Stephen T Chambers

Summary

Country: New Zealand

Publications

  1. ncbi request reprint Global polio eradication: progress, but determination and vigilance still needed
    Stephen T Chambers
    Department of Infectious Diseases, Christchurch Hospital, New Zealand
    N Z Med J 124:100-4. 2011
  2. pmc HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort
    Stephen T Chambers
    Department of Pathology, University of Otago, Christchurch and Christchurch Hospital, Christchurch, New Zealand
    PLoS ONE 8:e63181. 2013
  3. doi request reprint Developments in novel breath tests for bacterial and fungal pulmonary infection
    Stephen T Chambers
    Department of Pathology, University of Otago, and Department of Infectious Diseases, Christchurch Hospital, Christchurch, New Zealand
    Curr Opin Pulm Med 18:228-32. 2012
  4. ncbi request reprint Treatment of Staphylococcus epidermidis central vascular catheter infection with 70% ethanol locks: efficacy in a sheep model
    Stephen T Chambers
    Department of Pathology, Christchurch School of Medicine and Health Sciences, University of Otago, PO Box 4345, Christchurch, New Zealand
    J Antimicrob Chemother 59:779-82. 2007
  5. ncbi request reprint Diagnosis and management of staphylococcal infections of vascular grafts and stents
    S T Chambers
    Department of Infectious Diseases, Christchurch Hospital, New Zealand
    Intern Med J 35:S72-8. 2005
  6. ncbi request reprint Diagnosis and management of staphylococcal infections of pacemakers and cardiac defibrillators
    S T Chambers
    Department of Infectious Diseases, Christchurch Hospital, New Zealand
    Intern Med J 35:S63-71. 2005
  7. ncbi request reprint Ethanol disinfection of plastic-adherent micro-organisms
    S T Chambers
    Department of Pathology, Christchurch School of Medicine, University of Otago, New Zealand
    J Hosp Infect 63:193-6. 2006
  8. ncbi request reprint Reduction of exit-site infections of tunnelled intravascular catheters among neutropenic patients by sustained-release chlorhexidine dressings: results from a prospective randomized controlled trial
    S T Chambers
    Department of Pathology, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand Infectious Disease Department, Christchurch Hospital, New Zealand
    J Hosp Infect 61:53-61. 2005
  9. ncbi request reprint Campylobacter fetus prosthetic hip joint infection: successful management with device retention and review
    S T Chambers
    Department of Pathology, Christchurch School of Medicine, University of Otago, P O Box 4345, Christchurch, New Zealand
    J Infect 50:258-61. 2005
  10. doi request reprint Detection of 2-pentylfuran in the breath of patients with Aspergillus fumigatus
    Stephen T Chambers
    Department of Pathology, University of Otago Christchurch, Christchurch, New Zealand
    Med Mycol 47:468-76. 2009

Detail Information

Publications63

  1. ncbi request reprint Global polio eradication: progress, but determination and vigilance still needed
    Stephen T Chambers
    Department of Infectious Diseases, Christchurch Hospital, New Zealand
    N Z Med J 124:100-4. 2011
    ..To review recent events in the international effort to eradicate polio from earth and inform readers of recent changes in strategy that have implications for New Zealand..
  2. pmc HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort
    Stephen T Chambers
    Department of Pathology, University of Otago, Christchurch and Christchurch Hospital, Christchurch, New Zealand
    PLoS ONE 8:e63181. 2013
    ..The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences...
  3. doi request reprint Developments in novel breath tests for bacterial and fungal pulmonary infection
    Stephen T Chambers
    Department of Pathology, University of Otago, and Department of Infectious Diseases, Christchurch Hospital, Christchurch, New Zealand
    Curr Opin Pulm Med 18:228-32. 2012
    ..This review discusses the recent advances in breath analysis for the diagnosis of bacterial and fungal lower respiratory tract infections...
  4. ncbi request reprint Treatment of Staphylococcus epidermidis central vascular catheter infection with 70% ethanol locks: efficacy in a sheep model
    Stephen T Chambers
    Department of Pathology, Christchurch School of Medicine and Health Sciences, University of Otago, PO Box 4345, Christchurch, New Zealand
    J Antimicrob Chemother 59:779-82. 2007
    ..To determine whether a single treatment with ethanol/water (70:30) will sterilize infected vascular catheters...
