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Species | B M BuddleSummaryAffiliation: Ruakura Research Centre Country: New Zealand Publications
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Detail Information
Publications
Immunobiology of mycobacterial infections in marsupialsB M Buddle
AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
Dev Comp Immunol 24:517-29. 2000..This review examines possible reasons for the high susceptibility of marsupials to mycobacterial infections and investigates the prospects for developing vaccines to control these diseases...
Differentiation between Mycobacterium bovis BCG-vaccinated and M. bovis-infected cattle by using recombinant mycobacterial antigensB M Buddle
AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
Clin Diagn Lab Immunol 6:1-5. 1999..The results of the study indicate that of the four antigens tested in the IFN-gamma assay, only ESAT-6 would be suitable for differentiating BCG-vaccinated animals from those infected with bovine tuberculosis...- Immunological approaches to the control of tuberculosis in wildlife reservoirsB M Buddle
AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
Vet Immunol Immunopathol 74:1-16. 2000..The aim of this review is to address the problems and approaches involved in the control of wildlife tuberculosis from an immunological perspective... - Vaccination of cattle with Mycobacterium bovis culture filtrate proteins and CpG oligodeoxynucleotides induces protection against bovine tuberculosisD N Wedlock
AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
Vet Immunol Immunopathol 106:53-63. 2005..These results establish an important role for CpG ODN in stimulating protective Th1 responses to tuberculosis in cattle and indicate that a sub-unit protein vaccine can protect these animals against tuberculosis... - Immune responses induced in cattle by virulent and attenuated Mycobacterium bovis strains: correlation of delayed-type hypersensitivity with ability of strains to grow in macrophagesD N Wedlock
AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
Infect Immun 67:2172-7. 1999..Our study showed that skin test responsiveness to PPD correlated with the ability of the strains to grow in alveolar macrophages rather than to their pathogenicity in cattle... - Vaccination with DNA vaccines encoding MPB70 or MPB83 or a MPB70 DNA prime-protein boost does not protect cattle against bovine tuberculosisD N Wedlock
AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
Tuberculosis (Edinb) 83:339-49. 2003..Bovine tuberculosis is a problem in a number of countries and protection of cattle by vaccination could be an important control strategy... - A DNA prime-live vaccine boost strategy in mice can augment IFN-gamma responses to mycobacterial antigens but does not increase the protective efficacy of two attenuated strains of Mycobacterium bovis against bovine tuberculosisM A Skinner
AgResearch Ltd, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
Immunology 108:548-55. 2003..bovis vaccine enhanced IFN-gamma immune responses compared to vaccinating with an attenuated M. bovis vaccine alone, but did not increase protection against a virulent M. bovis infection... - Vaccination of cattle with Mycobacterium bovis culture filtrate proteins and interleukin-2 for protection against bovine tuberculosisD N Wedlock
AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
Infect Immun 68:5809-15. 2000..While vaccination of cattle with M. bovis CFP gave an encouraging reduction in tuberculous lesions and did not induce a delayed-type hypersensitivity response to PPD, future CFP vaccines must prevent any extrathoracic spread of disease... - The efficacy of live tuberculosis vaccines after presensitization with Mycobacterium aviumG W de Lisle
AgResearch, Wallaceville Animal Research Centre, PO Box 40 063, Upper Hutt, New Zealand
Tuberculosis (Edinb) 85:73-9. 2005..Presensitization of guinea pigs by the oral administration of M. avium+ provides a model for testing vaccines under conditions where the efficacy of BCG has been compromised by prior sensitization with environmental mycobacteria... - Vaccination of guinea pigs with nutritionally impaired avirulent mutants of Mycobacterium bovis protects against tuberculosisG W de Lisle
AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
Infect Immun 67:2624-6. 1999..In animals vaccinated with BCG or two of the other strains, the bacterial counts from the lungs were significantly lower than those of the nonvaccinated animals... - Oral vaccination of brushtail possums with BCG: Investigation into factors that may influence vaccine efficacy and determination of duration of protectionB M Buddle
AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
