D M Collins

Summary

Affiliation: Ruakura Research Centre
Country: New Zealand

Publications

  1. ncbi New tuberculosis vaccines based on attenuated strains of the Mycobacterium tuberculosis complex
    D M Collins
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Immunol Cell Biol 78:342-8. 2000
  2. ncbi In search of tuberculosis virulence genes
    D M Collins
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Trends Microbiol 4:426-30. 1996
  3. ncbi Vaccine and skin testing properties of two avirulent Mycobacterium bovis mutants with and without an additional esat-6 mutation
    D M Collins
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 83:361-6. 2003
  4. pmc Vaccination of guinea pigs with nutritionally impaired avirulent mutants of Mycobacterium bovis protects against tuberculosis
    G W de Lisle
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Infect Immun 67:2624-6. 1999
  5. ncbi An esat6 knockout mutant of Mycobacterium bovis produced by homologous recombination will contribute to the development of a live tuberculosis vaccine
    B J Wards
    Wallaceville Animal Research Centre, AgResearch, Upper Hutt, New Zealand
    Tuber Lung Dis 80:185-9. 2000
  6. pmc Immune responses induced in cattle by virulent and attenuated Mycobacterium bovis strains: correlation of delayed-type hypersensitivity with ability of strains to grow in macrophages
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Infect Immun 67:2172-7. 1999
  7. ncbi Production of avirulent mutants of Mycobacterium bovis with vaccine properties by the use of illegitimate recombination and screening of stationary-phase cultures
    D M Collins
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    Microbiology 148:3019-27. 2002
  8. ncbi Antisense RNA to ahpC, an oxidative stress defence gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence properties
    T Wilson
    Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Microbiology 144:2687-95. 1998
  9. ncbi The efficacy of live tuberculosis vaccines after presensitization with Mycobacterium avium
    G W de Lisle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40 063, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 85:73-9. 2005
  10. pmc A DNA prime-live vaccine boost strategy in mice can augment IFN-gamma responses to mycobacterial antigens but does not increase the protective efficacy of two attenuated strains of Mycobacterium bovis against bovine tuberculosis
    M A Skinner
    AgResearch Ltd, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Immunology 108:548-55. 2003

