S A Doggrell

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. ncbi request reprint The effects of lignocaine and tetrodotoxin on the action potentials and contractions of left ventricles from normo- and hypertensive rats
    S A Doggrell
    Cardiovascular Pharmacology Group, Faculty of Medicine and Health Science, The University of Auckland, New Zealand
    Gen Pharmacol 32:429-37. 1999
  2. ncbi request reprint Functional effects of 4-aminopyridine (4-AP) on pulmonary and systemic vessels from normoxic control and hypoxic pulmonary hypertensive rats
    S A Doggrell
    Cardiovascular Pharmacology Group, Faculty of Medicine and Health Science, The University of Auckland, New Zealand
    Naunyn Schmiedebergs Arch Pharmacol 360:317-23. 1999
  3. ncbi request reprint D-Sotalol: death by the SWORD or deserving of further consideration for clinical use?
    S A Doggrell
    Cardiovascular Pharmacology, Faculty of Medicine and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Expert Opin Investig Drugs 9:1625-34. 2000
  4. ncbi request reprint Effects of tetraethylammonium, 4-aminopyridine and bretylium on cardiovascular tissues from normo- and hypertensive rats
    V Nand
    Cardiovascular Pharmacology Group, Faculty of Medicine and Health Science, The University of Auckland, New Zealand
    J Pharm Pharmacol 51:631-40. 1999
  5. ncbi request reprint Effects of tedisamil on cardiovascular tissues isolated from normo- and hypertensive rats
    S A Doggrell
    Cardiovascular Pharmacology Group, Faculty of Medicine and Health Sciences, The University of Auckland, New Zealand
    J Cardiovasc Pharmacol Ther 6:261-72. 2001
  6. ncbi request reprint Potency, affinity constants and receptor reserves for noradrenaline and adrenaline on aortae from aged normo- and hypertensive rats
    S A Doggrell
    Cardiovascular Pharmacology Group, Faculty of Medicine and Health Sciences, The University of Auckland, New Zealand
    J Pharm Pharmacol 53:205-12. 2001
  7. ncbi request reprint Tedisamil: master switch of nature?
    S A Doggrell
    Doggrell Biomedical Communications, 47 Caronia Crescent, Lynfield, Auckland, New Zealand
    Expert Opin Investig Drugs 10:129-38. 2001
  8. ncbi request reprint Responsiveness, affinity constants and receptor reserves for serotonin on aortae of aged normotensive and hypertensive rats
    S A Doggrell
    Cardiovascular Pharmacology, Faculty of Medicine and Health Sciences, The University of Auckland, New Zealand
    J Pharm Pharmacol 53:1403-8. 2001
  9. ncbi request reprint The offset of beta-adrenoceptor antagonism of the responses of the rat right ventricle to isoprenaline
    S A Doggrell
    Department of Pharmacology, Medicine and Health Science Campus, The University of Auckland, New Zealand
    J Auton Pharmacol 18:263-9. 1998
  10. ncbi request reprint The spironolactone renaissance
    S A Doggrell
    Doggrell Biomedical Communications, 47 Caronia Crescent, Lynfield, Auckland, New Zealand
    Expert Opin Investig Drugs 10:943-54. 2001

