BRIAN LEE BROWNING

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. ncbi Efficient multilocus association testing for whole genome association studies using localized haplotype clustering
    Brian L Browning
    Department of Statistics, The University of Auckland, Auckland, New Zealand
    Genet Epidemiol 31:365-75. 2007
  2. ncbi Association of DLG5 variants with inflammatory bowel disease in the New Zealand Caucasian population and meta-analysis of the DLG5 R30Q variant
    Brian L Browning
    Discipline of Nutrition, Department of Statistics, University of Auckland, New Zealand, and Department of Gastroenterology, Box Hill Hospital, Monash, Australia
    Inflamm Bowel Dis 13:1069-76. 2007
  3. pmc Nucleotide-binding oligomerization domain containing 1 (NOD1) haplotypes and single nucleotide polymorphisms modify susceptibility to inflammatory bowel diseases in a New Zealand caucasian population: a case-control study
    Claudia Huebner
    Discipline of Nutrition, The University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    BMC Res Notes 2:52. 2009
  4. pmc Haplotypic analysis of Wellcome Trust Case Control Consortium data
    Brian L Browning
    Department of Statistics, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Hum Genet 123:273-80. 2008
  5. pmc A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals
    Brian L Browning
    Department of Statistics, University of Auckland, Auckland 1142, New Zealand
    Am J Hum Genet 84:210-23. 2009
  6. pmc PRESTO: rapid calculation of order statistic distributions and multiple-testing adjusted P-values via permutation for one and two-stage genetic association studies
    Brian L Browning
    Department of Statistics, The University of Auckland, Auckland, New Zealand
    BMC Bioinformatics 9:309. 2008
  7. pmc Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies
    Brian L Browning
    Department of Statistics, University of Auckland, Auckland 1142, New Zealand
    Am J Hum Genet 85:847-61. 2009
  8. doi Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort
    Ivonne Petermann
    Discipline of Nutrition, The University of Auckland, New Zealand
    Hum Immunol 70:440-6. 2009
  9. ncbi Has toll-like receptor 4 been prematurely dismissed as an inflammatory bowel disease gene? Association study combined with meta-analysis shows strong evidence for association
    Brian L Browning
    Discipline of Nutrition, The University of Auckland, Auckland, New Zealand
    Am J Gastroenterol 102:2504-12. 2007
  10. doi Genetic analysis of MDR1 and inflammatory bowel disease reveals protective effect of heterozygous variants for ulcerative colitis
    Claudia Huebner
    Discipline of Nutrition, FM and HS, University of Auckland, Auckland, New Zealand
    Inflamm Bowel Dis 15:1784-93. 2009

