Research Topics
| Brett DelahuntSummaryCountry: New Zealand Publications
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Publications
Fuhrman grading is not appropriate for chromophobe renal cell carcinomaBrett Delahunt
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, New Zealand
Am J Surg Pathol 31:957-60. 2007..It is concluded that neither Fuhrman grading, nor any of the components of the Fuhrman grading system, is useful as prognostic indicators for this tumor type...- The evolution of collagen expression in sarcomatoid renal cell carcinomaBrett Delahunt
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, PO Box 7343, Wellington South, New Zealand
Hum Pathol 38:1372-7. 2007.... - Thyroid gland clonality revisited: the embryonal patch size of the normal human thyroid gland is very large, suggesting X-chromosome inactivation tumor clonality studies of thyroid tumors have to be interpreted with cautionLidija Jovanovic
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, Wellington 6002, New Zealand
J Clin Endocrinol Metab 88:3284-91. 2003..Therefore, monoclonality in neoplastic and hyperplastic lesions may just be a reflection of normal thyroid epithelium clonal composition... 
Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinomaLidija Jovanovic
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand
Pathology 42:524-33. 2010..This study was undertaken to investigate the genetic factors underlying the development of multifocality and phenotypic diversity in multifocal papillary thyroid carcinoma (mPTC)...- Grading of clear cell renal cell carcinoma should be based on nucleolar prominenceBrett Delahunt
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago Wellington, Wellington, New Zealand
Am J Surg Pathol 35:1134-9. 2011..These findings indicate that worst nucleolar grading alone is a valid grading parameter for clear cell renal cell carcinoma... - Outcome prediction for renal cell carcinoma: evaluation of prognostic factors for tumours divided according to histological subtypeBrett Delahunt
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, Wellington South, New Zealand
Pathology 39:459-65. 2007..Although some of these markers have been shown to be significantly associated with survival, these findings remain to be confirmed in large scale follow-up studies... - Demographic and clinical factors as determinants of serum levels of prostate specific antigen and its derivativesMarion A Gray
Department of Public Health, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand
Anticancer Res 24:2069-72. 2004.... - Nucleolar grade but not Fuhrman grade is applicable to papillary renal cell carcinomaDianne Sika-Paotonu
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, Wellington, New Zealand
Am J Surg Pathol 30:1091-6. 2006.... - Prostate cancer--are ethnic minorities disadvantaged?David S Lamb
Department of Pathology and Molecular Medicine, University of Otago Wellington, P O Box 7343, Wellington 6242, New Zealand
Anticancer Res 28:3891-5. 2008.... - Gleason scoring: a comparison of classical and modified (international society of urological pathology) criteria using nadir PSA as a clinical end pointBrett Delahunt
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Heath Sciences, University of Otago, Wellington, New Zealand
Pathology 42:339-43. 2010..To compare the distribution and predictive performance of Gleason grade and scores derived using classical and modified (International Society of Urological Pathology) criteria... - Optimising restriction enzyme cleavage of DNA derived from archival histopathological samples: an improved HUMARA assayLidija Jovanovic
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, Wellington, New Zealand
Pathology 35:70-4. 2003..Analogous approaches are likely to allow optimisation of other restriction enzyme-based assays of FFPET samples... - High resolution loss of heterozygosity mapping of 17p13 in thyroid cancer: Hurthle cell carcinomas exhibit a small 411-kilobase common region of allelic imbalance, probably containing a novel tumor suppressor geneKathryn Farrand
Department of Pathology and Molecular Medicine, Wellington School of Medicine, New Zealand
J Clin Endocrinol Metab 87:4715-21. 2002..These data suggest that a TSG, involved in HCC pathogenesis, is contained within the D17S1308-D17S695 interval. There are several potential candidate TSGs in this region that are worthy of further study... - Gleason grading: past, present and futureBrett Delahunt
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand
Histopathology 60:75-86. 2012.... - History of the development of the classification of renal cell neoplasiaBrett Delahunt
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, 23A Mein Street, Wellington South, New Zealand
Clin Lab Med 25:231-46, v. 2005..This article reviews the history of the development of the classification of renal cell neoplasia... - Advances and controversies in grading and staging of renal cell carcinomaBrett Delahunt
