Alan G Fraser

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. ncbi request reprint Helicobacter pylori, Chlamydia pneumoniae and myocardial infarction
    A G Fraser
    University Department of Medicine, University of Auckland, Auckland, New Zealand
    Intern Med J 33:267-72. 2003
  2. pmc Genetic adult lactase persistence is associated with risk of Crohn's Disease in a New Zealand population
    Deborah J Nolan
    Smart Foods Centre, University of Wollongong, Northfields Ave, Wollongong, New South Wales, Australia
    BMC Res Notes 3:339. 2010
  3. ncbi request reprint Pharmacokinetic interactions between alcohol and other drugs
    A G Fraser
    Department of Medicine, University of Auckland, New Zealand
    Clin Pharmacokinet 33:79-90. 1997
  4. ncbi request reprint Helicobacter pylori: a historical perspective 1983-2003
    Alan Fraser
    Department of Medicine, University of Auckland, Auckland, New Zealand
    N Z Med J 117:U896. 2004
  5. ncbi request reprint Helicobacter pylori infection and iron deficiency in teenage females in New Zealand
    Alan G Fraser
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    N Z Med J 123:38-45. 2010
  6. ncbi request reprint Nurse-led dyspepsia clinic using the urea breath test for Helicobacter pylori
    Alan Fraser
    Department of Medicine, University of Auckland, Auckland, New Zealand
    N Z Med J 116:U479. 2003
  7. ncbi request reprint Methotrexate: first-line or second-line immunomodulator?
    Alan G Fraser
    University of Auckland, New Zealand
    Eur J Gastroenterol Hepatol 15:225-31. 2003
  8. ncbi request reprint Microscopic colitis: a clinical and pathological review
    A G Fraser
    Dept of Medicine, University of Auckland, New Zealand
    Scand J Gastroenterol 37:1241-5. 2002
  9. ncbi request reprint Long-term risk of malignancy after treatment of inflammatory bowel disease with azathioprine
    A G Fraser
    Department of Medicine, University of Auckland, New Zealand
    Aliment Pharmacol Ther 16:1225-32. 2002
  10. ncbi request reprint Follow up after successful eradication of Helicobacter pylori: symptoms and reinfection
    A G Fraser
    Department of Medicine, University of Auckland, New Zealand
    J Gastroenterol Hepatol 13:555-9. 1998

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Helicobacter pylori, Chlamydia pneumoniae and myocardial infarction
    A G Fraser
    University Department of Medicine, University of Auckland, Auckland, New Zealand
    Intern Med J 33:267-72. 2003
    ..The issue has been difficult to resolve because of the potential impact of several confounding factors, in particular, socioeconomic status for H. pylori and smoking for C. pneumoniae...
  2. pmc Genetic adult lactase persistence is associated with risk of Crohn's Disease in a New Zealand population
    Deborah J Nolan
    Smart Foods Centre, University of Wollongong, Northfields Ave, Wollongong, New South Wales, Australia
    BMC Res Notes 3:339. 2010
    ..abstract:..
  3. ncbi request reprint Pharmacokinetic interactions between alcohol and other drugs
    A G Fraser
    Department of Medicine, University of Auckland, New Zealand
    Clin Pharmacokinet 33:79-90. 1997
    ..g. impairment of gluconeogenesis and the risk of hypoglycaemia with oral hypoglycaemic agents). The combination of nonsteroidal anti-inflammatory drugs and alcohol intake increases the risk of gastrointestinal haemorrhage...
  4. ncbi request reprint Helicobacter pylori: a historical perspective 1983-2003
    Alan Fraser
    Department of Medicine, University of Auckland, Auckland, New Zealand
    N Z Med J 117:U896. 2004
  5. ncbi request reprint Helicobacter pylori infection and iron deficiency in teenage females in New Zealand
    Alan G Fraser
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    N Z Med J 123:38-45. 2010
    ..Iron deficiency is an important problem in New Zealand children and young adults. Iron deficiency and Helicobacter pylori (H. pylori) infection are each more common in Māori and Pacific Island ethnic groups...
