L R Ferguson

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. ncbi request reprint Has toll-like receptor 4 been prematurely dismissed as an inflammatory bowel disease gene? Association study combined with meta-analysis shows strong evidence for association
    Brian L Browning
    Discipline of Nutrition, The University of Auckland, Auckland, New Zealand
    Am J Gastroenterol 102:2504-12. 2007
  2. doi request reprint Nutrition and mutagenesis
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Annu Rev Nutr 28:313-29. 2008
  3. pmc The role of Vitamin D level and related single nucleotide polymorphisms in Crohn's disease
    Andre Y O M Carvalho
    Presbyterian University Mackenzie, R da Consolacao 930, Sao Paulo 01302 907, Brazil
    Nutrients 5:3898-909. 2013
  4. doi request reprint Transcriptomics to study the effect of a Mediterranean-inspired diet on inflammation in Crohn's disease patients
    Gareth Marlow
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland Private bag 92019, Auckland 1142, New Zealand
    Hum Genomics 7:24. 2013
  5. pmc Reduced genetic influence on childhood obesity in small for gestational age children
    Dug Yeo Han
    Discipline of Nutrition, FM and HS, The University of Auckland, Auckland, New Zealand
    BMC Med Genet 14:10. 2013
  6. doi request reprint Nutrigenetics, nutrigenomics and inflammatory bowel diseases
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand and Nutrigenomics New Zealand, Auckland, New Zealand
    Expert Rev Clin Immunol 9:717-26. 2013
  7. doi request reprint Selenium and its' role in the maintenance of genomic stability
    Lynnette R Ferguson
    Discipline of Nutrition, FM and HS, The University of Auckland, Auckland, New Zealand
    Mutat Res 733:100-10. 2012
  8. pmc Metallothionein genes: no association with Crohn's disease in a New Zealand population
    Angharad R Morgan
    Discipline of Nutrition, FMHS, The University of Auckland, Auckland, New Zealand
    J Negat Results Biomed 11:8. 2012
  9. doi request reprint Potential value of nutrigenomics in Crohn's disease
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Nat Rev Gastroenterol Hepatol 9:260-70. 2012
  10. doi request reprint Inhibition or enhancement by 4 Pacific Island food plants against cancers induced by 2 amino-3-methylimidazo[4,5-f]quinoline in male Fischer 344 rats
    Lynnette R Ferguson
    The University of Auckland, Auckland, New Zealand
    Nutr Cancer 64:218-27. 2012

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Has toll-like receptor 4 been prematurely dismissed as an inflammatory bowel disease gene? Association study combined with meta-analysis shows strong evidence for association
    Brian L Browning
    Discipline of Nutrition, The University of Auckland, Auckland, New Zealand
    Am J Gastroenterol 102:2504-12. 2007
    ..We tested two TLR4 variants for association with IBD in the New Zealand caucasian population and assessed the cumulative evidence for association of TLR4 Asp299Gly and IBD...
  2. doi request reprint Nutrition and mutagenesis
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Annu Rev Nutr 28:313-29. 2008
    ..Human studies utilizing nutrigenomic/nutrigenetic technologies will be essential to quantifying and overcoming diet-related mutagenesis...
  3. pmc The role of Vitamin D level and related single nucleotide polymorphisms in Crohn's disease
    Andre Y O M Carvalho
    Presbyterian University Mackenzie, R da Consolacao 930, Sao Paulo 01302 907, Brazil
    Nutrients 5:3898-909. 2013
    ..This study demonstrates a significant interaction between Vit D levels and CD susceptibility, as well as a significant association between Vit D levels and genotype...
  4. doi request reprint Transcriptomics to study the effect of a Mediterranean-inspired diet on inflammation in Crohn's disease patients
    Gareth Marlow
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland Private bag 92019, Auckland 1142, New Zealand
    Hum Genomics 7:24. 2013
    ..We examined changes in inflammation and also in the gut microbiota. We compared the results of established biomarkers, C-reactive protein and the micronuclei assay, of inflammation with results from a transcriptomic approach...
  5. pmc Reduced genetic influence on childhood obesity in small for gestational age children
    Dug Yeo Han
    Discipline of Nutrition, FM and HS, The University of Auckland, Auckland, New Zealand
    BMC Med Genet 14:10. 2013
    ....
  6. doi request reprint Nutrigenetics, nutrigenomics and inflammatory bowel diseases
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand and Nutrigenomics New Zealand, Auckland, New Zealand
    Expert Rev Clin Immunol 9:717-26. 2013
    ..Nutrigenetics may lead to personalized nutrition for disease prevention and treatment, while nutrigenomics may help to understand the nature of the disease and individual response to nutrients. ..
  7. doi request reprint Selenium and its' role in the maintenance of genomic stability
    Lynnette R Ferguson
    Discipline of Nutrition, FM and HS, The University of Auckland, Auckland, New Zealand
    Mutat Res 733:100-10. 2012
    ..New paradigms, possibly involving nutrigenomic tools, will be necessary to optimise the forms and levels of Se desirable for maximum protection of genomic stability in all humans...