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago Wellington, PO Box 7343, Wellington South, New Zealand
Mod Pathol 22:S24-36. 2009..Although the current TNM classification does provide useful prognostic information it would appear that further modifications are justified to enhance the predictive value of staging for RCC... - Prostate cancer: the new evidence base for diagnosis and treatmentDavid S Lamb
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, and Department of Radiation Oncology, Wellington Hospital, New Zealand
Pathology 39:537-44. 2007..These improvements mean that now most men aged 50-70 years diagnosed with PC will have clinically significant cancers that require treatment... - Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosisMarija Velickovic
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, Newtown, Wellington, New Zealand
Mod Pathol 15:479-85. 2002..Biallelic inactivation may preferentially occur by nonmutational mechanisms, or, alternatively, haploinsufficiency of PTEN/MMAC1 may be sufficient to affect tumor progression in cRCC... - Therapy-associated effects in the prostate glandJohn R Srigley
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
Histopathology 60:153-65. 2012..As new therapies are developed for prostate cancer, it is important to document their effects on benign and malignant prostate tissue and to understand possible implications for traditional prognostic factors, especially Gleason grade... - Recently described and unusual variants of urothelial carcinoma of the urinary bladderHemamali Samaratunga
Aquesta Pathology, Queensland, Australia
Pathology 44:407-18. 2012.... - Renal cell neoplasiaBrett Delahunt
Department of Pathology and Molecular Medicine, Wellington School of Medicine, New Zealand
Pathology 34:13-20. 2002 - Assessment of ethnic variation in serum levels of total, complexed and free prostate specific antigen. Comparison of Maori, Pacific Island and New Zealand European populationsMarion A Gray
Department of Public Health, Wellington School of Medicine and Health Sciences, PO Box 7343, University of Otago, Wellington South, New Zealand
Pathology 35:480-3. 2003..To determine whether age-adjusted levels of serum total (tPSA) and complexed (cPSA) prostate specific antigen and the ratio of free to tPSA (%fPSA) differ by ethnic group independent of symptomatic disease... - Chromosomal gains in the sarcomatoid transformation of chromophobe renal cell carcinomaMatteo Brunelli
Anatomia Patologica, Dipartimento di Patologia, Universita di Verona, Verona, Italy
Mod Pathol 20:303-9. 2007.... - Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer familiesMaija Kiuru
Department of Medical Genetics, Biomedicum Helsinki or Haartman Institute, University of Helsinki, FIN-00014 Helsinki, Finland
Cancer Res 62:4554-7. 2002..Whereas the two former lesions were shown to originate from a germ-line mutation, the soft tissue sarcoma is to our knowledge the first example of purely somatic inactivation of FH in tumors... - Chromosome 14q LOH in localized clear cell renal cell carcinomaKenji Mitsumori
Department of Biochemistry, University of Otago, Dunedin, New Zealand
J Pathol 198:110-4. 2002.... - Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytomaMatteo Brunelli
Department of Pathology and Laboratory Medicine, , Verona, Italy
Mod Pathol 18:161-9. 2005.... - Molecular genetic evidence for the independent origin of multifocal papillary tumors in patients with papillary renal cell carcinomasTimothy D Jones
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Clin Cancer Res 11:7226-33. 2005..Thus, intrarenal metastasis does not seem to play an important role in the spread of papillary renal cell carcinoma, a finding that has surgical, therapeutic, and prognostic implications... - Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinomaPaolo Cossu-Rocca
Department of Pathology, Indiana University Medical Center, University Hospital, Indianapolis, IN 46202, USA
Mod Pathol 19:488-93. 2006..FISH analysis with centromeric probes for these chromosomes is potentially helpful in differentiating mucinous tubular and spindle cell carcinomas from papillary renal cell carcinomas... - Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidneySamson W Fine
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Am J Surg Pathol 30:1554-60. 2006..Pathologists must be aware of the spectrum of histologic findings within MTSCs to ensure their accurate diagnosis... - Prognostic importance of tumor size for localized conventional (clear cell) renal cell carcinoma: assessment of TNM T1 and T2 tumor categories and comparison with other prognostic parametersBrett Delahunt
Department of Pathology, Wellington School of Medicine, University of Otago, Wellington, New Zealand
Cancer 94:658-64. 2002..This study investigates the prognostic significance of tumor size in a series of organ-confined clear cell renal cell carcinomas...