Nicola Dalbeth

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. ncbi Clinical images: three-dimensional computed tomography imaging of tophaceous gout
    Nicola Dalbeth
    University of Auckland, Auckland, New Zealand
    Arthritis Rheum 56:29. 2007
  2. pmc Reduced creatinine clearance is associated with early development of subcutaneous tophi in people with gout
    Nicola Dalbeth
    Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, New Zealand
    BMC Musculoskelet Disord 14:363. 2013
  3. ncbi New classification criteria for gout: a framework for progress
    Nicola Dalbeth
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
    Rheumatology (Oxford) 52:1748-53. 2013
  4. doi Tendon involvement in the feet of patients with gout: a dual-energy CT study
    Nicola Dalbeth
    Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Ann Rheum Dis 72:1545-8. 2013
  5. pmc Reliability of the TekScan MatScan® system for the measurement of postural stability in older people with rheumatoid arthritis
    Angela Brenton-Rule
    AUT University, Health and Rehabilitation Research Institute, Auckland, New Zealand
    J Foot Ankle Res 5:21. 2012
  6. pmc The renal urate transporter SLC17A1 locus: confirmation of association with gout
    Jade E Hollis-Moffatt
    Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9054, New Zealand
    Arthritis Res Ther 14:R92. 2012
  7. doi The experience and impact of gout in Māori and Pacific people: a prospective observational study
    Nicola Dalbeth
    University of Auckland, Auckland, New Zealand
    Clin Rheumatol 32:247-51. 2013
  8. doi Imaging in gout: insights into the pathological features of disease
    Nicola Dalbeth
    Auckland Rheumatology Imaging Group, University of Auckland, Grafton, Auckland, New Zealand
    Curr Opin Rheumatol 24:132-8. 2012
  9. doi No reduction in circulating preosteoclasts 18 months after treatment with zoledronate: analysis from a randomized placebo controlled trial
    Nicola Dalbeth
    Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand
    Calcif Tissue Int 92:1-5. 2013
  10. doi Imaging of gout: an overview
    Nicola Dalbeth
    Department of Medicine, University of Auckland, Grafton, Auckland, New Zealand
    Best Pract Res Clin Rheumatol 26:823-38. 2012

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. ncbi Clinical images: three-dimensional computed tomography imaging of tophaceous gout
    Nicola Dalbeth
    University of Auckland, Auckland, New Zealand
    Arthritis Rheum 56:29. 2007
  2. pmc Reduced creatinine clearance is associated with early development of subcutaneous tophi in people with gout
    Nicola Dalbeth
    Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, New Zealand
    BMC Musculoskelet Disord 14:363. 2013
    ..Although typically a late feature of gout, tophi may present early in the course of disease. The aim of this study was to identify factors associated with the presence of early tophaceous disease...
  3. ncbi New classification criteria for gout: a framework for progress
    Nicola Dalbeth
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
    Rheumatology (Oxford) 52:1748-53. 2013
    ..An international project is currently under way to develop new validated gout classification criteria. These criteria will be an essential step forward to advance the research agenda in the modern era of gout management. ..
  4. doi Tendon involvement in the feet of patients with gout: a dual-energy CT study
    Nicola Dalbeth
    Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Ann Rheum Dis 72:1545-8. 2013
    ..To examine the frequency and patterns of monosodium urate (MSU) crystal deposition in tendons and ligaments in patients with gout using dual-energy CT (DECT)...
  5. pmc Reliability of the TekScan MatScan® system for the measurement of postural stability in older people with rheumatoid arthritis
    Angela Brenton-Rule
    AUT University, Health and Rehabilitation Research Institute, Auckland, New Zealand
    J Foot Ankle Res 5:21. 2012
    ..abstract:..
  6. pmc The renal urate transporter SLC17A1 locus: confirmation of association with gout
    Jade E Hollis-Moffatt
    Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9054, New Zealand
    Arthritis Res Ther 14:R92. 2012
    ..However, evidence for association with gout is equivocal. We investigated the association of the SLC17A1 locus with gout in New Zealand sample sets...
  7. doi The experience and impact of gout in Māori and Pacific people: a prospective observational study
    Nicola Dalbeth
    University of Auckland, Auckland, New Zealand
    Clin Rheumatol 32:247-51. 2013
    ..Māori and Pacific ethnicity should be recognised as a prognostic factor for more severe outcomes in this disease, and intensive efforts should be made to work with these patients to control serum urate and prevent flares...
  8. doi Imaging in gout: insights into the pathological features of disease
    Nicola Dalbeth
    Auckland Rheumatology Imaging Group, University of Auckland, Grafton, Auckland, New Zealand
    Curr Opin Rheumatol 24:132-8. 2012
    ..This review discusses recent research examining the role of imaging to assess the manifestations of disease...
  9. doi No reduction in circulating preosteoclasts 18 months after treatment with zoledronate: analysis from a randomized placebo controlled trial
    Nicola Dalbeth
    Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand
    Calcif Tissue Int 92:1-5. 2013
    ..These results do not support the hypothesis that the inhibitory action of zoledronate contributes to its prolonged action on preosteoclasts within bone marrow...