Research Grants

Detail Information

Publications17

  1. ncbi Efficient multilocus association testing for whole genome association studies using localized haplotype clustering
    Brian L Browning
    Department of Statistics, The University of Auckland, Auckland, New Zealand
    Genet Epidemiol 31:365-75. 2007
    ....
  2. ncbi Association of DLG5 variants with inflammatory bowel disease in the New Zealand Caucasian population and meta-analysis of the DLG5 R30Q variant
    Brian L Browning
    Discipline of Nutrition, Department of Statistics, University of Auckland, New Zealand, and Department of Gastroenterology, Box Hill Hospital, Monash, Australia
    Inflamm Bowel Dis 13:1069-76. 2007
    ....
  3. pmc Nucleotide-binding oligomerization domain containing 1 (NOD1) haplotypes and single nucleotide polymorphisms modify susceptibility to inflammatory bowel diseases in a New Zealand caucasian population: a case-control study
    Claudia Huebner
    Discipline of Nutrition, The University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    BMC Res Notes 2:52. 2009
    ..Carrying specific SNPs in this gene significantly modifies the risk of CD and/or UC in a New Zealand Caucasian population...
  4. pmc Haplotypic analysis of Wellcome Trust Case Control Consortium data
    Brian L Browning
    Department of Statistics, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Hum Genet 123:273-80. 2008
    ..In addition, we demonstrate that it is possible to simultaneously phase 16,000 individuals genotyped on genome-wide data (450 K markers) using the Beagle software package...
  5. pmc A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals
    Brian L Browning
    Department of Statistics, University of Auckland, Auckland 1142, New Zealand
    Am J Hum Genet 84:210-23. 2009
    ..We present a useful measure of imputation accuracy, allelic R(2), and show that this measure can be estimated accurately from posterior genotype probabilities. Our methods are implemented in version 3.0 of the BEAGLE software package...
  6. pmc PRESTO: rapid calculation of order statistic distributions and multiple-testing adjusted P-values via permutation for one and two-stage genetic association studies
    Brian L Browning
    Department of Statistics, The University of Auckland, Auckland, New Zealand
    BMC Bioinformatics 9:309. 2008
    ..PRESTO is a new software package for genetic association studies that performs fast computation of multiple-testing adjusted P-values via permutation of the trait...
  7. pmc Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies
    Brian L Browning
    Department of Statistics, University of Auckland, Auckland 1142, New Zealand
    Am J Hum Genet 85:847-61. 2009
    ..Our new genotype-calling methods are implemented in the BEAGLE and BEAGLECALL software packages...
  8. doi Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort
    Ivonne Petermann
    Discipline of Nutrition, The University of Auckland, New Zealand
    Hum Immunol 70:440-6. 2009
    ..e. bacterial detection). There is evidence that carrying two SNPs in genes may lead to statistical significance for genes and SNPs that do not otherwise confirm as risk alleles for disease aetiology when analysed alone...
  9. ncbi Has toll-like receptor 4 been prematurely dismissed as an inflammatory bowel disease gene? Association study combined with meta-analysis shows strong evidence for association
    Brian L Browning
    Discipline of Nutrition, The University of Auckland, Auckland, New Zealand
    Am J Gastroenterol 102:2504-12. 2007
    ..We tested two TLR4 variants for association with IBD in the New Zealand caucasian population and assessed the cumulative evidence for association of TLR4 Asp299Gly and IBD...
  10. doi Genetic analysis of MDR1 and inflammatory bowel disease reveals protective effect of heterozygous variants for ulcerative colitis
    Claudia Huebner
    Discipline of Nutrition, FM and HS, University of Auckland, Auckland, New Zealand
    Inflamm Bowel Dis 15:1784-93. 2009
    ..The aims of this study were to genotype these variants and correlate them to disease phenotype in New Zealand IBD patients...
  11. pmc High-resolution detection of identity by descent in unrelated individuals
    Sharon R Browning
    Department of Statistics, University of Auckland, Auckland, New Zealand
    Am J Hum Genet 86:526-39. 2010
    ..We detect HBD in 4.7 individuals per 10,000 on average at a given location. Our methodology is implemented in the freely available BEAGLE software package...
  12. pmc Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering
    Sharon R Browning
    Department of Statistics, The University of Auckland, Auckland, New Zealand
    Am J Hum Genet 81:1084-97. 2007
    ..1 days of computing time, with 99% of masked alleles imputed correctly. Our method is implemented in the Beagle software package, which is freely available...
  13. ncbi Genes, diet and inflammatory bowel disease
    Lynnette R Ferguson
    Discipline of Nutrition, Faculty of Medical and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mutat Res 622:70-83. 2007
    ..A combination of human correlation studies with experimental models could provide a rational strategy for optimising nutrigenetic approaches to IBD...
  14. ncbi Triallelic single nucleotide polymorphisms and genotyping error in genetic epidemiology studies: MDR1 (ABCB1) G2677/T/A as an example
    Claudia Huebner
    Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Cancer Epidemiol Biomarkers Prev 16:1185-92. 2007
    ..The failure to recognize the triallic nature of a SNP may lead to underestimations of real genetic associations...
  15. ncbi Evaluation of Nyholt's procedure for multiple testing correction
    Daria Salyakina
    Max Planck Institute of Psychiatry, Munich, Germany
    Hum Hered 60:19-25; discussion 61-2. 2005
    ..We sought to carry out an empirical and theoretical evaluation of Nyholt's method...
  16. ncbi On reducing the statespace of hidden Markov models for the identity by descent process
    Sharon Browning
    Bioinformatics Research Center, North Carolina State University, Campus Box 7566, Raleigh, North Carolina 27695 7566, USA
    Theor Popul Biol 62:1-8. 2002
    ..We describe the maximal grouping together of states of the model to reduce the size of the statespace. This grouping is based on pedigree symmetries. We also present an efficient algorithm for finding the maximal grouping...
  17. ncbi Linkage analysis using single nucleotide polymorphisms
    Brian L Browning
    GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Hum Hered 57:220-7. 2004
    ..We also give an algorithm which extends the Lander-Green algorithm to permit multipoint linkage analysis of clusters of tightly linked markers with arbitrarily high levels of intracluster linkage disequilibrium...

Research Grants2

  1. Improving genotype accuracy and haplotypic analysis for genome-wide studies
    BRIAN LEE BROWNING; Fiscal Year: 2010
    ..These methods and tools will contribute to the prevention, diagnosis, and treatment of heritable diseases in the United States and throughout the world. ..