Matthew J During

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. pmc HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity
    Alisha E Jung
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Mol Ther 16:1048-55. 2008
  2. ncbi request reprint Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
    Matthew J During
    Department of Molecular Medicine and Pathology, University of Auckland, Private Bag 92019, Auckland 86716, New Zealand
    Nat Med 9:1173-9. 2003
  3. ncbi request reprint VEGF, a mediator of the effect of experience on hippocampal neurogenesis
    Matthew J During
    Department of Neurological Surgery, Weill Medical College of Cornell University, New York, USA
    Curr Alzheimer Res 3:29-33. 2006
  4. ncbi request reprint AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats
    Matthias Klugmann
    Department of Molecular Medicine and Pathology, Functional Genomics and Translational Neuroscience Laboratory, University of Auckland, Auckland, New Zealand
    Mol Cell Neurosci 28:347-60. 2005
  5. pmc Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo
    Xiqun Chen
    Department of Neurology, The College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 28:672-80. 2008
  6. pmc Knockdown and overexpression of NR1 modulates NMDA receptor function
    Maggie L Kalev-Zylinska
    Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
    Mol Cell Neurosci 41:383-96. 2009
  7. ncbi request reprint A novel role of circadian transcription factor DBP in hippocampal plasticity
    Matthias Klugmann
    Functional Genomics and Translational Neuroscience Laboratory, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
    Mol Cell Neurosci 31:303-14. 2006
  8. ncbi request reprint VEGF links hippocampal activity with neurogenesis, learning and memory
    Lei Cao
    Department of Neurological Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Genet 36:827-35. 2004
  9. ncbi request reprint Phosphorylation-dependent degradation of transgenic CREB protein initiated by heterodimerization
    Alexandre Mouravlev
    Department of Molecular Medicine and Pathology, The University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
    Brain Res 1130:31-7. 2007
  10. ncbi request reprint Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease
    Matthias Klugmann
    Laboratory of Functional Genomics and Translational Neuroscience, Department of Molecular Medicine and Pathology, University of Auckland School of Medicine, 85 Park Road, Auckland, New Zealand
    Mol Ther 11:745-53. 2005

Detail Information

Publications59

  1. pmc HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity
    Alisha E Jung
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Mol Ther 16:1048-55. 2008
    ..Our results suggest that a comparatively modest upregulation of multiple HSPs may be an effective approach for achieving significant neuroprotection in PD...
  2. ncbi request reprint Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
    Matthew J During
    Department of Molecular Medicine and Pathology, University of Auckland, Private Bag 92019, Auckland 86716, New Zealand
    Nat Med 9:1173-9. 2003
    ..Systemic administration of [Ser(2)]exendin(1-9) in wild-type animals prevents kainate-induced apoptosis of hippocampal neurons. Brain GLP-1R represents a promising new target for both cognitive-enhancing and neuroprotective agents...
  3. ncbi request reprint VEGF, a mediator of the effect of experience on hippocampal neurogenesis
    Matthew J During
    Department of Neurological Surgery, Weill Medical College of Cornell University, New York, USA
    Curr Alzheimer Res 3:29-33. 2006
    ..These data support a model whereby VEGF acting via KDR is a mediator of the effect of the environment on neurogenesis and cognition [1]...
  4. ncbi request reprint AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats
    Matthias Klugmann
    Department of Molecular Medicine and Pathology, Functional Genomics and Translational Neuroscience Laboratory, University of Auckland, Auckland, New Zealand
    Mol Cell Neurosci 28:347-60. 2005
    ..Homer 1g induced anxiety. Moreover, AAV-Homer 1a animals showed attenuation of electrographic seizures in a model of status epilepticus. These results suggest that Homer 1 proteins play an active role in behavioral plasticity...
  5. pmc Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo
    Xiqun Chen
    Department of Neurology, The College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 28:672-80. 2008
    ..We conclude that DLK acts primarily through c-jun phosphorylation to mediate cell death in this model...
  6. pmc Knockdown and overexpression of NR1 modulates NMDA receptor function
    Maggie L Kalev-Zylinska
    Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
    Mol Cell Neurosci 41:383-96. 2009
    ..In conclusion, the observed consequences of NR1 knockdown and overexpression underscore NMDAR requirement for neuronal plasticity, and are in agreement with its dichotomous functions...
