling with mild systemic hypothermia affect requirement for blood pressure support?
    Malcolm R Battin
    Newborn Services, National Women s Health, Auckland City Hospital, Private Bag 92 024, Auckland, New Zealand
    Pediatrics 123:1031-6. 2009
    ..Our goal was to evaluate whether head cooling with mild systemic hypothermia for neonatal encephalopathy is associated with greater requirement for volume or inotrope support...
  33. ncbi Connexin hemichannel blockade improves outcomes in a model of fetal ischemia
    Joanne O Davidson
    Department of Physiology, University of Auckland, Auckland, New Zealand
    Ann Neurol 71:121-32. 2012
    ..In this study, we tested the hypothesis that opening of hemichannels after cerebral ischemia may contribute to delayed evolution of injury...
  34. ncbi The effect of mild hypothermia on insulin-like growth factors after severe asphyxia in the preterm fetal sheep
    Vincent Roelfsema
    Department of Physiology, University of Auckland, Auckland, New Zealand
    J Soc Gynecol Investig 12:232-7. 2005
    ..The aim of this study was to examine the effects of prenatal asphyxia and cerebral hypothermia on changes in IGF-I and -II, IGF-binding protein 1 (IGFBP-1), and insulin levels...
  35. ncbi Transient NMDA receptor-mediated hypoperfusion following umbilical cord occlusion in preterm fetal sheep
    Justin M Dean
    Department of Physiology, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Exp Physiol 91:423-33. 2006
    ..The timing of this effect in the cerebral circulation corresponds closely to abnormal EEG activity, suggesting a pathological glutaminergic activation that we speculate is related to evolving brain injury...
  36. ncbi The incidence, clinical features, and treatment of type 2 diabetes in children <15 yr in a population-based cohort from Auckland, New Zealand, 1995–2007
    Craig Jefferies
    Starship Children s Hospital, Auckland District Health Board, Auckland, New Zealand
    Pediatr Diabetes 13:294-300. 2012
    ..The incidence of type 2 diabetes mellitus (T2DM) is increasing in adolescents in most western countries. The time-course of glycemic control and impact of early treatment remain poorly understood...
  37. ncbi ST waveform changes during repeated umbilical cord occlusions in near-term fetal sheep
    J A Westgate
    Department of Obstetrics and Gynecology and the Research Centre for Developmental Medicine and Biology, University of Auckland, New Zealand
    Am J Obstet Gynecol 184:743-51. 2001
    ..Interocclusion waveform height may be a better reflection of the severity of hypoxia. The appearance of biphasic and negative waveforms between occlusions may be a useful marker for severe decompensation...
  38. ncbi The fetal heart rate response to hypoxia: insights from animal models
    Laura Bennet
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Clin Perinatol 36:655-72. 2009
    ....
  39. ncbi Polyuria and impaired renal blood flow after asphyxia in preterm fetal sheep
    J S Quaedackers
    The Liggins Institute, The University of Auckland, Auckland, New Zealand
    Am J Physiol Regul Integr Comp Physiol 286:R576-83. 2004
    ..Despite a prolonged increase in RVR, there was only a modest effect on glomerular function...
  40. ncbi Endogenous alpha2-adrenergic receptor-mediated neuroprotection after severe hypoxia in preterm fetal sheep
    J M Dean
    Department of Physiology, Faculty of Medicine and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neuroscience 142:615-28. 2006
    ..01; r(2)=0.7). In conclusion, endogenous inhibitory alpha(2)-adrenergic receptor activation after severe hypoxia appears to significantly limit evolving hippocampal damage in the immature brain...
  41. pmc Maternal dexamethasone and EEG hyperactivity in preterm fetal sheep
    Joanne O Davidson
    Fetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    J Physiol 589:3823-35. 2011
    ..We postulate that these effects may contribute to improved neonatal outcomes...
  42. ncbi Neural plasticity and the Kennard principle: Does it work for the preterm brain?
    Laura Bennet
    Fetal Physiology and Neuroscience Groups, Department of Physiology, University of Auckland, Auckland, New Zealand
    Clin Exp Pharmacol Physiol 40:774-84. 2013
    ....
  43. ncbi Spontaneous hypoxia in multiple pregnancies is associated with early fetal decompensation and enhanced T-wave elevation during brief repeated cord occlusion in near-term fetal sheep
    Jenny A Westgate
    Department of Physiology, University of Auckland, Auckland, New Zealand
    Am J Obstet Gynecol 193:1526-33. 2005
    ....
  44. ncbi Missed congenital hypothyroidism in an identical twin
    Anita Azam
    Starship Children s Hospital, Auckland, New Zealand
    J Paediatr Child Health 48:936-8. 2012
    ..It is important to maintain a high index of suspicion in same-sex twin pregnancies of potential congenital hypothyroidism...
