Larry W Chamley

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. doi request reprint Review: where is the maternofetal interface?
    L W Chamley
    Department of Obstetrics and Gynaecology, The University of Auckland, Auckland, New Zealand Gravida the National Centre for Growth and Development, Auckland, New Zealand Electronic address
    Placenta 35:S74-80. 2014
  2. doi request reprint Trophoblast deportation: just a waste disposal system or antigen sharing?
    L W Chamley
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Park Rd, Grafton, Auckland, New Zealand
    J Reprod Immunol 88:99-105. 2011
  3. doi request reprint International Conference on Reproductive Immunology, 29 August to 1 September 2008, Shanghai, People's Republic of China
    Larry W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    J Reprod Immunol 80:146-9. 2009
  4. doi request reprint Nuclear localisation of the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (FAAH) in invasive trophoblasts and an association with recurrent miscarriage
    L W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    Placenta 29:970-5. 2008
  5. ncbi request reprint Antisperm antibodies and conception
    L W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    Semin Immunopathol 29:169-84. 2007
  6. ncbi request reprint Antiphospholipid antibodies or not? The role of beta 2 glycoprotein 1 in autoantibody-mediated pregnancy loss
    L W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, National Women s Hospital, New Zealand
    J Reprod Immunol 36:123-42. 1997
  7. pmc Conformationally altered beta 2-glycoprotein I is the antigen for anti-cardiolipin autoantibodies
    L W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, Women s Hospital, New Zealand
    Clin Exp Immunol 115:571-6. 1999
  8. ncbi request reprint Is interleukin-3 important in antiphospholipid antibody-mediated pregnancy failure?
    L W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, National Women s Hospital, Epsom, Auckland, New Zealand
    Fertil Steril 76:700-6. 2001
  9. ncbi request reprint Phagocytosis of necrotic but not apoptotic trophoblasts induces endothelial cell activation
    Qi Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Hypertension 47:116-21. 2006
  10. ncbi request reprint Antiphosphatidyl serine antibodies are more common in normotensive women with small for gestational age pregnancies
    Lesley M E McCowan
    Department of Obstetrics and Gynaecology, National Women s Hospital, University of Auckland, Auckland, New Zealand
    Aust N Z J Obstet Gynaecol 44:14-8. 2004

Detail Information

Publications34

  1. doi request reprint Review: where is the maternofetal interface?
    L W Chamley
    Department of Obstetrics and Gynaecology, The University of Auckland, Auckland, New Zealand Gravida the National Centre for Growth and Development, Auckland, New Zealand Electronic address
    Placenta 35:S74-80. 2014
    ..Trophoblast debris greatly expands the maternofetal interface and the nature of that debris is likely to strongly influence the responses of the maternal vascular and immune systems to the debris. ..
  2. doi request reprint Trophoblast deportation: just a waste disposal system or antigen sharing?
    L W Chamley
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Park Rd, Grafton, Auckland, New Zealand
    J Reprod Immunol 88:99-105. 2011
    ....
  3. doi request reprint International Conference on Reproductive Immunology, 29 August to 1 September 2008, Shanghai, People's Republic of China
    Larry W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    J Reprod Immunol 80:146-9. 2009
    ..This report describes some of the highlights of the meeting...
  4. doi request reprint Nuclear localisation of the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (FAAH) in invasive trophoblasts and an association with recurrent miscarriage
    L W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    Placenta 29:970-5. 2008
    ..This may reflect inadequate control of the cannabinoid system in the uterus of women who experience recurrent miscarriages. The functional significance of the unexpected nuclear localisation of FAAH in trophoblasts is not yet clear...
  5. ncbi request reprint Antisperm antibodies and conception
    L W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    Semin Immunopathol 29:169-84. 2007
    ..Secondly, because these antibodies can induce infertility they have the potential to be developed for contraceptive purposes in humans and also for the control of feral animal populations...
  6. ncbi request reprint Antiphospholipid antibodies or not? The role of beta 2 glycoprotein 1 in autoantibody-mediated pregnancy loss
    L W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, National Women s Hospital, New Zealand
    J Reprod Immunol 36:123-42. 1997
    ..However, a number of putative roles have been proposed which allow speculation as to the mechanism by which antiphospholipid antibodies may disrupt haemostasis and pregnancy...
  7. pmc Conformationally altered beta 2-glycoprotein I is the antigen for anti-cardiolipin autoantibodies
    L W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, Women s Hospital, New Zealand
    Clin Exp Immunol 115:571-6. 1999
    ....
  8. ncbi request reprint Is interleukin-3 important in antiphospholipid antibody-mediated pregnancy failure?
    L W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, National Women s Hospital, Epsom, Auckland, New Zealand
    Fertil Steril 76:700-6. 2001
    ..To investigate the effect of interleukin-3 (IL-3) on trophoblast proliferation and expression of beta2-glycoprotein I...
