Peter Gluckman

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. ncbi request reprint Early life events and their consequences for later disease: a life history and evolutionary perspective
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Private Bag 92019, Auckland, New Zealand
    Am J Hum Biol 19:1-19. 2007
  2. ncbi request reprint Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease
    Keith M Godfrey
    Centre for Developmental Origins of Health and Disease, University of Southampton, UK
    Pediatr Res 61:5R-10R. 2007
  3. doi request reprint Developmental perspectives on individual variation: implications for understanding nutritional needs
    Peter D Gluckman
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Nestle Nutr Workshop Ser Pediatr Program 62:1-9; disucssion 9-12. 2008
  4. pmc Early life opportunities for prevention of diabetes in low and middle income countries
    Mark A Hanson
    Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, Mailpoint 887, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    BMC Public Health 12:1025. 2012
  5. pmc Developmental origins of non-communicable disease: implications for research and public health
    Robert Barouki
    INSERM UMR S, Universite Paris Descartes, France
    Environ Health 11:42. 2012
  6. doi request reprint Match fitness: development, evolution, and behavior: comment on Frankenhuis and Del Giudice (2012)
    Peter D Gluckman
    Centre for Human Evolution, Adaptation, and Disease, Liggins Institute, University of Auckland, Auckland, New Zealand
    Dev Psychol 48:643-6. 2012
  7. doi request reprint Epigenetics and metabolism in 2011: Epigenetics, the life-course and metabolic disease
    Peter D Gluckman
    Liggins Institute, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Nat Rev Endocrinol 8:74-6. 2012
  8. pmc Gene expression profiling in the Cynomolgus macaque Macaca fascicularis shows variation within the normal birth range
    Bright Starling Emerald
    Growth, Development and Metabolism Programme, Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore
    BMC Genomics 12:509. 2011
  9. ncbi request reprint The developmental origins of the metabolic syndrome
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Trends Endocrinol Metab 15:183-7. 2004
  10. ncbi request reprint The consequences of being born small - an adaptive perspective
    P D Gluckman
    Liggins Institute and National Research Centre for Growth and Development, University of Auckland, New Zealand
    Horm Res 65:5-14. 2006

Research Grants

  1. INTRAUTERINE ASPHYXIAL ENCEPHALOPATHY
    Peter Gluckman; Fiscal Year: 1999
  2. INTRAUTERINE ASPHYXIAL ENCEPHALOPATHY
    Peter Gluckman; Fiscal Year: 2000
  3. INTRAUTERINE ASPHYXIAL ENCEPHALOPATHY
    Peter Gluckman; Fiscal Year: 2001

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Early life events and their consequences for later disease: a life history and evolutionary perspective
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Private Bag 92019, Auckland, New Zealand
    Am J Hum Biol 19:1-19. 2007
    ..This view of human disease from the perspectives of life history biology and evolutionary theory offers new approaches to prevention, diagnosis and intervention...
  2. ncbi request reprint Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease
    Keith M Godfrey
    Centre for Developmental Origins of Health and Disease, University of Southampton, UK
    Pediatr Res 61:5R-10R. 2007
    ..Future research into epigenetic processes may permit us to develop intervention strategies...
  3. doi request reprint Developmental perspectives on individual variation: implications for understanding nutritional needs
    Peter D Gluckman
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Nestle Nutr Workshop Ser Pediatr Program 62:1-9; disucssion 9-12. 2008
    ..Epigenetic biomarkers may be able to identify a risk of developmental mismatch and thus offer the opportunity for nutritional or other intervention...
  4. pmc Early life opportunities for prevention of diabetes in low and middle income countries
    Mark A Hanson
    Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, Mailpoint 887, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    BMC Public Health 12:1025. 2012
    ..However, interventions to promote diet and lifestyle in prospective parents before conception have not received sufficient attention, especially in low- and middle-income countries undergoing socio-economic transition...
  5. pmc Developmental origins of non-communicable disease: implications for research and public health
    Robert Barouki
    INSERM UMR S, Universite Paris Descartes, France
    Environ Health 11:42. 2012
    ....
  6. doi request reprint Match fitness: development, evolution, and behavior: comment on Frankenhuis and Del Giudice (2012)
    Peter D Gluckman
    Centre for Human Evolution, Adaptation, and Disease, Liggins Institute, University of Auckland, Auckland, New Zealand
    Dev Psychol 48:643-6. 2012
    ..Here we set a discussion of maladaptation and mismatch as a cause of psychopathology (Frankenhuis & Del Giudice, 2012) in the broader framework of developmental plasticity and life history trade-offs...
