John D Fraser

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. pmc Superantigens and streptococcal toxic shock syndrome
    Thomas Proft
    Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Emerg Infect Dis 9:1211-8. 2003
  2. pmc Metal-derivatized major histocompatibility complex: zeroing in on contact hypersensitivity
    Jacelyn Loh
    Division of Molecular Medicine and Pathology, Faculty of Medicine and Health Sciences, University of Auckland, Auckland 1, New Zealand
    J Exp Med 197:549-52. 2003
  3. pmc The streptococcal superantigen SMEZ exhibits wide allelic variation, mosaic structure, and significant antigenic variation
    T Proft
    Department of Molecular Medicine, School of Medicine, University of Auckland, Auckland, New Zealand
    J Exp Med 191:1765-76. 2000
  4. pmc Involvement of streptococcal mitogenic exotoxin Z in streptococcal toxic shock syndrome
    Lily Yang
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Clin Microbiol 43:3570-3. 2005
  5. ncbi request reprint Crystallographic and mutational data show that the streptococcal pyrogenic exotoxin J can use a common binding surface for T-cell receptor binding and dimerization
    Heather M Baker
    School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Biol Chem 279:38571-6. 2004
  6. ncbi request reprint The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition
    Matthew C Chung
    Maurice Wilkins Centre, University of Auckland, Auckland, New Zealand
    Mol Microbiol 66:1342-55. 2007
  7. doi request reprint The bacterial superantigen and superantigen-like proteins
    John D Fraser
    The Maurice Wilkins Centre for Molecular Biodiscovery and School of Medical Sciences, University of Auckland, Private Bag, Auckland, New Zealand
    Immunol Rev 225:226-43. 2008
  8. doi request reprint Specificity of staphylococcal superantigen-like protein 10 toward the human IgG1 Fc domain
    Deepa Patel
    School of Medical Sciences and Maurice Wilkins Centre of Excellence, University of Auckland, Auckland, New Zealand
    J Immunol 184:6283-92. 2010
  9. ncbi request reprint Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins
    Heather M Baker
    Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand
    J Mol Biol 374:1298-308. 2007
  10. pmc Structural and functional properties of staphylococcal superantigen-like protein 4
    Stefan J Hermans
    School of Medical Sciences, University of Auckland, Aukland, New Zealand
    Infect Immun 80:4004-13. 2012

