P Guilford

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. ncbi request reprint E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition
    Augustine Chen
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin 9054, New Zealand
    BMC Cancer 14:552. 2014
  2. pmc Increased levels of active c-Src distinguish invasive from in situ lobular lesions
    Donghui Zou
    Cancer Genetics Laboratory, Biochemistry Department, University of Otago, 710 Cumberland St, Dunedin 9054, Aotearoa New Zealand
    Breast Cancer Res 11:R45. 2009
  3. pmc A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population
    Soroush Nasri
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin 9054, Aotearoa New Zealand
    BMC Cancer 8:138. 2008
  4. ncbi request reprint The inherited susceptibility to cancer
    P Guilford
    Biochemistry Department, University of Otago, Dunedin, New Zealand
    Cell Mol Life Sci 57:589-603. 2000
  5. ncbi request reprint E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer
    P J Guilford
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Hum Mutat 14:249-55. 1999
  6. ncbi request reprint E-cadherin germline mutations in familial gastric cancer
    P Guilford
    Cancer Genetics Laboratory, Biochemistry Department, University of Otago, Dunedin, Aotearoa New Zealand
    Nature 392:402-5. 1998
  7. ncbi request reprint Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene
    H More
    Cancer Genetics Laboratory, University of Otago, Dunedin, Aotearoa, New Zealand
    Hum Mutat 28:203. 2007
  8. ncbi request reprint Hereditary diffuse gastric cancer
    A Dunbier
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Adv Cancer Res 83:55-65. 2001
  9. ncbi request reprint E-cadherin downregulation in cancer: fuel on the fire?
    P Guilford
    Cancer Genetics Laboratory, Biochemistry Dept, University of Otago, PO Box 56, Dunedin, New Zealand
    Mol Med Today 5:172-7. 1999
  10. doi request reprint Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades
    J J Evans
    Department of Obstetrics and Gynaecology, University of Otago, Christchurch, Christchurch, New Zealand
    Gynecol Oncol 125:214-9. 2012

Collaborators

  • Alpha S Yap
  • J J Evans
  • W M Grady
  • A Miller
  • J M Limacher
  • Robyn Lynne Ward
  • A Ramos de la Medina
  • D Shaw
  • Peter A Daly
  • Stephane Richard
  • D Forman
  • L H J Looijenga
  • David Cohen
  • N M Lindor
  • Kelly Anne Phillips
  • C Dode
  • H More
  • Augustine Chen
  • B Humar
  • F Graziano
  • Donghui Zou
  • Bostjan Humar
  • Soroush Nasri
  • A Ramos-de la Medina
  • W Weber
  • A Charlton
  • E A Rapley
  • Rashmi Priya
  • Henry Beetham
  • Joanne Guest
  • Bryony J Telford
  • George A R Wiggins
  • Tanis D Godwin
  • Michael A Black
  • A Dunbier
  • Han Seung Yoon
  • David Perez
  • Ahmad Anjomshoaa
  • Ryuji Fukuzawa
  • Emily Wilson
  • Cushla McKinney
  • Mauro Magnani
  • Tony Merriman
  • Annamaria Ruzzo
  • Helen More
  • Anita Dunbier
  • Francesco Graziano
  • E Acosta
  • M Harlan
  • C Lintott
  • A M Ruzzo
  • G Suriano
  • B Boman
  • P Ferreira
  • R Seruca
  • A Christian
  • L J Ortiz
  • J H Donohue
  • A Gamboa
  • H Medina-Franco
  • M H Greene
  • L Liubchenko
  • S A Tjulandin
  • S Hockley
  • K Tucker
  • G Crockford
  • L Johnson
  • R Lohynska
  • M McMaster
  • K Heimdal
  • A Heidenreich
  • D Easton
  • D T Oliver
  • H Stoll
  • M Friedlander
  • S D Fossa
  • V Blair
  • L Einhorn
  • E Olah
  • M A S Jewett
  • I Bodrogi
  • S Parry
  • W J Ormiston
  • W Warren
  • L Geczi
  • M R Stratton
  • D Hogg
  • R Huddart
  • G Daugaard
  • D T Bishop