  7. ncbi request reprint A novel role of circadian transcription factor DBP in hippocampal plasticity
    Matthias Klugmann
    Functional Genomics and Translational Neuroscience Laboratory, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
    Mol Cell Neurosci 31:303-14. 2006
    ..These data suggest that DBP may represent an important transcriptional link between GLP-1R activation and neuroplasticity in the hippocampus...
  8. ncbi request reprint VEGF links hippocampal activity with neurogenesis, learning and memory
    Lei Cao
    Department of Neurological Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Genet 36:827-35. 2004
    ..These data support a model in which VEGF, acting through KDR, mediates the effect of the environment on neurogenesis and cognition...
  9. ncbi request reprint Phosphorylation-dependent degradation of transgenic CREB protein initiated by heterodimerization
    Alexandre Mouravlev
    Department of Molecular Medicine and Pathology, The University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
    Brain Res 1130:31-7. 2007
    ..Hence, heterodimerization of unphosphorylated CREB with either A-CREB or ICER triggers CREB protein degradation, whereas phosphorylation prevents CREB from such degradation both in vitro and in vivo...
  10. ncbi request reprint Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease
    Matthias Klugmann
    Laboratory of Functional Genomics and Translational Neuroscience, Department of Molecular Medicine and Pathology, University of Auckland School of Medicine, 85 Park Road, Auckland, New Zealand
    Mol Ther 11:745-53. 2005
    ..Moreover, hypomyelination and motor deficits were not resolved by ASPA gene transfer. Our data suggest that NAA-mediated neuronal hyperexcitation but not oligodendrocyte dysfunction can be compensated for by neuronal ASPA expression...
  11. ncbi request reprint AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease
    Adrian P Kells
    Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Mol Ther 9:682-8. 2004
    ..These results indicate that AAV-mediated gene transfer of BDNF or GDNF into the striatum provides neuronal protection in a rodent model of HD...
  12. ncbi request reprint Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development
    En Ju D Lin
    Department of Molecular Medicine and Pathology, Faculty of Medicine and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
    Eur J Neurosci 18:2087-92. 2003
    ..The seizure suppression effect of galanin expression in the hippocampus by viral vectors may lead to novel therapeutic strategies for the treatment and management of intractable seizures with focal onset such as temporal lobe epilepsy...
  13. pmc Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats
    Alexandre Mouravlev
    Department of Molecular Medicine and Pathology, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Proc Natl Acad Sci U S A 103:4705-10. 2006
    ....
  14. ncbi request reprint Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial
    Michael G Kaplitt
    Department of Neurological Surgery, Weill Medical College of Cornell University, New York, NY, USA
    Lancet 369:2097-105. 2007
    ..We aimed to measure the safety, tolerability, and potential efficacy of transfer of glutamic acid decarboxylase (GAD) gene with adeno-associated virus (AAV) into the subthalamic nucleus of patients with Parkinson's disease...
  15. pmc Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates
    Patricia A Lawlor
    Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
    Mol Ther 17:1692-702. 2009
    ....
  16. ncbi request reprint Differential actions of NPY on seizure modulation via Y1 and Y2 receptors: evidence from receptor knockout mice
    En Ju Deborah Lin
    Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
    Epilepsia 47:773-80. 2006
    ..We also examined the effect of rAAV-mediated hippocampal NPY overexpression on seizure susceptibility in these receptor knockout mice...
  17. ncbi request reprint Over expression of ATF-3 protects rat hippocampal neurons from in vivo injection of kainic acid
    Jeremy S Francis
    Department of Molecular Medicine and Pathology, University of Auckland School of Medicine, Auckland, New Zealand
    Brain Res Mol Brain Res 124:199-203. 2004
    ..These results suggest a positive contribution to neuronal survival in the context of stress-induced death, and support an anti-apoptotic role for ATF-3 in the brain...
  18. pmc Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease
    Vincent Ries
    Department of Neurology, Columbia University College of Physicians and Surgeons, 650 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:18757-62. 2006
    ..Activation of intracellular neurotrophic signaling pathways by vector transfer is a feasible approach to neuroprotection and restorative treatment of neurodegenerative disease...
  19. pmc Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain
    Mihail Y Mastakov
    Functional Genomics and Translational Neuroscience Laboratory, Division of Molecular Medicine, Faculty of Medical and Health Sciences, University of Auckland, New Zealand
    J Virol 76:8446-54. 2002
    ..This study provides guidelines for more rational design of gene transfer studies in the rodent brain and, in addition, suggests the use of repeated administration of rAAV as a viable form of therapy for the treatment of chronic diseases...
