M T Rademaker

Summary

Affiliation: Christchurch School of Medicine and Health Sciences
Country: New Zealand

Publications

  1. ncbi request reprint Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: comparison with normal sheep
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    J Am Coll Cardiol 40:1495-505. 2002
  2. ncbi request reprint Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, Christchurch, New Zealand
    Clin Sci (Lond) 106:569-76. 2004
  3. ncbi request reprint Adrenomedullin and heart failure
    Miriam T Rademaker
    The Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand
    Regul Pept 112:51-60. 2003
  4. ncbi request reprint Four-day urocortin-I administration has sustained beneficial haemodynamic, hormonal, and renal effects in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Eur Heart J 26:2055-62. 2005
  5. ncbi request reprint Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure
    Miriam T Rademaker
    Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    Circulation 112:3624-32. 2005
  6. ncbi request reprint Long-term adrenomedullin administration in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, Christchurch, New Zealand
    Hypertension 40:667-72. 2002
  7. ncbi request reprint Urocortin 3: haemodynamic, hormonal, and renal effects in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, The Christchurch School of Medicine, PO Box 4345, Christchurch 8001, New Zealand
    Eur Heart J 27:2088-98. 2006
  8. ncbi request reprint Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, P O Box 4345, New Zealand
    Clin Sci (Lond) 102:653-60. 2002
  9. ncbi request reprint Urocortin 2 combined with angiotensin-converting enzyme inhibition in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    Clin Sci (Lond) 114:635-42. 2008
  10. ncbi request reprint Combined endopeptidase inhibition and adrenomedullin in sheep with experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, Christchurch, New Zealand
    Hypertension 39:93-8. 2002