  6. ncbi request reprint Nurse-led dyspepsia clinic using the urea breath test for Helicobacter pylori
    Alan Fraser
    Department of Medicine, University of Auckland, Auckland, New Zealand
    N Z Med J 116:U479. 2003
    ..To audit the results of a nurse-led dyspepsia clinic...
  7. ncbi request reprint Methotrexate: first-line or second-line immunomodulator?
    Alan G Fraser
    University of Auckland, New Zealand
    Eur J Gastroenterol Hepatol 15:225-31. 2003
    ..At present, the role of methotrexate is in the treatment of active or relapsing Crohn's disease for patients who are refractory to, or intolerant of, azathioprine or 6-mercaptopurine...
  8. ncbi request reprint Microscopic colitis: a clinical and pathological review
    A G Fraser
    Dept of Medicine, University of Auckland, New Zealand
    Scand J Gastroenterol 37:1241-5. 2002
  9. ncbi request reprint Long-term risk of malignancy after treatment of inflammatory bowel disease with azathioprine
    A G Fraser
    Department of Medicine, University of Auckland, New Zealand
    Aliment Pharmacol Ther 16:1225-32. 2002
    ..Data from renal transplant and rheumatoid arthritis patients suggest that there is an increased risk of malignancy after treatment with azathioprine. Whether this is true for patients with inflammatory bowel disease remains uncertain...
  10. ncbi request reprint Follow up after successful eradication of Helicobacter pylori: symptoms and reinfection
    A G Fraser
    Department of Medicine, University of Auckland, New Zealand
    J Gastroenterol Hepatol 13:555-9. 1998
    ..A second urea breath test 6-12 months after eradication is required to definitely prove eradication. Patients with a breath test delta value of 2-4 should have a repeat urea breath test...
  11. ncbi request reprint Intestinal metaplasia subtypes and Helicobacter pylori infection: a comparison of ethnic groups in New Zealand
    A G Fraser
    Department of Medicine, University of Auckland, New Zealand
    J Gastroenterol Hepatol 13:560-5. 1998
    ..pylori (P < 0.001) but not age, smoking, endoscopic diagnosis or gender. Intestinal metaplasia is more common and occurs at an earlier age in Maori and Pacific Island patients...
  12. ncbi request reprint Gastric juice ascorbic acid is related to Helicobacter pylori infection but not ethnicity
    A G Fraser
    Department of Medicine, University of Auckland, New Zealand
    J Gastroenterol Hepatol 14:1070-3. 1999
    ..This study aimed to examine the interrelationship between H. pylori and ethnicity in New Zealand...
  13. ncbi request reprint Helicobacter pylori treatment and antibiotic susceptibility: results of a five-year audit
    A G Fraser
    Department of Medicine, University of Auckland, New Zealand
    Aust N Z J Med 29:512-6. 1999
    ..Helicobacter pylori eradication treatment has been a rapidly evolving field. Audit of treatment results provides reassurance that trial data can be translated into routine clinical practice...
  14. pmc The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review
    A G Fraser
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Gut 50:485-9. 2002
    ..There are limited data on factors predicting response to azathioprine and uncertainty regarding the optimal duration of treatment...
  15. ncbi request reprint The efficacy of methotrexate for maintaining remission in inflammatory bowel disease
    A G Fraser
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Aliment Pharmacol Ther 16:693-7. 2002
    ..The management of patients with inflammatory bowel disease who are resistant to or intolerant of azathioprine remains a challenge. Low-dose methotrexate has been shown to be effective in inducing remission in Crohn's disease...
  16. ncbi request reprint TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort
    Jiwon Hong
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Gastroenterol Hepatol 22:1760-6. 2007
    ..Here we examined the association between candidate disease-susceptibility polymorphisms in the TLR2, TLR4 and TLR9 genes and CD in a New Zealand Caucasian population...