  20. ncbi request reprint Gene therapy for Parkinson's disease
    Patricia A Lawlor
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Expert Rev Mol Med 6:1-18. 2004
    ..The merits of these strategies are discussed here, along with remaining hurdles that might impede transfer of gene therapy technology to the clinic as a treatment for PD...
  21. ncbi request reprint Recombinant adeno-associated virus serotypes 2- and 5-mediated gene transfer in the mammalian brain: quantitative analysis of heparin co-infusion
    Mihail Y Mastakov
    Functional Genomics and Translational Neuroscience Laboratory, Division of Molecular Medicine, Faculty of Medical and Health Sciences, University of Auckland, New Zealand
    Mol Ther 5:371-80. 2002
    ....
  22. doi request reprint Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size
    Maggie L Kalev-Zylinska
    Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
    Stroke 44:2212-9. 2013
    ..We aimed to determine whether antibodies against subunit 1 (GluN1) of the N-methyl-D-aspartate receptor also develop after stroke and if so, whether they correlate with stroke characteristics...
  23. ncbi request reprint Identification and distribution of aspartoacylase in the postnatal rat brain
    Matthias Klugmann
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand m
    Neuroreport 14:1837-40. 2003
    ..Histologically, most abundant expression was observed in white matter tracts and thalamus. On the cellular level, aspartoacylase immunoreactivity is restricted to oligodendrocyte somata in both white and gray matter...
  24. ncbi request reprint Paradoxical facilitatory effect of low-dose alcohol consumption on memory mediated by NMDA receptors
    Maggie L Kalev-Zylinska
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, 1142 Auckland, New Zealand
    J Neurosci 27:10456-67. 2007
    ..In conclusion, adaptive changes in hippocampal NMDA receptor expression may contribute to the positive effects of ethanol on cognition...
  25. ncbi request reprint Molecular mechanisms of learning and memory
    Jane Dunning
    Department of Molecular Medicine and Pathology, University of Auckland, Auckland 1001, New Zealand
    Expert Rev Mol Med 5:1-11. 2003
    ..Here we review the molecular mechanisms thought to underlie memory acquisition and storage, as well as discuss recent evidence regarding the mechanisms of subsequent memory consolidation...
  26. ncbi request reprint Subthalamic GAD gene therapy in a Parkinson's disease rat model
    Jia Luo
    Functional Genomics and Translational Neuroscience Laboratory, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
    Science 298:425-9. 2002
    ..This strategy suggests that there is plasticity between excitatory and inhibitory neurotransmission in the mammalian brain that could be exploited for therapeutic benefit...
  27. ncbi request reprint ATF3 enhances c-Jun-mediated neurite sprouting
    Andree G Pearson
    Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res Mol Brain Res 120:38-45. 2003
    ..Our results suggest that a program of axonal regeneration is initiated when both c-Jun and ATF3 are upregulated in neurons in response to axotomy...
  28. ncbi request reprint Using the immune system to target epilepsy
    Deborah Young
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand
    Adv Exp Med Biol 548:134-44. 2004
  29. ncbi request reprint Molecular investigation of TBP allele length: a SCA17 cellular model and population study
    Suzanne J Reid
    Department of Molecular Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neurobiol Dis 13:37-45. 2003
    ..Importantly, overexpression of expanded TBP results in increased Cre-dependent transcriptional activity. As TBP is required for transcription by all RNA polymerases, this may indicate a mechanism for aberrant polyQ gain of function...
  30. ncbi request reprint Effect of altering titer, serotype, and promoter in recombinant adenoassociate virus gene therapy expression of spinal cord neurons and astrocytes
    James S Harrop
    Department of Neurosurgery, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Spine (Phila Pa 1976) 29:2787-92. 2004
    ..Descriptive histologic analysis of spinal cord gene therapy...
  31. ncbi request reprint Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABA(B) receptors in scopolamine-induced amnesia
    Jonathan Brouillette
    Department of Neurology and Neurosurgery, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    J Neurochem 102:1978-89. 2007
    ..Taken together, these results reveal novel genes and mechanisms involved in scopolamine-induced amnesia, and demonstrate the involvement of both GABA and glutamate neurotransmission in this animal model of cognitive dysfunctions...
