B M Buddle

Summary

Affiliation: Ruakura Research Centre
Country: New Zealand

Publications

  1. pmc Differentiation between Mycobacterium bovis BCG-vaccinated and M. bovis-infected cattle by using recombinant mycobacterial antigens
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Clin Diagn Lab Immunol 6:1-5. 1999
  2. ncbi Immunological approaches to the control of tuberculosis in wildlife reservoirs
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    Vet Immunol Immunopathol 74:1-16. 2000
  3. ncbi Immunobiology of mycobacterial infections in marsupials
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Dev Comp Immunol 24:517-29. 2000
  4. ncbi Vaccination of cattle with Mycobacterium bovis culture filtrate proteins and CpG oligodeoxynucleotides induces protection against bovine tuberculosis
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Vet Immunol Immunopathol 106:53-63. 2005
  5. pmc Immune responses induced in cattle by virulent and attenuated Mycobacterium bovis strains: correlation of delayed-type hypersensitivity with ability of strains to grow in macrophages
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Infect Immun 67:2172-7. 1999
  6. pmc A DNA prime-live vaccine boost strategy in mice can augment IFN-gamma responses to mycobacterial antigens but does not increase the protective efficacy of two attenuated strains of Mycobacterium bovis against bovine tuberculosis
    M A Skinner
    AgResearch Ltd, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Immunology 108:548-55. 2003
  7. ncbi Vaccination with DNA vaccines encoding MPB70 or MPB83 or a MPB70 DNA prime-protein boost does not protect cattle against bovine tuberculosis
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 83:339-49. 2003
  8. ncbi The efficacy of live tuberculosis vaccines after presensitization with Mycobacterium avium
    G W de Lisle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40 063, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 85:73-9. 2005
  9. pmc Vaccination of cattle with Mycobacterium bovis culture filtrate proteins and interleukin-2 for protection against bovine tuberculosis
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Infect Immun 68:5809-15. 2000
  10. ncbi Use of mycobacterial peptides and recombinant proteins for the diagnosis of bovine tuberculosis in skin test-positive cattle
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    Vet Rec 153:615-20. 2003