  8. pmc Metallothionein genes: no association with Crohn's disease in a New Zealand population
    Angharad R Morgan
    Discipline of Nutrition, FMHS, The University of Auckland, Auckland, New Zealand
    J Negat Results Biomed 11:8. 2012
    ..We did not find any evidence of association for MT genetic variation with CD. The lack of association indicates that genetic variants in the MT genes do not play a significant role in predisposing to CD in the New Zealand population...
  9. doi request reprint Potential value of nutrigenomics in Crohn's disease
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Nat Rev Gastroenterol Hepatol 9:260-70. 2012
    ..These methods have been successfully applied to animal models of Crohn's disease, and the time is right to move them to human studies...
  10. doi request reprint Inhibition or enhancement by 4 Pacific Island food plants against cancers induced by 2 amino-3-methylimidazo[4,5-f]quinoline in male Fischer 344 rats
    Lynnette R Ferguson
    The University of Auckland, Auckland, New Zealand
    Nutr Cancer 64:218-27. 2012
    ..In particular, the incidence of malignant liver tumors and gastrointestinal tumors were significantly increased in the taro-fed group in comparison with the kumara group...
  11. doi request reprint Comparative effects in rats of intact wheat bran and two wheat bran fractions on the disposition of the mutagen 2-amino-3-methylimidazo[4,5-f]quinoline
    Lynnette R Ferguson
    The University of Auckland, Auckland, New Zealand
    Mutat Res 716:59-65. 2011
    ....
  12. pmc Analysis of MMP2 promoter polymorphisms in childhood obesity
    Angharad R Morgan
    Discipline of Nutrition, FMHS, The University of Auckland, New Zealand
    BMC Res Notes 4:253. 2011
    ..abstract:..
  13. pmc Genetic adult lactase persistence is associated with risk of Crohn's Disease in a New Zealand population
    Deborah J Nolan
    Smart Foods Centre, University of Wollongong, Northfields Ave, Wollongong, New South Wales, Australia
    BMC Res Notes 3:339. 2010
    ..abstract:..
  14. pmc Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study
    Angharad R Morgan
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    BMC Med Genet 11:125. 2010
    ..However, in a large proportion of SGA, no underlying cause is evident, and these individuals may have a larger genetic contribution...
  15. ncbi request reprint Natural and human-made mutagens and carcinogens in the human diet
    Lynnette R Ferguson
    Discipline of Nutrition and Auckland Cancer Society Res Centre, The University of Auckland, Faculty of Medical and Health Sciences, Private Bag 92019, 1000 Auckland, New Zealand
    Toxicology 181:79-82. 2002
    ....
  16. pmc Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk
    Lynnette R Ferguson
    Discipline of Nutrition, The University of Auckland, Auckland, New Zealand
    World J Gastroenterol 14:4652-61. 2008
    ....
  17. ncbi request reprint The dietary fibre debate: more food for thought
    Lynnette R Ferguson
    Discipline of Nutrition, University of Auckland, Auckland, New Zealand
    Lancet 361:1487-8. 2003
  18. ncbi request reprint Contrasting effects of non-starch polysaccharide and resistant starch-based diets on the disposition and excretion of the food carcinogen, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), in a rat model
    Lynnette R Ferguson
    Discipline of Nutrition, University of Auckland Faculty of Medicine and Health Science, Private Bag 92019, Auckland, New Zealand
    Food Chem Toxicol 41:785-92. 2003
    ..Furthermore, the data reveal that the observation of enhanced laxation and faecal bulking does not necessarily imply a reduction in carcinogen bioavailability...
  19. doi request reprint Single nucleotide polymorphisms in human Paneth cell defensin A5 may confer susceptibility to inflammatory bowel disease in a New Zealand Caucasian population
    L R Ferguson
    Discipline of Nutrition, The University of Auckland, New Zealand
    Dig Liver Dis 40:723-30. 2008
    ..Since breakdown of normal mucosal antibacterial defence occurs in inflammatory bowel disease (IBD), variants in the DEFA5 gene could be associated with IBD risk...
  20. ncbi request reprint Bacterial antimutagenesis by hydroxycinnamic acids from plant cell walls
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medicine and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1000, New Zealand
    Mutat Res 542:49-58. 2003
    ..Providing the current data extrapolate to mammalian cells, they suggest that antimutagenic properties of hydroxycinnamic acids released from plant cell walls could play a role in dietary fibre protection against cancer...
  21. ncbi request reprint Cancer prevention by dietary bioactive components that target the immune response
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Curr Cancer Drug Targets 7:459-64. 2007
    ....
  22. ncbi request reprint Genes, diet and inflammatory bowel disease
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mutat Res 622:70-83. 2007
    ..A combination of human correlation studies with experimental models could provide a rational strategy for optimising nutrigenetic approaches to IBD...