N Z Vet J 54:224-30. 2006..To determine the duration of protective immunity following oral administration of BCG... - Use of mycobacterial peptides and recombinant proteins for the diagnosis of bovine tuberculosis in skin test-positive cattleB M Buddle
AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
Vet Rec 153:615-20. 2003.... - Revaccination of neonatal calves with Mycobacterium bovis BCG reduces the level of protection against bovine tuberculosis induced by a single vaccinationB M Buddle
AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
Infect Immun 71:6411-9. 2003..However, BCG revaccination of these young animals was contraindicated... - Vaccination of animals against Mycobacterium bovisM A Skinner
AgResearch, Wallaceville Animal Research Centre, P.O. Box 40063, Upper Hutt, New Zealand
Rev Sci Tech 20:112-32. 2001..Although progress has been made in the development of vaccine delivery systems for animals, the technical problems associated with vaccination of wildlife remain a challenge... - Oral vaccination of brushtail possums (Tichosurus vulpecula) with BCG: immune responses, persistence of BCG in lymphoid organs and excretion in faecesD N Wedlock
AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
N Z Vet J 53:301-6. 2005..To determine the duration of excretion and longevity of survival of BCG in the faeces of vaccinated animals... - Increased protection against bovine tuberculosis in the brushtail possum (Trichosurus vulpecula) when BCG is administered with killed Mycobacterium vaccaeM A Skinner
Wallaceville Animal Research Centre, AgResearch, Upper Hutt, New Zealand
Tuberculosis (Edinb) 82:15-22. 2002..The Australian brushtail possum is the major wildlife reservoir for Mycobacterium bovis infection in New Zealand. Development of an effective tuberculosis vaccine for possums will reduce the spread of infection to cattle and farmed deer... - Progress in the development of tuberculosis vaccines for cattle and wildlifeB M Buddle
AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
Vet Microbiol 112:191-200. 2006..Prospects for the development of improved vaccines against bovine tuberculosis are promising and vaccination approaches could become very valuable in the control and eradication of bovine tuberculosis... 
Newly attenuated Mycobacterium bovis mutants as vaccines against bovine tuberculosis, particularly for possumsD M Collins
AgResearch, Wallaceville, Upper Hutt, New Zealand
Vet Microbiol 151:99-103. 2011..Allelic exchange methods are now being used to produce vaccine strains with multiple specific mutations to improve safety and immunological characteristics...- Use of ESAT-6 in the interferon-gamma test for diagnosis of bovine tuberculosis following skin testingB M Buddle
AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
Vet Microbiol 80:37-46. 2001..An ESAT-6-based IFN-gamma test could be particularly useful to reduce the false positive rate, yet still maintain an acceptable level of sensitivity... - Effect of different adjuvants on the immune responses of cattle vaccinated with Mycobacterium tuberculosis culture filtrate proteinsD N Wedlock
AgResearch Ltd, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
Vet Immunol Immunopathol 86:79-88. 2002.... - Vaccination of cattle against Mycobacterium bovisB M Buddle
AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
Tuberculosis (Edinb) 81:125-32. 2001..Progress in the development of new tuberculosis vaccines has been very rapid in the past decade and the prospects for vaccination to control and eradicate bovine tuberculosis are encouraging... - Improving protective efficacy of BCG vaccination for wildlife against bovine tuberculosisM A Skinner
AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
Res Vet Sci 78:231-6. 2005..Vaccination with BCG alone only gave a reduction in loss in body weight. Agents that reduce gastric acidity may be useful in formulating BCG for oral bait delivery to wildlife for vaccination against bovine tuberculosis... - Advances in ante-mortem diagnosis of tuberculosis in cattleB M Buddle
AgResearch, Hopkirk Research Institute, Private Bag 11008, Palmerston North 4442, New Zealand
N Z Vet J 57:173-80. 2009..The use of these new ancillary tests in association with skin-testing will improve the detection of M. bovis-infected cattle and reduce the unnecessary slaughter of false-positive reactors... - New generation vaccines and delivery systems for control of bovine tuberculosis in cattle and wildlifeB M Buddle
AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
Vet Immunol Immunopathol 87:177-85. 2002..bovis vaccines administered via oral baits or aerosol spray to possums have already been shown to reduce the severity of a subsequent M. bovis infection... - Production of avirulent mutants of Mycobacterium bovis with vaccine properties by the use of illegitimate recombination and screening of stationary-phase culturesD M Collins
AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
Microbiology 148:3019-27. 2002..Improved models may be required to more clearly determine the difference in protective effect between BCG and potential new tuberculosis vaccines... - Differences of gene expression in bovine alveolar macrophages infected with virulent and attenuated isogenic strains of Mycobacterium bovisD N Wedlock
AgResearch, Wallaceville Animal Research Centre, Ward Street, Upper Hutt, New Zealand
Int Immunopharmacol 6:957-61. 2006..Microarray analysis of gene expression in macrophages infected with attenuated isogenic strains of M. bovis may identify key genes involved in early and protective immune responses to tuberculosis... - Nucleotide sequence of a marsupial interleukin-10 cDNA from the Australian brushtail possum (Trichosurus vulpecula)D N Wedlock
AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
DNA Seq 9:239-44. 1998..The expression of IL-10 was up-regulated in both LPS-stimulated and Mycobacterium bovis-infected possum alveolar macrophages... - Molecular cloning and physiological effects of brushtail possum interleukin-1betaD N Wedlock
AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
Vet Immunol Immunopathol 67:359-72. 1999..The studies have shown that the two recombinant forms of IL-1beta were biologically active in possums and that the IL-1beta with four fewer amino acids at the N-terminus was the more active... - Development of a vaccine to mitigate greenhouse gas emissions in agriculture: vaccination of sheep with methanogen fractions induces antibodies that block methane production in vitroD N Wedlock
AgResearch, Hopkirk Research Institute, Grasslands Research Centre, Private Bag 11008, Palmerston North 4442, New Zealand
N Z Vet J 58:29-36. 2010.... - Molecular cloning and characterization of tumor necrosis factor alpha (TNF-alpha) from the Australian common brushtail possum, Trichosurus vulpeculaD N Wedlock
AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
Immunol Cell Biol 74:151-8. 1996..Macrophages cultured in the presence of LPS showed enhanced transcription of TNF-alpha mRNA. This is the first report of the cloning and sequence analysis of the cDNA encoding a marsupial cytokine gene... - Advances in understanding disease epidemiology and implications for control and eradication of tuberculosis in livestock: the experience from New ZealandT J Ryan
New Zealand Food Safety Authority, 30 Malcolm Street, Hamilton, New Zealand
Vet Microbiol 112:211-9. 2006..bovis genotypes... - Progress in the development of vaccines and diagnostic reagents to control tuberculosis in cattleH M Vordermeier
Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
Vet J 171:229-44. 2006.... - Towards more accurate diagnosis of bovine tuberculosis using defined antigensJ M Pollock
Veterinary Sciences Division, Stormont, Belfast, UK
Tuberculosis (Edinb) 81:65-9. 2001.... - Bovine tuberculosis--another view from down underG W de Lisle
Vet J 173:233-4. 2007 - Vaccination of the brushtail possum (Trichosurus vulpecula) against Mycobacterium bovis infection with bacille Calmette-Guérin: the response to multiple dosesL A L Corner
Epicentre, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11 222, Palmerston North, New Zealand
Vet Microbiol 84:327-36. 2002..It was concluded that protection would be enhanced if vaccinations were repeated at short intervals (weekly), but no benefit or detriment resulted from revaccination after longer intervals (1-2 months)... - Experimental infection of brushtail possums (Trichosurus vulpecula) with Mycobacterium bovis by conjunctival instillationL A L Corner
Epicentre, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11 222, Palmerston North, New Zealand
Vet J 166:177-84. 2003..As a procedure for exposing possums to infection with M. bovis the conjunctival route has advantages in that it is simple and safe to perform, and possums need only to be sedated for infection... - Use of the bovine model of tuberculosis for the development of improved vaccines and diagnosticsR G Hewinson
TB Research Group, Department of Bacterial Diseases, VLA Weybridge, Addlestone, Surrey KT15 3NB, UK
Tuberculosis (Edinb) 83:119-30. 2003..Finally we have been able to use the model to develop a vaccine that improves the efficacy of BCG against M. bovis challenge... - Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomicsP J Cockle
TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency-Weybridge, New Haw, Addlestone, United Kingdom
Infect Immun 70:6996-7003. 2002..In particular, eight highly immunogenic antigens were identified whose potentials as diagnostic reagents or as subunit vaccines warrant further study (Rv1983, Rv1986, Rv3872, Rv3873, Rv3878, Rv3879c, Rv1979c, and Rv1769)...