Evan Begg

Summary

Affiliation: Christchurch School of Medicine and Health Sciences
Country: New Zealand

Publications

  1. ncbi request reprint The sorry saga of the statins in New Zealand--pharmacopolitics versus patient care
    Evan Begg
    Department of Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    N Z Med J 116:U360. 2003
  2. pmc Paroxetine in human milk
    E J Begg
    Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
    Br J Clin Pharmacol 48:142-7. 1999
  3. pmc Distribution of R- and S-methadone into human milk during multiple, medium to high oral dosing
    E J Begg
    Department of Clinical Pharmacology, Christchurch School of Medicine, New Zealand
    Br J Clin Pharmacol 52:681-5. 2001
  4. ncbi request reprint Individualized drug and dose: the clinical pharmacologist's calling or curse?
    E J Begg
    Department of Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    Clin Exp Pharmacol Physiol 32:975-8. 2005
  5. pmc Quinapril and its metabolite quinaprilat in human milk
    E J Begg
    Department of Clinical Pharmacology, Christchurch School of Medicine, New Zealand
    Br J Clin Pharmacol 51:478-81. 2001
  6. pmc The therapeutic monitoring of antimicrobial agents
    E J Begg
    Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
    Br J Clin Pharmacol 52:35S-43S. 2001
  7. ncbi request reprint Digoxin therapeutic drug monitoring: an audit and review
    Andrew Sidwell
    Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
    N Z Med J 116:U708. 2003
  8. ncbi request reprint An extended interval dosing method for gentamicin in neonates
    M D Stickland
    Department of Paediatrics, Neonatal Intensive Care Unit, Christchurch Womens Hospital, Christchurch, New Zealand
    J Antimicrob Chemother 48:887-93. 2001
  9. doi request reprint CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure
    C F Sharp
    Department of Pharmacy, Christchurch Hospital, Christchurch, New Zealand
    Pharmacogenomics J 9:175-84. 2009
  10. doi request reprint Prescribing and monitoring clozapine in Christchurch
    Andrew McKean
    Pharmacy Department, Hillmorton Hospital, Christchurch, New Zealand
    Australas Psychiatry 16:263-7. 2008