  10. doi Imaging of gout: an overview
    Nicola Dalbeth
    Department of Medicine, University of Auckland, Grafton, Auckland, New Zealand
    Best Pract Res Clin Rheumatol 26:823-38. 2012
    ..The observation that ultrasonographic appearances of monosodium urate crystal deposition can be observed in patients with hyperuricaemia but no other clinical features of gout raises important questions about disease definitions...
  11. doi Dual-energy computed tomography for gout diagnosis and management
    Nicola Dalbeth
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Curr Rheumatol Rep 15:301. 2013
    ..DECT images reveal variable urate deposition within tophi of the same physical size. The ability to visualise urate deposits in tissue may provide new insights into the pathology and mechanisms of gout...
  12. pmc Prescription and dosing of urate-lowering therapy, rather than patient behaviours, are the key modifiable factors associated with targeting serum urate in gout
    Nicola Dalbeth
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand
    BMC Musculoskelet Disord 13:174. 2012
    ..However, many studies have reported low achievement of SU targets. The aim of this cross-sectional study was to examine the clinical and psychological factors associated with SU targets in patients with gout...
  13. doi Effects of skim milk powder enriched with glycomacropeptide and G600 milk fat extract on frequency of gout flares: a proof-of-concept randomised controlled trial
    Nicola Dalbeth
    Bone and Joint Research Group, Department of Medicine, University of Auckland, Auckland, New Zealand
    Ann Rheum Dis 71:929-34. 2012
    ..The aim of this proof-of-concept clinical trial was to test the hypothesis that daily intake of skim milk powder (SMP) enriched with GMP and G600 can prevent gout flares...
  14. doi Nail disease in psoriatic arthritis: distal phalangeal bone edema detected by magnetic resonance imaging predicts development of onycholysis and hyperkeratosis
    Nicola Dalbeth
    Bone Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
    J Rheumatol 39:841-3. 2012
    ..To examine the association between magnetic resonance imaging (MRI) features of distal phalanx (DP) disease and the progression of nail pathology in psoriatic arthritis (PsA)...
  15. doi The patient's experience of gout: new insights to optimize management
    Nicola Dalbeth
    Bone Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
    Curr Rheumatol Rep 14:173-8. 2012
    ..Work is now required to identify the optimal models of care for patients with gout that can be tested in clinical trials using outcome measures of relevance to individuals with this disease...
  16. doi Assessment of tophus size: a comparison between physical measurement methods and dual-energy computed tomography scanning
    Nicola Dalbeth
    Department of Medicine, University of Auckland, Auckland, New Zealand
    J Clin Rheumatol 18:23-7. 2012
    ..Dual-energy computed tomography (DECT) has recently been described as a sensitive method to detect urate deposits in patients with gout...
  17. pmc The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity
    Jade E Hollis-Moffatt
    Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9012, New Zealand
    Arthritis Res Ther 13:R85. 2011
    ..There is no evidence for an association with gout in Caucasian populations. In the present study, we tested rs3733591 for association with gout in New Zealand (NZ) Māori, Pacific Island and Caucasian samples...
  18. pmc Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance
    Jade E Hollis-Moffatt
    Department of Biochemistry, 710 Cumberland Street, University of Otago, Dunedin 9054, New Zealand
    Arthritis Res Ther 12:R116. 2010
    ..Here we aimed to: one, confirm at a genome-wide level of significance association of rs6822844 with RA and, two, evaluate whether or not there were effects independent of rs6822844 on RA at the KIAA1109-TENR-IL2-IL21 locus...
  19. pmc Imaging of gout: findings and utility
    Fernando Perez-Ruiz
    Rheumatology Division, Hospital de Cruces, Baracaldo, Vizcaya, Spain
    Arthritis Res Ther 11:232. 2009
    ....
  20. pmc The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets
    Jade E Hollis-Moffatt
    Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9054, New Zealand
    Arthritis Res Ther 11:R152. 2009
    ..We therefore tested this association in an independent study using New Zealand (NZ) and Oxford (UK) RA case control samples...
  21. doi Identification of dairy fractions with anti-inflammatory properties in models of acute gout
    Nicola Dalbeth
    Bone Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
    Ann Rheum Dis 69:766-9. 2010
    ..It was hypothesised that factors within dairy fractions inhibit the inflammatory response to monosodium urate monohydrate (MSU) crystals...
  22. doi Cellular characterization of the gouty tophus: a quantitative analysis
    Nicola Dalbeth
    University of Auckland, Auckland, New Zealand
    Arthritis Rheum 62:1549-56. 2010
    ..To characterize the cellular architecture of the tophus and to determine the presence of cytokines implicated in the initiation and resolution of gouty inflammation...
  23. doi Acute effect of milk on serum urate concentrations: a randomised controlled crossover trial
    Nicola Dalbeth
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand
    Ann Rheum Dis 69:1677-82. 2010
    ..The aims of this study were to determine the acute effects of milk ingestion on serum urate concentrations and examine the mechanisms of these effects...