Collaborators

Detail Information

Publications24

  1. ncbi New tuberculosis vaccines based on attenuated strains of the Mycobacterium tuberculosis complex
    D M Collins
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Immunol Cell Biol 78:342-8. 2000
    ..Many mutants of the M. tuberculosis complex have now been produced and the vaccine properties of a substantial number will be assessed in the next 3 years...
  2. ncbi In search of tuberculosis virulence genes
    D M Collins
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Trends Microbiol 4:426-30. 1996
    ..Numerous putative virulence genes have been identified, but so far there is only conclusive evidence for the role of two genes, KatG and rpoV, in virulence...
  3. ncbi Vaccine and skin testing properties of two avirulent Mycobacterium bovis mutants with and without an additional esat-6 mutation
    D M Collins
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 83:361-6. 2003
    ..Molecular techniques are now available to develop new live tuberculosis vaccines by producing avirulent strains of the Mycobacterium tuberculosis complex with known genes deleted...
  4. pmc Vaccination of guinea pigs with nutritionally impaired avirulent mutants of Mycobacterium bovis protects against tuberculosis
    G W de Lisle
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Infect Immun 67:2624-6. 1999
    ..In animals vaccinated with BCG or two of the other strains, the bacterial counts from the lungs were significantly lower than those of the nonvaccinated animals...
  5. ncbi An esat6 knockout mutant of Mycobacterium bovis produced by homologous recombination will contribute to the development of a live tuberculosis vaccine
    B J Wards
    Wallaceville Animal Research Centre, AgResearch, Upper Hutt, New Zealand
    Tuber Lung Dis 80:185-9. 2000
    ....
  6. pmc Immune responses induced in cattle by virulent and attenuated Mycobacterium bovis strains: correlation of delayed-type hypersensitivity with ability of strains to grow in macrophages
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Infect Immun 67:2172-7. 1999
    ..Our study showed that skin test responsiveness to PPD correlated with the ability of the strains to grow in alveolar macrophages rather than to their pathogenicity in cattle...
  7. ncbi Production of avirulent mutants of Mycobacterium bovis with vaccine properties by the use of illegitimate recombination and screening of stationary-phase cultures
    D M Collins
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    Microbiology 148:3019-27. 2002
    ..Improved models may be required to more clearly determine the difference in protective effect between BCG and potential new tuberculosis vaccines...
  8. ncbi Antisense RNA to ahpC, an oxidative stress defence gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence properties
    T Wilson
    Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Microbiology 144:2687-95. 1998
    ..In addition, normal expression of AhpC is crucial for maintaining the virulence of wild-type M. bovis, which has normal catalase/peroxidase levels...
  9. ncbi The efficacy of live tuberculosis vaccines after presensitization with Mycobacterium avium
    G W de Lisle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40 063, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 85:73-9. 2005
    ..Presensitization of guinea pigs by the oral administration of M. avium+ provides a model for testing vaccines under conditions where the efficacy of BCG has been compromised by prior sensitization with environmental mycobacteria...
  10. pmc A DNA prime-live vaccine boost strategy in mice can augment IFN-gamma responses to mycobacterial antigens but does not increase the protective efficacy of two attenuated strains of Mycobacterium bovis against bovine tuberculosis
    M A Skinner
    AgResearch Ltd, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Immunology 108:548-55. 2003
    ..bovis vaccine enhanced IFN-gamma immune responses compared to vaccinating with an attenuated M. bovis vaccine alone, but did not increase protection against a virulent M. bovis infection...
  11. ncbi ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex
    T M Wilson
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Mol Microbiol 19:1025-34. 1996
    ..Increased expression of AhpC may account for some of the INH resistance of strains of the M. tuberculosis complex...
  12. pmc Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex
    D M Collins
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Proc Natl Acad Sci U S A 92:8036-40. 1995
    ..Study of genes and proteins differentially regulated by the mutant transcription factor should facilitate identification of further virulence factors...
  13. doi Newly attenuated Mycobacterium bovis mutants as vaccines against bovine tuberculosis, particularly for possums
    D M Collins
    AgResearch, Wallaceville, Upper Hutt, New Zealand
    Vet Microbiol 151:99-103. 2011
    ..Allelic exchange methods are now being used to produce vaccine strains with multiple specific mutations to improve safety and immunological characteristics...
  14. ncbi Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis
    T M Wilson
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Mol Microbiol 15:1009-15. 1995
    ..Integration of a functional katG gene into the most resistant strain restored full virulence. This clearly established that katG is a virulence factor for M. bovis and that mutation of the inhA gene has no effect on virulence...
  15. doi A bovine macrophage screening system for identifying attenuated transposon mutants of Mycobacterium avium subsp. paratuberculosis with vaccine potential
    G M Scandurra
    AgResearch, National Centre for Biosecurity and Infectious Disease, Wallaceville, Upper Hutt, New Zealand
    J Microbiol Methods 77:58-62. 2009
    ..These strains were found to be attenuated in vivo, thereby validating the further use of this macrophage screening system to identify MAP mutants with potential as candidate vaccines against Johne's disease...
  16. ncbi Differences of gene expression in bovine alveolar macrophages infected with virulent and attenuated isogenic strains of Mycobacterium bovis
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, Ward Street, Upper Hutt, New Zealand
    Int Immunopharmacol 6:957-61. 2006
    ..Microarray analysis of gene expression in macrophages infected with attenuated isogenic strains of M. bovis may identify key genes involved in early and protective immune responses to tuberculosis...
  17. ncbi Virulence factors of Mycobacterium bovis
    D M Collins
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 81:97-102. 2001
    ..Many putative virulence genes are now being investigated and only the inherent slowness with which mycobacterial work proceeds, delays the inevitable arrival of an exciting new phase in the understanding of mycobacterial disease...
  18. ncbi Electroporation at elevated temperatures substantially improves transformation efficiency of slow-growing mycobacteria
    B J Wards
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    FEMS Microbiol Lett 145:101-5. 1996
    ..Electroporation at 37 degrees C has been chosen as a standard condition for slow-growing species as it usually resulted in a transformation efficiency several orders of magnitude higher than that obtained at 0 degree C...
  19. ncbi Identification of a cadmium-induced gene in Mycobacterium bovis and Mycobacterium tuberculosis
    G S Hotter
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    FEMS Microbiol Lett 200:151-5. 2001
    ..Only the long fragment directed cadmium-inducible activity when electroporated into M. bovis. The cadI promoter has potential for both constitutive and inducible expression studies in M. bovis and M. tuberculosis...
  20. ncbi New generation vaccines and delivery systems for control of bovine tuberculosis in cattle and wildlife
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Vet Immunol Immunopathol 87:177-85. 2002
    ..bovis vaccines administered via oral baits or aerosol spray to possums have already been shown to reduce the severity of a subsequent M. bovis infection...
  21. ncbi Use of a polymerase chain reaction to subtype Mycobacterium avium subspecies paratuberculosis, an increasingly important pathogen from farmed deer in New Zealand
    G W de Lisle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40 063, Upper Hutt, New Zealand
    N Z Vet J 54:195-7. 2006
    ..paratuberculosis), using a highly specific polymerase chain reaction (PCR) test on samples from infected herds...
  22. ncbi Construction and screening of Mycobacterium paratuberculosis insertional mutant libraries
    S M Cavaignac
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Arch Microbiol 173:229-31. 2000
    ..Genes interrupted by insertion were identified for seven mutants isolated from the screening process. Two mutants had insertions in putative genes involved in synthesis of the cell wall...
  23. doi The evolution and distribution of phage ST160 within Salmonella enterica serotype Typhimurium
    M Price-Carter
    Infectious Diseases Group, AgResearch NCBID Wallaceville, PO Box 40063, Upper Hutt, New Zealand
    Epidemiol Infect 139:1262-71. 2011
    ..The emergence of S. Typhimurium DT160 as a significant pathogen in New Zealand is postulated to have occurred due to the sensitivity of the Salmonella strains to the ST160 phage when S. Typhimurium DT160 first arrived...
  24. ncbi Identification of an insertion sequence, IS1081, in Mycobacterium bovis
    D M Collins
    Central Animal Health Laboratory, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    FEMS Microbiol Lett 67:11-5. 1991
    ..IS1081 may be useful for genetic manipulations and for developing a diagnostic test for bovine tuberculosis based on the polymerase chain reaction...