  23. ncbi request reprint Genotoxicity of non-covalent interactions: DNA intercalators
    Lynnette R Ferguson
    Auckland Cancer Society Research Centre, Faculty of Medical and Health Science, The University of Auckland, New Zealand
    Mutat Res 623:14-23. 2007
    ..DNA intercalation may serve to position other, chemically reactive molecules, in specific ways on the DNA, leading to a distinctive (and wider) range of mutagenic properties, and possible carcinogenic potential...
  24. ncbi request reprint Multiple drug resistance, antimutagenesis and anticarcinogenesis
    Lynnette R Ferguson
    Discipline of Nutrition ACSRC, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mutat Res 591:24-33. 2005
    ....
  25. ncbi request reprint Epigenetic events and protection from colon cancer in New Zealand
    Lynnette R Ferguson
    Discipline of Nutrition and ACSRC, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Environ Mol Mutagen 44:36-43. 2004
    ....
  26. ncbi request reprint Antioxidant and antigenotoxic effects of plant cell wall hydroxycinnamic acids in cultured HT-29 cells
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medicine and Health Sciences The University of Auckland, Auckland, New Zealand
    Mol Nutr Food Res 49:585-93. 2005
    ..Thus, providing they can reach effective levels in the colon, they could provide an important mechanism by which dietary fibres of food plants, such as spinach or cereal, protect against colon cancer...
  27. ncbi request reprint Nutrigenomics in the whole-genome scanning era: Crohn's disease as example
    L R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Cell Mol Life Sci 64:3105-18. 2007
    ..New genomic technologies need to be matched with innovative methodologies to characterize the likely impact of foods and to take the field to another dimension of value for human diet development and optimized health...
  28. ncbi request reprint Meat consumption, cancer risk and population groups within New Zealand
    Lynnette R Ferguson
    Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mutat Res 506:215-24. 2002
    ..More detailed population studies are warranted to establish the role of meat, meat processing, cooking methods and the interaction with food plants and/or with genotype and phenotype in New Zealand...
  29. doi request reprint Dissecting the nutrigenomics, diabetes, and gastrointestinal disease interface: from risk assessment to health intervention
    Lynnette R Ferguson
    The University of Auckland, Auckland, New Zealand
    OMICS 12:237-44. 2008
    ..An even greater challenge may be in implementing population level changes in diet and behavior to fully exploit the potential of this field...
  30. ncbi request reprint Inhibitors of topoisomerase II enzymes: a unique group of environmental mutagens and carcinogens
    L R Ferguson
    Cancer Research Laboratory, University of Auckland Medical School, Private Bag 92019, Auckland 1000, New Zealand
    Mutat Res 400:271-8. 1998
    ..They are generally not point mutagens and may fail to provide distinctive fingerprints in mutation spectra. These characteristics may be limiting a realistic evaluation of their role in human carcinogenesis using current methodologies...
  31. ncbi request reprint Epigenetic regulation of gene expression as an anticancer drug target
    Lynnette R Ferguson
    Auckland Cancer Society Research Centre, Faculty of Medical and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Curr Cancer Drug Targets 11:199-212. 2011
    ..Because of the interdependence of epigenetic processes, combinations of these approaches may have maximum clinical efficacy...
  32. doi request reprint Dietary influences on mutagenesis--where is this field going?
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Science, The University of Auckland, Auckland, New Zealand
    Environ Mol Mutagen 51:909-18. 2010
    ..With improved methodologies for DNA sequencing and epigenetic changes, it is time to apply more sophisticated approaches to recognizing and proving the role of diet as a primary modulator of mutagenesis in humans...
  33. ncbi request reprint Dietary fibres may protect or enhance carcinogenesis
    P J Harris
    School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mutat Res 443:95-110. 1999
    ..However, so far only a few animal carcinogenesis experiments have been reported using these materials, and no human intervention studies. We believe caution should be exercised in the addition of such materials to food...
  34. ncbi request reprint Natural and man-made mutagens and carcinogens in the human diet
    L R Ferguson
    Auckland Cancer Society Research Centre, Faculty of Medicine and Health Science, The University of Auckland, New Zealand
    Mutat Res 443:1-10. 1999
    ..Such experimental approaches might be expected to lead a better understanding of the interplay between different dietary factors and also between diet, hereditary and the environment...
  35. ncbi request reprint Prospects for cancer prevention
    L R Ferguson
    Auckland Cancer Society Research Centre, Faculty of Medicine and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mutat Res 428:329-38. 1999
    ..The enhanced cancer incidence in the beta-carotene trial illustrates the potential benefit of utilising surrogate endpoints of malignant disease rather than incident cancer as a trial endpoint...
  36. doi request reprint Nutrigenomics and inflammatory bowel diseases
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Expert Rev Clin Immunol 6:573-83. 2010
    ..Such studies suggest nutrigenomic approaches to maintaining disease remission at present, and preventing disease development in the future...