  24. doi Illness perceptions in patients with gout and the relationship with progression of musculoskeletal disability
    Nicola Dalbeth
    University of Auckland, New Zealand
    Arthritis Care Res (Hoboken) 63:1605-12. 2011
    ..Although suboptimal disease management has been reported in patients with gout, patients' perceptions of illness have not been systematically studied. The aim of this study was to examine illness perceptions in patients with gout...
  25. pmc Circulating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion
    Nicola Dalbeth
    Department of Medicine, University of Auckland, Auckland 1010, New Zealand
    Arthritis Res Ther 12:R164. 2010
    ..The aim of this study was to examine the role of soluble mediators of bone remodeling within the circulation of patients with PsA...
  26. doi Development of a computed tomography method of scoring bone erosion in patients with gout: validation and clinical implications
    Nicola Dalbeth
    Department of Medicine, University of Auckland, Grafton, Auckland, New Zealand
    Rheumatology (Oxford) 50:410-6. 2011
    ..To develop a method of scoring bone erosion in the feet of patients with gout using CT as an outcome measure for chronic gout studies, consistent with the components of the OMERACT filter...
  27. doi Effects of dairy intake on hyperuricemia and gout
    Nicola Dalbeth
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
    Curr Rheumatol Rep 13:132-7. 2011
    ..Well-controlled intervention studies in patients with gout are now needed to determine the clinical relevance of these observations in order to guide dietary recommendations for this disease...
  28. doi Methods of tophus assessment in clinical trials of chronic gout: a systematic literature review and pictorial reference guide
    Nicola Dalbeth
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
    Ann Rheum Dis 70:597-604. 2011
    ..To identify methods of tophus measurement for gout studies, summarise the properties of these methods and compile a detailed pictorial reference guide to demonstrate the methods...
  29. pmc Tophus measurement as an outcome measure for clinical trials of chronic gout: progress and research priorities
    Nicola Dalbeth
    Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Rheumatol 38:1458-61. 2011
    ..Further information is also required regarding which method of physical measurement is best for use in future clinical trials. The need to develop and test a patient-reported outcome measure of tophus burden is also highlighted...
  30. doi Cellular characterisation of magnetic resonance imaging bone oedema in rheumatoid arthritis; implications for pathogenesis of erosive disease
    N Dalbeth
    Bone Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand
    Ann Rheum Dis 68:279-82. 2009
    ..This study aimed to determine the cellular components of MRI bone oedema, and clarify the relationship between bone erosion and MRI bone oedema...
  31. doi Use of imaging to evaluate gout and other crystal deposition disorders
    Nicola Dalbeth
    University of Auckland, New Zealand
    Curr Opin Rheumatol 21:124-31. 2009
    ..This review summarizes recent advances in plain radiography and advanced imaging for gout, calcium pyrophosphate dihydrate crystal arthropathy and basic calcium phosphate crystal arthropathy...
  32. ncbi Tophaceous joint disease strongly predicts hand function in patients with gout
    N Dalbeth
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand
    Rheumatology (Oxford) 46:1804-7. 2007
    ..The functional impact of gout is poorly understood. The aim of this study was to determine predictors of hand function in gout...
  33. ncbi Validation of a radiographic damage index in chronic gout
    Nicola Dalbeth
    University of Auckland, Grafton, Auckland, New Zealand
    Arthritis Rheum 57:1067-73. 2007
    ..To identify a valid method to measure radiographic damage in patients with chronic gout...
  34. ncbi Dose adjustment of allopurinol according to creatinine clearance does not provide adequate control of hyperuricemia in patients with gout
    Nicola Dalbeth
    Department of Medicine, University of Auckland, Auckland, New Zealand
    J Rheumatol 33:1646-50. 2006
    ..Published guidelines state that allopurinol doses should be adjusted according to creatinine clearance. We investigated whether such dosing provides adequate control of hyperuricemia...
  35. doi Enhanced osteoclastogenesis in patients with tophaceous gout: urate crystals promote osteoclast development through interactions with stromal cells
    Nicola Dalbeth
    University of Auckland, Grafton, Auckland, New Zealand
    Arthritis Rheum 58:1854-65. 2008
    ..To analyze cellular mechanisms of bone erosion in gout...
  36. doi Mechanisms of bone erosion in gout: a quantitative analysis using plain radiography and computed tomography
    N Dalbeth
    Bone Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
    Ann Rheum Dis 68:1290-5. 2009
    ..The underlying basis of bone erosion in gout remains speculative. The aim of this study was to understand the mechanisms of bone erosion in gout using non-invasive imaging techniques...
  37. doi Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout
    N Dalbeth
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Private Bag 92019, Auckland, New Zealand
    Rheumatology (Oxford) 48:222-6. 2009
    ..Disordered osteoclastogenesis in patients with chronic gout highlights potential therapies for prevention of joint damage. This review summarizes these findings and the potential relevance for future management of gout...
  38. ncbi Allopurinol dosing in renal impairment: walking the tightrope between adequate urate lowering and adverse events
    Nicola Dalbeth
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Semin Dial 20:391-5. 2007
    ..Further work is needed to clarify the safety and efficacy of allopurinol dose escalation, particularly in patients with renal impairment...