  45. ncbi Insulin-like growth factor (IGF)-1 suppresses oligodendrocyte caspase-3 activation and increases glial proliferation after ischemia in near-term fetal sheep
    Yun Cao
    The Liggins Institute, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
    J Cereb Blood Flow Metab 23:739-47. 2003
    ..In contrast, the increase in reactive glia was related only to proliferation. Speculatively, reactive glia may partly mediate IGF-1 white matter protection...
  46. ncbi Selective neuroprotective effects with insulin-like growth factor-1 in phenotypic striatal neurons following ischemic brain injury in fetal sheep
    J Guan
    Research Center for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand
    Neuroscience 95:831-9. 2000
    ..These data suggest a potential role for insulin-like growth factor-1 in preventing cerebral palsy due to perinatal asphyxia...
  47. ncbi Hypoxic-ischemic brain injury in the newborn: pathophysiology and potential strategies for intervention
    P D Gluckman
    The Liggins Institute for Medical Research, The University of Auckland, Auckland 1, New Zealand
    Semin Neonatol 6:109-20. 2001
    ..Application of this knowledge will allow us to identify strategies for early intervention and prevent the course of damage caused by hypoxic-ischemic injury...
  48. pmc Differential changes in insulin-like growth factors and their binding proteins following asphyxia in the preterm fetal sheep
    L Bennet
    Research Centre for Developmental Medicine and Biology, Department of Paediatrics, The University of Auckland, Auckland, New Zealand
    J Physiol 531:835-41. 2001
    ..Alternatively, as IGFs play a role in wound repair, the acute changes in IGF-I and IGFBP-1 may reflect transport of IGF-I from the circulatory pool to injured tissues to promote wound repair...
  49. pmc The cardiovascular and cerebrovascular responses of the immature fetal sheep to acute umbilical cord occlusion
    L Bennet
    Research Centre for Developmental Medicine and Biology, Department of Paediatrics, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Physiol 517:247-57. 1999
    ..These cardiovascular and cerebrovascular responses may contribute to the patterns of cerebral injury seen in the human preterm fetus...
  50. ncbi Insulin-like growth factor-1 and post-ischemic brain injury
    J Guan
    Faculty of Medicine and Health Sciences, The Liggins Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Prog Neurobiol 70:443-62. 2003
    ..Such a combined approach is likely to be essential for any clinical treatment...
  51. ncbi Potential role for growth hormone in human lactation insufficiency
    S R Milsom
    Research Centre for Developmental Medicine and Biology, University of Auckland, New Zealand
    Horm Res 50:147-50. 1998
    ..2 IU/kg/day (n = 6) but by only 4.7 +/- 9.7%, (p < 0.04) in the combined lower dose group (n = 10). In conclusion, these data suggest that moderate dose hGH therapy in mothers with lactation insufficiency can improve galactopoiesis...
  52. ncbi Fetal heart rate overshoot during repeated umbilical cord occlusion in sheep
    J A Westgate
    Department of Obstetrics and Gynecology, University of Auckland, Auckland, New Zealand
    Obstet Gynecol 97:454-9. 2001
    ..To assess the clinical utility of overshoot fetal heart rate (FHR) decelerations by examining their occurrence after umbilical cord occlusions of varying frequency and length in near-term fetal sheep...
  53. ncbi Treatment in animal models
    J Guan
    The Liggins Institute, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand
    Endocr Dev 9:31-43. 2005
    ..Peripheral administration of GPE also prevents the loss of dopamine neurons and improves long-term functional recovery following 6-OHDA lesion. However, GPE is unlikely to contribute significantly to the direct effects of IGF-1...
  54. pmc Relationship between evolving epileptiform activity and delayed loss of mitochondrial activity after asphyxia measured by near-infrared spectroscopy in preterm fetal sheep
    L Bennet
    Department of Physiology, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Physiol 572:141-54. 2006
    ..In contrast, the combination of relative cerebral deoxygenation with evolving epileptiform transients in the early recovery phase raises the possibility that these early events accelerate or worsen the subsequent mitochondrial failure...
  55. ncbi Acute systemic complications in the preterm fetus after asphyxia: role of cardiovascular and blood flow responses
    L Bennet
    Department of Physiology, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand
    Clin Exp Pharmacol Physiol 33:291-9. 2006
    ..4. This knowledge is essential to develop and refine ways of improving perfusion of the kidneys and other vital organs in premature babies...
  56. ncbi Adenosine A(1) receptor mediated suppression of adrenal activity in near-term fetal sheep
    E C Jensen
    Dept of Physiology, Faculty of Medical and Health Sciences, The Univ of Auckland, Auckland, New Zealand
    Am J Physiol Regul Integr Comp Physiol 298:R700-6. 2010
    ..In conclusion, fetal cortisol concentrations are suppressed by adenosine A(1) receptor activity, largely though a direct adrenal mechanism. This suppression can be partially overcome by supraphysiological stimuli such as asphyxia...
  57. pmc Potential biomarkers for hypoxic-ischemic encephalopathy
    L Bennet
    Fetal Physiology and Neuroscience Group, Department of Physiology, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Semin Fetal Neonatal Med 15:253-60. 2010
    ..This is an important area for further research...