  32. ncbi request reprint Viral restoration of dopamine to the nucleus accumbens is sufficient to induce a locomotor response to amphetamine
    Carrie L Heusner
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Brain Res 980:266-74. 2003
    ..These data support previous studies in which accumbal dopamine is required for producing a normal locomotor response to amphetamine and further show that release of dopamine restricted to the NAc is sufficient for this response..
  33. pmc Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease
    Andrew Feigin
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 104:19559-64. 2007
    ..Network biomarkers may be used as physiological assays in early-phase trials of experimental therapies for PD and other neurodegenerative disease...
  34. ncbi request reprint Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF
    Jodi L McBride
    Department of Neurological Sciences, Rush Presbyterian, St Luke s Medical Center, Chicago, IL 60612, USA
    Exp Neurol 181:213-23. 2003
    ..These data indicate that the viral-mediated gene transfer of GDNF into the striatum provides neuroanatomical and behavioral protection in a rodent model of HD...
  35. doi request reprint NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning
    Andreas T Sørensen
    Experimental Epilepsy Group, Wallenberg Neuroscience Center, BMC A 11, Lund University Hospital, Lund, Sweden
    Hippocampus 18:564-74. 2008
    ....
  36. pmc NMDA receptors inhibit synapse unsilencing during brain development
    Hillel Adesnik
    Departments of Cellular and Molecular Pharmacology, Physiology, and Neurology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 105:5597-602. 2008
    ....
  37. pmc AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease
    Nicholas R Franich
    1Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
    Mol Ther 16:947-56. 2008
    ..These results provide further support for the use of AAV vector-mediated RNAi as a therapeutic strategy for HD...
  38. ncbi request reprint Development and optimization of adeno-associated virus vector transfer into the central nervous system
    Matthew J During
    CNS Gene Therapy Center, Department of Neurosurgery, Jefferson Medical College, Philadelphia, PA, USA
    Methods Mol Med 76:221-36. 2003
  39. doi request reprint Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy
    Francesco Noe
    Department of Neuroscience, Mario Negri Inst for Pharmacol Res, Via G La Masa 19, 20156 Milano, Italy
    Brain 131:1506-15. 2008
    ..Our data show that this gene therapy strategy decreases spontaneous seizures and suppresses their progression in chronic epileptic rats, thus representing a promising new therapeutic strategy...
  40. ncbi request reprint Brain uptake of the glucagon-like peptide-1 antagonist exendin(9-39) after intranasal administration
    William A Banks
    Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center St Louis, Missouri, USA
    J Pharmacol Exp Ther 309:469-75. 2004
    ..These results show that intranasal administration is an effective means of delivering peptide to the brain, especially the olfactory bulb...
  41. ncbi request reprint Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus
    Cristina Richichi
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    J Neurosci 24:3051-9. 2004
    ..Thus, targeted NPY gene transfer provides a potential therapeutic principle for the treatment of drug-resistant partial epilepsies...
  42. ncbi request reprint Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolism
    Marina E Emborg
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA
    J Cereb Blood Flow Metab 27:501-9. 2007
    ..The changes in motor cortical glucose utilization observed after gene therapy are consistent with the modulation of metabolic brain networks associated with this disorder...
  43. ncbi request reprint Dysregulation of striatal dopamine signaling by amphetamine inhibits feeding by hungry mice
    Claire Matson Cannon
    Department of Biochemistry and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Neuron 44:509-20. 2004
    ..We suggest that, at this moderate dose of AMPH, dysregulation of striatal DA is the primary cause of AMPH-induced hypophagia and that regulated striatal dopaminergic signaling may be necessary for normal feeding behaviors...
  44. ncbi request reprint Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function
    Kevin D Lominac
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 25:11586-94. 2005
    ....
  45. ncbi request reprint A role for dopamine in feeding responses produced by orexigenic agents
    Thomas S Hnasko
    Neurobiology and Behavior Graduate Program, University of Washington, Seattle, WA 98195, USA
    Brain Res 1023:309-18. 2004
    ..Since dopamine signaling in the CPu is not sufficient for glucoprivation-induced feeding, we propose that this feeding behavior may be mediated by dopamine in an anatomically distinct brain region...
  46. ncbi request reprint Local dopamine production in the dorsal striatum restores goal-directed behavior in dopamine-deficient mice
    Siobhan Robinson
    Neurobiology and Behavior Program, University of Washington, Seattle, WA 98195, USA
    Behav Neurosci 120:196-200. 2006
    ..The authors conclude that finely tuned dopaminergic signaling within the dorsal striatum is sufficient for performance of goal-directed behavior...