  7. doi request reprint Epigenetics and metabolism in 2011: Epigenetics, the life-course and metabolic disease
    Peter D Gluckman
    Liggins Institute, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Nat Rev Endocrinol 8:74-6. 2012
    ..Data published in 2011 suggest that epigenetic analysis could potentially have utility as a marker of early metabolic pathology and might enable early life prophylaxis...
  8. pmc Gene expression profiling in the Cynomolgus macaque Macaca fascicularis shows variation within the normal birth range
    Bright Starling Emerald
    Growth, Development and Metabolism Programme, Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore
    BMC Genomics 12:509. 2011
    ..Importantly, emerging evidence suggests that these effects operate within the normal range of birth weights and involve mechanisms of developmental palsticity rather than pathology...
  9. ncbi request reprint The developmental origins of the metabolic syndrome
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Trends Endocrinol Metab 15:183-7. 2004
    ..In this article, we review the clinical and experimental perspectives on the "developmental origins of disease" model in the context of these new concepts...
  10. ncbi request reprint The consequences of being born small - an adaptive perspective
    P D Gluckman
    Liggins Institute and National Research Centre for Growth and Development, University of Auckland, New Zealand
    Horm Res 65:5-14. 2006
    ..Such considerations suggest different approaches to intervention and prevention in population-specific contexts...
  11. doi request reprint Developmental and epigenetic pathways to obesity: an evolutionary-developmental perspective
    P D Gluckman
    Liggins Institute, The University of Auckland, Auckland, New Zealand
    Int J Obes (Lond) 32:S62-71. 2008
    ..Secondly, maternal diabetes, maternal obesity and infant overfeeding are associated with a greater risk of later obesity. Early life offers a potential point for preventative intervention...
  12. ncbi request reprint Hypoxic-ischemic brain injury in the newborn: pathophysiology and potential strategies for intervention
    P D Gluckman
    The Liggins Institute for Medical Research, The University of Auckland, Auckland 1, New Zealand
    Semin Neonatol 6:109-20. 2001
    ..Application of this knowledge will allow us to identify strategies for early intervention and prevent the course of damage caused by hypoxic-ischemic injury...
  13. doi request reprint Epigenetic mechanisms that underpin metabolic and cardiovascular diseases
    Peter D Gluckman
    Centre for Human Evolution, Adaptation and Disease, Liggins Institute, The University of Auckland, New Zealand
    Nat Rev Endocrinol 5:401-8. 2009
    ....
  14. pmc Developmental origins of health and disease: reducing the burden of chronic disease in the next generation
    Peter D Gluckman
    Liggins Institute, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Genome Med 2:14. 2010
    ....
  15. ncbi request reprint Regulation of fetal growth by the somatotrophic axis
    Peter D Gluckman
    The Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Nutr 133:1741S-1746S. 2003
    ..Thus, fetal growth not only reflects the immediate fetal environment but events surrounding conception and embryonic life...
  16. ncbi request reprint Maternal-placental-fetal interactions in the endocrine regulation of fetal growth: role of somatotrophic axes
    Peter D Gluckman
    The Liggins Institute, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Endocrine 19:81-9. 2002
    ..This review addresses the contributions made by the placental, maternal, and fetal somatotrophic axes to the regulation of fetal growth...
  17. doi request reprint The role of developmental plasticity and epigenetics in human health
    Peter D Gluckman
    Centre for Human Evolution, Adaptation and Disease, Liggins Institute, The University of Auckland, New Zealand
    Birth Defects Res C Embryo Today 93:12-8. 2011
    ....
  18. ncbi request reprint Developmental origins of disease paradigm: a mechanistic and evolutionary perspective
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, Private Bag 92019, Auckland, New Zealand
    Pediatr Res 56:311-7. 2004
    ..The developmental origins paradigm and its underlying mechanistic and evolutionary basis have major implications for addressing the increasing burden of metabolic and cardiovascular disease...
  19. ncbi request reprint Living with the past: evolution, development, and patterns of disease
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Science 305:1733-6. 2004
    ..This "developmental origins of health and disease" concept may have important biological, medical, and socioeconomic implications...
  20. ncbi request reprint Life-long echoes--a critical analysis of the developmental origins of adult disease model
    Peter D Gluckman
    Liggins Institute, University of Auckland, Grafton, Private Bag 92019, Auckland, New Zealand
    Biol Neonate 87:127-39. 2005
    ..A model of the relationship between the developmental and mature environment is proposed and suggests interventional strategies that will vary in different population settings...
  21. ncbi request reprint Changing times: the evolution of puberty
    P D Gluckman
    The Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mol Cell Endocrinol 254:26-31. 2006
    ..Moreover, a life history perspective can reconcile the apparently conflicting observations that both poor fetal growth and better childhood nutrition are associated with earlier menarche...