  5. ncbi request reprint Diagnosis and management of staphylococcal infections of vascular grafts and stents
    S T Chambers
    Department of Infectious Diseases, Christchurch Hospital, New Zealand
    Intern Med J 35:S72-8. 2005
    ..Antimicrobial therapy can be stopped 4-6 weeks after surgery if arterial stump cultures are negative but should be continued long-term, and perhaps indefinitely, if they are positive...
  6. ncbi request reprint Diagnosis and management of staphylococcal infections of pacemakers and cardiac defibrillators
    S T Chambers
    Department of Infectious Diseases, Christchurch Hospital, New Zealand
    Intern Med J 35:S63-71. 2005
    ..The duration of antimicrobial therapy and timing of replacement of the device have not been determined but 2 weeks treatment before removal and 2-4 weeks treatment after replacement is commonly administered...
  7. ncbi request reprint Ethanol disinfection of plastic-adherent micro-organisms
    S T Chambers
    Department of Pathology, Christchurch School of Medicine, University of Otago, New Zealand
    J Hosp Infect 63:193-6. 2006
    ..These results suggest that in contrast to log phase organisms, which are killed by ethanol/water solutions in seconds, plastic-adherent organisms are more resistant to the bactericidal activity of ethanol...
  8. ncbi request reprint Reduction of exit-site infections of tunnelled intravascular catheters among neutropenic patients by sustained-release chlorhexidine dressings: results from a prospective randomized controlled trial
    S T Chambers
    Department of Pathology, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand Infectious Disease Department, Christchurch Hospital, New Zealand
    J Hosp Infect 61:53-61. 2005
    ....
  9. ncbi request reprint Campylobacter fetus prosthetic hip joint infection: successful management with device retention and review
    S T Chambers
    Department of Pathology, Christchurch School of Medicine, University of Otago, P O Box 4345, Christchurch, New Zealand
    J Infect 50:258-61. 2005
  10. doi request reprint Detection of 2-pentylfuran in the breath of patients with Aspergillus fumigatus
    Stephen T Chambers
    Department of Pathology, University of Otago Christchurch, Christchurch, New Zealand
    Med Mycol 47:468-76. 2009
    ..As 2-PF is not normally found in human breath its presence may reflect the active metabolism of A. fumigatus in the airways and form the basis of a new diagnostic breath test for Aspergillus infection...
  11. doi request reprint Novel diagnostics: progress toward a breath test for invasive Aspergillus fumigatus
    Stephen T Chambers
    University of Otago, Christchurch, New Zealand
    Med Mycol 49:S54-61. 2011
    ....
  12. ncbi request reprint Māori have a much higher incidence of community-acquired pneumonia and pneumococcal pneumonia than non-Māori: findings from two New Zealand hospitals
    Stephen Chambers
    Department of Pathology, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    N Z Med J 119:U1978. 2006
    ..These ethnic disparities are of major concern, and policy planners should consider further interventions to improve the efficacy of current anti-smoking campaigns and to undertake studies of conjugate pneumococcal vaccines for Maori...
  13. pmc Betaine and secondary events in an acute coronary syndrome cohort
    Michael Lever
    Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    PLoS ONE 7:e37883. 2012
    ..Betaine insufficiency is associated with unfavourable vascular risk profiles in metabolic syndrome patients. We investigated associations between betaine insufficiency and secondary events in acute coronary syndrome patients...
  14. pmc The contrasting relationships between betaine and homocysteine in two clinical cohorts are associated with plasma lipids and drug treatments
    Michael Lever
    Canterbury Health Laboratories, Clinical Biochemistry Unit, Christchurch, New Zealand
    PLoS ONE 7:e32460. 2012
    ..Urinary betaine excretion positively correlated with plasma homocysteine in outpatients attending a lipid disorders clinic (lipid clinic study). We aimed to confirm this in subjects with established vascular disease...
  15. pmc Plasma lipids and betaine are related in an acute coronary syndrome cohort
    Michael Lever
    Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    PLoS ONE 6:e21666. 2011
    ..We aimed to measure the relationships between plasma and urine betaine and plasma lipids, and the effects of lipid-lowering drugs on these...
  16. doi request reprint Assessment of potential causes of falsely positive Mycobacterium tuberculosis breath test
    Amy Scott-Thomas
    Department of Pathology, University of Otago, Christchurch, PO Box 4345, Christchurch 8140, New Zealand
    Tuberculosis (Edinb) 93:312-7. 2013
    ..These results justify further clinical studies to further explore these markers as specific indicators of M. tuberculosis infection...