  58. pmc The neural and vascular effects of killed Su-Streptococcus pyogenes (OK-432) in preterm fetal sheep
    L Bennet
    Department of Physiology, The University of Auckland, New Zealand
    Am J Physiol Regul Integr Comp Physiol 299:R664-72. 2010
    ..We conclude that a single low-dose injection of OK-432 can be associated with risk of focal cerebral injury in the preterm fetus and chronic central and peripheral vasodilatation that does not appear to be mediated by nitric oxide...
  59. ncbi Randomized controlled trial of a car safety seat insert to reduce hypoxia in term infants
    Christine G McIntosh
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Pediatrics 132:326-31. 2013
    ..To test the hypothesis that a foam plastic insert that allows the infant head to rest in a neutral position in sleep may prevent obstruction of the upper airway and thus reduce episodes of reduced oxygenation in term infants in car seats...
  60. pmc Glucocorticoids and preterm hypoxic-ischemic brain injury: the good and the bad
    Laura Bennet
    Fetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland 1142, New Zealand
    J Pregnancy 2012:751694. 2012
    ..We review the clinical and experimental evidence on how glucocorticoids may affect the developing brain and highlight the need for systematic research...
  61. ncbi Impact of insulin pumps on glycaemic control in a pump-naïve paediatric regional population
    Martin de Bock
    The Liggins Institute Department of Physiology, University of Auckland, Auckland, New Zealand
    J Paediatr Child Health 48:247-52. 2012
    ..To examine the clinical impact of insulin-pump therapy for children with type 1 diabetes mellitus (T1DM) in a regional paediatric service, Auckland, New Zealand...
  62. ncbi Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia
    M R Battin
    Newborn Service, National Women s Hospital, Auckland, New Zealand
    Pediatrics 107:480-4. 2001
    ..To determine the neurodevelopmental outcome of infants treated with head cooling with systemic hypothermia after hypoxic-ischemic encephalopathy...
  63. ncbi What brakes the preterm brain? An arresting story
    Justin M Dean
    Department of Physiology, University of Auckland, Auckland, New Zealand
    Pediatr Res 75:227-33. 2014
    ..These findings offer the promise that better understanding of impairment of neural connectivity may allow us to promote normal development and growth of the cortex after preterm birth. ..
  64. pmc Post-hypoxic hypoperfusion is associated with suppression of cerebral metabolism and increased tissue oxygenation in near-term fetal sheep
    E C Jensen
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Physiol 572:131-9. 2006
    ..These data suggest that posthypoxic hypoperfusion is actively mediated and reflects suppressed cerebral metabolism...
  65. ncbi Insulin-like growth factor-1 reduces postischemic white matter injury in fetal sheep
    J Guan
    Research Center for Developmental Medicine and Biology, Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
    J Cereb Blood Flow Metab 21:493-502. 2001
    ..After ischemia there was a close association of PLP mRNA labeled cells with reactive astrocytes and macrophages/microglia. In conclusion, IGF-1 can prevent delayed, postischemic oligodendrocyte cell loss and associated demyelination...
  66. pmc Apparently life threatening events in infant car safety seats
    Shirley L Tonkin
    New Zealand Cot Death Association, Auckland, New Zealand
    BMJ 333:1205-6. 2006
  67. ncbi Initial growth deceleration during GnRH analogue therapy for precocious puberty
    Frances Mouat
    The Liggins Institute, University of Auckland, Auckland, New Zealand
    Clin Endocrinol (Oxf) 70:751-6. 2009
    ..To compare the efficacy of goserelin and leuprolide on initial deceleration of growth and weight gain during the first 12 months of GnRH analogue treatment for precocious puberty...
  68. ncbi Ethnicity and social deprivation independently influence metabolic control in children with type 1 diabetes
    P J Carter
    Paediatric Diabetes Service, Greenlane Clinical Centre, Starship Children s Health, Auckland, New Zealand
    Diabetologia 51:1835-42. 2008
    ....
  69. ncbi The impact of ethnicity on the presentation of polycystic ovarian syndrome
    K Williamson
    Department of Reproductive Medicine, National Women's Hospital, Auckland, New Zealand
    Aust N Z J Obstet Gynaecol 41:202-6. 2001
    ..The adverse metabolic profile of many of these women, particularly the Maori and Pacific Islanders, is very likely to predispose them to early cardiovascular disease...
  70. ncbi What is the mechanism of sudden infant deaths associated with co-sleeping?
    Christine G McIntosh
    Dept of Physiology, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    N Z Med J 122:69-75. 2009
    ..Further research is needed, but on present evidence, all parents should be advised to sleep their baby in a cot or similar next to their parent's bed, until baby is at least 6 months of age...
  71. ncbi Memories of the fetal heart
    Laura Bennet
    Am J Physiol Regul Integr Comp Physiol 285:R517-8. 2003