  22. ncbi request reprint Evolution, development and timing of puberty
    Peter D Gluckman
    The Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Trends Endocrinol Metab 17:7-12. 2006
    ....
  23. ncbi request reprint The developmental origins of adult disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Matern Child Nutr 1:130-41. 2005
    ..These experimental, clinical and conceptual considerations have important implications for prevention and intervention in the current epidemic of childhood obesity and adult metabolic and cardiovascular disorders...
  24. ncbi request reprint Developmental plasticity and human disease: research directions
    P D Gluckman
    Centre for Human Evolution, Adaptation and Disease, Liggins Institute, University of Auckland, Auckland, New Zealand
    J Intern Med 261:461-71. 2007
    ..A focused agenda of research is needed to convince policy makers of the importance of developmental factors in human disease...
  25. ncbi request reprint Asphyxial brain injury--the role of the IGF system
    P D Gluckman
    Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand
    Mol Cell Endocrinol 140:95-9. 1998
    ..Together these results indicate considerable potential of these agents to treat stroke, perinatal asphyxia and other forms of acute brain injury...
  26. pmc Migrating ovaries: early life influences on later gonadal function
    Peter D Gluckman
    Liggins Institute, The University of Auckland, Auckland, New Zealand
    PLoS Med 4:e190. 2007
  27. pmc Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
    Peter D Gluckman
    Liggins Institute, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    Proc Natl Acad Sci U S A 104:12796-800. 2007
    ....
  28. ncbi request reprint The fetal, neonatal, and infant environments-the long-term consequences for disease risk
    Peter D Gluckman
    Liggins Institute and National Research Centre for Growth and Development, University of Auckland, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Early Hum Dev 81:51-9. 2005
    ..There is increasing evidence that prematurity can be associated with long-term consequences, and this is to be anticipated from conceptual considerations. Different preventative strategies may be relevant in different populations...
  29. ncbi request reprint Maternal constraint of fetal growth and its consequences
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Semin Fetal Neonatal Med 9:419-25. 2004
    ..Changing demography means that maternal constraint must increasingly be considered as a significant factor in determining the pattern of disease...
  30. pmc Evolving a definition of disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Arch Dis Child 92:1053-4. 2007
  31. pmc Effect of in utero and early-life conditions on adult health and disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
    N Engl J Med 359:61-73. 2008
  32. doi request reprint Losing the war against obesity: the need for a developmental perspective
    Peter D Gluckman
    Liggins Institute, The University of Auckland, Auckland 1142, New Zealand
    Sci Transl Med 3:93cm19. 2011
    ..To stem the rising obesity burden in developing countries, scientists and policy-makers must address obesity-promoting factors from early development to adulthood...
  33. ncbi request reprint Neuroprotective effects of the N-terminal tripeptide of IGF-1, glycine-proline-glutamate, in the immature rat brain after hypoxic-ischemic injury
    S V Sizonenko
    Liggins Institute, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res 922:42-50. 2001
    ..In addition, systemic administration of GPE showed a more widespread neuroprotective effect. GPE may represent a complementary pathway for central and systemic IGF-1's antiapoptotic effects...
  34. ncbi request reprint Growth hormone as a neuronal rescue factor during recovery from CNS injury
    A Scheepens
    Research Center for Developmental Medicine and Biology, Faculty of Medicine and Health Science, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neuroscience 104:677-87. 2001
    ..These results further suggest that a neural growth hormone axis is activated during recovery from injury and that this may act to restrict the extent of neuronal death...
  35. ncbi request reprint Chronic pulsatile infusion of growth hormone to growth-restricted fetal sheep increases circulating fetal insulin-like growth factor-I levels but not fetal growth
    M K Bauer
    The Liggins Institute, Faculty of Medical and Health Science, University of Auckland, Private Bag 92019, New Zealand
    J Endocrinol 177:83-92. 2003
    ..Thus, fetal GH therapy does not seem a promising treatment stratagem for the IUGR fetus...
  36. ncbi request reprint Modulation of growth hormone secretion by thermogenically derived free fatty acids in the perinatal lamb
    K T Ball
    Department of Paediatrics, School of Medicine, University of Auckland, New Zealand
    Endocrinology 131:337-43. 1992
    ..These studies provide direct evidence that the pattern of change in plasma GH concentrations at birth in the sheep is determined in part by the rise in plasma FFAs of thermogenic origin...
  37. ncbi request reprint Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts
    R I G Holt
    Fetal Origins of Adult Disease Division, School of Medicine, University of Southampton, Southampton, UK
    Acta Physiol Scand 180:359-66. 2004
    ..Fetal programming of the growth hormone-insulin-like growth factor (GH-IGF) axis may provide a mechanism for these epidemiological findings...