Detail Information

Publications20

  1. ncbi request reprint E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition
    Augustine Chen
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin 9054, New Zealand
    BMC Cancer 14:552. 2014
    ..Its downregulation is commonly observed in epithelial tumours and is a hallmark of the epithelial to mesenchymal transition (EMT)...
  2. pmc Increased levels of active c-Src distinguish invasive from in situ lobular lesions
    Donghui Zou
    Cancer Genetics Laboratory, Biochemistry Department, University of Otago, 710 Cumberland St, Dunedin 9054, Aotearoa New Zealand
    Breast Cancer Res 11:R45. 2009
    ..Here, we investigated whether c-Src kinase, an established inducer of invasive states, contributes to the progression from ALH/LCIS to ILC...
  3. pmc A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population
    Soroush Nasri
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin 9054, Aotearoa New Zealand
    BMC Cancer 8:138. 2008
    ..Recently, a new regulatory region essential for CDH1 transcription has been identified in CDH1 intron 2...
  4. ncbi request reprint The inherited susceptibility to cancer
    P Guilford
    Biochemistry Department, University of Otago, Dunedin, New Zealand
    Cell Mol Life Sci 57:589-603. 2000
    ..All the recessively inherited genes have been implicated in the maintenance of genome stability. This review summarises our current understanding of the functions of the major cancer susceptibility genes...
  5. ncbi request reprint E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer
    P J Guilford
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Hum Mutat 14:249-55. 1999
    ..These results demonstrate that germline mutation of the E-cadherin gene is a common cause of hereditary diffuse gastric cancer and suggest a role for these mutations in the incidence of breast cancer...
  6. ncbi request reprint E-cadherin germline mutations in familial gastric cancer
    P Guilford
    Cancer Genetics Laboratory, Biochemistry Department, University of Otago, Dunedin, Aotearoa New Zealand
    Nature 392:402-5. 1998
    ..These results describe, to our knowledge for the first time, a molecular basis for familial gastric cancer, and confirm the important role of E-cadherin mutations in cancer...
  7. ncbi request reprint Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene
    H More
    Cancer Genetics Laboratory, University of Otago, Dunedin, Aotearoa, New Zealand
    Hum Mutat 28:203. 2007
    ..Together with the occurrence of extra-gastric tumours such as lobular breast and colorectal cancer, these findings further extend the types of CDH1 mutations and the spectrum of tumours associated with HDGC...
  8. ncbi request reprint Hereditary diffuse gastric cancer
    A Dunbier
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Adv Cancer Res 83:55-65. 2001
    ..Here, we review the identified families, mutations, and proposed mechanisms by which E-cadherin loss promotes tumorigenesis...
  9. ncbi request reprint E-cadherin downregulation in cancer: fuel on the fire?
    P Guilford
    Cancer Genetics Laboratory, Biochemistry Dept, University of Otago, PO Box 56, Dunedin, New Zealand
    Mol Med Today 5:172-7. 1999
    ..Germline mutation of the E-cadherin gene predisposes to diffuse, poorly differentiated gastric cancer, and its downregulation in sporadic tumours is associated with poor clinical prognosis...
  10. doi request reprint Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades
    J J Evans
    Department of Obstetrics and Gynaecology, University of Otago, Christchurch, Christchurch, New Zealand
    Gynecol Oncol 125:214-9. 2012
    ..The study investigated characteristics of adrenomedullin in endometrial cancer to assist in identifying targets for developing treatments...
  11. ncbi request reprint Single nucleotide polymorphisms (SNPs) at CDH1 promoter region in familial gastric cancer
    A Ramos-de la Medina
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Rev Esp Enferm Dig 98:36-41. 2006