  37. ncbi request reprint Transcriptional blockages in a cell-free system by sequence-selective DNA alkylating agents
    L R Ferguson
    Auckland Cancer Society Research Centre, Faculty of Medicine and Health Science, The University of Auckland, New Zealand
    Chem Biol Interact 126:15-31. 2000
    ..The results suggest that the bisbenzimidazole-linked mustard does cause alkylation and transcription blockage at novel DNA sites. in addition to sites characteristic of untargeted mustards...
  38. doi request reprint Meat and cancer
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Meat Sci 84:308-13. 2010
    ..Adjusting the balance between meat and other dietary components may be critical to protecting against potential cancer risks...
  39. ncbi request reprint Role of plant polyphenols in genomic stability
    L R Ferguson
    Faculty of Medical and Health Science, Auckland Cancer Society Research Centre, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mutat Res 475:89-111. 2001
    ..More focused human studies are necessary before recommending specific polyphenolic supplements at specific doses in the human population...
  40. doi request reprint Role of dietary mutagens in cancer and atherosclerosis
    Lynnette R Ferguson
    Faculty of Medical and Health Sciences, Discipline of Nutrition, The University of Auckland, Auckland, New Zealand
    Curr Opin Clin Nutr Metab Care 12:343-9. 2009
    ..To provide an updated summary of dietary mutagens and their potential role in the etiology of cancer and atherosclerosis...
  41. pmc Nucleotide-binding oligomerization domain containing 1 (NOD1) haplotypes and single nucleotide polymorphisms modify susceptibility to inflammatory bowel diseases in a New Zealand caucasian population: a case-control study
    Claudia Huebner
    Discipline of Nutrition, The University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    BMC Res Notes 2:52. 2009
    ..Carrying specific SNPs in this gene significantly modifies the risk of CD and/or UC in a New Zealand Caucasian population...
  42. doi request reprint Nutrigenomics approaches to functional foods
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Am Diet Assoc 109:452-8. 2009
    ....
  43. doi request reprint The potential role of nutritional genomics tools in validating high health foods for cancer control: broccoli as example
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand, New Zealand
    Mol Nutr Food Res 56:126-46. 2012
    ..Jointly, these technologies can provide proof of human efficacy, and may be essential to ensure effective market transfer and uptake of broccoli and related foods...
  44. ncbi request reprint Modulation of mutagenic properties in a series of DNA-directed alkylating agents by variation of chain length and alkylator reactivity
    L R Ferguson
    Cancer Research Laboratory, University of Auckland School of Medicine, New Zealand
    Mutat Res 265:181-93. 1992
    ..The results indicate clear structure-activity relationships for the spectrum of mutagenic activity, which relate to both chain length and alkylator reactivity, for these compounds...
  45. ncbi request reprint Changing concepts of dietary fiber: implications for carcinogenesis
    L R Ferguson
    Discipline of Nutrition, Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Nutr Cancer 39:155-69. 2001
    ..However, the new definitions make it possible to increase "dietary fiber" without consuming any such materials. We suggest that this could have negative connotations for cancer risk in human populations...
  46. ncbi request reprint 'Petite' mutagenesis and mitotic crossing-over in yeast by DNA-targeted alkylating agents
    L R Ferguson
    Cancer Research Laboratory, University of Auckland School of Medicine, Private Bag, New Zealand
    Mutat Res 215:213-22. 1989
    ..These data suggest very different modes of action between the DNA-targeted alkylators and their non-targeted counterparts...
  47. ncbi request reprint Relationships between structure, toxicity and genetic effects in Salmonella typhimurium and Saccharomyces cerevisiae for substituted aniline mustards
    L R Ferguson
    Cancer Research Laboratory, University of Auckland School of Medicine, New Zealand
    Mutat Res 224:95-104. 1989
    ..In contrast, the most chemically reactive compounds were the most toxic and most recombinogenic in yeast...
  48. ncbi request reprint Anaerobic incubation and mutagenicity of nitracrine analogues in Salmonella typhimurium
    L R Ferguson
    Cancer Research Laboratory, University of Auckland Medical School, New Zealand
    Mutagenesis 2:253-7. 1987
    ..If this result extends to other compounds, experiments of this nature using the bacterial strains could provide a novel and useful screening system to identify hypoxia-selective cytotoxic anticancer drugs of potential clinical value...
  49. ncbi request reprint DNA-directed aniline mustards with high selectivity for adenine or guanine bases: mutagenesis in a variety of Salmonella typhimurium strains differing in DNA-repair capability
    L R Ferguson
    Cancer Research Laboratory, University of Auckland, School of Medicine, New Zealand
    Mutat Res 321:27-34. 1994
    ....
  50. ncbi request reprint Potential functional foods in the traditional Maori diet
    Richard C Cambie
    Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mutat Res 523:109-17. 2003
    ..Leaves of the "hen and chickens" fern (Asplenium bulbiferum) contain antioxidant flavonoids such as kaempferol glucosides. Native seaweeds also have useful nutritive properties...