  38. pmc Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs
    A J Gunn
    Research Centre for Developmental Medicine and Biology, Department of Paediatrics, School of Medicine, University of Auckland, New Zealand
    J Clin Invest 99:248-56. 1997
    ..g., 40 vs. 99% in the parasagittal cortex, P < 0.001). Selective head cooling, maintained throughout the secondary phase of injury, is noninvasive and safe and shows potential for improving neonatal outcome after perinatal asphyxia...
  39. pmc The cardiovascular and cerebrovascular responses of the immature fetal sheep to acute umbilical cord occlusion
    L Bennet
    Research Centre for Developmental Medicine and Biology, Department of Paediatrics, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Physiol 517:247-57. 1999
    ..These cardiovascular and cerebrovascular responses may contribute to the patterns of cerebral injury seen in the human preterm fetus...
  40. ncbi request reprint Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system
    P E Hughes
    Department of Pharmacology and Clinical Pharmacology and Research Centre for Developmental Medicine and Biology, School of Medicine, The University of Auckland, New Zealand
    Prog Neurobiol 57:421-50. 1999
    ..Here we discuss our results which show that pharmacological enhancement of this response with exogenous application of IGF-1 or TGF-beta reduces neuronal loss after brain injury...
  41. doi request reprint 20-kDa placental hGH-V has diminished diabetogenic and lactogenic activities compared with 22-kDa hGH-N while retaining antilipogenic activity
    M H Vickers
    Liggins Institute and the National Research Centre for Growth and Development, Auckland, New Zealand
    Am J Physiol Endocrinol Metab 297:E629-37. 2009
    ..In summary, placental 20-kDa hGH-V retains some of the growth-promoting and all antilipogenic activities of pituitary 22-kDa hGH-N but has diminished diabetogenic and lactogenic properties compared with the native 22-kDa hGH-N...
  42. ncbi request reprint Potential role for growth hormone in human lactation insufficiency
    S R Milsom
    Research Centre for Developmental Medicine and Biology, University of Auckland, New Zealand
    Horm Res 50:147-50. 1998
    ..2 IU/kg/day (n = 6) but by only 4.7 +/- 9.7%, (p < 0.04) in the combined lower dose group (n = 10). In conclusion, these data suggest that moderate dose hGH therapy in mothers with lactation insufficiency can improve galactopoiesis...
  43. ncbi request reprint Fetal growth and placental function
    M K Bauer
    Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, New Zealand
    Mol Cell Endocrinol 140:115-20. 1998
    ..Thus the placenta can no longer be considered merely a passive conduit for fetal nutrition. Rather, it is actively involved in the integration of nutritional and endocrine signals from the maternal and fetal somatotrophic axes...
  44. ncbi request reprint Combination therapy with acipimox enhances the effect of growth hormone treatment on linear body growth in the normal and small-for-gestational-age rat
    M H Vickers
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Am J Physiol Endocrinol Metab 291:E1212-9. 2006
    ....
  45. ncbi request reprint Maternal growth hormone treatment increases placental diffusion capacity but not fetal or placental growth in sheep
    J E Harding
    Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, New Zealand
    Endocrinology 138:5352-8. 1997
    ..We conclude that maternal GH treatment increases placental transport capacity, but that anabolic effects in the mother may limit fetal substrate supply and therefore prevent an increase in fetal growth...
  46. ncbi request reprint Neonatal leptin treatment reverses developmental programming
    M H Vickers
    Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland 1020, New Zealand
    Endocrinology 146:4211-6. 2005
    ..The complete normalization of the programmed phenotype by neonatal leptin treatment implies that leptin has effects that reverse the prenatal adaptations resulting from relative fetal undernutrition...
  47. ncbi request reprint The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease
    T Alexi
    School of Medicine, University of Auckland, Auckland, New Zealand
    Exp Neurol 159:84-97. 1999
    ....
  48. ncbi request reprint Intracerebral transportation and cellular localisation of insulin-like growth factor-1 following central administration to rats with hypoxic-ischemic brain injury
    J Guan
    Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res 853:163-73. 2000
    ..Our results indicate that centrally administered IGF-1 can be translocated to neurons and glia via the perivascular circulation and the ependymal cell-white matter tract pathways...
  49. ncbi request reprint Selective neuroprotective effects with insulin-like growth factor-1 in phenotypic striatal neurons following ischemic brain injury in fetal sheep
    J Guan
    Research Center for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand
    Neuroscience 95:831-9. 2000
    ..These data suggest a potential role for insulin-like growth factor-1 in preventing cerebral palsy due to perinatal asphyxia...
