S Gardiner

Summary

Country: New Zealand

Publications

  1. ncbi request reprint Fifteen years of drug information in Christchurch Hospital
    S Gardiner
    Department of Clinical Pharmacology, Christchurch School of Medicine
    N Z Med J 114:393-5. 2001
  2. ncbi request reprint Breastfeeding during tacrolimus therapy
    Sharon J Gardiner
    Department of Medicine, Christchurch School of Medicine and Christchurch Hospital, Christchurch, New Zealand
    Obstet Gynecol 107:453-5. 2006
  3. ncbi request reprint Transfer of rofecoxib into human milk
    Sharon J Gardiner
    Department of Clinical Pharmacology, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand
    Eur J Clin Pharmacol 61:405-8. 2005
  4. ncbi request reprint Pharmacogenetic testing for drug metabolizing enzymes: is it happening in practice?
    Sharon J Gardiner
    Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Pharmacogenet Genomics 15:365-9. 2005
  5. ncbi request reprint Genotyping for drug-metabolizing enzymes--does the promise meet the reality?
    Sharon J Gardiner
    Department of Medicine, Christchurch School of Medicine, Private Bag 4345, Christchurch, New Zealand
    Pharmacogenomics 5:1033-6. 2004
  6. ncbi request reprint Pharmacogenetics, drug-metabolizing enzymes, and clinical practice
    Sharon J Gardiner
    Department of Medicine, Christchurch School of Medicine, Private Bag 4345, Christchurch, New Zealand
    Pharmacol Rev 58:521-90. 2006
  7. pmc Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs
    Sharon J Gardiner
    Department of Clinical Pharmacology, Christchurch Hospital and Christchurch School of Medicine, Christchurch, New Zealand
    Br J Clin Pharmacol 62:453-6. 2006
  8. pmc Two cases of thiopurine methyltransferase (TPMT) deficiency--a lucky save and a near miss with azathioprine
    Sharon J Gardiner
    Department of Clinical Pharmacology, Christchurch Hospital and Christchurch School of Medicine, Private Bag, Christchurch, New Zealand
    Br J Clin Pharmacol 62:473-6. 2006
  9. ncbi request reprint Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants
    Sharon J Gardiner
    Department of Clinical Pharmacology, Christchurh Hospital, New Zealand
    Am J Psychiatry 160:1428-31. 2003
  10. ncbi request reprint Transfer of metformin into human milk
    Sharon J Gardiner
    Department of Clinical Pharmacology and Diabetes Centre, Christchurch Hospital, Christchurch, New Zealand
    Clin Pharmacol Ther 73:71-7. 2003