  51. ncbi request reprint Microbial mutagenic effects of the DNA minor groove binder pibenzimol (Hoechst 33258) and a series of mustard analogues
    L R Ferguson
    Cancer Research Laboratory, University of Auckland School of Medicine, New Zealand
    Mutat Res 329:19-27. 1995
    ..The significant antitumor activity and low mutagenic potential shown by these compounds make them worthy of further study...
  52. ncbi request reprint Adsorption of a hydrophobic mutagen to cereal brans and cereal bran dietary fibres
    P J Harris
    School of Biological Sciences, The University of Auckland, Private Bag, New Zealand
    Mutat Res 412:323-31. 1998
    ..The possible relationship between adsorptive ability and ability of the bran from a particular species to protect against colorectal cancer is discussed...
  53. ncbi request reprint Heterocyclic amine content of cooked meat and risk of prostate cancer
    A E Norrish
    Department of Community Health, University of Auckland, New Zealand
    J Natl Cancer Inst 91:2038-44. 1999
    ..This study examined associations between prostate cancer risk and 1) estimated daily intake of heterocyclic amines from cooked meat and 2) level of cooked-meat doneness...
  54. ncbi request reprint Mutagenic activity of nitracrine derivatives in Salmonella typhimurium: relationship to drug physicochemical parameters, and to bacterial uvrB and recA genes and plasmid pKM101
    L R Ferguson
    Cancer Research Laboratory, University of Auckland Medical School, New Zealand
    Mutat Res 223:13-22. 1989
    ..Of the compounds studied, the 4-OMe derivative appears to best retain the desirable antitumour properties of nitracrine while showing greatly-reduced mutagenic potential, and is an interesting lead for further development...
  55. ncbi request reprint In vitro and in vivo mutagenicity studies on sporidesmin, the toxin associated with facial eczema in ruminants
    L R Ferguson
    Cancer Research Laboratory, University of Auckland Medical School, Private Bag, New Zealand
    Mutat Res 268:199-210. 1992
    ....
  56. doi request reprint Mushroom intolerance: a novel diet-gene interaction in Crohn's disease
    Ivonne Petermann
    Discipline of Nutrition, The University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    Br J Nutr 102:506-8. 2009
    ..Nutrigenomic approaches to dietary recommendations may be appropriate in this group...
  57. doi request reprint Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort
    Ivonne Petermann
    Discipline of Nutrition, The University of Auckland, New Zealand
    Hum Immunol 70:440-6. 2009
    ..e. bacterial detection). There is evidence that carrying two SNPs in genes may lead to statistical significance for genes and SNPs that do not otherwise confirm as risk alleles for disease aetiology when analysed alone...
  58. ncbi request reprint Mutagenic and clastogenic activity of nitracrine analogues in cultured V79 Chinese hamster cells
    L R Ferguson
    Cancer Research Laboratory, University of Auckland Medical School, New Zealand
    Mutat Res 204:655-63. 1988
    ..Both of these compounds were potent inducers of micronuclei in V79-171b cells, indicating high clastogenic activity. It would appear prudent to regard both of these compounds as potential human carcinogens...
  59. doi request reprint PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population
    A R Morgan
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Tissue Antigens 76:119-25. 2010
    ..There was no evidence for an association with PTPN22...
  60. ncbi request reprint Evidence for epidermal growth factor receptor-enhanced chemosensitivity in combinations of cisplatin and the new irreversible tyrosine kinase inhibitor CI-1033
    M A Gieseg
    Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1000, New Zealand
    Anticancer Drugs 12:683-90. 2001
    ..Given the current clinical data, this combination may be of more than theoretical interest...
  61. ncbi request reprint Contrasting effects of acute and chronic dietary exposure to 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) on xenobiotic metabolising enzymes in the male Fischer 344 rat: implications for chemoprevention studies
    R A McPherson
    Division of Pharmacology and Clinical Pharmacology, University of Auckland, Private Bag 92019, Auckland 1000, New Zealand
    Eur J Nutr 40:39-47. 2001
    ..There is a danger that chemopreventive strategies developed using acute models may be misleading, since the mechanism is unlikely to occur during human dietary exposures...
  62. doi request reprint Evaluation of the cytoprotective effects of bovine lactoferrin against intestinal toxins using cellular model systems
    Hong Tian
    School of Engineering and Advanced Technology, College of Sciences, Massey University, Auckland, New Zealand
    Biometals 23:589-92. 2010
    ..BLf caused significant reduction of faecal genotoxin-induced DNA damage in HT29 cells, and down-regulation of lipopolysaccharide (LPS)-induced macrophage cell stress and endotoxic response, in an infection status...