Collaborators

Detail Information

Publications13

  1. ncbi request reprint The effects of lignocaine and tetrodotoxin on the action potentials and contractions of left ventricles from normo- and hypertensive rats
    S A Doggrell
    Cardiovascular Pharmacology Group, Faculty of Medicine and Health Science, The University of Auckland, New Zealand
    Gen Pharmacol 32:429-37. 1999
    ..In contrast, the effects of tetrodotoxin on contractions are similar, and thus the binding or access of tetrodotoxin to the receptor is not altered in the hypertrophied left ventricle of the SHR...
  2. ncbi request reprint Functional effects of 4-aminopyridine (4-AP) on pulmonary and systemic vessels from normoxic control and hypoxic pulmonary hypertensive rats
    S A Doggrell
    Cardiovascular Pharmacology Group, Faculty of Medicine and Health Science, The University of Auckland, New Zealand
    Naunyn Schmiedebergs Arch Pharmacol 360:317-23. 1999
    ..Hence, we conclude that the sensitization to 5-hydroxytryptamine may be due to downregulation of 4-aminopyridine-sensitive potassium channels...
  3. ncbi request reprint D-Sotalol: death by the SWORD or deserving of further consideration for clinical use?
    S A Doggrell
    Cardiovascular Pharmacology, Faculty of Medicine and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Expert Opin Investig Drugs 9:1625-34. 2000
    ..D-Sotalol could still be considered for short-term hospital use in resistant arrhythmias and for longer-term use to prevent atrial fibrillation in those with remote myocardial infarction and poor left ventricular function...
  4. ncbi request reprint Effects of tetraethylammonium, 4-aminopyridine and bretylium on cardiovascular tissues from normo- and hypertensive rats
    V Nand
    Cardiovascular Pharmacology Group, Faculty of Medicine and Health Science, The University of Auckland, New Zealand
    J Pharm Pharmacol 51:631-40. 1999
    ..The potential of bretylium and some of the newer selective potassium-channel blockers as positive inotropes requires further evaluation...
  5. ncbi request reprint Effects of tedisamil on cardiovascular tissues isolated from normo- and hypertensive rats
    S A Doggrell
    Cardiovascular Pharmacology Group, Faculty of Medicine and Health Sciences, The University of Auckland, New Zealand
    J Cardiovasc Pharmacol Ther 6:261-72. 2001
    ..In contrast, the vasoconstrictor action of tedisamil will be detrimental in heart failure...
  6. ncbi request reprint Potency, affinity constants and receptor reserves for noradrenaline and adrenaline on aortae from aged normo- and hypertensive rats
    S A Doggrell
    Cardiovascular Pharmacology Group, Faculty of Medicine and Health Sciences, The University of Auckland, New Zealand
    J Pharm Pharmacol 53:205-12. 2001
    ..There were no additional changes in the sensitivity and alpha1-adrenoceptor reserves, but a small additional change in affinity for noradrenaline and adrenaline in hypertension/heart failure on the aortae of 20-month-old SHRs...
  7. ncbi request reprint Tedisamil: master switch of nature?
    S A Doggrell
    Doggrell Biomedical Communications, 47 Caronia Crescent, Lynfield, Auckland, New Zealand
    Expert Opin Investig Drugs 10:129-38. 2001
    ..A drug that is bradycardic without increasing blood pressure would be an improvement on tedisamil as the master switch of nature for ischaemic heart disease...
  8. ncbi request reprint Responsiveness, affinity constants and receptor reserves for serotonin on aortae of aged normotensive and hypertensive rats
    S A Doggrell
    Cardiovascular Pharmacology, Faculty of Medicine and Health Sciences, The University of Auckland, New Zealand
    J Pharm Pharmacol 53:1403-8. 2001
    ..In summary, we have shown changes in sensitivity, affinity and 5-HT2A-receptor reserves for serotonin on the aorta with ageing and in hypertension/heart failure...
  9. ncbi request reprint The offset of beta-adrenoceptor antagonism of the responses of the rat right ventricle to isoprenaline
    S A Doggrell
    Department of Pharmacology, Medicine and Health Science Campus, The University of Auckland, New Zealand
    J Auton Pharmacol 18:263-9. 1998
    ..It is suggested that bopindolol is a very slowly reversible beta-blocker, and that this contributes to its slow offset of action...
  10. ncbi request reprint The spironolactone renaissance
    S A Doggrell
    Doggrell Biomedical Communications, 47 Caronia Crescent, Lynfield, Auckland, New Zealand
    Expert Opin Investig Drugs 10:943-54. 2001
    ..There have also been some recent small clinical trials of spironolactone as an anti-androgen showing potential in acne, hirsutism and precocious puberty...
  11. ncbi request reprint Responsiveness, affinity constants and beta 2-adrenoceptor reserves for isoprenaline on portal veins from normo- and pre- and hypertensive rats
    Y Y Chen
    Cardiovascular Pharmacology Group, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Auton Autacoid Pharmacol 23:43-9. 2003
    ..Thus, there are major changes in beta2-adrenoceptor structure and reserve in maturation on the portal vein that are irrespective of the development of hypertension...
  12. ncbi request reprint Moxonidine: some controversy
    S A Doggrell
    Doggrell Biomedical Communications, 47 Caronia Crescent, Lynfield, Auckland, New Zealand
    Expert Opin Pharmacother 2:337-50. 2001
    ..Moxonidine should not be used in patients with heart failure, but there are no obvious reasons to stop its use as an antihypertensive, or its development for other clinical uses...
  13. ncbi request reprint ALT-711 decreases cardiovascular stiffness and has potential in diabetes, hypertension and heart failure
    S A Doggrell
    Doggrell Biomedical Communications, Lynfield, Auckland, New Zealand
    Expert Opin Investig Drugs 10:981-3. 2001
    ..ALT-711 also decreases myocardial stiffness in the monkeys but this effect is not reversible in 39 weeks. ALT-711 has potential in the treatment of the stiffness associated with diabetes, hypertension and heart failure...