Detail Information

Publications40

  1. pmc Differentiation between Mycobacterium bovis BCG-vaccinated and M. bovis-infected cattle by using recombinant mycobacterial antigens
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Clin Diagn Lab Immunol 6:1-5. 1999
    ..The results of the study indicate that of the four antigens tested in the IFN-gamma assay, only ESAT-6 would be suitable for differentiating BCG-vaccinated animals from those infected with bovine tuberculosis...
  2. ncbi Immunological approaches to the control of tuberculosis in wildlife reservoirs
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    Vet Immunol Immunopathol 74:1-16. 2000
    ..The aim of this review is to address the problems and approaches involved in the control of wildlife tuberculosis from an immunological perspective...
  3. ncbi Immunobiology of mycobacterial infections in marsupials
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Dev Comp Immunol 24:517-29. 2000
    ..This review examines possible reasons for the high susceptibility of marsupials to mycobacterial infections and investigates the prospects for developing vaccines to control these diseases...
  4. ncbi Vaccination of cattle with Mycobacterium bovis culture filtrate proteins and CpG oligodeoxynucleotides induces protection against bovine tuberculosis
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Vet Immunol Immunopathol 106:53-63. 2005
    ..These results establish an important role for CpG ODN in stimulating protective Th1 responses to tuberculosis in cattle and indicate that a sub-unit protein vaccine can protect these animals against tuberculosis...
  5. pmc Immune responses induced in cattle by virulent and attenuated Mycobacterium bovis strains: correlation of delayed-type hypersensitivity with ability of strains to grow in macrophages
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Infect Immun 67:2172-7. 1999
    ..Our study showed that skin test responsiveness to PPD correlated with the ability of the strains to grow in alveolar macrophages rather than to their pathogenicity in cattle...
  6. pmc A DNA prime-live vaccine boost strategy in mice can augment IFN-gamma responses to mycobacterial antigens but does not increase the protective efficacy of two attenuated strains of Mycobacterium bovis against bovine tuberculosis
    M A Skinner
    AgResearch Ltd, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Immunology 108:548-55. 2003
    ..bovis vaccine enhanced IFN-gamma immune responses compared to vaccinating with an attenuated M. bovis vaccine alone, but did not increase protection against a virulent M. bovis infection...
  7. ncbi Vaccination with DNA vaccines encoding MPB70 or MPB83 or a MPB70 DNA prime-protein boost does not protect cattle against bovine tuberculosis
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 83:339-49. 2003
    ..Bovine tuberculosis is a problem in a number of countries and protection of cattle by vaccination could be an important control strategy...
  8. ncbi The efficacy of live tuberculosis vaccines after presensitization with Mycobacterium avium
    G W de Lisle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40 063, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 85:73-9. 2005
    ..Presensitization of guinea pigs by the oral administration of M. avium+ provides a model for testing vaccines under conditions where the efficacy of BCG has been compromised by prior sensitization with environmental mycobacteria...
  9. pmc Vaccination of cattle with Mycobacterium bovis culture filtrate proteins and interleukin-2 for protection against bovine tuberculosis
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Infect Immun 68:5809-15. 2000
    ..While vaccination of cattle with M. bovis CFP gave an encouraging reduction in tuberculous lesions and did not induce a delayed-type hypersensitivity response to PPD, future CFP vaccines must prevent any extrathoracic spread of disease...
  10. ncbi Use of mycobacterial peptides and recombinant proteins for the diagnosis of bovine tuberculosis in skin test-positive cattle
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    Vet Rec 153:615-20. 2003
    ....
  11. ncbi Oral vaccination of brushtail possums with BCG: Investigation into factors that may influence vaccine efficacy and determination of duration of protection
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    N Z Vet J 54:224-30. 2006
    ..To determine the duration of protective immunity following oral administration of BCG...
  12. pmc Vaccination of guinea pigs with nutritionally impaired avirulent mutants of Mycobacterium bovis protects against tuberculosis
    G W de Lisle
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Infect Immun 67:2624-6. 1999
    ..In animals vaccinated with BCG or two of the other strains, the bacterial counts from the lungs were significantly lower than those of the nonvaccinated animals...
  13. ncbi Vaccination of animals against Mycobacterium bovis
    M A Skinner
    AgResearch, Wallaceville Animal Research Centre, P.O. Box 40063, Upper Hutt, New Zealand
    Rev Sci Tech 20:112-32. 2001