  63. ncbi request reprint Mutagenic properties of topoisomerase-targeted drugs
    B C Baguley
    Auckland Cancer Society Research Centre, University of Auckland Medical School, Private Bag 92019, Auckland, New Zealand
    Biochim Biophys Acta 1400:213-22. 1998
    ..Mutagenicity of topoisomerase-directed agents has been underestimated in the past, since these drugs are not usually capable of reacting covalently with DNA and usually have low mutagenicity in microbial assays...
  64. ncbi request reprint Does a diet rich in dietary fibre really reduce the risk of colon cancer?
    L R Ferguson
    The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Dig Liver Dis 37:139-41. 2005
  65. ncbi request reprint Chromosomal changes in Chinese hamster AA8 cells caused by podophyllin, a common treatment for genital warts
    L R Ferguson
    Cancer Research Laboratory, University of Auckland Medical School, New Zealand
    Mutat Res 266:231-9. 1992
    ..We suggest that podophyllin could potentiate these effects and question its continued widespread use...
  66. doi request reprint Environmental factors in the development of chronic inflammation: a case-control study on risk factors for Crohn's disease within New Zealand
    Dug Yeo Han
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mutat Res 690:116-22. 2010
    ..We conclude that, in addition to strong evidence for genetic associations, factors likely to impact on immune response or reduce early exposure to microbes provide a main risk factor for CD in this New Zealand population...
  67. ncbi request reprint Immunonutrition and cancer
    Martin Philpott
    Discipline of Nutrition and ACSRC, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mutat Res 551:29-42. 2004
    ..We suggest that immunonutrition may provide a less invasive alternative to immunotherapy in protection against cancers associated with chronic inflammation...
  68. pmc Dietary protection against free radicals: a case for multiple testing to establish structure-activity relationships for antioxidant potential of anthocyanic plant species
    Martin Philpott
    The University of Auckland, New Zealand
    Int J Mol Sci 10:1081-103. 2009
    ..Subsequent studies might usefully consider complex mixtures and a battery of assays...
  69. doi request reprint Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population
    Lynnette R Ferguson
    Discipline of Nutrition, FM and HS, The University of Auckland, Auckland, New Zealand Nutrigenomics New Zealand, New Zealand
    Mutat Res 690:108-15. 2010
    ..It will be of interest to follow up CD patients carrying either JAK2 or STAT3 risk alleles for development of further secondary effects, including cancer...
  70. doi request reprint Characterization of single-nucleotide polymorphisms relevant to inflammatory bowel disease in commonly used gastrointestinal cell lines
    Claudia Huebner
    Discipline of Nutrition, FM and HS, The University of Auckland, Auckland, New Zealand
    Inflamm Bowel Dis 16:282-95. 2010
    ..Here, we genotyped 50 IBD markers across 32 susceptibility genes in 9 commonly used gastrointestinal cell lines...
  71. doi request reprint Chronic inflammation and mutagenesis
    Lynnette R Ferguson
    Discipline of Nutrition and ACSRC, FM and HS, The University of Auckland, Auckland, New Zealand
    Mutat Res 690:3-11. 2010
    ..Mutations may provide at least part of the cause of enhanced susceptibility to chronic diseases associated with chronic inflammation...
  72. doi request reprint Dietary factors in chronic inflammation: food tolerances and intolerances of a New Zealand Caucasian Crohn's disease population
    Christopher M Triggs
    Statistics Department, The University of Auckland, New Zealand Nutrigenomics New Zealand, New Zealand
    Mutat Res 690:123-38. 2010
    ..The wide range of detrimental items suggests that dietary maintenance of remission is likely to be difficult, and to exclude a substantial number of foods. Personalised diets may be especially important to these individuals...
  73. doi request reprint Association analysis of 3p21 with Crohn's disease in a New Zealand population
    Angharad R Morgan
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Hum Immunol 71:602-9. 2010
    ..The results from this study support the accumulating evidence that suggests the 3p21 region is a CD-associated locus, although it remains unclear which is the causative SNP and/or gene...
  74. ncbi request reprint Association of DLG5 variants with inflammatory bowel disease in the New Zealand Caucasian population and meta-analysis of the DLG5 R30Q variant
    Brian L Browning
    Discipline of Nutrition, Department of Statistics, University of Auckland, New Zealand, and Department of Gastroenterology, Box Hill Hospital, Monash, Australia
    Inflamm Bowel Dis 13:1069-76. 2007
    ....
  75. ncbi request reprint Oxidative DNA damage and repair: significance and biomarkers
    Lynnette R Ferguson
    Discipline of Nutrition, The University of Auckland, Auckland, New Zealand
    J Nutr 136:2687S-9S. 2006
  76. ncbi request reprint Genetic variation in human disease and a new role for copy number variants
    Andrew N Shelling
    Department of Obstetrics and Gynaecology, The University of Auckland, New Zealand Nutrigenomics New Zealand, New Zealand
    Mutat Res 622:33-41. 2007
    ..As complex disease is related to changes in gene expression, any variation in the human genome that alters gene expression is now a candidate for being involved in the disease process...
