D R Grattan

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. ncbi request reprint The actions of prolactin in the brain during pregnancy and lactation
    D R Grattan
    Department of Anatomy and Structural Biology, School of Medical Sciences, Neuroscience Research Centre, University of Otago, P O Box 913, Dunedin, New Zealand
    Prog Brain Res 133:153-71. 2001
  2. doi request reprint Hormone interactions regulating energy balance during pregnancy
    S R Ladyman
    Department of Anatomy and Structural Biology and Centre for Neuroendocrinology, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 22:805-17. 2010
  3. doi request reprint Prolactin signalling in the mouse hypothalamus is primarily mediated by signal transducer and activator of transcription factor 5b but not 5a
    S H Yip
    Department of Anatomy, Centre for Neuroendocrinology, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 24:1484-91. 2012
  4. ncbi request reprint Expression of ovarian steroid hormone receptors in tuberoinfundibular dopaminergic neurones during pregnancy and lactation
    F J Steyn
    Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, Dunedin, New Zealand
    J Neuroendocrinol 19:788-93. 2007
  5. ncbi request reprint Suppression of leptin receptor messenger ribonucleic acid and leptin responsiveness in the ventromedial nucleus of the hypothalamus during pregnancy in the rat
    S R Ladyman
    Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Endocrinology 146:3868-74. 2005
  6. doi request reprint Loss of hypothalamic response to leptin during pregnancy associated with development of melanocortin resistance
    S R Ladyman
    Centre for Neuroendocrinology, Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 21:449-56. 2009
  7. ncbi request reprint Expression of mRNA for prolactin receptor (long form) in dopamine and pro-opiomelanocortin neurones in the arcuate nucleus of non-pregnant and lactating rats
    I C Kokay
    Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 17:827-35. 2005
  8. doi request reprint Differential actions of prolactin on electrical activity and intracellular signal transduction in hypothalamic neurons
    R S E Brown
    Department of Anatomy, University of Otago, P O Box 913, Dunedin 9054, New Zealand
    Endocrinology 153:2375-84. 2012
  9. doi request reprint Suppression of leptin-induced hypothalamic JAK/STAT signalling and feeding response during pregnancy in the mouse
    S R Ladyman
    Department of Anatomy and Centre for Neuroendocrinology, School of Medical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand
    Reproduction 144:83-90. 2012
  10. doi request reprint Differential changes in responses of hypothalamic and brainstem neuronal populations to prolactin during lactation in the mouse
    R S E Brown
    Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    Biol Reprod 84:826-36. 2011