    ..Germline mutations in the E-cadherin gene (CHD1) have been described that result in the development of diffuse hereditary gastric cancer in young patients...
  12. pmc Chromoendoscopic surveillance in hereditary diffuse gastric cancer: an alternative to prophylactic gastrectomy?
    D Shaw
    Tauranga Hospital, Private Bag 12 024, Tauranga, New Zealand
    Gut 54:461-8. 2005
    ..The results of annual chromoendoscopic surveillance using the methylene blue/congo red technique in 33 mutation carriers over a five year period are described...
  13. pmc Somatic mutations of KIT in familial testicular germ cell tumours
    E A Rapley
    Section of Cancer Genetics, Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK
    Br J Cancer 90:2397-401. 2004
    ..They also lend support to the hypothesis that KIT mutations primarily take place during embryogenesis such that primordial germ cells with KIT mutations are distributed to both testes...
  14. pmc Hereditary diffuse gastric cancer: predominance of multiple foci of signet ring cell carcinoma in distal stomach and transitional zone
    A Charlton
    Department of Pathology, Middlemore Hospital, Otahuhu, Auckland, New Zealand
    Gut 53:814-20. 2004
    ..We aimed to describe the size and distribution of foci in relation to mucosal zones and anatomical location...
  15. ncbi request reprint The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice
    F Graziano
    Medical Oncology Unit, Hospital of Urbino, Italy
    Ann Oncol 14:1705-13. 2003
    ..CDH1 promoter hypermethylation seems a key event in the carcinogenetic process of poorly differentiated, diffuse gastric cancer and it deserves further investigation as a new target for anticancer therapies with demethylating agents...
  16. ncbi request reprint A YAC contig and an EST map in the pericentromeric region of chromosome 13 surrounding the loci for neurosensory nonsyndromic deafness (DFNB1 and DFNA3) and limb-girdle muscular dystrophy type 2C (LGMD2C)
    P Guilford
    Unite de Genetique Moleculaire Humaine, URA CNRS 1968, Institut Pasteur, Paris, France
    Genomics 29:163-9. 1995
    ..YAC screening of a cDNA library derived from mouse cochlea allowed us to identify an alpha-tubulin gene (TUBA2) that was subsequently precisely mapped within the candidate region...
  17. ncbi request reprint A non-syndrome form of neurosensory, recessive deafness maps to the pericentromeric region of chromosome 13q
    P Guilford
    Unite de Genetique Moleculaire Humaine, URA CNRS 1445, Institut Pasteur, Paris, France
    Nat Genet 6:24-8. 1994
    ..These data map this neurosensory deafness gene to the same region of chromosome 13q as the gene for severe, childhood autosomal recessive muscular dystrophy...
  18. ncbi request reprint A human gene responsible for neurosensory, non-syndromic recessive deafness is a candidate homologue of the mouse sh-1 gene
    P Guilford
    Unite de Genetique Moleculaire Humaine, Institut Pasteur, Paris, France
    Hum Mol Genet 3:989-93. 1994
    ..The murine homologue of OMP is tightly linked to the autosomal recessive deafness gene sh-1. These results, and clinical data, suggest that NSRD2 is the human homologue of the mouse sh-1 gene...
  19. ncbi request reprint A gene responsible for a dominant form of neurosensory non-syndromic deafness maps to the NSRD1 recessive deafness gene interval
    H Chaib
    Unite de Genetique Moleculaire Humaine, URA CNRS 1445, Institut Pasteur, Paris, France
    Hum Mol Genet 3:2219-22. 1994
    ..A multipoint analysis gave a maximum lod score of 4.66 with a most likely location close to locus D13S175. This suggests that different mutations in NSRD1 may cause both dominant and recessive neurosensory deafness...
  20. ncbi request reprint Defective myosin VIIA gene responsible for Usher syndrome type 1B
    D Weil
    Unité de Génétique Moléculaire Humaine URA CNRS 1968, Institut Pasteur, Paris, France
    Nature 374:60-1. 1995
    ..Thus USH1B appears as a primary cytoskeletal protein defect. These results implicate the genes encoding other unconventional myosins and their interacting proteins as candidates for other genetic forms of Usher syndrome...