  39. doi Zoledronic acid does not reduce MRI erosive progression in PsA but may suppress bone oedema: the Zoledronic Acid in Psoriatic Arthritis (ZAPA) Study
    Fiona McQueen
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand
    Ann Rheum Dis 70:1091-4. 2011
    ..The effect of zoledronic acid (ZA) on articular bone in patients with psoriatic arthritis (PsA) was investigated using MRI...
  40. doi Monosodium urate monohydrate crystals inhibit osteoblast viability and function: implications for development of bone erosion in gout
    Ashika Chhana
    Bone Research Group, Department of Medicine, University of Auckland, Auckland, New Zealand
    Ann Rheum Dis 70:1684-91. 2011
    ..Bone erosion is a common manifestation of chronic tophaceous gout...
  41. doi Bringing it all together: a novel approach to the development of response criteria for chronic gout clinical trials
    William J Taylor
    Department of Medicine, University of Otago, Wellington, New Zealand
    J Rheumatol 38:1467-70. 2011
    ..To review a novel approach for constructing composite response criteria for use in chronic gout clinical trials that implements a method of multicriteria decision-making...
  42. doi Mechanisms of joint damage in gout: evidence from cellular and imaging studies
    Fiona M McQueen
    Department of Molecular Medicine and Pathology, University of Auckland, Park Road, Grafton, Auckland 1023, New Zealand
    Nat Rev Rheumatol 8:173-81. 2012
    ..Imaging is also increasingly being used to monitor the progression of joint damage and regression of tophi with effective urate-lowering therapy...
  43. pmc Serum urate in chronic gout--will it be the first validated soluble biomarker in rheumatology?
    Lisa K Stamp
    Department of Medicine, University of Otago, Christchurch, New Zealand
    J Rheumatol 38:1462-6. 2011
    ..To summarize evidence for and endorsement of serum urate (SU) as having fulfilled the OMERACT filter as a soluble biomarker in chronic gout at the 2010 Outcome Measures in Rheumatology Meeting (OMERACT 10)...
  44. ncbi Population-specific influence of SLC2A9 genotype on the acute hyperuricaemic response to a fructose load
    Nicola Dalbeth
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Ann Rheum Dis 72:1868-73. 2013
    ..SLC2A9 (GLUT9) is a high capacity urate transporter and reportedly transports glucose and fructose. Intake of fructose-containing beverages is associated with development of hyperuricaemia and gout...
  45. doi The experience and impact of living with gout: a study of men with chronic gout using a qualitative grounded theory approach
    Karen Lindsay
    Department of Rheumatology, Middlemore Hospital, Counties Manukau District Health Board, Auckland, New Zealand
    J Clin Rheumatol 17:1-6. 2011
    ..Gout is commonly undertreated and can lead to significant disability. Few data are available about the lived experience of gout or the barriers to effective urate-lowering therapy in men with gout...
  46. ncbi Potential unmet need for gout diagnosis and treatment: capture-recapture analysis of a national administrative dataset
    Gary Jackson
    Health Partners Consulting Group, PO Box 147209, Ponsonby, Auckland, New Zealand
    Rheumatology (Oxford) 51:1820-4. 2012
    ..To estimate the degree of undercount of people diagnosed with gout in administrative datasets using capture-recapture methods...
  47. doi Foot pain, impairment, and disability in patients with acute gout flares: A prospective observational study
    Keith Rome
    Auckland University of Technology, Auckland, New Zealand
    Arthritis Care Res (Hoboken) 64:384-8. 2012
    ..To evaluate the impact of acute gout on foot pain, impairment, and disability...
  48. doi Measuring bone erosion and edema in rheumatoid arthritis: a comparison of manual segmentation and RAMRIS methods
    Angela R Crowley
    Department of Rheumatology, Greenlane Clinical Centre, Auckland District Health Board, Auckland, New Zealand
    J Magn Reson Imaging 33:364-71. 2011
    ..To investigate the reliability, feasibility, and validity of a computer-assisted manual segmentation (outlining) technique for measuring magnetic resonance imaging (MRI) bone erosion and edema at the wrist in rheumatoid arthritis (RA)...
  49. doi Progress in measurement instruments for acute and chronic gout studies
    Rebecca Grainger
    Department of Medicine, University of Otago, and the Malaghan Institute of Medical Research, Wellington 6242, New Zealand
    J Rheumatol 36:2346-55. 2009
    ..Priorities for future research include measurement of joint inflammation in acute gout and disability in acute and chronic gout...
  50. doi Bone erosions in patients with chronic gouty arthropathy are associated with tophi but not bone oedema or synovitis: new insights from a 3 T MRI study
    Fiona M McQueen
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland 1023, New Zealand
    Rheumatology (Oxford) 53:95-103. 2014
    ..Our aims in this prospective 3 T MRI study were to investigate the frequency of these features in gout and determine their relation to one another...
  51. doi Factors associated with recurrent hospital admissions for gout: a case-control study
    Ingrid Hutton
    Rheumatology Department, Counties Manukau District Health Board, Auckland, New Zealand
    J Clin Rheumatol 15:271-4. 2009
    ..The aim of this study was to identify factors associated with recurrent hospital admissions with gout...