  50. ncbi request reprint Insulin-like growth factor-1 improves somatosensory function and reduces the extent of cortical infarction and ongoing neuronal loss after hypoxia-ischemia in rats
    J Guan
    Liggins Institute, Faculty of Medicine and Health Sciences, The University of Auckland, New Zealand
    Neuroscience 105:299-306. 2001
    ..From these data we suggest that insulin-like growth factor-1 improves somatosensory function by reducing both the extent of cortical infarction and ongoing progressive neuronal death during brain recovery from hypoxic-ischemic injury...
  51. ncbi request reprint The metabolic effects of endotoxin are differentially affected by the pattern of GH administration in the rat
    V Roelfsema
    Liggins Institute, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Endocrinol 171:173-81. 2001
    ..In conclusion, the effects of endotoxin on plasma electrolytes, lipids, urea, glucose and insulin are differentially affected by the pattern of GH administration in the rat...
  52. ncbi request reprint Insulin-like growth factor-1 and post-ischemic brain injury
    J Guan
    Faculty of Medicine and Health Sciences, The Liggins Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Prog Neurobiol 70:443-62. 2003
    ..Such a combined approach is likely to be essential for any clinical treatment...
  53. ncbi request reprint Does head cooling with mild systemic hypothermia affect requirement for blood pressure support?
    Malcolm R Battin
    Newborn Services, National Women s Health, Auckland City Hospital, Private Bag 92 024, Auckland, New Zealand
    Pediatrics 123:1031-6. 2009
    ..Our goal was to evaluate whether head cooling with mild systemic hypothermia for neonatal encephalopathy is associated with greater requirement for volume or inotrope support...
  54. ncbi request reprint Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases
    T Alexi
    Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand
    Prog Neurobiol 60:409-70. 2000
    ..Most of these approaches hold promise as potential therapies in the treatment of these disorders...
  55. ncbi request reprint Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic-ischemic adult rats
    J Guan
    The Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, 2 6 Park Avenue, Grafton, Auckland, New Zealand
    Neuropharmacology 47:892-903. 2004
    ..With injury specific central penetration, GPE has considerable promise as a systemic neuroprotective treatment after acute encephalopathies...
  56. ncbi request reprint A role for the somatotropic axis in neural development, injury and disease
    A Scheepens
    Research Centre for Developmental Medicine and Biology, Faculty of Medical and Health Science, University of Auckland, New Zealand
    J Pediatr Endocrinol Metab 13:1483-91. 2000
    ..The implications of these findings in regard to the growth, development and injury response of the CNS are discussed...
  57. ncbi request reprint Treatment in animal models
    J Guan
    The Liggins Institute, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand
    Endocr Dev 9:31-43. 2005
    ..Peripheral administration of GPE also prevents the loss of dopamine neurons and improves long-term functional recovery following 6-OHDA lesion. However, GPE is unlikely to contribute significantly to the direct effects of IGF-1...
  58. ncbi request reprint Regional specificity of magnetic resonance imaging and histopathology following cerebral ischemia in preterm fetal sheep
    Mhoyra Fraser
    Liggins Institute, University of Auckland, New Zealand m fraser auckland ac nz
    Reprod Sci 14:182-91. 2007
    ....
  59. ncbi request reprint Physiological responses to somatotropin in the ruminant
    B H Breier
    Department of Paediatrics, University of Auckland, New Zealand
    J Dairy Sci 74:20-34. 1991
    ..However, the relative role of the insulin-like growth factors and the multiple forms of their plasma-binding proteins and receptors remain to be resolved...
  60. doi request reprint Phenotypic diversity and epigenomic variation - The utility of mass spectrometric analysis of DNA methylation
    Cameron McLean
    AgResearch, New Zealand Liggins Institute, University of Auckland, New Zealand
    J Proteomics 75:3400-9. 2012
    ..This article is part of a Special Section entitled: Understanding genome regulation and genetic diversity by mass spectrometry...
  61. doi request reprint Developmental origins of noncommunicable disease: population and public health implications
    Mark Hanson
    University of Southampton, Institute of Developmental Sciences, Southampton General Hospital, Southampton, United Kingdom
    Am J Clin Nutr 94:1754S-1758S. 2011
    ..We highlight the biomedical implications of this developmental origins of health and disease (DOHaD) concept of NCDs and discuss the implications for health policy...
  62. ncbi request reprint Ovine glucose transporter-1 and -3: cDNA partial sequences and developmental gene expression in the placenta
    M J Currie
    Research Centre for Developmental Medicine and Biology, Faculty of Medicine and Health Science, University of Auckland, New Zealand
    Placenta 18:393-401. 1997
    ..The nucleotide sequences reported in this paper have been submitted to the GenBank/EMBL Data Bank under accession numbers U89029 (oGLUT1) and U89030 (oGLUT3)...