  17. ncbi request reprint Polymorphisms in NFKBIA and ICAM-1 genes in New Zealand Caucasian Crohn's disease patients
    Jiwon Hong
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Gastroenterol Hepatol 22:1666-70. 2007
    ..Here we examined whether the NFKBIA 2758G/A and ICAM-1 K469E variants, recently shown to be CD susceptibility genes in Caucasian populations in Germany and the United Kingdom, are associated with CD in Caucasian patients in New Zealand...
  18. pmc Selenium, selenoprotein genes and Crohn's disease in a case-control population from Auckland, New Zealand
    Liljana Gentschew
    Discipline of Nutrition, FM and HS, University of Auckland, New Zealand
    Nutrients 4:1247-59. 2012
    ..These three SNPs have not been reported elsewhere as being significantly associated with selenium or CD. It is unclear as to whether lower selenium levels are a cause or an effect of the disease...
  19. doi request reprint Genetic variation within TLR10 is associated with Crohn's disease in a New Zealand population
    Angharad R Morgan
    Discipline of Nutrition, The University of Auckland, Auckland, New Zealand
    Hum Immunol 73:416-20. 2012
    ..This study provides evidence to suggest that genetic variation in TLR10 plays a role in interindividual differences in CD susceptibility and clinical outcome...
  20. ncbi request reprint Polymorphisms in the organic cation transporter genes SLC22A4 and SLC22A5 and Crohn's disease in a New Zealand Caucasian cohort
    Euphemia Leung
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Immunol Cell Biol 84:233-6. 2006
    ..0007) of ileocolonic involvement. The population-attributable risk for the SLC22A-TC haplotype is 15.1%. Thus, SLC22A-TC is associated with an increased risk of CD and disease phenotype in our New Zealand CD cohort...
  21. doi request reprint Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population
    Lynnette R Ferguson
    Discipline of Nutrition, FM and HS, The University of Auckland, Auckland, New Zealand Nutrigenomics New Zealand, New Zealand
    Mutat Res 690:108-15. 2010
    ..It will be of interest to follow up CD patients carrying either JAK2 or STAT3 risk alleles for development of further secondary effects, including cancer...
  22. doi request reprint The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population
    Alice H Wang
    Discipline of Nutrition, FMHS, The University of Auckland, Auckland, New Zealand
    Hum Immunol 72:431-5. 2011
    ....
  23. pmc Metallothionein genes: no association with Crohn's disease in a New Zealand population
    Angharad R Morgan
    Discipline of Nutrition, FMHS, The University of Auckland, Auckland, New Zealand
    J Negat Results Biomed 11:8. 2012
    ..We did not find any evidence of association for MT genetic variation with CD. The lack of association indicates that genetic variants in the MT genes do not play a significant role in predisposing to CD in the New Zealand population...
  24. doi request reprint Genetic variations in matrix metalloproteinases may be associated with increased risk of ulcerative colitis
    Angharad R Morgan
    Discipline of Nutrition, FMHS, The University of Auckland, Auckland, New Zealand
    Hum Immunol 72:1117-27. 2011
    ..Further studies are needed in other cohorts to determine the robustness of these observations in different populations...
  25. doi request reprint Association analysis of 3p21 with Crohn's disease in a New Zealand population
    Angharad R Morgan
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Hum Immunol 71:602-9. 2010
    ..The results from this study support the accumulating evidence that suggests the 3p21 region is a CD-associated locus, although it remains unclear which is the causative SNP and/or gene...
  26. pmc IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, 1142, New Zealand
    Gastroenterol Res Pract 2010:539461. 2010
    ..Certain haplotypes very strongly modified risk. There was evidence for interactions of IL-23R variants with the NOD2 wild-type (d/d) genotype. Down-regulating the function of the IL-23R gene may decrease CD risk in the normal population...