Detail Information

Publications41

  1. ncbi request reprint Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: comparison with normal sheep
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    J Am Coll Cardiol 40:1495-505. 2002
    ..The goal of this study was to determine the bioactivity of urocortin (Ucn) in experimental heart failure (HF)...
  2. ncbi request reprint Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, Christchurch, New Zealand
    Clin Sci (Lond) 106:569-76. 2004
    ....
  3. ncbi request reprint Adrenomedullin and heart failure
    Miriam T Rademaker
    The Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand
    Regul Pept 112:51-60. 2003
    ..Manipulation of the AM system holds promise as a therapeutic strategy in cardiac disease...
  4. ncbi request reprint Four-day urocortin-I administration has sustained beneficial haemodynamic, hormonal, and renal effects in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Eur Heart J 26:2055-62. 2005
    ..To investigate the subacute effects of a sustained intravenous infusion of urocortin-I (Ucn-I) in experimental heart failure (HF)...
  5. ncbi request reprint Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure
    Miriam T Rademaker
    Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    Circulation 112:3624-32. 2005
    ..Urocortin 2 (Ucn2) has potent cardiovascular actions and may participate in the pathophysiology of heart failure (HF). The integrated hemodynamic, endocrine, and renal effects of Ucn2 are unknown...
  6. ncbi request reprint Long-term adrenomedullin administration in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, Christchurch, New Zealand
    Hypertension 40:667-72. 2002
    ..These findings support the concept of adrenomedullin as a protective hormone during hemodynamic compromise with therapeutic potential in heart failure...
  7. ncbi request reprint Urocortin 3: haemodynamic, hormonal, and renal effects in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, The Christchurch School of Medicine, PO Box 4345, Christchurch 8001, New Zealand
    Eur Heart J 27:2088-98. 2006
    ..To investigate the haemodynamic, hormonal, and renal effects of peripheral urocortin 3 (Ucn3) administration for the first time in either normal health or heart failure (HF)...
  8. ncbi request reprint Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, P O Box 4345, New Zealand
    Clin Sci (Lond) 102:653-60. 2002
    ..Despite the greater falls in blood pressure (and presumably renal perfusion pressure), renal function was maintained at a level similar to that observed with captopril alone...
  9. ncbi request reprint Urocortin 2 combined with angiotensin-converting enzyme inhibition in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    Clin Sci (Lond) 114:635-42. 2008
    ..These results indicate that dual treatment with these two agents is beneficial...
  10. ncbi request reprint Combined endopeptidase inhibition and adrenomedullin in sheep with experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, Christchurch, New Zealand
    Hypertension 39:93-8. 2002
    ..In conclusion, cotreatment with adrenomedullin and an endopeptidase inhibitor has beneficial hemodynamic and renal effects in heart failure beyond those of either agent separately...
  11. ncbi request reprint Endogenous urocortins reduce vascular tone and renin-aldosterone/endothelin activity in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand
    Eur Heart J 26:2046-54. 2005
    ..To investigate the role of the endogenous urocortin peptides in heart failure (HF) through blockade of the corticotropin-releasing factor receptor 2 (CRF-R2)...
  12. ncbi request reprint Urocortin 1 administration from onset of rapid left ventricular pacing represses progression to overt heart failure
    Miriam T Rademaker
    Department of Medicine, Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand
    Am J Physiol Heart Circ Physiol 293:H1536-44. 2007
    ..These data strongly support a use for Ucn1 as a therapeutic option early in the course of the disease...
  13. doi request reprint Hemodynamic, hormonal, and renal actions of adrenomedullin 2 in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, University of Otago, Christchurch, New Zealand
    Circ Heart Fail 1:134-42. 2008
    ..The effects of AM2 in heart failure have not been investigated previously...
  14. doi request reprint Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    Circ Heart Fail 2:532-40. 2009
    ..Because any prospective new treatment is likely to be used in conjunction with standard diuretic therapy, it is necessary to investigate the combined effects of these agents...
  15. ncbi request reprint Neurohormones in an ovine model of compensated postinfarction left ventricular dysfunction
    M T Rademaker
    Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine, Christchurch, New Zealand
    Am J Physiol Heart Circ Physiol 278:H731-40. 2000
    ..This is a reproducible model that reflects the clinical condition and should prove suitable for investigating the pathophysiology of, and experimental therapies in, early left ventricular dysfunction...
  16. ncbi request reprint Cardiac natriuretic peptides for cardiac health
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Clin Sci (Lond) 108:23-36. 2005
    ..The favourable biological properties of the natriuretic peptides have also led to their use as therapeutic agents...
  17. ncbi request reprint Comparative actions of adrenomedullin and nitroprusside: interactions with ANG II and norepinephrine
    C J Charles
    Cardioendocrine Research Group, Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand
    Am J Physiol Regul Integr Comp Physiol 281:R1887-94. 2001
    ..001). In conclusion, ADM induces a different spectrum of hemodynamic, renal, and endocrine actions to NP. These results clarify mechanisms by which ADM might contribute to volume and pressure homeostasis...
  18. ncbi request reprint Hemodynamic, hormonal, and renal effects of intracerebroventricular adrenomedullin in conscious sheep
    C J Charles
    Department of Medicine, Christchurch School of Medicine, New Zealand
    Endocrinology 139:1746-51. 1998
    ..In conclusion, adrenomedullin within the central nervous system may have at least two roles: modulation of the hypothalamo-pituitary-adrenal axis and protection against fluid overload...
  19. ncbi request reprint Adrenomedullin modulates the neurohumoral response to acute volume loading in normal conscious sheep
    C J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand
    J Endocrinol 173:123-9. 2002
    ..These results provide further evidence that ADM plays a physiological role in volume and pressure homeostasis...
  20. ncbi request reprint Adrenomedullin augments the neurohumoral response to haemorrhage in non-pregnant but not in pregnant sheep
    C J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    J Endocrinol 171:363-71. 2001
    ..039) and adrenocorticotrophic hormone (P=0.012) were decreased by ADM. In conclusion, ADM-induced augmentation of the RAS and HPA responses to hypotensive haemorrhage is abolished in the pregnant state...
  21. ncbi request reprint Adrenomedullin attenuates pressor response to angiotensin II in conscious sheep
    C J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, New Zealand
    J Cardiovasc Pharmacol 36:526-32. 2000
    ..The data suggest a possible role for adrenomedullin in cardiovascular homeostasis in part through antagonism of the vasopressor action of angiotensin II...
  22. ncbi request reprint Atrial (ANP) and brain natriuretic peptide (BNP) expression after myocardial infarction in sheep: ANP is synthesized by fibroblasts infiltrating the infarct
    V A Cameron
