S E Luty

..Interpersonal psychotherapy and cognitive-behavioural therapy (CBT) are established as effective treatments for major depression. Controversy remains regarding their effectiveness for severe and melancholic depression...

..These results do not support the concept of specific augmentation of drive-related behaviour by noradrenergic medication. This challenges the earlier findings relating to drive enhancement and social adjustment using such medication...

..An additional objective is to examine the differences between levels of interpersonal sensitivity in depressive subtypes...

..Previous research has not examined how social adjustment in depression varies by source of sample (clinical vs. community) or the associations with personality...

..We examined how the seven TCI scales and their subscales are correlated with depression severity before and after treatment. We also examined whether changes in personality measures could be attributed to changes in depression severity...

..Gender differences in the clinical manifestation of depression and related variables were examined in 170 depressed outpatients...

..To measure changes in suicidal behaviours during 6 months of treatment with antidepressants...

....

..To consider the impact of age and gender on the antidepressant response to nortriptyline and fluoxetine in melancholic depression...

..Childhood sexual abuse was not as predictive of personality dysfunction as might be expected, thereby raising questions as to the importance placed on child sexual abuse as a general risk factor for personality psychopathology...

..This paper outlines the rationale for treating individuals with anorexia nervosa using interpersonal psychotherapy...

..PBI scores and family histories did not differ significantly. Treatment outcome did not vary, except that subjects with lifetime alcohol dependence and current heavy drinking did less well...

....

..The goals of this study were to determine the course of illness in a cohort of depressed patients undergoing treatment for 6 months and whether there are clinically useful predictors of their course of illness...

..To examine whether the T allele of G protein beta3 (GNbeta3) is associated with self-mutilation in depressed patients...

..We conclude that DRD3 may contribute to the development of OCPD...

..We were interested in differences in genetic and developmental risk factors between depressed patients with or without a co-morbid BPD...

..This article presents the rationale for, and description of, a nonspecialized therapy for anorexia nervosa, called specialist supportive clinical management (SSCM)...

..To evaluate the impact of childhood abuse and parental bonding on cortisol levels in depressed adults...

..Interpersonal psychotherapy and cognitive-behavioural therapy are widely accepted as effective treatments for major depression. There is little evidence on how personality disorder or personality traits affect treatment response...

..To compare the current sexual functioning of women in an intimate relationship with anorexia nervosa, with major depression, and in the postpartum period...

....

..Although diurnal variation of mood is a widely recognized symptom of depression, the clinical, neurobiological and psychopharmacological significance of this symptom has not previously been reported...

..Cognitive behavior therapy and interpersonal psychotherapy are effective in a related disorder, bulimia nervosa. There are theoretical and treatment indications for these therapies in anorexia nervosa...

..The aim of this study was to evaluate the recruitment and retention of depressed pregnant women, identified initially through screening, to a randomized controlled psychotherapy trial...

..The second objective was to report on the demographic and diagnostic predictors of the response and recovery in these depressed patients...

..After 6 months, those with BPD had a favorable outcome in regard to depressive symptoms, social adjustment, and even improvement in the character measure of self-directedness. Those with the poorest outcome were those with OPD...

..Personality disorders appear to be common among patients with depression, suggesting potentially significant treatment implications for a large group of patients...

..Our results suggest that genetic polymorphisms of DRD4 and DRD3 may well be associated with personality traits, and that conflicting findings to date may arise from the problem of phenotype definition...

....

..There is some consensus that noradrenergic drugs are ineffective in adolescent depression. The aim of this study was to see whether this poor response extended to young adults...

..These differential pharmacogenetic predictors of antidepressant response by age, may provide clues to understanding the discontinuities in pharmacological responsiveness of child/adolescent and adult depressive disorders...

..To evaluate childhood experiences (neglect and abuse), temperament and childhood and adolescent psychopathology as risk factors for avoidant and borderline personality disorders in depressed outpatients...

..Thus, for clinicians prescribing antidepressant monotherapy, CYP2D6 polymorphisms are probably not of relevance to antidepressant side effects and therapy...

....

..A temperament derived measure of "rejection sensitivity" defines a group of depressed patients with a differential antidepressant response, regardless of reversed vegetative symptoms...

..To compare the personality traits and disorders of patients with bipolar II disorder and major depression and to examine the impact on treatment outcome of a bipolar II diagnosis...

..Our findings suggest that the CYP2D6 polymorphism may impact on personality, and one potential mechanism for this would be by influencing the generation of endogenous neurotransmitters in the brain...

..A focus on the specific areas of impact and targeting interventions that facilitate acceptance and integration thus promoting self and identity development would be recommended...