Joel M Neutel

Summary

Publications

  1. ncbi request reprint Ambulatory blood pressure monitoring to assess the comparative efficacy and duration of action of a novel new angiotensin II receptor blocker--telmisartan
    J M Neutel
    Orange County Heart Institute and Research Center, Orange, California 92868, USA
    Blood Press Suppl 1:27-32. 2001
  2. doi request reprint Choosing among renin-angiotensin system blockers for the management of hypertension: from pharmacology to clinical efficacy
    J M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    Curr Med Res Opin 26:213-22. 2010
  3. doi request reprint Adding nebivolol to ongoing antihypertensive therapy improves blood pressure and response rates in patients with uncontrolled stage I-II hypertension
    J M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Hum Hypertens 24:64-73. 2010
  4. doi request reprint Prescribing patterns in hypertension: the emerging role of fixed-dose combinations for attaining BP goals in hypertensive patients
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    Curr Med Res Opin 24:2389-401. 2008
  5. ncbi request reprint A comparison of the efficacy and safety of irbesartan/HCTZ combination therapy with irbesartan and HCTZ monotherapy in the treatment of moderate hypertension
    J M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Hum Hypertens 22:266-74. 2008
  6. doi request reprint Efficacy of amlodipine/olmesartan ± hydrochlorothiazide in patients uncontrolled on prior calcium channel blocker or angiotensin II receptor blocker monotherapy
    Joel Neutel
    Department of Clinical Pharmacology, Orange County Research Center, Tustin, CA 92780, USA
    Adv Ther 29:508-23. 2012
  7. doi request reprint Single-pill combination of telmisartan/amlodipine in patients with severe hypertension: results from the TEAMSTA severe HTN study
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 14:206-15. 2012
  8. doi request reprint Magnitude of the early morning blood pressure surge in untreated hypertensive patients: a pooled analysis
    J M Neutel
    Orange County Research Centre, Tustin, CA, USA
    Int J Clin Pract 62:1654-63. 2008
  9. ncbi request reprint Hypertension control in the elderly
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 10:33-9. 2008
  10. ncbi request reprint Hypertension and its management: a problem in need of new treatment strategies
    J M Neutel
    Veterans Affairs Medical Center, Long Beach, Calfornia, USA
    J Renin Angiotensin Aldosterone Syst 1:S10-3. 2000