Collaborators

Detail Information

Publications35

  1. pmc Superantigens and streptococcal toxic shock syndrome
    Thomas Proft
    Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Emerg Infect Dis 9:1211-8. 2003
  2. pmc Metal-derivatized major histocompatibility complex: zeroing in on contact hypersensitivity
    Jacelyn Loh
    Division of Molecular Medicine and Pathology, Faculty of Medicine and Health Sciences, University of Auckland, Auckland 1, New Zealand
    J Exp Med 197:549-52. 2003
  3. pmc The streptococcal superantigen SMEZ exhibits wide allelic variation, mosaic structure, and significant antigenic variation
    T Proft
    Department of Molecular Medicine, School of Medicine, University of Auckland, Auckland, New Zealand
    J Exp Med 191:1765-76. 2000
    ..SMEZ-specific Vbeta8 activity was found in culture supernatants of 66% of the GAS isolates, indicating a potential base for the development of a SMEZ targeting vaccine...
  4. pmc Involvement of streptococcal mitogenic exotoxin Z in streptococcal toxic shock syndrome
    Lily Yang
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Clin Microbiol 43:3570-3. 2005
    ..This variant was responsible for the major mitogenic activity in the cell culture supernatant. Patient sera showed seroconversion toward SMEZ, implying a role for this toxin in STSS...
  5. ncbi request reprint Crystallographic and mutational data show that the streptococcal pyrogenic exotoxin J can use a common binding surface for T-cell receptor binding and dimerization
    Heather M Baker
    School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Biol Chem 279:38571-6. 2004
    ..We infer that SPE-J cross-links TCR and MHC-II as a monomer but that dimers may form on the antigen-presenting cell surface, cross-linking MHC-II and eliciting intracellular signaling...
  6. ncbi request reprint The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition
    Matthew C Chung
    Maurice Wilkins Centre, University of Auckland, Auckland, New Zealand
    Mol Microbiol 66:1342-55. 2007
    ..A single amino acid mutation in the carbohydrate binding site abolished all SSL11 binding. Thus, SSL11 is a staphylococcal protein that targets myeloid cells by binding sialyllactosamine-containing glycoproteins...
  7. doi request reprint The bacterial superantigen and superantigen-like proteins
    John D Fraser
    The Maurice Wilkins Centre for Molecular Biodiscovery and School of Medical Sciences, University of Auckland, Private Bag, Auckland, New Zealand
    Immunol Rev 225:226-43. 2008
    ....
  8. doi request reprint Specificity of staphylococcal superantigen-like protein 10 toward the human IgG1 Fc domain
    Deepa Patel
    School of Medical Sciences and Maurice Wilkins Centre of Excellence, University of Auckland, Auckland, New Zealand
    J Immunol 184:6283-92. 2010
    ..SSL10 is a potential virulence factor for S. aureus targeting IgG1-mediated immunity...
  9. ncbi request reprint Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins
    Heather M Baker
    Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand
    J Mol Biol 374:1298-308. 2007
    ..Structural comparisons also showed that the Sia binding site in SSL5 contains a substructure that is shared by other Sia binding proteins from bacteria as well as viruses and represents a common binding motif...
  10. pmc Structural and functional properties of staphylococcal superantigen-like protein 4
    Stefan J Hermans
    School of Medical Sciences, University of Auckland, Aukland, New Zealand
    Infect Immun 80:4004-13. 2012
    ..Together with cell binding data, this shows how S. aureus produces multiple related proteins that target myeloid cells through specific sialyllactosamine-containing glycoproteins...
  11. ncbi request reprint Full functional activity of SSL7 requires binding of both complement C5 and IgA
    Natalie Lorenz
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, School of Medical Sciences and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand
    Immunol Cell Biol 91:469-76. 2013
    ..SSL7 is an important staphylococcal virulence factor with potent anti-inflammatory properties, which are mediated by targeting complement C5 and IgA. ..
  12. ncbi request reprint Molecular epidemiology of group A streptococcus from pharyngeal isolates in Auckland, New Zealand, 2013
    Deborah A Williamson
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    N Z Med J 127:55-60. 2014
    ..To describe the molecular epidemiology of emm types associated with circulating pharyngeal group A streptococcus (GAS) isolates in Auckland, New Zealand...
  13. ncbi request reprint Nasal carriage of Staphylococcus aureus in healthy Aucklanders
    Nicola Best
    University of Auckland, Auckland, New Zealand
    N Z Med J 124:31-9. 2011
    ..Studies have reported higher rates of diseases caused by Staphylococcus aureus (S. aureus) amongst Maori and Pacific people, compared with people of other ethnicities...
  14. ncbi request reprint Variations in the protective immune response against streptococcal superantigens in populations of different ethnicity
    Lily P H Yang
    Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
    Med Microbiol Immunol 195:37-43. 2006
    ..Levels of serum antibodies against SAgs could not be used to predict disease susceptibility in groups with existing high levels of SAg-neutralizing antibodies...
  15. ncbi request reprint Streptococcal superantigens
    Thomas Proft
    Department of Molecular Medicine and Pathology, School of Medicine, University of Auckland, Auckland, New Zealand
    Chem Immunol Allergy 93:1-23. 2007
    ..This chapter will also discuss the potential involvement of SAgs in severe GAS disease, in particular the highly lethal streptococcal toxic shock syndrome...
  16. ncbi request reprint Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: implications for treatment of streptococcal toxic shock syndrome
    Birgit Schrage
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Clin Infect Dis 43:743-6. 2006
    ..0001) was observed. These results might be helpful for optimizing the type and dose of intravenous immunoglobulin used in adjunctive therapy for severe invasive streptococcal disease...
  17. ncbi request reprint The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA-Fc alpha RI binding and serum killing of bacteria
    Ries Langley
    Centre for Molecular Biodiscovery and School of Medical Sciences, University of Auckland, Auckland, New Zealand