  52. doi Assessment of cartilage loss at the wrist in rheumatoid arthritis using a new MRI scoring system
    Fiona McQueen
    Department of Molecular Medicine and Pathology, University of Auckland, New Zealand
    Ann Rheum Dis 69:1971-5. 2010
    ..To develop and test an MRI cartilage scoring system for use at the wrist in rheumatoid arthritis (RA)...
  53. pmc MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage
    Yu M Tan
    Department of Molecular Medicine and Pathology, University of Auckland, Park Road, Auckland 1010, New Zealand
    Arthritis Res Ther 11:R2. 2009
    ..The aim of this study was to investigate the magnetic resonance imaging (MRI) features of bone disease in the arthritis mutilans (AM) form of psoriatic arthritis (PsA)...
  54. doi Footwear characteristics and factors influencing footwear choice in patients with gout
    Keith Rome
    AUT University, Health and Rehabilitation Research Institute, Auckland, New Zealand
    Arthritis Care Res (Hoboken) 63:1599-604. 2011
    ..The aim of this study was to assess footwear characteristics and key factors influencing footwear choice in patients with gout. We also wanted to evaluate the relationship between footwear characteristics and foot disability...
  55. ncbi Zoledronate for prevention of bone erosion in tophaceous gout: a randomised, double-blind, placebo-controlled trial
    Nicola Dalbeth
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Ann Rheum Dis 73:1044-51. 2014
    ..The osteoclast has been implicated in development of bone erosion in gout. The aim of this study was to determine whether zoledronate, a potent antiosteoclast drug, influences bone erosion in people with tophaceous gout...
  56. doi Exploratory study of radiographic change in patients with tophaceous gout treated with intensive urate-lowering therapy
    Nicola Dalbeth
    University of Auckland, Auckland, New Zealand
    Arthritis Care Res (Hoboken) 66:82-5. 2014
    ..Pegloticase leads to dramatic reductions in serum urate and subcutaneous tophi in treatment responders. The aim of this analysis was to examine whether profound urate lowering can alter radiographic findings in gout...
  57. doi Functional and biomechanical characteristics of foot disease in chronic gout: A case-control study
    Keith Rome
    AUT University, Health and Rehabilitation Research Institute, Auckland, New Zealand
    Clin Biomech (Bristol, Avon) 26:90-4. 2011
    ..The aim of this study was to describe the effects of chronic gout upon function and selected biomechanical parameters associated with gait...
  58. doi Serum urate as a soluble biomarker in chronic gout-evidence that serum urate fulfills the OMERACT validation criteria for soluble biomarkers
    Lisa K Stamp
    Department of Medicine, University of Otago, Christchurch, New Zealand
    Semin Arthritis Rheum 40:483-500. 2011
    ..To determine whether serum urate (SU) fulfills the Outcome measures in Rheumatology (OMERACT) soluble biomarker criteria...
  59. doi The Work Instability Scale predicts absenteeism in people with gout and suggests a higher risk for those in manual occupations
    William J Taylor
    Rehabilitation Teaching and Research Unit, Department of Medicine, University of Otago Wellington, Auckland, New Zealand
    J Clin Rheumatol 18:405-10. 2012
    ..Gout occurs in working-age people and may be associated with significant work disability. There are no longitudinal studies to examine risk factors for work disability in people with gout...
  60. ncbi Computed tomography measurement of tophus volume: comparison with physical measurement
    Nicola Dalbeth
    University of Auckland, Auckland, New Zealand
    Arthritis Rheum 57:461-5. 2007
    ..Computed tomography (CT) has high accuracy for tophus detection. This study assessed reliability of CT measurement of tophus volume and compared reproducibility of CT with physical measurement of tophus size...
  61. doi Quantifying synovitis in rheumatoid arthritis using computer-assisted manual segmentation with 3 Tesla MRI scanning
    Arista S Chand
    Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
    J Magn Reson Imaging 33:1106-13. 2011
    ..To investigate the reliability, validity and feasibility of a computer-assisted manual segmentation method for determining the synovial membrane volume as a surrogate measure for synovitis in patients with rheumatoid arthritis (RA)...
  62. doi The effects of monosodium urate monohydrate crystals on chondrocyte viability and function: implications for development of cartilage damage in gout
    Ashika Chhana
    From the Bone and Joint Research Group, Department of Medicine and the Department of Orthopaedic Surgery, University of Auckland, Auckland and the Department of Histology, Waikato Hospital, Hamilton, New Zealand
    J Rheumatol 40:2067-74. 2013
    ..Cartilage damage is frequently observed in advanced destructive gout. The aim of our study was to investigate the effects of monosodium urate monohydrate (MSU) crystals on chondrocyte viability and function...
  63. ncbi Evaluating intratester reliability of manual masking of plantar pressure measurements associated with chronic gout
    Keith Rome
    School of Podiatry, AUT University, Auckland, New Zealand
    J Am Podiatr Med Assoc 101:424-9. 2011
    ..The aim of this study was to evaluate intratester reliability associated with manual masking of plantar pressure measurements in patients with gout...