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The sorry saga of the statins in New Zealand--pharmacopolitics versus patient care
    Evan Begg
    Department of Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    N Z Med J 116:U360. 2003
  2. pmc Paroxetine in human milk
    E J Begg
    Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
    Br J Clin Pharmacol 48:142-7. 1999
    ..Secondary aims were to compare single point and area under the curve (AUC) estimates of M/P, to assess variability of M/P in fore and hind milk, and to compare the observed M/P with that predicted by a model...
  3. pmc Distribution of R- and S-methadone into human milk during multiple, medium to high oral dosing
    E J Begg
    Department of Clinical Pharmacology, Christchurch School of Medicine, New Zealand
    Br J Clin Pharmacol 52:681-5. 2001
    ..To measure the interdose milk to plasma ratio (M/P) of R- and S-methadone during multiple dosing in lactating mothers taking medium to high doses of methadone (> 40 mg daily), and to assess likely infant exposure...
  4. ncbi request reprint Individualized drug and dose: the clinical pharmacologist's calling or curse?
    E J Begg
    Department of Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    Clin Exp Pharmacol Physiol 32:975-8. 2005
    ..5. Pharmacogenetics is a field widely acclaimed as having a huge future in terms of individualization of drug therapy. Our early studies in this area lend only cautious support to this optimism...
  5. pmc Quinapril and its metabolite quinaprilat in human milk
    E J Begg
    Department of Clinical Pharmacology, Christchurch School of Medicine, New Zealand
    Br J Clin Pharmacol 51:478-81. 2001
    ..To measure the milk to plasma ratio (M/P) of quinapril and its active metabolite quinaprilat in lactating mothers and to assess likely infant exposure...
  6. pmc The therapeutic monitoring of antimicrobial agents
    E J Begg
    Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
    Br J Clin Pharmacol 52:35S-43S. 2001
    ..To review the basis and optimal use of therapeutic drug monitoring of antimicrobial agents...
  7. ncbi request reprint Digoxin therapeutic drug monitoring: an audit and review
    Andrew Sidwell
    Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
    N Z Med J 116:U708. 2003
    ..The measurement and assessment of digoxin concentrations are often performed poorly. We have conducted an audit to assess the appropriateness of digoxin therapeutic drug monitoring in Christchurch Hospital...
  8. ncbi request reprint An extended interval dosing method for gentamicin in neonates
    M D Stickland
    Department of Paediatrics, Neonatal Intensive Care Unit, Christchurch Womens Hospital, Christchurch, New Zealand
    J Antimicrob Chemother 48:887-93. 2001
    ..The extended interval dosing achieved higher Cmax values while ensuring that overall exposure per 24 h was acceptable. Prospective testing of the method demonstrated good predictive ability...
  9. doi request reprint CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure
    C F Sharp
    Department of Pharmacy, Christchurch Hospital, Christchurch, New Zealand
    Pharmacogenomics J 9:175-84. 2009
    ..Although the number with no functional alleles was too small (n=3) to show effects, in patients with 1 functional allele other sources of variance are likely to be obscuring differences in clinical effects...
  10. doi request reprint Prescribing and monitoring clozapine in Christchurch
    Andrew McKean
    Pharmacy Department, Hillmorton Hospital, Christchurch, New Zealand
    Australas Psychiatry 16:263-7. 2008
    ..The aim of the study was to identify the pattern of usage of clozapine in Christchurch, New Zealand, including daily dose, indication and use of drug concentration monitoring...
  11. ncbi request reprint A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression
    R L Roberts
    Department of Pathology, Christchurch School of Medicine, Christchurch, New Zealand
    Pharmacogenomics J 2:191-6. 2002
    ..78, df = 2, P = 0.034). Our results suggest that homozygosity for 3435T alleles of ABCB1 is a risk factor for occurrence of nortriptyline-induced postural hypotension (OR = 1.37, P = 0.042, 95% CI 1.01-1.86)...
  12. ncbi request reprint Aminoglycoside adaptive resistance: importance for effective dosage regimens
    M L Barclay
    Department of Clinical Pharmacology, Christchurch Hospital, New Zealand
    Drugs 61:713-21. 2001
    ..Dose administration at 24 hour intervals, or longer, may increase efficacy by allowing time for adaptive resistance to reverse...
  13. pmc Is cytochrome P450 2C9 genotype associated with NSAID gastric ulceration?
    J H Martin
    Department of Clinical Pharmacology, Christchurch Hospital, New Zealand
    Br J Clin Pharmacol 51:627-30. 2001
    ..The hypothesis tested was that CYP2C9 poor metabolizer genotype would predict higher risk of gastric ulceration in patients on NSAIDs that are metabolized by CYP2C9, due to higher plasma NSAID concentrations...
  14. pmc Individualizing drug therapy, and 'men behaving badly'
    E J Begg
    Department of Clinical Pharmacology, The Christchurch School of Medicine, University Department of Medicine, Christchurch Hospital, PO Box 4345, Christchurch, New Zealand
    Br J Clin Pharmacol 58:449-51. 2004
  15. ncbi request reprint Effect of pregnancy on the pharmacokinetics of metformin
    R C E Hughes
    Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
    Diabet Med 23:323-6. 2006
    ..To determine the effects of pregnancy on metformin pharmacokinetics...
  16. pmc The pharmacokinetics of oral fleroxacin and ciprofloxacin in plasma and sputum during acute and chronic dosing
    E J Begg
    Department of Clinical Pharmacology, Christchurch Hospital, New Zealand
    Br J Clin Pharmacol 49:32-8. 2000
    ..To examine the pharmacokinetics of ciprofloxacin and fleroxacin in plasma and sputum of patients with an acute exacerbation of chronic bronchitis or bronchiectasis following the first dose and again during the third day of treatment...
  17. ncbi request reprint Development of a general method of limited sampling for the determination of AUC for a drug that displays two-compartment pharmacokinetics
    S B Duffull
    Department of Clinical Pharmacology, Christchurch Hospital, New Zealand
    Eur J Clin Pharmacol 55:213-9. 1999
    ..To develop a method of limited sampling that would enable accurate estimation of the area under the concentration time curve (AUC) when using the log trapezoidal method...
  18. ncbi request reprint The practice of digoxin therapeutic drug monitoring
    Murray Barclay
    N Z Med J 116:U704. 2003
  19. ncbi request reprint Independent nurse prescribing in New Zealand
    Peter Moller
    N Z Med J 118:U1724. 2005