    J Immunol 174:2926-33. 2005
    ..SSL7 is a superantigen-like protein secreted from Staphylococcus aureus that blocks IgA-FcR interactions and inhibits complement, leading to increased survival of a sensitive bacterium in blood...
  18. pmc Two novel superantigens found in both group A and group C Streptococcus
    Thomas Proft
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Infect Immun 71:1361-9. 2003
    ..Interestingly, the speL gene is highly associated with S. pyogenes M89, a serotype that is linked to acute rheumatic fever in New Zealand...
  19. pmc Antigen targeting to major histocompatibility complex class II with streptococcal mitogenic exotoxin Z-2 M1, a superantigen-based vaccine carrier
    Fiona J Radcliff
    School of Medical Sciences and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand
    Clin Vaccine Immunol 19:574-86. 2012
    ..Coupling of a TCR-defective superantigen toxoid presents a new strategy for conjugate vaccines with the additional benefit of targeted delivery to MHC class II-bearing cells...
  20. ncbi request reprint Staphylococcal superantigen super-domains in immune evasion
    Ries Langley
    The Maurice Wilkins Centre for Research, University of Auckland, New Zealand
    Crit Rev Immunol 30:149-65. 2010
    ..This brief review focuses on the structural features of SAgs and SSLs and their individual functions as we currently understand them...
  21. ncbi request reprint Identification & characterisation of the two novel streptococcal pyrogenic exotoxins SPE-L & SPE-M
    Proft Thomas
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences University of Auckland, Private Bag 92019, Auckland, New Zealand
    Indian J Med Res 119:37-43. 2004
    ..The aim of this study was to search unfinished streptococcal genomes for novel superantigens, to generate recombinant proteins from potential open reading frames (ORFs) and to analyse them for superantigen activity...
  22. ncbi request reprint Working towards a Group A Streptococcal vaccine: Report of a collaborative Trans-Tasman workshop
    Nicole J Moreland
    School of Biological Sciences and the Maurice Wilkins Centre, University of Auckland, Auckland, New Zealand
    Vaccine 32:3713-20. 2014
    ....
  23. ncbi request reprint The cytokine response to streptococcal superantigens varies between individual toxins and between individuals: implications for the pathogenesis of group A streptococcal diseases
    Thomas Proft
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Interferon Cytokine Res 27:553-7. 2007
    ..Our results suggest that streptococcal SAgs might be involved not only in acute streptococcal diseases but also in chronic inflammation and autoimmune diseases...
  24. ncbi request reprint Synthesis of the 2-methylene analogue of the HRV 3C protease inhibitor thysanone (2-carbathysanone)
    Katrin Schünemann
    School of Chemical Sciences, The University of Auckland, 23 Symonds St, Auckland, New Zealand
    Org Biomol Chem 12:905-12. 2014
    ....
  25. pmc Clinical and molecular epidemiology of methicillin-resistant Staphylococcus aureus in New Zealand: rapid emergence of sequence type 5 (ST5)-SCCmec-IV as the dominant community-associated MRSA clone
    Deborah A Williamson
    Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    PLoS ONE 8:e62020. 2013
    ..Ongoing molecular surveillance is essential to prevent these MRSA strains becoming endemic in the New Zealand healthcare setting...
  26. doi request reprint Incidence, trends and demographics of Staphylococcus aureus infections in Auckland, New Zealand, 2001-2011
    Deborah A Williamson
    Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    BMC Infect Dis 13:569. 2013
    ..aureus (MSSA), although relatively little is known about the comparative demographics of MSSA and methicillin-resistant S. aureus (MRSA) infections in New Zealand...
  27. pmc Characterization of a mouse-adapted Staphylococcus aureus strain
    Silva Holtfreter
    Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
    PLoS ONE 8:e71142. 2013
    ..In conclusion, the mouse-adapted strain JSNZ may represent a valuable tool for studying aspects of mucosal colonization and for screening novel vaccines and therapies directed at preventing colonization. ..
  28. ncbi request reprint Immobilization of proteins to biacore sensor chips using Staphylococcus aureus sortase A
    Fiona Clow
    Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Biotechnol Lett 30:1603-7. 2008
    ..Notably, the high specificity of the sortase allows immobilization of proteins from less than pure protein samples allowing short cuts in protein purification protocols...
  29. ncbi request reprint The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome
    Vickery L Arcus
    School of Biological Sciences, University of Auckland, Private Bag 92 019 Auckland, New Zealand
    J Biol Chem 277:32274-81. 2002
    ..The fact that the whole gene family is clustered within the pathogenicity island SaIn2 of the S. aureus genome suggests that they are involved in host/pathogen interactions...
  30. ncbi request reprint Demographic variation in community-based MRSA skin and soft tissue infection in Auckland, New Zealand
    Stephen R Ritchie
    Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
    N Z Med J 124:21-30. 2011
    ..To estimate the burden of skin and soft tissue infection caused by Staphylococcus aureus (S. aureus), and to determine the effects of ethnicity and age on the rate of skin and soft tissue due to MRSA in the Auckland community...
  31. doi request reprint Intramucosal bacterial microcolonies exist in chronic rhinosinusitis without inducing a local immune response
    Andrew J Wood
    Department of Otolaryngology Head and Neck Surgery, Auckland City Hospital, Auckland, New Zealand
    Am J Rhinol Allergy 26:265-70. 2012
    ....
  32. doi request reprint A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors
    Katrin Schünemann
    School of Chemical Sciences, The University of Auckland, Auckland, New Zealand
    Bioorg Med Chem Lett 22:5018-24. 2012
    ....
  33. ncbi request reprint Uptake of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and activation of NF-kappaB in human tumor cell lines
    See Tarn Woon
    Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Oncol Res 13:95-101. 2002
    ..The observed activation of NF-kappaB in some lines suggests that the effects of DMXAA on tumor cells, as well as host cells, must be considered in understanding its antitumoraction...