  64. doi Hyperuricaemia and gout: state of the art and future perspectives
    Nicola Dalbeth
    Bone and Joint Research Group, Department of Medicine, University of Auckland, Auckland, New Zealand
    Ann Rheum Dis 69:1738-43. 2010
    ..This review summarises these advances and highlights the research agenda for the next decade...
  65. doi Obstacles to action in arthritis: a community case-control study
    Ingrid Hutton
    Counties Manukau District Health Board, University of Auckland, Auckland, New Zealand
    Int J Rheum Dis 12:107-17. 2009
    ..Despite the benefits of physical activity, people with arthritis are less active than the general population. The aim of this study was to determine the motivators and obstacles to physical activity for adults with arthritis...
  66. ncbi Cardiovascular disease risk factor assessment and management in gout: an analysis using guideline-based electronic clinical decision support
    Keith Colvine
    Department of Medicine, North Shore Hospital, Shakespeare Road, Private Bag 93 503, Takapuna, Auckland, New Zealand
    N Z Med J 121:73-81. 2008
    ..To assess the need for cardiovascular disease (CVD) risk management in patients with gout...
  67. doi Application of the OMERACT filter to measures of core outcome domains in recent clinical studies of acute gout
    William J Taylor
    From the Department of Medicine, University of Otago, Wellington, New Zealand Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA Department of Medicine, University of Auckland, Auckland, New Zealand University of Pennsylvania and Veterans Affairs VA Medical Center, Philadelphia, Pennsylvania, USA Department of Medicine, University of Florida, Gainesville, Florida, USA SDG LLC, Cambridge, Massachusetts, USA and Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG, Basel, Switzerland Pfizer Inc, New York, New York, USA Epidemiology, Merck Sharp and Dohme Corp, Whitehouse Station, New Jersey, USA Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, New Jersey, USA Health and Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology, Auckland, New Zealand and Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Rheumatol 41:574-80. 2014
    ..To determine the extent to which instruments that measure core outcome domains in acute gout fulfill the Outcome Measures in Rheumatology (OMERACT) filter requirements of truth, discrimination, and feasibility...
  68. doi OMERACT endorsement of measures of outcome for studies of acute gout
    Jasvinder A Singh
    From Birmingham Veterans Affairs Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA Department of Medicine, University of Otago, Wellington Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand SDG LLC, Cambridge, Massachusetts, Duke University School of Medicine, Durham, North Carolina, USA, and Duke National University of Singapore Graduate Medical School, Singapore Schlosspark Klinik Teaching Hospital of the Charité, University Medicine Berlin, Berlin, Germany University of Sydney Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital, Sydney, Australia Stanford University Division of Immunology and Rheumatology, Portolo Valley, California, USA University of Ottawa, London, Ontario, Canada University of Michigan Medical School, Ann Arbor, Michigan, USA University of Auckland, Department of Molecular Medicine and Pathology, Grafton, Auckland, New Zealand Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA Maastricht University Medical Center, Division of Rheumatology, and CAPHRI Research Institute, University Maastricht VU University Medical Center, Amsterdam, the Netherlands University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, Service de Neurochirurgie
    J Rheumatol 41:569-73. 2014
    ....
  69. doi Efficacy and tolerability of probenecid as urate-lowering therapy in gout; clinical experience in high-prevalence population
    Karen Pui
    Department of Rheumatology, Middlemore Hospital, South Auckland, Auckland, New Zealand
    J Rheumatol 40:872-6. 2013
    ..The aim of our study was to determine the efficacy of probenecid to achieve serum urate (SU) targets (< 0.36 mmol/l) in clinical practice...
  70. ncbi More allopurinol is needed to get gout patients < 0.36 mmol/l: a gout audit in the form of a before-after trial
    Bruce Arroll
    Department of General Practice and Primary Health Care, School of Population Health, Faculty of Medical and Health Sciences, The University of Auckland, PB 92019 Auckland, New Zealand
    J Prim Health Care 1:315-8. 2009
    ..36 mmol/L, assess patients' understanding of their preventive medication and trial a mail and phone intervention to improve gout control...
  71. ncbi Assessment of outcome in clinical trials of gout--a review of current measures
    W J Taylor
    Department of Medicine, Wellington School of Medicine and Health Sciences, University of Otago, PO Box 7343, Wellington 6242, New Zealand
    Rheumatology (Oxford) 46:1751-6. 2007
    ..The absence of a valid definition of gout-flare or how flare reduction defines response is problematic; this forms the basis for a current ACR-EULAR sponsored project...
  72. doi Do patient preferences for core outcome domains for chronic gout studies support the validity of composite response criteria?
    William J Taylor
    Department of Medicine, University of Otago, Wellington, New Zealand
    Arthritis Care Res (Hoboken) 65:1259-64. 2013
    ..To determine patient-derived weights or prioritization for core outcome domains in chronic gout clinical studies...
  73. doi New insights into an old disease: advanced imaging in the diagnosis and management of gout
    Fiona Marion McQueen
    Department of Molecular Medicine and Pathology, University of Auckland, 85 Park Rd, Grafton, Auckland 1023, New Zealand
    Postgrad Med J 89:87-93. 2013
    ..This review discusses the clinical and research applications of advanced imaging in gout with particular focus on diagnosis and monitoring of joint inflammation and damage...