  17. ncbi request reprint Dietary and supplementary betaine: acute effects on plasma betaine and homocysteine concentrations under standard and postmethionine load conditions in healthy male subjects
    Wendy Atkinson
    Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    Am J Clin Nutr 87:577-85. 2008
    ..Betaine comes from the diet and from choline, and it is associated with vascular disease in some patient groups. Betaine supplementation lowers plasma total homocysteine...
  18. pmc Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses: an observational study
    Michael Lever
    Biochemistry Unit, Canterbury Health Laboratories, PO Box 151, Christchurch, 8140, New Zealand
    Cardiovasc Diabetol 11:34. 2012
    ..The post-methionine load test is reported to be both an independent vascular risk factor and a measure of betaine sufficiency...
  19. doi request reprint Investigation into the production of 2-Pentylfuran by Aspergillus fumigatus and other respiratory pathogens in vitro and human breath samples
    Mona Syhre
    Otago University, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Med Mycol 46:209-15. 2008
    ..Breath analysis has the potential of being a non-invasive diagnostic method of detecting respiratory infection including invasive aspergillosis...
  20. doi request reprint Plasma and urine betaine and dimethylglycine variation in healthy young male subjects
    Michael Lever
    Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    Clin Biochem 42:706-12. 2009
    ..We aimed to compare the individuality (within subject consistency) of plasma and urine betaine and N,N-dimethylglycine...
  21. ncbi request reprint Fibrates plus betaine: a winning combination?
    Michael Lever
    Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    N Z Med J 123:74-8. 2010
    ..Clinical trials of combinations of betaine and fibrate, to complement statin therapy, are needed to determine the value of these agents in reducing the residual cardiovascular disease risk...
  22. doi request reprint Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
    Michael Lever
    Biochemistry Unit, Canterbury Health Laboratories, P O Box 151, Christchurch, 8140, New Zealand
    Cardiovasc Drugs Ther 23:395-401. 2009
    ..These patients are often treated with fibrates which alter renal function and raise plasma homocysteine concentrations. We suggest there is a connection between fibrate treatment and betaine excretion...
  23. pmc 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung
    Amy J Scott-Thomas
    Christchurch School of Medicine and Health Sciences, Department of Pathology, University of Otago, Christchurch, 8140, New Zealand
    BMC Pulm Med 10:56. 2010
    ..Growth of Ps. aeruginosa releases a "grape-like" odour that has been identified as the microbial volatile organic compound 2-aminoacetophenone (2-AA)...
  24. ncbi request reprint Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic
    Michael Lever
    Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    Clin Biochem 40:1225-31. 2007
    ..To find whether the control of betaine metabolism differs between male and female patients and identify the effects of insulin and other hormones...
  25. doi request reprint The scent of Mycobacterium tuberculosis
    Mona Syhre
    University of Otago, Christchurch School of Medicine and Health Sciences, Department of Pathology, 2 Riccarton Avenue, P O Box 4345, Christchurch 8140, New Zealand
    Tuberculosis (Edinb) 88:317-23. 2008
    ..These compounds are detectable before the visual appearance of colonies, potentially useful as the basis of a non-invasive diagnostic test for TB and have characteristic odors...
  26. ncbi request reprint Plasma betaine concentrations correlate with plasma cortisol but not with C-reactive protein in an elderly population
    Michael Lever
    Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    Clin Chem Lab Med 50:1635-40. 2012
    ..We aimed to compare plasma cortisol (a stress marker) and C-reactive protein (an inflammation marker) as statistical predictors of plasma betaine concentrations...
  27. doi request reprint Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial
    David R Murdoch
    Department of Pathology, University of Otago, Christchurch, PO Box 4345, Christchurch 8011, New Zealand
    JAMA 308:1333-9. 2012
    ..However, results of clinical trials of vitamin D supplementation have been inconclusive...
  28. ncbi request reprint Successful antimicrobial therapy and implant retention for streptococcal infection of prosthetic joints
    Richard J Everts
    Department of Infectious Diseases, Christchurch Hospital, Christchurch, New Zealand
    ANZ J Surg 74:210-4. 2004
    ..Streptococci cause up to 20% of prosthetic joint infections but this has received little attention in the published literature...