    Department of Medicine, Christchurch School of Medicine, New Zealand
    Endocrinology 141:4690-7. 2000
    ..This is the first report of ANP expression and synthesis by cardiac fibroblasts invading the fibrotic scar, suggesting that ANP may be involved in regulating fibroblast proliferation during reparative fibrosis...
  23. ncbi request reprint Myocardial infarction with and without reperfusion in sheep: early cardiac and neurohumoral changes
    C J Charles
    Christchurch Cardioendocrine Research Group, Department of Medicine, Christchurch School of Medicine, P O Box 4345, Christchurch, New Zealand
    Clin Sci (Lond) 98:703-11. 2000
    ..Acute changes in biochemical markers, haemodynamics, neurohormones and LV function confirm that these are excellent models of open- and closed-artery myocardial infarction leading to asymptomatic LV dysfunction...
  24. doi request reprint Adrenomedullin 2 attenuates the pressor but not adrenal responses to angiotensin II in conscious sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, University of Otago, Christchurch, New Zealand
    Peptides 31:878-82. 2010
    ..In contrast to AM, AM2 had no restraining influence on the aldosterone response to Ang II. The data suggest a possible role for AM2 in cardiovascular homeostasis in part through antagonism of the vasopressor action of Ang II...
  25. ncbi request reprint Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    J Hypertens 26:53-60. 2008
    ..Urocortin 1 (Ucn1) and the sympathetic nervous system both participate in cardiac and circulatory regulation, but little is known about their possible interactions...
  26. ncbi request reprint Urocortin 2 infusion in healthy humans: hemodynamic, neurohormonal, and renal responses
    Mark E Davis
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    J Am Coll Cardiol 49:461-71. 2007
    ..We sought to examine the effects of urocortin (UCN) 2 infusion on hemodynamic status, cardiovascular hormones, and renal function in healthy humans...
  27. ncbi request reprint Urocortin 1 modulates the neurohumoral response to acute nitroprusside-induced hypotension in sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Clin Sci (Lond) 112:485-91. 2007
    ..The threshold for the action of Ucn1 on the natriuretic peptides and endothelin-1 appears to be below that of other actions of Ucn1...
  28. ncbi request reprint Urocortins: putative role in cardiovascular disease
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Curr Med Chem Cardiovasc Hematol Agents 2:43-7. 2004
    ..Clearly, further study is essential to confirm whether manipulation of this new family of peptides (especially Ucn II and Ucn III) offers benefit to the syndrome of heart failure with potential clinical applications in humans...
  29. ncbi request reprint Apelin-13 induces a biphasic haemodynamic response and hormonal activation in normal conscious sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    J Endocrinol 189:701-10. 2006
    ..Apelin also increases circulating levels of a number of vasoactive hormones. Taken together, these results suggest a potential role for apelin in pressure/volume homeostasis...
  30. ncbi request reprint Plasma urocortin 1 in sheep: regional sampling and effects of experimental heart failure
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Peptides 27:1801-5. 2006
    ..This is the first report identifying sources of circulating Ucn-1...
  31. ncbi request reprint Urocortin-1 infusion in normal humans
    Mark E Davis
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch 8001, New Zealand
    J Clin Endocrinol Metab 89:1402-9. 2004
    ..The latter effect might contribute to the anorexic action of Ucn-1...
  32. ncbi request reprint Adrenomedullin and the renin-angiotensin-aldosterone system
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand
    Regul Pept 112:41-9. 2003
    ..Thus, these results clearly point to a role for AM in pressure and volume homeostasis acting, at least in part, by interaction with the renin-angiotensin-aldosterone system (RAAS)...
  33. ncbi request reprint Effect of urocortin 1 infusion in humans with stable congestive cardiac failure
    Mark E Davis
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch 8001, New Zealand
    Clin Sci (Lond) 109:381-8. 2005
    ..ANP and ghrelin were unchanged, and no haemodynamic or renal effects were seen. In conclusion, a brief intravenous infusion of 50 microg of Ucn 1 stimulates corticotropin and cortisol in male volunteers with stable HF...
  34. ncbi request reprint Natriuretic peptides maintain sodium homoeostasis during chronic volume loading post-myocardial infarction in sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Clin Sci (Lond) 104:429-36. 2003
    ..This study provides evidence that natriuretic peptides play a pivotal role in preserving volume/electrolyte balance in the early stages of post-MI cardiac dysfunction...
  35. ncbi request reprint Regional sampling and the effects of experimental heart failure in sheep: differential responses in A, B and C-type natriuretic peptides
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, P O Box 4345, Christchurch, New Zealand
    Peptides 27:62-8. 2006
    ..Circulating levels of CNP and NT-CNP were raised in heart failure but to a much lesser degree than ANP and BNP. There was no evidence of net extraction of CNP or NT-CNP across any tissue bed...
  36. ncbi request reprint Urotensin II: evidence for cardiac, hepatic and renal production
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch 8001, New Zealand
    Peptides 26:2211-4. 2005
    ..Significant arteriovenous gradients were observed across the heart (36%), liver (40%) and kidney (44%). This is the first report to identify the heart, liver and kidney as sources of UII in the circulation...
  37. ncbi request reprint Hemodynamic, hormonal, and renal actions of adrenomedullin-2 in normal conscious sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, New Zealand
    Endocrinology 147:1871-7. 2006
    ..Thus, AM-2 may be another important regulator of volume and pressure homeostasis and may play a role in the pathophysiology of heart disease...
  38. doi request reprint Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, University of Otago, Christchurch, Christchurch 8140, New Zealand
    J Endocrinol 204:181-9. 2010
    ..These findings suggest an important role for UCN2 in cardiovascular homeostasis and warrant further investigation for potential therapeutic applications in acute myocardial injury and heart disease...
  39. ncbi request reprint Urocortin 2 infusion in human heart failure
    Mark E Davis
    Department of Medicine, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch 8140, New Zealand
    Eur Heart J 28:2589-97. 2007
    ..To document the haemodynamic, neurohormonal, and renal responses to Urocortin 2 (UCN2) infused in human heart failure (HF)...
  40. ncbi request reprint Adrenomedullin in heart failure
    M Gary Nicholls
    Department of Medicine, Christchurch Hospital, Christchurch, New Zealand
    Hypertens Res 26:S135-40. 2003
    ..An improved understanding of the role of adrenomedullin in heart failure might lead to the development of therapeutic agents acting through adrenomedullin receptors...
  41. ncbi request reprint Comparison of infarct-derived and control ovine cardiac myofibroblasts in culture: response to cytokines and natriuretic peptide receptor expression profiles
    Martin D Jarvis
    Dept of Medicine, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Am J Physiol Heart Circ Physiol 291:H1952-8. 2006
    ..Moreover, whether the cultured cardiac fibroblasts are from infarct tissue is a major determinant of NPR expression levels and cytokine responses, even after four to five passages...