  74. doi Is serum urate causally associated with incident cardiovascular disease?
    Simon Thornley
    Section of Epidemiology and Biostatistics, Level 4, School of Population Health, Tamaki Innovation Campus, Corner of Merton and Morrin Roads, Glen Innes, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Rheumatology (Oxford) 52:135-42. 2013
    ..With studies reporting both positive and negative associations, the influence of serum urate on incident cardiovascular disease (CVD) is uncertain. We sought to determine whether serum urate is causally associated with incident CVD...
  75. pmc Imaging in gout--what can we learn from MRI, CT, DECT and US?
    Fiona M McQueen
    Department of Molecular Medicine and Pathology, Faculty of Medicine and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand
    Arthritis Res Ther 13:246. 2011
    ..Imaging can also provide outcome measures, such as change in tophus volume, for monitoring the response to urate-lowering therapy and this is an important application in the clinical trial setting...
  76. doi Prevalence of airway and parenchymal abnormalities in newly diagnosed rheumatoid arthritis
    Margaret Wilsher
    Green Lane Respiratory Services, Auckland District Health Board, Private Bag 92024, Auckland 1142, New Zealand
    Respir Med 106:1441-6. 2012
    ..The objective of this study was to determine the prevalence of airway and parenchymal abnormalities in newly diagnosed patients with RA and to correlate these with clinical measures of RA severity and laboratory tests...
  77. doi Nurse-led cardiovascular disease risk management intervention for patients with gout
    Andy McLachlan
    Department of Cardiology, Middlemore Hospital, Auckland, New Zealand
    Eur J Cardiovasc Nurs 10:94-100. 2011
    ..Patients with gout are at high risk for cardiovascular disease (CVD), and this risk is frequently under-managed...
  78. pmc High-grade MRI bone oedema is common within the surgical field in rheumatoid arthritis patients undergoing joint replacement and is associated with osteitis in subchondral bone
    F M McQueen
    Department of Molecular Medicine and Pathology, Faculty of Medicine and Health Sciences, University of Auckland, Park Rd, Private Bag 92019 Auckland, New Zealand
    Ann Rheum Dis 66:1581-7. 2007
    ..We studied MRI scans from RA patients undergoing surgery, seeking to identify regions of bone oedema and examine its histopathological equivalent in resected bone...
  79. pmc Assessment of foot and ankle muscle strength using hand held dynamometry in patients with established rheumatoid arthritis
    Matthew Carroll
    AUT University, Health and Rehabilitation Research Institute, Auckland, New Zealand
    J Foot Ankle Res 6:10. 2013
    ..The aim of the study was to evaluate significant differences in foot and ankle muscle strength between patients with established RA against age and sex-matched controls using hand-held dynamometry...
  80. ncbi High prevalence of gout in patients with Type 2 diabetes: male sex, renal impairment, and diuretic use are major risk factors
    Ravi Suppiah
    Department of Rheumatology, Middlemore Hospital, Counties Manukau District Health Board, Private Bag 93311, Otahuhu, Auckland, New Zealand
    N Z Med J 121:43-50. 2008
    ..Gout and hyperuricaemia are recognised features of the metabolic syndrome. The objective of this study was to determine the prevalence of gout in patients with diabetes...
  81. doi The six-minute walk test using forehead oximetry is reliable in the assessment of scleroderma lung disease
    Margaret Wilsher
    Green Lane Respiratory, Auckland District Health Board, University of Auckland, Auckland, New Zealand
    Respirology 17:647-52. 2012
    ..The aim of this study was to determine the reliability of the 6MWT in patients with SSc and correlate results with morphological and functional measures of disease severity...
  82. ncbi Podiatry services for patients with arthritis: an unmet need
    Keith Rome
    Health and Rehabilitation Research Centre, AUT University, Auckland, New Zealand
    N Z Med J 123:91-7. 2010
    ..The aim of this paper is to highlight the major issues related to foot care for patients with arthritis and provide key recommendations that should implemented to improve access to podiatric services in New Zealand...
  83. pmc 'Choosing shoes': a preliminary study into the challenges facing clinicians in assessing footwear for rheumatoid patients
    Renee N Silvester
    AUT University, Health and Rehabilitation Research Institute, Auckland, New Zealand
    J Foot Ankle Res 3:24. 2010
    ..The aims of this study were to identify current footwear styles, footwear characteristics, and factors that influence footwear choice experienced by patients with RA...
  84. doi The natural killer cell: a further innate mediator of gouty inflammation?
    Victoria G Empson
    Bone Research Group, Department of Medicine, University of Auckland, Grafton, Auckland, New Zealand
    Immunol Cell Biol 88:24-31. 2010
    ..NK cells also interact with cells of the innate immune system such as monocytes and macrophages. This review outlines the biology of NK cells and the potential role of NK cells in modulating gouty inflammation...
