J Guan

Summary

Country: New Zealand

Publications

  1. ncbi request reprint N-terminal tripeptide of IGF-1 (GPE) prevents the loss of TH positive neurons after 6-OHDA induced nigral lesion in rats
    J Guan
    Research Center for Developmental Medicine, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res 859:286-92. 2000
  2. ncbi request reprint Selective neuroprotective effects with insulin-like growth factor-1 in phenotypic striatal neurons following ischemic brain injury in fetal sheep
    J Guan
    Research Center for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand
    Neuroscience 95:831-9. 2000
  3. ncbi request reprint N-terminal tripeptide of IGF-1 improves functional deficits after 6-OHDA lesion in rats
    Rita Krishnamurthi
    Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neuroreport 15:1601-4. 2004
  4. pmc A novel diketopiperazine improves functional recovery given after the onset of 6-OHDA-induced motor deficit in rats
    R V M Krishnamurthi
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Br J Pharmacol 156:662-72. 2009
  5. ncbi request reprint Insulin-like growth factor-1 reduces postischemic white matter injury in fetal sheep
    J Guan
    Research Center for Developmental Medicine and Biology, Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
    J Cereb Blood Flow Metab 21:493-502. 2001
  6. ncbi request reprint Peripheral administration of a novel diketopiperazine, NNZ 2591, prevents brain injury and improves somatosensory-motor function following hypoxia-ischemia in adult rats
    J Guan
    The Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neuropharmacology 53:749-62. 2007
  7. ncbi request reprint Asphyxial brain injury--the role of the IGF system
    P D Gluckman
    Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand
    Mol Cell Endocrinol 140:95-9. 1998
  8. ncbi request reprint Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic-ischemic adult rats
    J Guan
    The Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, 2 6 Park Avenue, Grafton, Auckland, New Zealand
    Neuropharmacology 47:892-903. 2004
  9. ncbi request reprint Central penetration and stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat
    A M Baker
    Liggins Institute, Faculty of Medical and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neuropeptides 39:81-7. 2005
  10. ncbi request reprint Treatment in animal models
    J Guan
    The Liggins Institute, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand
    Endocr Dev 9:31-43. 2005

Collaborators

  • L Bennet
  • H Lin
  • G B Thomas
  • A Scheepens
  • D C Batchelor
  • B H Breier
  • A J Gunn
  • R V M Krishnamurthi
  • S George
  • A M Baker
  • Rita Krishnamurthi
  • R Zhang
  • S Mathai
  • A H Kim
  • J M Dean
  • R L M Faull
  • H J Waldvogel
  • J Scotter
  • P D Gluckman
  • J Y Wen
  • M Rafiee
  • Richard L M Faull
  • Matt Maingay
  • P Gluckman
  • Dianne McCarthy
  • Simon Stott
  • J S Quaedackers
  • E Heineman
  • C Williams
  • A Gunn