  47. ncbi request reprint Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain
    Anke Tappe
    Pharmacology Institute, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Nat Med 12:677-81. 2006
    ..Thus, Homer1 function is crucially involved in pain plasticity and constitutes a promising therapeutic target for the treatment of chronic inflammatory pain...
  48. ncbi request reprint Gene therapy for spinal cord injury and disease
    David J Poulsen
    University of Montana, Department of Pharmaceutical Sciences, Missoula 59812 1552, USA
    J Spinal Cord Med 25:2-9. 2002
    ..This review summarizes the current state of knowledge regarding the limitations and recent advances in gene therapy and potential application of this technology toward spinal cord injury and disease...
  49. ncbi request reprint Promoters and regulatory elements that improve adeno-associated virus transgene expression in the brain
    Helen L Fitzsimons
    CNS Gene Therapy Center, Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Methods 28:227-36. 2002
    ..This review summarizes and compares different promoters and regulatory elements that have been used with rAAV as a reference toward achieving a high level of rAAV-mediated transgene expression in the CNS...
  50. pmc Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo
    Juliet Rashidian
    Ottawa Health Research Institute, Neuroscience Group, Ottawa, ON, Canada K1H 8M5
    Proc Natl Acad Sci U S A 102:14080-5. 2005
    ..Hence, our data both characterize the functional significance of the cell cycle Cdk4 and neuronal Cdk5 signals as well as define the pathways and circumstances by which they act to control ischemic/hypoxic damage...
  51. ncbi request reprint Fasting inhibits the growth and reproductive axes via distinct Y2 and Y4 receptor-mediated pathways
    Shu Lin
    Neuroscience Research Program, The Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Sydney, Australia
    Endocrinology 148:2056-65. 2007
    ..Together these data show that fasting inhibits the somatotropic axis via direct action on Y2 receptors in the Arc and indirectly inhibits the gonadotropic axis via Y4 receptors...
  52. ncbi request reprint Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis
    Paul A Baldock
    Bone and Mineral Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Biol Chem 282:19092-102. 2007
    ..Thus Y1 receptor pathways act powerfully to inhibit bone production and adiposity by nonhypothalamic pathways, with potentially direct effects on bone tissue through a single pathway with Y2 receptors...
  53. ncbi request reprint Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo
    Francesco Trapasso
    Kimmel Cancer Institute, Thomas Jefferson University, 233S 10th Street, Philadelphia, PA 19107, USA
    Carcinogenesis 25:2107-14. 2004
    ..The data suggest that restoration of DEP-1/HPTPeta expression could be a useful tool for the gene therapy of human pancreatic cancers...
  54. ncbi request reprint Role of noradrenergic signaling by the nucleus tractus solitarius in mediating opiate reward
    Valerie G Olson
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Science 311:1017-20. 2006
    ..Morphine-induced locomotion was partially restored by DBH expression in either brain region. These data suggest that NE signaling by the nucleus tractus solitarius is necessary for morphine reward...
  55. ncbi request reprint Regression of upper gastric cancer in mice by FHIT gene delivery
    Hideshi Ishii
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    FASEB J 17:1768-70. 2003
    ..This dramatic reduction in tumor burden emphasizes the efficacy of targeting the FHIT apoptotic pathway for tumor eradication...
  56. ncbi request reprint Homer proteins regulate sensitivity to cocaine
    Karen K Szumlinski
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuron 43:401-13. 2004
    ..These data show that Homer deletion mimics the behavioral and neurochemical phenotype produced by repeated cocaine administration and implicate Homer in regulating addiction to cocaine...
  57. pmc The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage
    Hossein Aleyasin
    Ottawa Health Research Institute, Neuroscience Group, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5
    Proc Natl Acad Sci U S A 104:18748-53. 2007
    ..It also highlights the important commonalities among differing neuropathologies...
  58. ncbi request reprint Viral mediated neuropeptide Y expression in the rat paraventricular nucleus results in obesity
    Birgitte Tiesjema
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Obesity (Silver Spring) 15:2424-35. 2007
    ..The aim of this study was to further unravel the contribution of NPY signaling in the PVN to energy balance...
  59. ncbi request reprint Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemia
    Walid M Abi-Saab
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Cereb Blood Flow Metab 22:271-9. 2002
    ....