  9. ncbi request reprint Phagocytosis of necrotic but not apoptotic trophoblasts induces endothelial cell activation
    Qi Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Hypertension 47:116-21. 2006
    ..This work suggests that endothelial cells can phagocytose deported trophoblasts and that the mechanism of trophoblast death (apoptotic or necrotic) could have major effects on the maternal vascular response to shed trophoblasts...
  10. ncbi request reprint Antiphosphatidyl serine antibodies are more common in normotensive women with small for gestational age pregnancies
    Lesley M E McCowan
    Department of Obstetrics and Gynaecology, National Women s Hospital, University of Auckland, Auckland, New Zealand
    Aust N Z J Obstet Gynaecol 44:14-8. 2004
    ..Small for gestational age (SGA) babies are more common in women with antiphospholipid antibodies but data are limited about the prevalence of antiphospholipid antibodies in women who have delivered SGA babies...
  11. doi request reprint MHC haplotypes and response to immunocontraceptive vaccines in the brushtail possum
    Olivia J Holland
    National Research Centre for Possum Biocontrol, New Zealand
    J Reprod Immunol 82:57-65. 2009
    ....
  12. ncbi request reprint The effects of oxygen concentration and gestational age on extravillous trophoblast outgrowth in a human first trimester villous explant model
    Joanna L James
    Department of Obstetrics and Gynecology, University of Auckland, Auckland, New Zealand
    Hum Reprod 21:2699-705. 2006
    ..This work aimed to quantify the effects of gestational age and oxygen concentration on extravillous trophoblast outgrowth...
  13. ncbi request reprint Activated endothelial cells resist displacement by trophoblast in vitro
    Q Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, 85 Park Road, Grafton, Auckland 1001, New Zealand
    Placenta 28:743-7. 2007
    ..The aim of this study was to investigate further the hypothesis that spiral artery endothelial cells can contribute to the mechanism of shallow trophoblast invasion...
  14. ncbi request reprint Antibody-binding proteins in human seminal plasma
    W W C Chiu
    Department of Obstetrics and Gynaecology, University of Auckland, National Women s Hospital, Epsom, Auckland, New Zealand
    Am J Reprod Immunol 48:269-74. 2002
    ..Seminal plasma contains immunosuppressive factors, one such factor may be antibody-binding proteins (ABP's)...
  15. ncbi request reprint Lipiodol fertility enhancement: two-year follow-up of a randomized trial suggests a transient benefit in endometriosis, but a sustained benefit in unexplained infertility
    N P Johnson
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    Hum Reprod 22:2857-62. 2007
    ..A New Zealand randomized trial has shown that lipiodol treatment enhances fertility with high short-term effectiveness for women with endometriosis...
  16. ncbi request reprint Sex of bovine embryos may be related to mothers' preovulatory follicular testosterone
    V J Grant
    Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1142, New Zealand
    Biol Reprod 78:812-5. 2008
    ..009). Thus, bovine ova that developed in follicular fluid with high concentrations of testosterone in vivo were significantly more likely to be fertilized by Y chromosome-bearing spermatozoa...
  17. ncbi request reprint Antiphospholipid antibodies: biological basis and prospects for treatment
    L W Chamley
    Department of Obstetrics and Gynaecology, University of Auckland, National Women s Hospital, Epsom, New Zealand
    J Reprod Immunol 57:185-202. 2002
    ....
  18. doi request reprint A critical assessment of the role of antiphospholipid antibodies in infertility
    K L Buckingham
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    J Reprod Immunol 80:132-45. 2009
    ..We also demonstrate that there is no evidence that supposedly aPL-induced infertility or implantation failure after IVF can be treated with pharmacological interventions...
  19. ncbi request reprint An in vitro model of human placental trophoblast deportation/shedding
    M H Abumaree
    Department of Obstetrics and Gynaecology, University of Auckland School of Medicine, Auckland, New Zealand
    Mol Hum Reprod 12:687-94. 2006
    ..Our preliminary investigations confirm that apoptosis plays an important role in trophoblast shedding/deportation...
  20. ncbi request reprint Human seminal plasma antibody-binding proteins
    W W C Chiu
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    Am J Reprod Immunol 50:196-201. 2003
    ..The physiological role of antibody-binding proteins in human seminal plasma and the potential role of these proteins in infertility is relatively unknown...
  21. ncbi request reprint Antiphospholipid antibodies bind to activated but not resting endothelial cells: is an independent triggering event required to induce antiphospholipid antibody-mediated disease?
    Q Chen
    Department of Obstetrics and Gynecology, Faculty of Medical and Health Science, The University of Auckland Auckland, New Zealand
    Thromb Res 114:101-11. 2004
    ..However, as phosphatidyl serine is absent from resting endothelial cell membranes, we questioned this hypothesis...