  77. ncbi request reprint Cell culture models in developing nutrigenomics foods for inflammatory bowel disease
    Martin Philpott
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mutat Res 622:94-102. 2007
    ..Such screens provide a scientific basis for the rational choice of foods to be more rigorously investigated in animal models of IBD...
  78. ncbi request reprint Non-covalent ligand/DNA interactions: minor groove binding agents
    Stephanie M Nelson
    Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 10000, New Zealand
    Mutat Res 623:24-40. 2007
    ..Recent developments with other minor groove binding small molecules and technological advances are also discussed...
  79. doi request reprint Genetic analysis of MDR1 and inflammatory bowel disease reveals protective effect of heterozygous variants for ulcerative colitis
    Claudia Huebner
    Discipline of Nutrition, FM and HS, University of Auckland, Auckland, New Zealand
    Inflamm Bowel Dis 15:1784-93. 2009
    ..The aims of this study were to genotype these variants and correlate them to disease phenotype in New Zealand IBD patients...
  80. ncbi request reprint Modeling inflammatory bowel disease: the zebrafish as a way forward
    Donald R Love
    University of Auckland, School of Biological Sciences, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    Expert Rev Mol Diagn 7:177-93. 2007
    ..The second is in the application and further development of gene targeting approaches. These twin features will be addressed in this review in the context of modeling inflammatory bowel disease...
  81. ncbi request reprint Dietary cancer and prevention using antimutagens
    Lynnette R Ferguson
    Discipline of Nutrition and ACSRC, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Toxicology 198:147-59. 2004
    ..Dietary supplementation may provide an alternative approach...
  82. ncbi request reprint Production and characterisation of two wheat-bran fractions: an aleurone-rich and a pericarp-rich fraction
    Philip J Harris
    School of Biological Sciences, The University of Auckland, Auckland, New Zealand
    Mol Nutr Food Res 49:536-45. 2005
    ..When the fractions were fed as a dietary supplement to rats and walls were isolated from the faeces, it was found that the pericarp walls were not degraded, but the aleurone walls were partially degraded...
  83. ncbi request reprint Dietary fibres as "prebiotics": implications for colorectal cancer
    Chiara C Lim
    Discipline of Nutrition, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand
    Mol Nutr Food Res 49:609-19. 2005
    ..However, their mechanisms of action in humans are speculative, and research aimed at providing an integrated view of the gut microbiota and dietary fibre nutrition of humans needs to be developed...
  84. ncbi request reprint Demonstration by real-time polymerase chain reaction that cellular DNA alkylation by novel aminoindoline compounds affects expression of the protooncogene c-myc
    Stephanie M Nelson
    Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 10000, New Zealand
    Chem Res Toxicol 18:239-48. 2005
    ....
  85. ncbi request reprint In situ and in vitro antioxidant activity of sweetpotato anthocyanins
    Martin Philpott
    Discipline of Nutrition, Faculty of Medicine and Health Sciences, and School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Agric Food Chem 52:1511-3. 2004
    ....
  86. ncbi request reprint Triallelic single nucleotide polymorphisms and genotyping error in genetic epidemiology studies: MDR1 (ABCB1) G2677/T/A as an example
    Claudia Huebner
    Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Cancer Epidemiol Biomarkers Prev 16:1185-92. 2007
    ..The failure to recognize the triallic nature of a SNP may lead to underestimations of real genetic associations...
  87. ncbi request reprint Biochemical evidence that high concentrations of the antidepressant amoxapine may cause inhibition of mitochondrial electron transport
    A M Roberton
    Department of Biochemistry, University of Auckland, New Zealand
    Toxicol Appl Pharmacol 93:118-26. 1988
    ..We speculate that lactic acid accumulation in patients with amoxapine overdose may be caused by loss of electron acceptor activity in tissues...
  88. ncbi request reprint The use of 32P-postlabelling to detect DNA adducts produced by experimental anticancer drugs: DNA-directed nitrogen mustards
    L R Ferguson
    Cancer Research Laboratory, University of Auckland School of Medicine, New Zealand
    Anticancer Drug Des 9:239-49. 1994
    ....
  89. ncbi request reprint Mechanisms by which resistant starches and non-starch polysaccharide sources affect the metabolism and disposition of the food carcinogen, 2-amino-3-methylimidazo[4,5-f]quinoline
    P Kestell
    Faculty of Medicine and Health Science, Auckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Chromatogr B Analyt Technol Biomed Life Sci 802:201-10. 2004
    ..We conclude that changes in activity and expression of xenobiotic metabolising enzymes could play a role in the contrasting effects of these two types of dietary fibre on carcinogen uptake and disposition...
  90. ncbi request reprint DNA stability and serum selenium levels in a high-risk group for prostate cancer
    Nishi Karunasinghe
    Discipline of Nutrition, The University of Auckland, Auckland, New Zealand
    Cancer Epidemiol Biomarkers Prev 13:391-7. 2004
    ..It also raises the question as to whether glutathione peroxidase saturation levels are appropriate indicators of the optimal selenium levels for a given population...