    ..Although progress has been made in the development of vaccine delivery systems for animals, the technical problems associated with vaccination of wildlife remain a challenge...
  14. pmc Revaccination of neonatal calves with Mycobacterium bovis BCG reduces the level of protection against bovine tuberculosis induced by a single vaccination
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Infect Immun 71:6411-9. 2003
    ..However, BCG revaccination of these young animals was contraindicated...
  15. ncbi Oral vaccination of brushtail possums (Tichosurus vulpecula) with BCG: immune responses, persistence of BCG in lymphoid organs and excretion in faeces
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    N Z Vet J 53:301-6. 2005
    ..To determine the duration of excretion and longevity of survival of BCG in the faeces of vaccinated animals...
  16. ncbi Progress in the development of tuberculosis vaccines for cattle and wildlife
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Vet Microbiol 112:191-200. 2006
    ..Prospects for the development of improved vaccines against bovine tuberculosis are promising and vaccination approaches could become very valuable in the control and eradication of bovine tuberculosis...
  17. ncbi Increased protection against bovine tuberculosis in the brushtail possum (Trichosurus vulpecula) when BCG is administered with killed Mycobacterium vaccae
    M A Skinner
    Wallaceville Animal Research Centre, AgResearch, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 82:15-22. 2002
    ..The Australian brushtail possum is the major wildlife reservoir for Mycobacterium bovis infection in New Zealand. Development of an effective tuberculosis vaccine for possums will reduce the spread of infection to cattle and farmed deer...
  18. ncbi Use of ESAT-6 in the interferon-gamma test for diagnosis of bovine tuberculosis following skin testing
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Vet Microbiol 80:37-46. 2001
    ..An ESAT-6-based IFN-gamma test could be particularly useful to reduce the false positive rate, yet still maintain an acceptable level of sensitivity...
  19. doi Newly attenuated Mycobacterium bovis mutants as vaccines against bovine tuberculosis, particularly for possums
    D M Collins
    AgResearch, Wallaceville, Upper Hutt, New Zealand
    Vet Microbiol 151:99-103. 2011
    ..Allelic exchange methods are now being used to produce vaccine strains with multiple specific mutations to improve safety and immunological characteristics...
  20. ncbi Effect of different adjuvants on the immune responses of cattle vaccinated with Mycobacterium tuberculosis culture filtrate proteins
    D N Wedlock
    AgResearch Ltd, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Vet Immunol Immunopathol 86:79-88. 2002
    ....
  21. ncbi Improving protective efficacy of BCG vaccination for wildlife against bovine tuberculosis
    M A Skinner
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Res Vet Sci 78:231-6. 2005
    ..Vaccination with BCG alone only gave a reduction in loss in body weight. Agents that reduce gastric acidity may be useful in formulating BCG for oral bait delivery to wildlife for vaccination against bovine tuberculosis...
  22. ncbi Vaccination of cattle against Mycobacterium bovis
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 81:125-32. 2001
    ..Progress in the development of new tuberculosis vaccines has been very rapid in the past decade and the prospects for vaccination to control and eradicate bovine tuberculosis are encouraging...
  23. doi Advances in ante-mortem diagnosis of tuberculosis in cattle
    B M Buddle
    AgResearch, Hopkirk Research Institute, Private Bag 11008, Palmerston North 4442, New Zealand
    N Z Vet J 57:173-80. 2009
    ..The use of these new ancillary tests in association with skin-testing will improve the detection of M. bovis-infected cattle and reduce the unnecessary slaughter of false-positive reactors...
  24. ncbi Production of avirulent mutants of Mycobacterium bovis with vaccine properties by the use of illegitimate recombination and screening of stationary-phase cultures
    D M Collins
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    Microbiology 148:3019-27. 2002
    ..Improved models may be required to more clearly determine the difference in protective effect between BCG and potential new tuberculosis vaccines...
  25. ncbi New generation vaccines and delivery systems for control of bovine tuberculosis in cattle and wildlife
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Vet Immunol Immunopathol 87:177-85. 2002
    ..bovis vaccines administered via oral baits or aerosol spray to possums have already been shown to reduce the severity of a subsequent M. bovis infection...
  26. ncbi Differences of gene expression in bovine alveolar macrophages infected with virulent and attenuated isogenic strains of Mycobacterium bovis
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, Ward Street, Upper Hutt, New Zealand
    Int Immunopharmacol 6:957-61. 2006
    ..Microarray analysis of gene expression in macrophages infected with attenuated isogenic strains of M. bovis may identify key genes involved in early and protective immune responses to tuberculosis...