  63. ncbi request reprint The effect of the frequency of subcutaneous insulin-like growth factor-1 administration on weight gain in growth hormone deficient mice
    S M Woodall
    Department of Paediatrics, University of Auckland, New Zealand
    Horm Metab Res 23:581-4. 1991
    ..Frequent subcutaneous IGF-1 administration is one approach to growth enhancement in GH deficiency; higher doses administered less frequently do not promote growth and may cause hypoglycaemia...
  64. ncbi request reprint Elevated s-adenosylhomocysteine alters adipocyte functionality with corresponding changes in gene expression and associated epigenetic marks
    Sherry Ngo
    Developmental Epigenetics Group, Liggins Institute, The University of Auckland, Auckland, New Zealand
    Diabetes 63:2273-83. 2014
    ..Our findings implicate micronutrient imbalance in subsequent modulation of adipocyte function. ..
  65. doi request reprint A model for phenotype change in a stochastic framework
    Graeme Wake
    National Research Centre for Growth and Development and Institute of Information and Mathematical Sciences, Massey University, Private Bag 102904, Albany, Auckland, New Zealand
    Math Biosci Eng 7:719-28. 2010
    ..It is found that the value of the mean waiting time that maximises fitness depends linearly on the variance of the waiting time...
  66. ncbi request reprint A potential role for adenosine in the inhibition of nonshivering thermogenesis in the fetal sheep
    K T Ball
    Department of Paediatrics, School of Medicine, University of Auckland, New Zealand
    Pediatr Res 37:303-9. 1995
    ..89 +/- 0.39 degrees C (p < 0.001); and fetal arterial BP decreased to 38 +/- 5 mm Hg (p < 0.004) in 30 min. A stepped dose-response study was performed in three fetal sheep.(ABSTRACT TRUNCATED AT 250 WORDS)..
  67. ncbi request reprint Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia
    M R Battin
    Newborn Service, National Women s Hospital, Auckland, New Zealand
    Pediatrics 107:480-4. 2001
    ..To determine the neurodevelopmental outcome of infants treated with head cooling with systemic hypothermia after hypoxic-ischemic encephalopathy...
  68. ncbi request reprint Insulin-like growth factor-1 reduces postischemic white matter injury in fetal sheep
    J Guan
    Research Center for Developmental Medicine and Biology, Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
    J Cereb Blood Flow Metab 21:493-502. 2001
    ..After ischemia there was a close association of PLP mRNA labeled cells with reactive astrocytes and macrophages/microglia. In conclusion, IGF-1 can prevent delayed, postischemic oligodendrocyte cell loss and associated demyelination...
  69. ncbi request reprint DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells
    F Shafiei
    National Research Centre for Growth and Development and the Liggins Institute, University of Auckland, Auckland, New Zealand
    Oncogene 27:2602-12. 2008
    ..Autocrine hGH, therefore, utilizes DNA methylation as a mechanism to exert its oncogenic effects in mammary carcinoma cells...
  70. ncbi request reprint Almitrine mimics hypoxia in fetal sheep with lateral pontine lesions
    B M Johnston
    Department of Paediatrics, School of Medicine, University of Auckland, New Zealand
    J Appl Physiol (1985) 69:1330-5. 1990
    ..We conclude that the action of almitrine is like that of hypoxia and that, because it acts specifically on the chemoreceptors, it may prove to be a useful tool in the study of possible central chemoreceptor mechanisms...
  71. ncbi request reprint Sedentary behavior during postnatal life is determined by the prenatal environment and exacerbated by postnatal hypercaloric nutrition
    M H Vickers
    FRS, Liggins Institute, Faculty of Medical and Health Sciences, Univ of Auckland, Auckland, New Zealand
    Am J Physiol Regul Integr Comp Physiol 285:R271-3. 2003
    ....
  72. ncbi request reprint HOXA1-stimulated oncogenicity is mediated by selective upregulation of components of the p44/42 MAP kinase pathway in human mammary carcinoma cells
    K M Mohankumar
    The Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    Oncogene 26:3998-4008. 2007
    ..Thus, modulation of the p44/42 MAP kinase pathway is one mechanism by which HOXA1 mediates oncogenic transformation of the human mammary epithelial cell...
  73. doi request reprint Predictive adaptive responses in perspective
    Peter D Gluckman
    Trends Endocrinol Metab 19:109-10; author reply 112. 2008
  74. ncbi request reprint Cortical electroencephalogram suppression is associated with post-ischemic cortical injury in 0.65 gestation fetal sheep
    Mhoyra Fraser
    The Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res Dev Brain Res 154:45-55. 2005
    ..There was no difference in baseline SE values or post-ischemic responses between the left and right hemisphere. These findings suggest that persistent suppression of EEG SE is primarily a consequence of cortical grey matter injury...