  27. doi request reprint Environmental factors in the development of chronic inflammation: a case-control study on risk factors for Crohn's disease within New Zealand
    Dug Yeo Han
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mutat Res 690:116-22. 2010
    ..We conclude that, in addition to strong evidence for genetic associations, factors likely to impact on immune response or reduce early exposure to microbes provide a main risk factor for CD in this New Zealand population...
  28. ncbi request reprint Polymorphisms of CARD15/NOD2 and CD14 genes in New Zealand Crohn's disease patients
    Euphemia Leung
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Immunol Cell Biol 83:498-503. 2005
    ....
  29. ncbi request reprint Mechanisms of reduction of mitral regurgitation by cardiac resynchronization therapy
    Dragos Vinereanu
    University of Medicine and Pharmacy Carol Davila, Bucharest, Romania
    J Am Soc Echocardiogr 20:54-62. 2007
    ..We sought to investigate the effects of improved left ventricular (LV) synchrony on secondary mitral regurgitation in patients receiving cardiac resynchronization therapy for severe heart failure...
  30. ncbi request reprint Gender differences in management after acute myocardial infarction: not 'sexism' but a reflection of age at presentation
    R Ian Williams
    Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN
    J Public Health (Oxf) 26:259-63. 2004
    ..To test whether women receive less intensive treatment and fewer risk stratification tests following acute myocardial infarction (MI), than men...
  31. ncbi request reprint Colony-stimulating factor-1 receptor gene polymorphisms and Crohn's disease
    Euphemia Leung
    Int J Colorectal Dis 22:995-6. 2007
  32. ncbi request reprint Reduced left ventricular functional reserve in hypertensive patients with preserved function at rest
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa School of Medicine, Italy
    Hypertension 45:619-24. 2005
    ..This alteration seems to be related mainly to increase in left ventricular relative wall thickness...
  33. ncbi request reprint Peroxisome proliferator-activated receptor-gamma gene polymorphisms and Crohn's disease
    Euphemia Leung
    Int J Colorectal Dis 22:453-4. 2007
  34. ncbi request reprint Subclinical cardiac involvement in myotonic dystrophy manifesting as decreased myocardial Doppler velocities
    Dragos Vinereanu
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Neuromuscul Disord 14:188-94. 2004
    ..63 respectively, both P<0.01), but they did not correlate with the CTG-repeat size. Patients with MD1 have subclinical cardiac impairment revealed by measurement of myocardial velocities using tissue Doppler echocardiography...
  35. ncbi request reprint IL4, IL10, IL16, and TNF polymorphisms in New Zealand Caucasian Crohn's disease patients
    Jiwon Hong
    Int J Colorectal Dis 23:335-7. 2008
  36. ncbi request reprint Subclinical left ventricular dysfunction in asymptomatic patients with Type II diabetes mellitus, related to serum lipids and glycated haemoglobin
    Dragos Vinereanu
    Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Clin Sci (Lond) 105:591-9. 2003
    ....
  37. ncbi request reprint Wave intensity analysis from the common carotid artery: a new noninvasive index of cerebral vasomotor tone
    Robert A Bleasdale
    Department of Cardiology, Wales Heart Research Institute, Heath Park, Cardiff Cardiff, UK
    Heart Vessels 18:202-6. 2003
    ..01). Carotid wave reflection was significantly decreased during cerebral vasodilatation induced by increased arterial pCO(2). Wave intensity may provide a simple noninvasive means of assessing changes in cerebral vasomotor tone in vivo...
  38. ncbi request reprint Low utilization and wide interhospital variation in investigation of patients after acute myocardial infarction: inadequate resources or insufficient evidence?
    R Ian Williams
    Wales Heart Research Institute, University of Wales College of Medicine, Cardiff CF14 4XN, UK
    J Eval Clin Pract 11:388-96. 2005
    ..Guidelines for the management of patients with acute myocardial infarction are available, but implementation may be difficult when resources are limited...