Detail Information

Publications24

  1. ncbi request reprint Fifteen years of drug information in Christchurch Hospital
    S Gardiner
    Department of Clinical Pharmacology, Christchurch School of Medicine
    N Z Med J 114:393-5. 2001
    ..To determine changes in numbers, demography and type of questions posed to the drug information service (DIS) at Christchurch Hospital over the last fifteen years...
  2. ncbi request reprint Breastfeeding during tacrolimus therapy
    Sharon J Gardiner
    Department of Medicine, Christchurch School of Medicine and Christchurch Hospital, Christchurch, New Zealand
    Obstet Gynecol 107:453-5. 2006
    ..Limited data suggest that infant exposure to tacrolimus via milk is low. This report characterizes the milk-to-blood ratio for tacrolimus using area under the concentration-time curve analysis in a renal transplant patient...
  3. ncbi request reprint Transfer of rofecoxib into human milk
    Sharon J Gardiner
    Department of Clinical Pharmacology, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand
    Eur J Clin Pharmacol 61:405-8. 2005
    ..To determine the milk-to-plasma (M/P) concentration ratio of rofecoxib in lactating mothers and estimate likely infant exposure...
  4. ncbi request reprint Pharmacogenetic testing for drug metabolizing enzymes: is it happening in practice?
    Sharon J Gardiner
    Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Pharmacogenet Genomics 15:365-9. 2005
    ..The low clinical utilization reflects a poor evidence base, unestablished clinical relevance and, in the few cases with the strongest rationale, a slow translation to the clinical setting...
  5. ncbi request reprint Genotyping for drug-metabolizing enzymes--does the promise meet the reality?
    Sharon J Gardiner
    Department of Medicine, Christchurch School of Medicine, Private Bag 4345, Christchurch, New Zealand
    Pharmacogenomics 5:1033-6. 2004
  6. ncbi request reprint Pharmacogenetics, drug-metabolizing enzymes, and clinical practice
    Sharon J Gardiner
    Department of Medicine, Christchurch School of Medicine, Private Bag 4345, Christchurch, New Zealand
    Pharmacol Rev 58:521-90. 2006
    ..In this review we summarize the current evidence base for pharmacogenetics in relation to drug-metabolizing enzymes...
  7. pmc Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs
    Sharon J Gardiner
    Department of Clinical Pharmacology, Christchurch Hospital and Christchurch School of Medicine, Christchurch, New Zealand
    Br J Clin Pharmacol 62:453-6. 2006
    ..To determine infant exposure to 6-thioguanine and 6-methylmercaptopurine nucleotides (6-TGN and 6-MMPN, respectively) during maternal use of azathioprine in breastfeeding...
  8. pmc Two cases of thiopurine methyltransferase (TPMT) deficiency--a lucky save and a near miss with azathioprine
    Sharon J Gardiner
    Department of Clinical Pharmacology, Christchurch Hospital and Christchurch School of Medicine, Private Bag, Christchurch, New Zealand
    Br J Clin Pharmacol 62:473-6. 2006
    ..CASE 2: The second patient was identified as deficient early in treatment and myelosuppression was avoided by treating with a greatly decreased dose (25 mg per week)...
  9. ncbi request reprint Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants
    Sharon J Gardiner
    Department of Clinical Pharmacology, Christchurh Hospital, New Zealand
    Am J Psychiatry 160:1428-31. 2003
    ..This study characterized infant drug doses and breast-milk-to-plasma area-under-the-curve ratios for olanzapine and determined plasma concentrations and effects of this drug on breast-feeding infants...
  10. ncbi request reprint Transfer of metformin into human milk
    Sharon J Gardiner
    Department of Clinical Pharmacology and Diabetes Centre, Christchurch Hospital, Christchurch, New Zealand
    Clin Pharmacol Ther 73:71-7. 2003
    ..Our objectives were to determine the milk-to-plasma ratio of metformin in lactating mothers and to estimate infant exposure...
  11. doi request reprint Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold
    Sharon J Gardiner
    Department of Medicine, Christchurch Hospital and Christchurch School of Medicine, Christchurch, New Zealand
    Clin Gastroenterol Hepatol 6:654-60; quiz 604. 2008
    ..The purpose of this study was to determine thiopurine dose requirements in intermediate versus normal TPMT metabolism status...
  12. pmc Quantification of infant exposure to celecoxib through breast milk
    Sharon J Gardiner
    Department of Clinical Pharmacology, Christchurch Hospital and Christchurch School of Medicine, Christchurch, New Zealand
    Br J Clin Pharmacol 61:101-4. 2006
    ..To determine the milk-to-plasma (M/P) concentration ratio of celecoxib, and estimate likely infant exposure...
  13. ncbi request reprint Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease
    Virginia L Priest
    Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
    Pharmacoeconomics 24:767-81. 2006
    ....
  14. doi request reprint Development and validation of a stereoselective liquid chromatography-tandem mass spectrometry assay for quantification of S- and R-metoprolol in human plasma
    Berit P Jensen
    Clinical Pharmacology, Department of Medicine, University of Otago, Christchurch, New Zealand
    J Chromatogr B Analyt Technol Biomed Life Sci 865:48-54. 2008
    ..5 microg/L representing the limit of quantification. In this range, relative standard deviations were <6% for intra-day precision and <10% for inter-day precision. The accuracy was within the range of 92-105%...
  15. ncbi request reprint Determination of celecoxib in human plasma and breast milk by high-performance liquid chromatographic assay
    Mei Zhang
    Clinical Pharmacology, Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand
    J Chromatogr B Analyt Technol Biomed Life Sci 830:245-8. 2006
    ..99). Bias was </=+/-15% from 20 to 2000 microg/L in both matrices, intra- and inter-day coefficients of variation (imprecision) were <10%, and the limit of quantification was 10 microg/L...
  16. ncbi request reprint Rapid and simple high-performance liquid chromatographic assay for the determination of metformin in human plasma and breast milk
    Mei Zhang
    Department of Clinical Pharmacology, Christchurch Hospital, New Zealand
    J Chromatogr B Analyt Technol Biomed Life Sci 766:175-9. 2002
    ..Standard curves were linear over the concentration range 20.0-4000 microg/l. Intra- and inter-day coefficients of variation were <9.0% and the limit of quantification was around 20 microg/l...
  17. ncbi request reprint Determination of rofecoxib in human plasma and breast milk by high-performance liquid chromatographic assay
    Mei Zhang
    Department of Clinical Pharmacology, Christchurch School of Medicine and Health Sciences, University of Otago, P O Box 4345, Christchurch, New Zealand
    J Chromatogr B Analyt Technol Biomed Life Sci 807:217-21. 2004
    ..Standard curves were linear over the concentration range 10-2000 microg/L (r2 >0.99). Intra- and inter-day coefficients of variation for both matrices were <10% and the limit of quantification was around 10 microg/L...
  18. doi request reprint Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides
    Sharon J Gardiner
    Department of Clinical Pharmacology, Christchurch Hospital, University of Otago, Christchurch, New Zealand
    Eur J Gastroenterol Hepatol 20:1238-42. 2008
    ..These cases illustrate a risk with thiopurine dose adjustment based on monitoring of 6-TGN metabolites without also monitoring 6-MMPN...
  19. ncbi request reprint The effect of dihydropyrimidine dehydrogenase deficiency on outcomes with fluorouracil
    Sharon J Gardiner
    Department of Clinical Pharmacology, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand
    Adverse Drug React Toxicol Rev 21:1-16. 2002
    ..Despite the considerable inroads that have been made, further study is needed before the best means of optimising fluorouracil treatment is determined...
  20. ncbi request reprint Transfer of risperidone and 9-hydroxyrisperidone into human milk
    Kenneth F Ilett
    Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    Ann Pharmacother 38:273-6. 2004
    ..3%, 2.8%, and 4.7% (as risperidone equivalents) of the maternal weight-adjusted doses. Risperidone and 9-hydroxyrisperidone were not detected in the plasma of the 2 breast-fed infants studied, and no adverse effects were noted...
  21. ncbi request reprint Thiopurine treatment in inflammatory bowel disease
    Sharon J Gardiner
    Clin Pharmacokinet 46:803-4; author reply 805. 2007
  22. ncbi request reprint Metformin therapy and diabetes in pregnancy
    Sharon J Gardiner
    Med J Aust 181:174-5; author reply 175. 2004
  23. ncbi request reprint Comment: Breast-feeding during maternal use of azathioprine
    Sharon J Gardiner
    Ann Pharmacother 41:719-20; author reply 720. 2007
  24. ncbi request reprint Prediction of milk/plasma concentration ratio of drugs
    Matthew P Doogue
    Ann Pharmacother 38:174-6; author's reply 176. 2004