  85. ncbi MRI in psoriatic arthritis: insights into pathogenesis and treatment response
    Fiona M McQueen
    Department of Molecular Medicine and Pathology, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Curr Rheumatol Rep 10:303-10. 2008
    ..Finally, MRI can be used to score and quantify these pathologic features, providing a sensitive tool with which to evaluate disease progression...
  86. pmc Clinical audit of foot problems in patients with rheumatoid arthritis treated at Counties Manukau District Health Board, Auckland, New Zealand
    Keith Rome
    Health and Rehabilitation Research Centre and Discipline of Podiatry, AUT University, Auckland, New Zealand
    J Foot Ankle Res 2:16. 2009
    ..The aim of this study was to undertake a clinical audit of foot problems in patients with RA treated at Counties Manukau District Health Board...
  87. doi Will Jill come tumbling after? The case for a JAK2-type mutation as a prequel to the connective tissue disorders
    Fiona M McQueen
    Dept of Molecular Medicine and Pathology, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand
    Med Hypotheses 73:651-4. 2009
    ..The success of B cell depletion therapy in rheumatoid arthritis and systemic lupus erythematosus is also strong circumstantial evidence for this hypothesis...
  88. ncbi A modified Delphi exercise to determine the extent of consensus with OMERACT outcome domains for studies of acute and chronic gout
    W J Taylor
    Department of Medicine, University of Otago, Wellington 6242, New Zealand
    Ann Rheum Dis 67:888-91. 2008
    ..To reach consensus with recommendations made by an OMERACT Special Interest Group (SIG)...
  89. ncbi The Health Assessment Questionnaire Disability Index is a valid measure of physical function in gout
    W J Taylor
    Department of Medicine, University of Otago, Wellington, New Zealand
    Clin Exp Rheumatol 26:620-6. 2008
    ..The aim of this study was to determine the construct validity of the Health Assessment Questionnaire Disability Index (HAQ-DI) in gout and the internal validity using Rasch analysis...
  90. doi Effects of cryotherapy on arthrogenic muscle inhibition using an experimental model of knee swelling
    David Rice
    AUT University, Auckland, New Zealand
    Arthritis Rheum 61:78-83. 2009
    ..This laboratory-based study examined the efficacy of cryotherapy in reducing quadriceps AMI caused by intraarticular swelling...
  91. pmc A randomised placebo controlled trial of delipidated, deglycolipidated Mycobacterium vaccae as immunotherapy for psoriatic arthritis
    N Dalbeth
    Department of Rheumatology, Auckland Healthcare, Auckland, New Zealand
    Ann Rheum Dis 63:718-22. 2004
    ..To test the hypothesis that PVAC, delipidated, deglycolipidated heat killed Mycobacterium vaccae, is an effective and safe treatment for psoriatic arthritis (PsA). This treatment has shown promising results in psoriasis...
  92. ncbi Inflammation and tissue damage in crystal deposition diseases
    Nicola Dalbeth
    Eric Bywaters Centre, Faculty of Medicine, Imperial College London, Hammersmith Campus, London, UK
    Curr Opin Rheumatol 17:314-8. 2005
    ..This review summarizes recent advances in the understanding of the cellular responses to monosodium urate, calcium pyrophosphate dihydrate and basic calcium phosphate crystals...
  93. ncbi Colchicine prescribing and safety monitoring in patients with gout
    Jason Ly
    Department of Rheumatology, Middlemore Hospital, Otahuhu, Auckland
    N Z Med J 120:U2808. 2007
    ..To assess current colchicine prescribing and safety monitoring in patients with gout...
  94. ncbi Debunking the myths to provide 21st Century management of gout
    Doone Winnard
    Counties Manukau District Health Board, Private Bag 94052, South Auckland Mail Centre, Manukau City, New Zealand
    N Z Med J 121:79-85. 2008
    ....
  95. ncbi Outcome evaluations in gout
    H Ralph Schumacher
    Division of Rheumatology, University of Pennsylvania School of Medicine, and Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Rheumatol 34:1381-5. 2007
    ..Final validation of these outcomes has not yet been achieved. In summary, the unique problems of evaluating outcomes in gout are finally being addressed. While no measures are available for use yet, an agenda has been developed...
  96. ncbi Prevention of colchicine toxicity in patients with gout
    Nicola Dalbeth
    N Z Med J 120:U2503. 2007
  97. ncbi CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation
    Nicola Dalbeth
    Division of Medicine, Imperial College London, Commonwealth Building, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    J Immunol 173:6418-26. 2004
    ..Such a positive feedback loop is likely to be important in the pathogenesis of chronic inflammatory conditions such as rheumatoid arthritis...
  98. ncbi Gastrointestinal disease and psoriatic arthritis
    Lyn Williamson
    J Rheumatol 31:1469-70. 2004
  99. ncbi Phenotypic and functional analysis of synovial natural killer cells
    Nicola Dalbeth
    Department of Immunology, Imperial College London, Hammersmith Hospital Campus, UK
    Methods Mol Med 136:149-63. 2007
    ..This chapter outlines methods of assessing the phenotype of NK cells through analysis of NK-cell markers and the function of NK cells through cytotoxicity assays and measurement of cytokine production...