  75. ncbi request reprint Head cooling for neonatal encephalopathy: the state of the art
    Alistair Jan Gunn
    Department of Physiology, The University of Auckland, Auckland, New Zealand
    Clin Obstet Gynecol 50:636-51. 2007
    ..The key remaining issues are to finding better ways of identifying babies who are most likely to benefit, to define the optimal mode and conditions of hypothermia and to find ways to further improve the effectiveness of treatment...
  76. doi request reprint Developmental origins of health and disease: new insights
    Mark A Hanson
    Division of Developmental Origins of Health and Disease, University of Southampton, Southampton, UK
    Basic Clin Pharmacol Toxicol 102:90-3. 2008
    ..Appropriate interventions may have long-term multigenerational effects to reduce the risk of chronic disease...
  77. doi request reprint The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy
    Mark H Vickers
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Endocrinology 149:1906-13. 2008
    ..These data further reinforce the importance of leptin in determining long-term energy homeostasis, and suggest that leptin's effects are modulated by gender and both prenatal and postnatal nutritional status...
  78. ncbi request reprint Periconceptional undernutrition in sheep accelerates maturation of the fetal hypothalamic-pituitary-adrenal axis in late gestation
    Frank H Bloomfield
    Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Endocrinology 145:4278-85. 2004
    ....
  79. ncbi request reprint TGF beta-1 and neurological function after hypoxia-ischemia in adult rats
    Jian Guan
    Liggins Institute, Faculty of Medicine and Health Sciences The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neuroreport 15:961-4. 2004
    ..In contrast, after 40 days recovery TGFbeta-1 neither improved neuronal outcome nor neurological function, suggesting TGFbeta-1 can transiently improve functional and histological recovery from hypoxia-ischemia...
  80. ncbi request reprint Brief undernutrition in late-gestation sheep programs the hypothalamic-pituitary-adrenal axis in adult offspring
    Frank H Bloomfield
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 144:2933-40. 2003
    ..In contrast to our previous findings, these HPA effects are independent of birth weight and current weight, suggesting that different mechanisms may be involved in programming different physiological axes...
  81. pmc Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone
    Svetlana Mukhina
    Institute of Molecular and Cell Biology, 30 Medical Drive, Republic of Singapore 117609
    Proc Natl Acad Sci U S A 101:15166-71. 2004
    ..Therapeutic targeting of autocrine hGH may provide a mechanistic approach to prevent metastatic extension of human mammary carcinoma...
  82. ncbi request reprint Insulin-like growth factor (IGF)-1 suppresses oligodendrocyte caspase-3 activation and increases glial proliferation after ischemia in near-term fetal sheep
    Yun Cao
    The Liggins Institute, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
    J Cereb Blood Flow Metab 23:739-47. 2003
    ..In contrast, the increase in reactive glia was related only to proliferation. Speculatively, reactive glia may partly mediate IGF-1 white matter protection...
  83. ncbi request reprint Selective cortical alteration after hypoxic-ischemic injury in the very immature rat brain
    Stephane V Sizonenko
    Unité de développement, Departement de Pediatrie, Hopital des Enfants, 6 Rue Willy Donze, 1211 Geneva 14 Switzerland
    Pediatr Res 54:263-9. 2003
    ..These alterations induced at P3 by unilateral HI share neuropathological similarities with the diffuse white matter lesions found in VLBW infants...
  84. ncbi request reprint A periconceptional nutritional origin for noninfectious preterm birth
    Frank H Bloomfield
    Department of Physiology, University of Toronto, Toronto, Canada
    Science 300:606. 2003
  85. ncbi request reprint Amniotic IGF-I supplements improve gut growth but reduce circulating IGF-I in growth-restricted fetal sheep
    Frank H Bloomfield
    Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Am J Physiol Endocrinol Metab 282:E259-69. 2002
    ..Amniotic fluid IGF-I supplementation may provide the basis of future therapeutic approaches to IUGR, but the systemic effects require further investigation...
  86. ncbi request reprint Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy
    Alistair J Gunn
    Department of Physiology, University of Auckland, Auckland, New Zealand
    J Pediatr 152:55-8, 58.e1. 2008
    ..To evaluate whether therapeutic hypothermia alters the prognostic value of clinical grading of neonatal encephalopathy...
  87. ncbi request reprint Metabolic disease: evolutionary, developmental and transgenerational influences
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, Grafton, New Zealand
    Nestle Nutr Workshop Ser Pediatr Program 55:17-27. 2005
  88. ncbi request reprint Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development NIH, 6100 Executive Boulevard, MSC 7510, Bethesda, MD 20892, USA
    J Pediatr 148:170-175. 2006
  89. ncbi request reprint The role of growth hormone in neural development
    Arjan Scheepens
    Liggins Institute, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
    Horm Res 64:66-72. 2005
    ..The potential role of GH as a therapeutic agent to influence brain development and function is discussed...