Collaborators

Detail Information

Publications31

  1. ncbi request reprint The actions of prolactin in the brain during pregnancy and lactation
    D R Grattan
    Department of Anatomy and Structural Biology, School of Medical Sciences, Neuroscience Research Centre, University of Otago, P O Box 913, Dunedin, New Zealand
    Prog Brain Res 133:153-71. 2001
    ..Hence, prolactin may be a key player in the coordination of neuroendocrine and behavioral adaptations of the maternal brain...
  2. doi request reprint Hormone interactions regulating energy balance during pregnancy
    S R Ladyman
    Department of Anatomy and Structural Biology and Centre for Neuroendocrinology, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 22:805-17. 2010
    ..Our studies show complex hormone-induced adaptations in the normal hypothalamic pathways regulating body weight homeostasis during pregnancy...
  3. doi request reprint Prolactin signalling in the mouse hypothalamus is primarily mediated by signal transducer and activator of transcription factor 5b but not 5a
    S H Yip
    Department of Anatomy, Centre for Neuroendocrinology, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 24:1484-91. 2012
    ..Despite the similarity between the two STAT5 isoforms, STAT5a was unable to compensate for the absence of STAT5b, suggesting that each isoform exhibits a unique biological activity...
  4. ncbi request reprint Expression of ovarian steroid hormone receptors in tuberoinfundibular dopaminergic neurones during pregnancy and lactation
    F J Steyn
    Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, Dunedin, New Zealand
    J Neuroendocrinol 19:788-93. 2007
    ..The relatively stable level of expression during late pregnancy suggests that a shift in steroid receptor expression during late pregnancy does not contribute to the change in TIDA responsiveness to prolactin at this time...
  5. ncbi request reprint Suppression of leptin receptor messenger ribonucleic acid and leptin responsiveness in the ventromedial nucleus of the hypothalamus during pregnancy in the rat
    S R Ladyman
    Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Endocrinology 146:3868-74. 2005
    ..Hence, diminished transport of leptin into the brain may also contribute to pregnancy-induced leptin resistance...
  6. doi request reprint Loss of hypothalamic response to leptin during pregnancy associated with development of melanocortin resistance
    S R Ladyman
    Centre for Neuroendocrinology, Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 21:449-56. 2009
    ..As well as a loss of responses in first-order leptin-responsive neurones in the arcuate nucleus, there is also a downstream disruption in the melanocortin system...
  7. ncbi request reprint Expression of mRNA for prolactin receptor (long form) in dopamine and pro-opiomelanocortin neurones in the arcuate nucleus of non-pregnant and lactating rats
    I C Kokay
    Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 17:827-35. 2005
    ..Moreover, the persistent expression of PRL-R(L) in arcuate neuroendocrine circuits suggests that PRL-R-mediated signalling continues to be important in these neurones during lactation...
  8. doi request reprint Differential actions of prolactin on electrical activity and intracellular signal transduction in hypothalamic neurons
    R S E Brown
    Department of Anatomy, University of Otago, P O Box 913, Dunedin 9054, New Zealand
    Endocrinology 153:2375-84. 2012
    ..This may be critical in establishing appropriate responses to prolactin under different physiological conditions...
  9. doi request reprint Suppression of leptin-induced hypothalamic JAK/STAT signalling and feeding response during pregnancy in the mouse
    S R Ladyman
    Department of Anatomy and Centre for Neuroendocrinology, School of Medical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand
    Reproduction 144:83-90. 2012
    ..Overall, these results demonstrate that during pregnancy in the mouse, a state of leptin resistance develops, and this is associated with a reduced sensitivity of the VMN to leptin...
  10. doi request reprint Differential changes in responses of hypothalamic and brainstem neuronal populations to prolactin during lactation in the mouse
    R S E Brown
    Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    Biol Reprod 84:826-36. 2011
    ..These data are consistent with the hypothesis that prolactin might mediate widespread adaptive responses in the maternal brain...
  11. ncbi request reprint Quantitation of prolactin receptor mRNA in the maternal rat brain during pregnancy and lactation
    R A Augustine
    Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand
    J Mol Endocrinol 31:221-32. 2003
    ..Together with expression of long-form PRL-R mRNA in specific hypothalamic nuclei, these results support a role for prolactin in regulating neuroendocrine and behavioural adaptations in the maternal brain...
  12. doi request reprint Prolactin: a pleiotropic neuroendocrine hormone
    D R Grattan
    Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 20:752-63. 2008
    ..Finally, we discuss a hypothesis that provides a unifying explanation for the pleiotrophic actions of prolactin in the brain...
  13. ncbi request reprint Dissociation of prolactin secretion from tuberoinfundibular dopamine activity in late pregnant rats
    Z B Andrews
    Department of Anatomy and Structural Biology and Neuroscience Research Center, University of Otago School of Medical Sciences, Dunedin, New Zealand
    Endocrinology 142:2719-24. 2001
    ..Despite the prolonged reduction in activity of TIDA neurons during late pregnancy, PRL secretion still occurs as a nocturnal surge, suggesting that dopamine is not the only regulator of PRL secretion at this time...
  14. ncbi request reprint Prolactin receptors in the brain during pregnancy and lactation: implications for behavior
    D R Grattan
    Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Horm Behav 40:115-24. 2001
    ....
  15. ncbi request reprint Region-specific reduction in leptin-induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) in the rat hypothalamus is associated with leptin resistance during pregnancy
    S R Ladyman
    Department of Anatomy and Structural Biology, University of Otago, Dunedin 9001, New Zealand
    Endocrinology 145:3704-11. 2004
    ..Furthermore, leptin-induced activation of the STAT3 is impaired during pregnancy, specifically in the arcuate nucleus and VMH. These data support the hypothesis that pregnancy is a state of hypothalamic leptin resistance...
  16. doi request reprint Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus
    A Tups
    Department of Anatomy and Structural Biology, Centre for Neuroendocrinology, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 22:534-42. 2010
    ..The role of PI3K in leptin action is less clear, but it may be involved by means of an insulin-dependent sensitisation of leptin action...
  17. ncbi request reprint Expression of the long form of the prolactin receptor in magnocellular oxytocin neurons is associated with specific prolactin regulation of oxytocin neurons
    I C Kokay
    Centre for Neuroendocrinology and Dept of Anatomy and Structural Biology, Univ of Otago, P O Box 913, Dunedin, New Zealand
    Am J Physiol Regul Integr Comp Physiol 290:R1216-25. 2006
    ..There was no effect of prolactin on the activity of vasopressin neurons. Together, these data provide strong evidence that prolactin directly and specifically regulates activity of oxytocin neurons...
  18. ncbi request reprint Increased prolactin receptor immunoreactivity in the hypothalamus of lactating rats
    X J Pi
    Department of Anatomy and Structural Biology, School of Medical Sciences and Neuroscience Research Centre, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 11:693-705. 1999
    ..These observations assist our understanding of the multiple sites of PRL effects on brain function during lactation...
  19. ncbi request reprint Lactation alters gamma-aminobutyric acid neuronal activity in the hypothalamus and cerebral cortex in the rat
    J J Kornblatt
    Department of Anatomy and Structural Biology, School of Medical Sciences and Neuroscience Research Centre, University of Otago, PO Box 913, Dunedin, New Zealand
    Neuroendocrinology 73:175-84. 2001
    ..There were no significant changes in other brain regions examined. The results demonstrate that activity of GABAergic neurons in specific parts of the hypothalamus and cerebral cortex is altered during lactation...
  20. ncbi request reprint The roles of dopamine and the neurointermediate lobe of the pituitary in the regulation of prolactin secretion during late pregnancy in rats
    Z B Andrews
    Center for Neuroendocrinology and Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 16:859-65. 2004
    ....
  21. doi request reprint Loss of acute satiety response to cholecystokinin in pregnant rats
    S R Ladyman
    Centre for Neuroendocrinology and Department of Anatomy, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 23:1091-8. 2011
    ..These results indicate that pregnant rats are no longer responsive to the actions of CCK on short-term food intake and that CCK action in the NTS is reduced during pregnancy...
  22. ncbi request reprint Opioid receptor subtypes involved in the regulation of prolactin secretion during pregnancy and lactation
    Z B Andrews
    Department of Anatomy and Structural Biology and Neuroscience Research Centre, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    J Neuroendocrinol 15:227-36. 2003
    ....
  23. doi request reprint Lactational anovulation in mice results from a selective loss of kisspeptin input to GnRH neurons
    X Liu
    Centre for Neuroendocrinology and Departments of Physiology X L, A E H and Anatomy R S E B, D R G, School of Medical Sciences, University of Otago, Dunedin, 9054 New Zealand
    Endocrinology 155:193-203. 2014
    ..These data demonstrate that a selective loss of RP3V kisspeptin inputs to GnRH neurons during lactation is the likely mechanism causing lactational anovulation in the mouse. ..
  24. doi request reprint Prolactin, neurogenesis, and maternal behaviors
    C M Larsen
    Centre for Neuroendocrinology, Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    Brain Behav Immun 26:201-9. 2012
    ..This mini-review aims to summarize the evidence showing that the prolactin-induced increase in SVZ neurogenesis during pregnancy underlies normal postpartum maternal interactions with pups...
  25. ncbi request reprint Feedback regulation of PRL secretion is mediated by the transcription factor, signal transducer, and activator of transcription 5b
    D R Grattan
    Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    Endocrinology 142:3935-40. 2001
    ....
  26. ncbi request reprint Male and female prolactin receptor mRNA expression in the brain of a biparental and a uniparental hamster, phodopus, before and after the birth of a litter
    E Ma
    Department of Biology, Queen s University, Kingston, Canada
    J Neuroendocrinol 17:81-90. 2005
    ..sungorus males had elevated PRL-R mRNA transcript levels on G17 relative to unpaired males. We conclude that PRL-R mRNA in the ChP is differentially regulated before and after birth in a paternal and a nonpaternal male...
  27. ncbi request reprint STAT5b is required for GH-induced liver IGF-I gene expression
    H W Davey
    AgResearch, Ruakura Research Centre, Hamilton 2001, New Zealand
    Endocrinology 142:3836-41. 2001
    ..Thus, STAT5b plays an important and specific role in liver Igf-I gene expression...
  28. ncbi request reprint Prolactin is involved in glial responses following a focal injury to the juvenile rat brain
    T A E Möderscheim
    Liggins Institute, University of Auckland, 2 6 Park Avenue, Grafton, Auckland, New Zealand
    Neuroscience 145:963-73. 2007
    ..Its strong relation to glial reactions and its gliatrophic effects suggest that the prolactin axis is primarily involved in a gliogenic response during recovery from cerebral injury...
  29. ncbi request reprint STAT5b-deficient mice are growth hormone pulse-resistant. Role of STAT5b in sex-specific liver p450 expression
    H W Davey
    AgResearch, Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand
    J Biol Chem 274:35331-6. 1999
    ..STAT5b-deficient mice are thus GH pulse-resistant, supporting the proposed role of STAT5b as a key intracellular mediator of the stimulatory effects of plasma GH pulses on the male pattern of liver gene expression...
  30. ncbi request reprint Quantification of prolactin-releasing peptide (PrRP) mRNA expression in specific brain regions of the rat during the oestrous cycle and in lactation
    S T Anderson
    School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Brain Res 973:64-73. 2003
    ....
  31. ncbi request reprint Differential effects of centrally-administered oestrogen antagonist ICI-182,780 on oestrogen-sensitive functions in the hypothalamus
    F J Steyn
    Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, Dunedin 9054, New Zealand
    J Neuroendocrinol 19:26-33. 2007
    ..Thus, it appears that there is a differential sensitivity to the inhibition of central oestrogen actions by ICI...