  29. ncbi request reprint Impact of routine systematic polymerase chain reaction testing on case finding for Legionnaires' disease: a pre-post comparison study
    David R Murdoch
    Department of Pathology, University of Otago
    Clin Infect Dis 57:1275-81. 2013
    ..PCR is the most sensitive diagnostic tool for Legionnaires' disease...
  30. pmc Prevalence of concurrent deep vein thrombosis in patients with lower limb cellulitis: a prospective cohort study
    Michael J Maze
    Department of Infectious Diseases, Christchurch Hospital, Christchurch, 8002, New Zealand
    BMC Infect Dis 13:141. 2013
    ..This study aimed to determine the prevalence of deep vein thrombosis (DVT) in patients with lower limb cellulitis and to investigate the utility of applying the Wells algorithm to this patient group...
  31. ncbi request reprint Inter- and intra-individual variations in normal urinary glycine betaine excretion
    Michael Lever
    Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Clin Biochem 40:447-53. 2007
    ..To establish whether normal human subjects excrete glycine betaine at a constant rate...
  32. ncbi request reprint The scent of Mycobacterium tuberculosis--part II breath
    Mona Syhre
    Otago University, Christchurch School of Medicine and Health Sciences, New Zealand
    Tuberculosis (Edinb) 89:263-6. 2009
    ..We have converted the free acid into methyl nicotinate and detected statistically significant differences in the breath of smear positive patients compared with healthy (smear negative) subjects...
  33. pmc Campylobacter fetus-associated epidural abscess and bacteremia
    Jenny S J Wong
    Department of Microbiology, Canterbury Health Laboratories, Christchurch, New Zealand
    J Clin Microbiol 47:857-8. 2009
    ..Campylobacter fetus has been isolated as an infrequent cause of abscesses. We report a case of Campylobacter fetus epidural abscess and bacteremia in a debilitated elderly man who had a fatal outcome...
  34. pmc Comparison of galactomannan detection, PCR-enzyme-linked immunosorbent assay, and real-time PCR for diagnosis of invasive aspergillosis in a neutropenic rat model and effect of caspofungin acetate
    Jennifer M Scotter
    Microbiology Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    Clin Diagn Lab Immunol 12:1322-7. 2005
    ..We conclude that PCR-ELISA is a more sensitive and reliable method for laboratory diagnosis of IA...
  35. ncbi request reprint Effects of orange juice and proline betaine on glycine betaine and homocysteine in healthy male subjects
    Wendy Atkinson
    Clinical Biochemistry Unit, Canterbury Health Laboratories, PO Box 151, Christchurch, New Zealand
    Eur J Nutr 46:446-52. 2007
    ..Proline betaine (PB), a glycine betaine (GB) analogue found in citrus foods, increases urinary GB loss and plasma total homocysteine (tHcy) concentrations in rats. Its presence in human plasma is associated with increased GB excretion...
  36. ncbi request reprint An abnormal urinary excretion of glycine betaine may persist for years
    Michael Lever
    Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Clin Biochem 40:798-801. 2007
    ..Does abnormal betaine excretion persist?..
  37. ncbi request reprint Homocysteine, glycine betaine, and N,N-dimethylglycine in patients attending a lipid clinic
    Michael Lever
    Biochemistry Unit, Canterbury Health Laboratories, PO Box 151, Christchurch, New Zealand
    Metabolism 54:1-14. 2005
    ..50), and this relationship may be stronger in patients with known vascular disease. Urinary loss of glycine betaine may contribute to hyperhomocysteinemia and the development of cardiovascular disease...
  38. ncbi request reprint Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure
    David O McGregor
    Department of Nephrology, Christchurch Hospital and School of Medicine, Private Bag 4710, Christchurch, New Zealand
    Kidney Int 61:1040-6. 2002
    ..Glycine betaine (GB) is known to decrease tHcy in other clinical settings, but whether it is beneficial in chronic renal failure has not been established...
  39. ncbi request reprint Stability of benzylpenicillin during continuous home intravenous therapy
    Jane W A Vella-Brincat
    Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
    J Antimicrob Chemother 53:675-7. 2004
    ..9% at constant and variable temperatures...
  40. doi request reprint Outpatient intravenous treatment for infective endocarditis: safety, effectiveness and one-year outcomes
    Matthew R Amodeo
    Department of Microbiology, Canterbury Health Laboratories, Corner Hagley Ave and Tuam Street, Christchurch 8011, New Zealand
    J Infect 59:387-93. 2009
    ..To describe the use and outcomes of outpatient antimicrobial therapy (OPAT) for infective endocarditis (IE) within the Canterbury region of New Zealand over an 8 year period...