  90. ncbi request reprint Therapeutic hypothermia: from lab to NICU
    Alistair Jan Gunn
    University of Auckland, Auckland, New Zealand
    J Perinat Med 33:340-6. 2005
    ..Both long-term followup studies and further large studies of whole body cooling are in progress...
  91. ncbi request reprint Birth weight rather than maternal nutrition influences glucose tolerance, blood pressure, and IGF-I levels in sheep
    Mark H Oliver
    Liggins Institute, Faculty of Medicine and Health Science, University of Auckland, Auckland, New Zealand
    Pediatr Res 52:516-24. 2002
    ..These data suggest that size at birth is more closely related to processes that determine postnatal phenotype than is maternal nutrition in late gestation...
  92. ncbi request reprint Non-genomic transgenerational inheritance of disease risk
    Peter D Gluckman
    Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    Bioessays 29:145-54. 2007
    ....
  93. ncbi request reprint Low birthweight and subsequent obesity in Japan
    Peter D Gluckman
    Lancet 369:1081-2. 2007
  94. pmc Environmental influences during development and their later consequences for health and disease: implications for the interpretation of empirical studies
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Proc Biol Sci 272:671-7. 2005
    ..The paper reviews these concepts and explores ways in which such distinctions may be made in practice...
  95. ncbi request reprint Determinants of outcomes after head cooling for neonatal encephalopathy
    John S Wyatt
    Department of Paediatrics and Child Health, University College London, London, United Kingdom
    Pediatrics 119:912-21. 2007
    ..The goal of this study was to evaluate the role of factors that may determine the efficacy of treatment with delayed head cooling and mild systemic hypothermia for neonatal encephalopathy...
  96. ncbi request reprint Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial
    Peter D Gluckman
    The Liggins Institute, University of Auckland, Auckland, New Zealand
    Lancet 365:663-70. 2005
    ..We did a multicentre randomised controlled trial to find out if delayed head cooling can improve neurodevelopmental outcome in babies with neonatal encephalopathy...
  97. pmc The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, SO16 6YD, UK
    Br J Nutr 99:540-9. 2008
    ..Prevention by increased folic acid intake of an altered metabolic phenotype by maternal protein-restriction may be at the expense of somatic growth...
  98. ncbi request reprint Distinctive neuropathologic alterations in the deep layers of the parietal cortex after moderate ischemic-hypoxic injury in the P3 immature rat brain
    Stephane V Sizonenko
    Unité de Dévelopment, Department of Pediatrics, University of Geneva, 1211 Geneva, Switzerland
    Pediatr Res 57:865-72. 2005
    ..This model offers new possibilities for investigating the cellular and molecular mechanisms of damage and repair after neonatal HI injury...
  99. ncbi request reprint Maternal betamethasone administration reduces binucleate cell number and placental lactogen in sheep
    Thorsten Braun
    Department of Physiology and Obstetrics and Gynecology, University of Toronto, MSB, 1 King s College Circle, Toronto, Ontario, Canada
    J Endocrinol 194:337-47. 2007
    ..These data may suggest a placental role in growth restrictive effects of prenatal maternal BET exposure through alterations in placental output of oPL, a key metabolic hormone of pregnancy...
  100. pmc Developmental processes and the induction of cardiovascular function: conceptual aspects
    Mark A Hanson
    Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital Level F 887, Coxford Road, Southampton S016 5YA, UK
    J Physiol 565:27-34. 2005
    ....

Research Grants6

  1. INTRAUTERINE ASPHYXIAL ENCEPHALOPATHY
    Peter Gluckman; Fiscal Year: 1999
    ..By further elucidating the pathogenesis of prenatal and perinatal asphyxial encephalopathy these studies will provide important information towards improving perinatal diagnosis, monitoring and intervention. ..
  2. INTRAUTERINE ASPHYXIAL ENCEPHALOPATHY
    Peter Gluckman; Fiscal Year: 2000
    ..By further elucidating the pathogenesis of prenatal and perinatal asphyxial encephalopathy these studies will provide important information towards improving perinatal diagnosis, monitoring and intervention. ..
  3. INTRAUTERINE ASPHYXIAL ENCEPHALOPATHY
    Peter Gluckman; Fiscal Year: 2001
    ..By further elucidating the pathogenesis of prenatal and perinatal asphyxial encephalopathy these studies will provide important information towards improving perinatal diagnosis, monitoring and intervention. ..