Research Topics
| Anthony M PooleSummaryAffiliation: Massey University Country: New Zealand Publications
|
Detail Information
Publications
Confounded cytosine! Tinkering and the evolution of DNAA Poole
Institute of Molecular Biosciences, PO Box 11222, Massey University, Palmerston North, New Zealand
Nat Rev Mol Cell Biol 2:147-51. 2001..Any engineer would have replaced cytosine, but evolution is a tinkerer not an engineer. By keeping cytosine and replacing uracil the problem was never eliminated, returning once again with the advent of DNA methylation...- The evolution of the ribonucleotide reductases: much ado about oxygenAnthony M Poole
Institute of Molecular Biology and Functional Genomics, Stockholm University, SE 106 91 Stockholm, Sweden
J Mol Evol 55:180-96. 2002..The work is of broader interest, as it also sheds light on the process of adaptation to oxygenic environments consequent to the evolution of atmospheric oxygen... 
Ribonucleotide reduction - horizontal transfer of a required function spans all three domainsDaniel Lundin
Department of Molecular Biology and Functional Genomics, Stockholm University, SE 106 91 Stockholm, Sweden
BMC Evol Biol 10:383. 2010..We also examine to what extent environmental factors may have impacted the distribution of RNR classes...- Getting from an RNA world to modern cells just got a little easierAnthony M Poole
Department of Molecular Biology and Functional Genomics, Stockholm University, SE 106 91 Stockholm, Sweden
Bioessays 28:105-8. 2006..Kun and colleagues put empirical meat on theoretical bone by analysing ribozyme mutagenesis data, concluding that modest replication fidelities could permit a primordial genome with up to 100 genes... - Modern mRNA proofreading and repair: clues that the last universal common ancestor possessed an RNA genome?Anthony M Poole
Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
Mol Biol Evol 22:1444-55. 2005..However, while this lends credibility to the proposal that the LUCA had an RNA genome, the alternative, that LUCA had a DNA genome, cannot be completely ruled out... 
An overview of the introns-first theoryDavid Penny
Allan Wilson Center, Massey University, Palmerston North, New Zealand
J Mol Evol 69:527-40. 2009..e. well established in LECA), and regardless of which is ultimately correct, it pays to separate out various questions and to focus on testing the predictions of sub-theories...- Reconciling an archaeal origin of eukaryotes with engulfment: a biologically plausible update of the Eocyte hypothesisAnthony M Poole
Department of Molecular Biology and Functional Genomics, Stockholm University, SE 10691 Stockholm, Sweden
Res Microbiol 162:71-6. 2011.... - The nature of the last universal common ancestorD Penny
Institute of Molecular Biosciences, Massey University, PO Box 11 222, New Zealand
Curr Opin Genet Dev 9:672-7. 1999..The last universal common ancestor may have been mesophilic and could have had many features of the eukaryote genome, but its cytology is unknown... - Evaluating hypotheses for the origin of eukaryotesAnthony M Poole
Department of Molecular Biology and Functional Genomics, Stockholm University, Sweden
Bioessays 29:74-84. 2007..Significantly, the absence of ancestrally amitochondriate eukaryotes (archezoa) among extant eukaryotes is neither evidence for an archaeal host for the ancestor of mitochondria, nor evidence against a eukaryotic host... - Comparative genomic evidence for a complete nuclear pore complex in the last eukaryotic common ancestorNadja Neumann
Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
PLoS ONE 5:e13241. 2010..Nups are broadly conserved between yeast, vertebrates and plants, but few have been identified among other major eukaryotic groups... - Using ancestral sequences to uncover potential gene homologuesLesley J Collins
Allan Wilson Centre for Molecular Ecology and Evolution, Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
Appl Bioinformatics 2:S85-95. 2003..Overall, including ancestral sequences in searches with BLAST and/or HMMER was the most successful approach in the recovery of potential RNase P protein gene homologues, making this a useful technique in early homologue identification... - RNRdb, a curated database of the universal enzyme family ribonucleotide reductase, reveals a high level of misannotation in sequences deposited to GenbankDaniel Lundin
Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
BMC Genomics 10:589. 2009..These differences result in distinct operational constraints (anaerobicity, iron/oxygen dependence and cobalamin dependence), and form the basis for the classification of RNRs into three classes... - Evolutionarily Stable Association of Intronic snoRNAs and microRNAs with Their Host GenesMarc P Hoeppner
Department of Molecular Biology and Functional Genomics, Stockholm University, SE 106 91 Stockholm, Sweden
Genome Biol Evol 2009:420-8. 2009..Our results indicate evolutionarily stable associations of numerous intronic snoRNAs and miRNAs and their host genes, with probable continued diversification of snoRNA function from an ancestral role in ribosome biogenesis... - Early evolution: prokaryotes, the new kids on the blockA Poole
Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
Bioessays 21:880-9. 1999..The later derivation of prokaryote RNA metabolism and genome structure can be accounted for by the two complementary mechanisms of r-selection and thermoreduction... - Can identification of a fourth domain of life be made from sequence data alone, and could it be done on Mars?Anthony M Poole
Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
Astrobiology 7:801-14. 2007.... - Testing fundamental evolutionary hypothesesDavid Penny
Allan Wilson Center for Molecular Ecology and Evolution, Massey University, Palmerston North, New Zealand
J Theor Biol 223:377-85. 2003..The uniqueness (or not) of the origin of life, though still difficult, is similarly amenable to the testing of alternative hypotheses... - Prokaryote and eukaryote evolvabilityAnthony M Poole
Allan Wilson Centre for Molecular Ecology and Evolution, Institute of Molecular Biosciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
Biosystems 69:163-85. 2003..Multicellular organisms evolve largely through morphological changes, not through extensive changes to cellular biochemistry... - Endosymbiont gene functions impaired and rescued by polymerase infidelity at poly(A) tractsIvica Tamas
Department of Molecular Evolution, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
Proc Natl Acad Sci U S A 105:14934-9. 2008..These features of homopolymeric tracts could be exploited to manipulate gene expression in small synthetic genomes... - Response to Dagan and MartinAnthony M Poole
Bioessays 29:611-4. 2007 - A search for H/ACA snoRNAs in yeast using MFE secondary structure predictionSverker Edvardsson
Department of Information Technology, Mid Sweden University, S-851 70, Sundsvall, Sweden
Bioinformatics 19:865-73. 2003..From genomic context, we identify three strong H/ACA snoRNA candidates. These together with a further 47 candidates obtained by our analysis are being experimentally screened... - Life up north: meeting report: nordic astrobiology 2006: origins & distribution of life in the universeAnthony M Poole
Astrobiology 6:815-8. 2006