D F Gorman

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. ncbi request reprint Prolonged exposure to one percent carbon monoxide causes a leucoencephalopathy in un-anaesthetised sheep
    D F Gorman
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Toxicology 165:97-107. 2001
  2. ncbi request reprint The clinical toxicology of carbon monoxide
    Des Gorman
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Toxicology 187:25-38. 2003
  3. ncbi request reprint A narcotic dose of carbon monoxide induces neuronal haeme oxygenase and nitric oxide synthetase in sheep
    Des Gorman
    Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Toxicology 179:79-84. 2002
  4. ncbi request reprint A lignocaine infusion worsens the leukoencephalopathy due to a carbon monoxide exposure in sheep
    Des Gorman
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Toxicology 186:143-50. 2003
  5. ncbi request reprint Avoiding osteoradionecrosis
    Des Gorman
    N Z Dent J 99:77. 2003
  6. ncbi request reprint Blockade of haem oxygenase and nitric oxide synthetase causes cortical dysfunction in sheep exposed to carbon monoxide
    Des Gorman
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Toxicology 209:237-43. 2005
  7. ncbi request reprint Early evidence of a regulated response to hypoxaemia in sheep that preserves the brain cortex
    Des Gorman
    Department of Medicine, University of Auckland, New Zealand
    Neurosci Lett 394:174-8. 2006
  8. doi request reprint Haeme oxygenase and nitric oxide synthetase blockade and brain blood flow in sheep exposed to carbon monoxide
    Des Gorman
    The School of Medicine, The University of Auckland, Auckland, New Zealand
    Neurosci Lett 444:203-7. 2008

Detail Information

Publications8

  1. ncbi request reprint Prolonged exposure to one percent carbon monoxide causes a leucoencephalopathy in un-anaesthetised sheep
    D F Gorman
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Toxicology 165:97-107. 2001
    ..This damage was concentrated about necrotic micro-foci in the peri-ventricular white matter. These results suggest that a leucoencephalopathy is a primary consequence of acute and sub-acute CO toxicity...
  2. ncbi request reprint The clinical toxicology of carbon monoxide
    Des Gorman
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Toxicology 187:25-38. 2003
    ..Delayed brain injuries due to a CO exposure may be preventable by hyperbaric O(2). However, the ideal dose of O(2) in this context, if any, is unknown and other potential treatments need to be tested...
  3. ncbi request reprint A narcotic dose of carbon monoxide induces neuronal haeme oxygenase and nitric oxide synthetase in sheep
    Des Gorman
    Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Toxicology 179:79-84. 2002
    ..The mechanism of the induction is not established here, but cellular theories of CO toxicity will need to be re-examined given these results...
  4. ncbi request reprint A lignocaine infusion worsens the leukoencephalopathy due to a carbon monoxide exposure in sheep
    Des Gorman
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Toxicology 186:143-50. 2003
    ..The mechanism of this adverse interaction is neither established here nor is it deducible from other published data; alternative antidotes to CO clearly need to be tested...
  5. ncbi request reprint Avoiding osteoradionecrosis
    Des Gorman
    N Z Dent J 99:77. 2003
  6. ncbi request reprint Blockade of haem oxygenase and nitric oxide synthetase causes cortical dysfunction in sheep exposed to carbon monoxide
    Des Gorman
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Toxicology 209:237-43. 2005
    ..We intend to study this further by both selective and collective enzyme blockade and by measuring regional BBF changes...
  7. ncbi request reprint Early evidence of a regulated response to hypoxaemia in sheep that preserves the brain cortex
    Des Gorman
    Department of Medicine, University of Auckland, New Zealand
    Neurosci Lett 394:174-8. 2006
    ..It would seem reasonable to hypothesise both that the amygdala is important in the processes by which the hypoxaemic effects of CO on the brain are prevented, delayed and/or mitigated and that these processes are regulated...
  8. doi request reprint Haeme oxygenase and nitric oxide synthetase blockade and brain blood flow in sheep exposed to carbon monoxide
    Des Gorman
    The School of Medicine, The University of Auckland, Auckland, New Zealand
    Neurosci Lett 444:203-7. 2008
    ..These results confirm our earlier findings that the induction of HO and NOS by CO inhalation is protective, but, suggest a relationship between tissue injury and blood flow that is perhaps partly causal...