  41. ncbi request reprint Dimethylglycine supplementation does not affect plasma homocysteine concentrations in pre-dialysis chronic renal failure patients
    Sandy Slow
    Biochemistry Unit, Canterbury Health Laboratories, PO Box 151 Christchurch, New Zealand
    Clin Biochem 37:974-6. 2004
    ..To determine whether daily dimethylglycine supplementation affects plasma homocysteine concentrations...
  42. ncbi request reprint Cutaneous larva migrans (hookworm) acquired in Christchurch, New Zealand
    Laurens Manning
    Christchurch Hospital, Christchurch, New Zealand
    N Z Med J 119:U1910. 2006
    ..Cutaneous larva migrans is common in returned travellers from the tropics. It is rare in New Zealand, however. Presumably there were very specific, favourable local factors to allow maturation and transmission of the larva in this case...
  43. ncbi request reprint Dimethylthetin treatment causes diffuse alveolar lung damage: a pilot study in a sheep model of Continuous Ambulatory Peritoneal Dialysis (CAPD)
    Sandy Slow
    Biochemistry Unit, Canterbury Health Laboratories, P O Box 151, Christchurch, New Zealand
    Exp Toxicol Pathol 58:285-90. 2007
    ..Toxicity associated with DMT treatment raises concerns for its use in further studies. However, sub-acute administration of DMT to sheep may provide a useful model of acute alveolar damage...
  44. ncbi request reprint Betaine analogues alter homocysteine metabolism in rats
    Sandy Slow
    Biochemistry Unit, Canterbury Health Laboratories, PO Box 151, Christchurch, New Zealand
    Int J Biochem Cell Biol 36:870-80. 2004
    ..The study shows that glycine betaine analogues have multiple effects on homocysteine metabolism (250)...
  45. doi request reprint Betaine excretion correlates with plasma homocysteine when plasma lipids are elevated
    Michael Lever
    Clinical Biochemistry Unit, Canterbury Health Laboratories, New Zealand
    Clin Biochem 45:154-6. 2012
    ..To reconcile observing a positive correlation of betaine excretion with homocysteine in lipid disorder patients but not other study groups...
  46. ncbi request reprint Short and long-term variation of plasma glycine betaine concentrations in humans
    Michael Lever
    Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    Clin Biochem 37:184-90. 2004
    ..Glycine betaine is important in cell volume regulation and in remethylating homocysteine, a vascular risk factor...
  47. ncbi request reprint Use of ethanol locks to prevent recurrent central line sepsis
    Sarah C L Metcalf
    Department of Infectious Diseases, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand
    J Infect 49:20-2. 2004
    ..Ethanol is an effective antiseptic. We describe a case of a patient with recurrent CRS successfully treated with 70% ethanol locks...
  48. ncbi request reprint Comparison of PCR-ELISA and galactomannan detection for the diagnosis of invasive aspergillosis
    Jennifer M Scotter
    Microbiology Unit, Canterbury Health Laboratories, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Pathology 37:246-53. 2005
    ..To compare PCR with galactomannan antigen detection for the diagnosis of invasive aspergillosis (IA)...
  49. ncbi request reprint Association between HACEK bacteraemia and endocarditis
    Haur Sen Yew
    Christchurch Hospital, Christchurch, New Zealand
    J Med Microbiol 63:892-5. 2014
    ..The overall positive predictive value (PPV) of HACEK bacteraemia for endocarditis was 60 %. The PPV varied with different HACEK species from 0 % (E. corrodens) to 100 % (A. actinomycetemcomitans)...
  50. pmc Recurrent breast abscess caused by Gordonia bronchialis in an immunocompetent patient
    Anja M Werno
    Microbiology Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    J Clin Microbiol 43:3009-10. 2005
    ..We present the first reported case of a recurrent breast infection caused by Gordonia bronchialis. The infection occurred in a 43-year-old immunocompetent female, and species level identification was obtained with 16S rRNA sequencing...
  51. pmc Protein binding of cefazolin is saturable in vivo both between and within patients
    Jane W A Vella-Brincat
    Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
    Br J Clin Pharmacol 63:753-7. 2007
    ....
  52. ncbi request reprint Atypical pneumonia--time to breathe new life into a useful term?