  91. ncbi request reprint Mechanistic approaches to chemoprevention of mutation and cancer
    Lynnette R Ferguson
    The University of Auckland, School of Medical Sciences, Faculty of Medical and Health Sciences, Discipline of Nutrition ACSRC, Private Bag 92019, Auckland 1000, New Zealand
    Mutat Res 591:3-7. 2005
    ..There is increasing reason to believe that the long-term use of a combination of anticarcinogens, over an extended time span, may provide a realistic prospect of reducing the current burden of human cancers...
  92. doi request reprint Anthocyanidin-containing compounds occur in the periderm cell walls of the storage roots of sweet potato (Ipomoea batatas)
    Martin Philpott
    Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Plant Physiol 166:1112-7. 2009
    ..It is concluded that the periderm cell walls contain covalently bound anthocyanidin-containing compounds, possibly anthocyanins...
  93. ncbi request reprint The mutagenic spectrum of acridine-linked aniline nitrogen mustards in AS52 cells: implications of DNA targeting with high selectivity for adenine or guanine bases
    L R Ferguson
    Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, 1000, Auckland, New Zealand
    Mutat Res 469:115-26. 2000
    ..In contrast, the longer chain length targeted mustards, which form >90% of initial adducts at adenine N(1) sites, generated also formed transversion mutations, but these overwhelmingly (24/27) involved AT base pairs...
  94. doi request reprint Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease
    Hui Ming Lin
    School of Medical Sciences, University of Auckland, New Zealand
    J Proteome Res 9:1965-75. 2010
    ..These metabolite differences may be associated with residual genes from the embryonic stem cells of the 129P2 mouse strain that were used to create the IL10(-/-) mouse, or may indicate novel functions of IL10 unrelated to inflammation...
  95. ncbi request reprint Mode of cell death induced in Chinese hamster cells by sequence-selective DNA minor groove binding nitrogen mustards: comparison with untargeted mustards and with Hoechst 33342
    Glenn Whiteside
    Auckland Cancer Society Research Centre, The University of Auckland, PB92019, Auckland, New Zealand
    Oncol Res 13:491-502. 2003
    ..Exploring these different mechanisms of apoptosis may provide new directions for the development of antitumor drugs...
  96. ncbi request reprint Nutrigenomics: integrating genomic approaches into nutrition research
    Lynnette R Ferguson
    Discipline of Nutrition Auckland Cancer Society Research Centre ACSRC, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Mol Diagn Ther 10:101-8. 2006
    ..New developments allow identification of up to 500,000 SNPs in an individual, and with increasingly lowered pricings these developments may explode the population-level potential for dietary optimization based on nutrigenomic approaches...
  97. doi request reprint Quinazolines as novel anti-inflammatory histone deacetylase inhibitors
    Zhigang Lin
    Auckland Cancer Society Research Centre, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Mutat Res 690:81-8. 2010
    ..Several of the compounds showed in vitro HDAC inhibition ability in PC3, HCT116 and NIH-3T3 cell lines comparable to that of SAHA...
  98. ncbi request reprint Hemolysate thioredoxin reductase and glutathione peroxidase activities correlate with serum selenium in a group of New Zealand men at high prostate cancer risk
    Nishi Karunasinghe
    Discipline of Nutrition, University of Auckland, Auckland 1023, New Zealand
    J Nutr 136:2232-5. 2006
    ..In contrast, 6 mo of selenium supplementation did not affect GPx activity. This study presents, to our knowledge for the first time, both measurements of human hemolysate TR activity and its relation to serum selenium...
  99. doi request reprint Nontargeted urinary metabolite profiling of a mouse model of Crohn's disease
    Hui Ming Lin
    School of Medical Sciences, University of Auckland, Auckland, New Zealand
    J Proteome Res 8:2045-57. 2009
    ..This study demonstrates that nontargeted GCMS metabolite profiling of IL10-/- mice can provide insights into the metabolic effects of IL10-deficiency and identify potential markers of intestinal inflammation...
  100. doi request reprint Kiwifruit-based polyphenols and related antioxidants for functional foods: kiwifruit extract-enhanced gluten-free bread
    Dongxiao Sun-Waterhouse
    The New Zealand Institure for Plant and Food Research Limited, Auckland, New Zealand
    Int J Food Sci Nutr 60:251-64. 2009
    ..Thus, the aqueous extract of kiwifruit puree containing health-beneficial constituents can be considered a functional ingredient for gluten-free bread formulation...
  101. pmc Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population
    Lynnette R Ferguson
    Discipline of Nutrition, The University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    Gastroenterol Res Pract 2009:591704. 2009
    ..g., haplotype of GGC was 2.9-fold more in the CD or UCpatients) or decrease (e.g., TGT was 0.47-fold less in UC patients) the risk of IBD in a New Zealand Caucasian population...