  27. ncbi Nucleotide sequence of a marsupial interleukin-10 cDNA from the Australian brushtail possum (Trichosurus vulpecula)
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    DNA Seq 9:239-44. 1998
    ..The expression of IL-10 was up-regulated in both LPS-stimulated and Mycobacterium bovis-infected possum alveolar macrophages...
  28. doi Progress in the development of vaccines against rumen methanogens
    D N Wedlock
    AgResearch, Hopkirk Research Institute, Private Bag 11008, Palmerston North 4442, New Zealand
    Animal 7:244-52. 2013
    ..In addition, there is a need to identify adjuvants that stimulate high levels of salivary antibody and are suitable for formulating with protein antigens to produce a low-cost and effective vaccine...
  29. ncbi Molecular cloning and physiological effects of brushtail possum interleukin-1beta
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Vet Immunol Immunopathol 67:359-72. 1999
    ..The studies have shown that the two recombinant forms of IL-1beta were biologically active in possums and that the IL-1beta with four fewer amino acids at the N-terminus was the more active...
  30. doi Development of a vaccine to mitigate greenhouse gas emissions in agriculture: vaccination of sheep with methanogen fractions induces antibodies that block methane production in vitro
    D N Wedlock
    AgResearch, Hopkirk Research Institute, Grasslands Research Centre, Private Bag 11008, Palmerston North 4442, New Zealand
    N Z Vet J 58:29-36. 2010
    ....
  31. doi Overview of vaccination trials for control of tuberculosis in cattle, wildlife and humans
    B M Buddle
    AgResearch, Hopkirk Research Institute, Grasslands Research Centre, Palmerston North, New Zealand
    Transbound Emerg Dis 60:136-46. 2013
    ..bovis in possums, badgers, wild boar and white-tailed deer and against natural exposure to M. bovis in possums. Recent progress in TB vaccine development has provided much impetus for their future use...
  32. ncbi Molecular cloning and characterization of tumor necrosis factor alpha (TNF-alpha) from the Australian common brushtail possum, Trichosurus vulpecula
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Immunol Cell Biol 74:151-8. 1996
    ..Macrophages cultured in the presence of LPS showed enhanced transcription of TNF-alpha mRNA. This is the first report of the cloning and sequence analysis of the cDNA encoding a marsupial cytokine gene...
  33. ncbi Advances in understanding disease epidemiology and implications for control and eradication of tuberculosis in livestock: the experience from New Zealand
    T J Ryan
    New Zealand Food Safety Authority, 30 Malcolm Street, Hamilton, New Zealand
    Vet Microbiol 112:211-9. 2006
    ..bovis genotypes...
  34. ncbi Progress in the development of vaccines and diagnostic reagents to control tuberculosis in cattle
    H M Vordermeier
    Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vet J 171:229-44. 2006
    ....
  35. ncbi Bovine tuberculosis--another view from down under
    G W de Lisle
    Vet J 173:233-4. 2007
  36. ncbi Experimental infection of brushtail possums (Trichosurus vulpecula) with Mycobacterium bovis by conjunctival instillation
    L A L Corner
    Epicentre, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11 222, Palmerston North, New Zealand
    Vet J 166:177-84. 2003
    ..As a procedure for exposing possums to infection with M. bovis the conjunctival route has advantages in that it is simple and safe to perform, and possums need only to be sedated for infection...
  37. pmc Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics
    P J Cockle
    TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, United Kingdom
    Infect Immun 70:6996-7003. 2002
    ..In particular, eight highly immunogenic antigens were identified whose potentials as diagnostic reagents or as subunit vaccines warrant further study (Rv1983, Rv1986, Rv3872, Rv3873, Rv3878, Rv3879c, Rv1979c, and Rv1769)...
  38. ncbi Vaccination of the brushtail possum (Trichosurus vulpecula) against Mycobacterium bovis infection with bacille Calmette-Guérin: the response to multiple doses
    L A L Corner
    Epicentre, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11 222, Palmerston North, New Zealand
    Vet Microbiol 84:327-36. 2002
    ..It was concluded that protection would be enhanced if vaccinations were repeated at short intervals (weekly), but no benefit or detriment resulted from revaccination after longer intervals (1-2 months)...
  39. ncbi Towards more accurate diagnosis of bovine tuberculosis using defined antigens
    J M Pollock
    Veterinary Sciences Division, Stormont, Belfast, UK
    Tuberculosis (Edinb) 81:65-9. 2001
    ....
  40. ncbi Use of the bovine model of tuberculosis for the development of improved vaccines and diagnostics
    R G Hewinson
    TB Research Group, Department of Bacterial Diseases, VLA Weybridge, Addlestone, Surrey KT15 3NB, UK
    Tuberculosis (Edinb) 83:119-30. 2003
    ..Finally we have been able to use the model to develop a vaccine that improves the efficacy of BCG against M. bovis challenge...