    David R Murdoch
    Department of Pathology, University of Otago, Christchurch, New Zealand
    Lancet Infect Dis 9:512-9. 2009
    ..We need to return to the original meaning of atypical pneumonia and restrict its use to describe pneumonia that is truly unusual in clinical presentation, epidemiology, or both...
  53. pmc Evaluation of a PCR assay for detection of Streptococcus pneumoniae in respiratory and nonrespiratory samples from adults with community-acquired pneumonia
    David R Murdoch
    Microbiology Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    J Clin Microbiol 41:63-6. 2003
    ..We conclude that the pneumolysin PCR assay adds little to existing diagnostic tests for S. pneumoniae and is unable to distinguish colonization from infection when respiratory samples are tested...
  54. ncbi request reprint Assessment of antimicrobial activity of hydrophilic betaines in osmotically stressed bacteria
    Barbara A Peddie
    Department of Nephrology, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand
    Antonie Van Leeuwenhoek 83:175-81. 2003
    ..4-Methylthiazolium betaine was the only one that showed significant antibacterial activity towards Escherichia coli under hyperosmotic conditions. None of the tested betaines showed any evidence of osmoprotection or urea protection...
  55. pmc Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study
    David R Murdoch
    Department of Pathology, University of Otago, Christchurch, PO Box 4345, Christchurch, New Zealand
    Arch Intern Med 169:463-73. 2009
    ..We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide...
  56. ncbi request reprint Free and total cefazolin plasma and interstitial fluid concentrations at steady state during continuous infusion
    Grant W Howard
    Department of Clinical Pharmacology, Christchurch Hospital, PO Box 4710, Christchurch, New Zealand
    J Antimicrob Chemother 50:429-32. 2002
    ..82, P = 0.005 versus r(2) = 0.54, P = 0.056). In all patients, the free concentrations in the interstitial fluid were at least two-fold the MIC(90) for Staphylococcus aureus...
  57. pmc Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients
    Barry R Palmer
    Christchurch Heart Institute, Department of Medicine, University of Otago, Christchurch, New Zealand Genetics Otago, University of Otago, Christchurch, New Zealand Institute of Food, Nutrition and Human Health, Massey University, Wellington, New Zealand
    PLoS ONE 9:e89029. 2014
    ..We investigated the association between rs6922269 and known metabolic risk factors and survival in two independent cohorts of coronary heart disease patients...
  58. ncbi request reprint An audit of venous duplex ultrasonography in patients with lower limb cellulitis
    Michael J Maze
    Department of Infectious Diseases, Christchurch Hospital, Riccarton Ave, Private Bag 4710, Christchurch, New Zealand
    N Z Med J 124:53-6. 2011
    ..To audit the use and value of venous duplex ultrasound in patients hospitalised for cellulitis at Christchurch Hospital, New Zealand...
  59. ncbi request reprint Increased rates of trimethoprim resistance in uncomplicated urinary tract infection: cause for concern?
    Dee Mangin
    Department of Public Health and General Practice, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    N Z Med J 118:U1726. 2005
    ..To assess changes in trimethoprim resistance over 2 years in bacteria causing uncomplicated urinary tract infections (UTIs) presenting to a representative group of general practitioners (GPs) in Christchurch...
  60. ncbi request reprint Home intravenous antimicrobial service--twelve months experience in Christchurch
    Stephen Chambers
    Department of Infectious Diseases, Christchurch Hospital
    N Z Med J 115:216-8. 2002
    ..To review the clinical practice and complications of the home intravenous antimicrobial service at Christchurch Hospital after twelve months of full operation...
  61. pmc Randomised controlled trial of intravenous antibiotic treatment for cellulitis at home compared with hospital
    Paul Corwin
    Department of Public Health and General Practice, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    BMJ 330:129. 2005
    ..To compare the efficacy, safety, and acceptability of treatment with intravenous antibiotics for cellulitis at home and in hospital...
  62. ncbi request reprint Antibiotic resistance in uncomplicated urinary tract infection: problems with interpreting cumulative resistance rates from local community laboratories
    Derelie A Richards
    Department of Public Health and General Practice, Christchurch School of Medicine and Health Sciences
    N Z Med J 115:12-4. 2002
    ..To determine the resistance rates and patterns in bacteria causing uncomplicated urinary tract infections (UTIs) presenting to general practitioners (GPs) in Christchurch...
  63. pmc Contamination of Qiagen DNA extraction kits with Legionella DNA
    Gloria E Evans
    J Clin Microbiol 41:3452-3. 2003