  22. ncbi request reprint Interaction of Jar choriocarcinoma cells with endothelial cell monolayers
    Q Chen
    Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Placenta 26:617-25. 2005
    ..Our results suggest that endothelial cells may not simply be passive targets for invading trophoblasts during the remodeling of the spiral arteries...
  23. ncbi request reprint The regulation of trophoblast differentiation by oxygen in the first trimester of pregnancy
    J L James
    Department of Obstetrics and Gynecology, University of Auckland, Auckland, New Zealand
    Hum Reprod Update 12:137-44. 2006
    ..However, there is currently a large body of conflicting experimental evidence concerning this topic. This review examines the experimental evidence to date on the role of oxygen in trophoblast differentiation...
  24. pmc Minor histocompatibility antigens are expressed in syncytiotrophoblast and trophoblast debris: implications for maternal alloreactivity to the fetus
    Olivia J Holland
    Department of Obstetrics and Gynecology, University of Auckland, Auckland, New Zealand
    Am J Pathol 180:256-66. 2012
    ..The data, thus, suggest a mechanism by which the maternal immune system is exposed to fetal alloantigens, possibly explaining the relationship between parity and graft-versus-host disease...
  25. ncbi request reprint SPRASA, a novel sperm protein involved in immune-mediated infertility
    W W C Chiu
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    Hum Reprod 19:243-9. 2004
    ..Identification of the sperm proteins that ASA bind to may aid the development of more useful diagnostic tests...
  26. doi request reprint Novel alleles in classical major histocompatibility complex class II loci of the brushtail possum (Trichosurus vulpecula)
    Olivia J Holland
    National Research Centre for Possum Biocontrol, Landcare Research, Auckland, New Zealand
    Immunogenetics 60:449-60. 2008
    ..The extensive variation demonstrated in possums reinforces the need for further research to assess the risk that such MHC variation poses for long-term immunocontraceptive vaccine efficacy...
  27. ncbi request reprint Comparison of the expression of human leukocyte antigen (HLA)-G and HLA-E in women with normal pregnancy and those with recurrent miscarriage
    A Bhalla
    Department of Obstetrics and Gynaecology, Room 3241, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Reproduction 131:583-9. 2006
    ..There was no difference in the pattern of HLA-E expression between women with recurrent miscarriage and those with normal pregnancies...
  28. ncbi request reprint Antiphospholipid antibodies in serum and follicular fluid--is there a correlation with IVF implantation failure?
    K L Buckingham
    Department of Obstetrics and Gynaecology, University of Auckland, and Fertility Plus, Greenlane Clinical Centre, Private Bag 92189, Auckland 1003, New Zealand
    Hum Reprod 21:728-34. 2006
    ..We aimed to investigate the finding that aPLs are concentrated in follicular fluid and to establish if this is associated with a poorer outcome from IVF...
  29. ncbi request reprint Identification of novel major histocompatibility complex class I sequences in a marsupial, the brushtail possum (Trichosurus vulpecula)
    Olivia J Holland
    National Research Centre for Possum Biocontrol, Landcare Research, Auckland, New Zealand
    Immunogenetics 60:609-19. 2008
    ..The remaining sequences are highly divergent from other possum sequences and clusters with American marsupials in phylogenetic analysis, indicating they may have changed little since the separation of Australian and American marsupials...
  30. ncbi request reprint CD83(+)dendritic cells in the decidua of women with recurrent miscarriage and normal pregnancy
    K Askelund
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    Placenta 25:140-5. 2004
    ..This suggests dendritic cells may play a role in the aetiology of some cases of recurrent miscarriage...
  31. ncbi request reprint The effects of apoptotic, deported human placental trophoblast on macrophages: possible consequences for pregnancy
    M H Abumaree
    Department of Obstetrics and Gynaecology, University of Auckland School of Medicine, Auckland, New Zealand
    J Reprod Immunol 72:33-45. 2006
    ....
  32. ncbi request reprint Extravillous trophoblast apoptosis--a workshop report
    B Huppertz
    Department of Anatomy II, University Hospital RWTH Aachen, Wendlingweg 2, 52057 Aachen, Germany
    Placenta 26:S46-8. 2005
    ..On the other hand, apoptosis of intramural/endovascular trophoblast seems to be highly relevant for a correct transformation of spiral arteries...
  33. doi request reprint A caution on the use of HLA-G isoforms as markers of extravillous trophoblasts
    J L James
    Placenta 29:305-6; author reply 307. 2008
  34. pmc The association of anti-phospholipid antibodies with parity in placental malaria
    S Owens
    MRC Laboratories, Atlantic Road, Fajara, The Gambia
    Clin Exp Immunol 142:512-8. 2005
    ..It is of significance in the context of the known parity differences in pregnancy malaria immunity...