Detail Information

Publications15

  1. ncbi request reprint N-terminal tripeptide of IGF-1 (GPE) prevents the loss of TH positive neurons after 6-OHDA induced nigral lesion in rats
    J Guan
    Research Center for Developmental Medicine, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res 859:286-92. 2000
    ..001) and restored the TH immunoreactivity in both the SNc and the striatum compared with the vehicle control group (n=9, p<0.001). The results suggest that GPE showed promise as a potential treatment for Parkinson's disease...
  2. ncbi request reprint Selective neuroprotective effects with insulin-like growth factor-1 in phenotypic striatal neurons following ischemic brain injury in fetal sheep
    J Guan
    Research Center for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand
    Neuroscience 95:831-9. 2000
    ..These data suggest a potential role for insulin-like growth factor-1 in preventing cerebral palsy due to perinatal asphyxia...
  3. ncbi request reprint N-terminal tripeptide of IGF-1 improves functional deficits after 6-OHDA lesion in rats
    Rita Krishnamurthi
    Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neuroreport 15:1601-4. 2004
    ..The study suggests that peripheral administration of GPE after onset of nigrostriatal dopamine depletion improves long-term Parkinsonian motor deficits, independent of neuronal outcome...
  4. pmc A novel diketopiperazine improves functional recovery given after the onset of 6-OHDA-induced motor deficit in rats
    R V M Krishnamurthi
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Br J Pharmacol 156:662-72. 2009
    ..The present studies were designed to examine both the neuroprotective and neurotrophic actions of NNZ-2591 on neurochemical and behavioural changes in a rat model of Parkinson's disease...
  5. ncbi request reprint Insulin-like growth factor-1 reduces postischemic white matter injury in fetal sheep
    J Guan
    Research Center for Developmental Medicine and Biology, Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
    J Cereb Blood Flow Metab 21:493-502. 2001
    ..After ischemia there was a close association of PLP mRNA labeled cells with reactive astrocytes and macrophages/microglia. In conclusion, IGF-1 can prevent delayed, postischemic oligodendrocyte cell loss and associated demyelination...
  6. ncbi request reprint Peripheral administration of a novel diketopiperazine, NNZ 2591, prevents brain injury and improves somatosensory-motor function following hypoxia-ischemia in adult rats
    J Guan
    The Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neuropharmacology 53:749-62. 2007
    ..The pharmacokinetic profile and potent long-term protective effects of NNZ 2591 suggests its utility for the treatment of ischemic brain injury and other neurological conditions requiring chronic intervention...
  7. ncbi request reprint Asphyxial brain injury--the role of the IGF system
    P D Gluckman
    Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand
    Mol Cell Endocrinol 140:95-9. 1998
    ..Together these results indicate considerable potential of these agents to treat stroke, perinatal asphyxia and other forms of acute brain injury...
  8. ncbi request reprint Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic-ischemic adult rats
    J Guan
    The Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, 2 6 Park Avenue, Grafton, Auckland, New Zealand
    Neuropharmacology 47:892-903. 2004
    ..With injury specific central penetration, GPE has considerable promise as a systemic neuroprotective treatment after acute encephalopathies...
  9. ncbi request reprint Central penetration and stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat
    A M Baker
    Liggins Institute, Faculty of Medical and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neuropeptides 39:81-7. 2005
    ..These results indicated that GPE crosses the blood-CSF and the functional CSF-brain barriers. The longer half-life of GPE in the CNS may be due to its unique enzymatic stability...
  10. ncbi request reprint Treatment in animal models
    J Guan
    The Liggins Institute, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand
    Endocr Dev 9:31-43. 2005
    ..Peripheral administration of GPE also prevents the loss of dopamine neurons and improves long-term functional recovery following 6-OHDA lesion. However, GPE is unlikely to contribute significantly to the direct effects of IGF-1...
  11. ncbi request reprint Induced cerebral hypothermia reduces post-hypoxic loss of phenotypic striatal neurons in preterm fetal sheep
    S George
    Department of Physiology, Faculty of Medicine and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Exp Neurol 203:137-47. 2007
    ..These findings suggest that head cooling may help reduce basal ganglia injury in some premature babies...
  12. ncbi request reprint Intracerebral transportation and cellular localisation of insulin-like growth factor-1 following central administration to rats with hypoxic-ischemic brain injury
    J Guan
    Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res 853:163-73. 2000
    ..Our results indicate that centrally administered IGF-1 can be translocated to neurons and glia via the perivascular circulation and the ependymal cell-white matter tract pathways...
  13. ncbi request reprint The premature fetus: not as defenseless as we thought, but still paradoxically vulnerable?
    A J Gunn
    Liggins Institute and Department of Pediatrics, University of Auckland, New Zealand
    Dev Neurosci 23:175-9. 2001
    ....
  14. ncbi request reprint A role for the somatotropic axis in neural development, injury and disease
    A Scheepens
    Research Centre for Developmental Medicine and Biology, Faculty of Medical and Health Science, University of Auckland, New Zealand
    J Pediatr Endocrinol Metab 13:1483-91. 2000
    ..The implications of these findings in regard to the growth, development and injury response of the CNS are discussed...
  15. ncbi request reprint Insulin-like growth factor-1 and post-ischemic brain injury
    J Guan
    Faculty of Medicine and Health Sciences, The Liggins Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Prog Neurobiol 70:443-62. 2003
    ..Such a combined approach is likely to be essential for any clinical treatment...