Detail Information

Publications50

  1. ncbi request reprint Ambulatory blood pressure monitoring to assess the comparative efficacy and duration of action of a novel new angiotensin II receptor blocker--telmisartan
    J M Neutel
    Orange County Heart Institute and Research Center, Orange, California 92868, USA
    Blood Press Suppl 1:27-32. 2001
    ..Thus, telmisartan given once daily provides high efficacy and tolerability, and will hopefully assist in improving both blood pressure control rates and cardiovascular outcomes in the future...
  2. doi request reprint Choosing among renin-angiotensin system blockers for the management of hypertension: from pharmacology to clinical efficacy
    J M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    Curr Med Res Opin 26:213-22. 2010
    ..Physicians are confronted with an array of antihypertensive agents, accompanied by increasingly complex and often conflicting evidence regarding their efficacy and tolerability...
  3. doi request reprint Adding nebivolol to ongoing antihypertensive therapy improves blood pressure and response rates in patients with uncontrolled stage I-II hypertension
    J M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Hum Hypertens 24:64-73. 2010
    ..9%, respectively; P=0.763). Addition of once-daily nebivolol to ongoing antihypertensive therapy provided significant additional BP reductions and better response rates in patients with uncontrolled hypertension and was well tolerated...
  4. doi request reprint Prescribing patterns in hypertension: the emerging role of fixed-dose combinations for attaining BP goals in hypertensive patients
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    Curr Med Res Opin 24:2389-401. 2008
    ..g., fixed-dose combination [FDC] therapy), is needed to achieve the recommended BP goals of <140/90 mmHg for most patients, and <130/80 mmHg for high-risk patients...
  5. ncbi request reprint A comparison of the efficacy and safety of irbesartan/HCTZ combination therapy with irbesartan and HCTZ monotherapy in the treatment of moderate hypertension
    J M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Hum Hypertens 22:266-74. 2008
    ..In conclusion, irbesartan/HCTZ (300/25 mg) is well tolerated and achieves rapid and sustained reductions in both systolic blood pressure and diastolic blood pressure in patients with moderate hypertension...
  6. doi request reprint Efficacy of amlodipine/olmesartan ± hydrochlorothiazide in patients uncontrolled on prior calcium channel blocker or angiotensin II receptor blocker monotherapy
    Joel Neutel
    Department of Clinical Pharmacology, Orange County Research Center, Tustin, CA 92780, USA
    Adv Ther 29:508-23. 2012
    ....
  7. doi request reprint Single-pill combination of telmisartan/amlodipine in patients with severe hypertension: results from the TEAMSTA severe HTN study
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 14:206-15. 2012
    ..T/A SPCs were well tolerated...
  8. doi request reprint Magnitude of the early morning blood pressure surge in untreated hypertensive patients: a pooled analysis
    J M Neutel
    Orange County Research Centre, Tustin, CA, USA
    Int J Clin Pract 62:1654-63. 2008
    ..ramipril using ambulatory blood pressure monitoring I and II) with identical design...
  9. ncbi request reprint Hypertension control in the elderly
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 10:33-9. 2008
    ..Such multiple drug regimens are well tolerated in older patients...
  10. ncbi request reprint Hypertension and its management: a problem in need of new treatment strategies
    J M Neutel
    Veterans Affairs Medical Center, Long Beach, Calfornia, USA
    J Renin Angiotensin Aldosterone Syst 1:S10-3. 2000
    ..These agents are well-tolerated and have a once-daily regimen that improves compliance. They bring multiple cardiovascular benefits beyond blood pressure (BP) control, such as renoprotection and cardiovascular growth reduction...
  11. ncbi request reprint Efficacy and safety of irbesartan/HCTZ combination therapy as initial treatment for rapid control of severe hypertension
    Joel M Neutel
    Orange County Heart Institute and Research Center, 14351 Myford Road, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 8:850-7; quiz 858-9. 2006
    ..7 mm Hg and 9.7 mm Hg (P<.0001). Greater and more rapid BP reduction with irbesartan/HCTZ was achieved without additional side effects...
  12. ncbi request reprint The role of combination therapy in the management of hypertension
    Joel M Neutel
    Orange County Research Center, Tustin, CA, USA
    Nephrol Dial Transplant 21:1469-73. 2006
  13. ncbi request reprint Efficacy of combination therapy with amlodipine besylate/benazepril hydrochloride for lowering systolic blood pressure in stage 2 hypertension
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    Am J Geriatr Cardiol 15:142-50. 2006
    ..Adverse event rates were low and similar in all treatment groups. This study demonstrated that combination therapy is superior to monotherapy in older patients with stage 2 systolic hypertension and is well tolerated...
  14. doi request reprint The use of a single-pill calcium channel blocker/statin combination in the management of hypertension and dyslipidemia: a randomized, placebo-controlled, multicenter study
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 11:22-30. 2009
    ..Therapy with single-pill amlodipine/atorvastatin plus TLC in these patients significantly increased dual blood pressure/low-density lipoprotein cholesterol goal attainment compared with placebo plus TLC...
  15. doi request reprint Complementary mechanisms of angiotensin receptor blockers and calcium channel blockers in managing hypertension
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    Postgrad Med 121:40-8. 2009
    ....
  16. doi request reprint A comparison of the efficacy and safety of irbesartan/hydrochlorothiazide combination therapy with irbesartan monotherapy in the treatment of moderate or severe hypertension in diabetic and obese hypertensive patients: a post-hoc analysis review
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    Postgrad Med 123:126-34. 2011
    ..In patients with moderate or severe hypertension and with a BMI ≥ 30 kg/m(2), initial treatment with irbesartan/HCTZ combination therapy was more effective than irbesartan monotherapy...
  17. doi request reprint Blood pressure-lowering efficacy of an olmesartan medoxomil/hydrochlorothiazide-based treatment algorithm in elderly patients (age ≥65 years) stratified by age, sex and race: subgroup analysis of a 12-week, open-label, single-arm, dose-titration study
    Joel Neutel
    Orange County Research Center, Tustin, California, USA
    Drugs Aging 28:477-90. 2011
    ..Hypertension is a leading risk factor for development of heart failure, stroke and renal disease in the elderly...
  18. doi request reprint Long-term blood pressure control: what can we do?
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    Postgrad Med 123:88-93. 2011
    ..Together with supportive measures, CCB/ARB combinations are a compelling alternative for the long-term treatment of hypertension...
  19. doi request reprint An olmesartan medoxomil-based treatment algorithm is effective in achieving 24-hour BP control in patients with type 2 diabetes mellitus, regardless of age, race, sex, or severity of hypertension: subgroup analysis of the BENIFICIARY study
    Joel M Neutel
    Orange County Research Center, Tustin, California, USA
    Am J Cardiovasc Drugs 10:289-303. 2010
    ..The currently recommended BP goal of <130/80 mmHg for patients with type 2 diabetes is achieved in only 37.5% of treated patients with diabetes and hypertension...
  20. doi request reprint Predicted coronary heart disease risk reduction and dual blood pressure/cholesterol goal attainment in patients with hypertension treated in real-world clinical practice
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 12:396-406. 2010
    ..The findings were driven by greater dual goal attainment for patients prescribed single-pill amlodipine/atorvastatin (50.2%) compared with amlodipine monotherapy (31.7%, P<.05) and co-prescribed amlodipine + statin (37.5%, P<.05)...
  21. doi request reprint Effects of an olmesartan medoxomil based treatment algorithm on 24-hour blood pressure control in patients with hypertension and type 2 diabetes
    Joel M Neutel
    Orange County Research Center, Tustin, CA, USA
    Curr Med Res Opin 26:721-8. 2010
    ....
  22. doi request reprint Safety and tolerability of fixed-dose irbesartan/hydrochlorothiazide for rapid control of severe hypertension
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    Clin Exp Hypertens 31:572-84. 2009
    ..33%; P = 0.0005). Despite more rapid and aggressive BP lowering, initial fixed-dose irbesartan/HCTZ demonstrated a comparable AE profile to irbesartan monotherapy in patients with severe hypertension...
  23. ncbi request reprint Comparison of monotherapy with irbesartan 150 mg or amlodipine 5 mg for treatment of mild-to-moderate hypertension
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Renin Angiotensin Aldosterone Syst 6:84-9. 2005
    ....
  24. ncbi request reprint Effects of a structured treatment algorithm on blood pressure goal rates in both stage 1 and stage 2 hypertension
    J M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Hum Hypertens 20:255-62. 2006
    ..Mean SBP/DBP reductions in stage 2 patients were 18.4/10.0, 32.7/16.3, and 39.1/19.4 mmHg for mono-, double, and triple therapy, respectively. Overall, most patients with stage 1 or stage 2 hypertension achieved goal BP...
  25. ncbi request reprint Ambulatory blood pressure comparison of the anti-hypertensive efficacy of fixed combinations of irbesartan/hydrochlorothiazide and losartan/hydrochlorothiazide in patients with mild-to-moderate hypertension
    J M Neutel
    Orange County Research Center, Tustin, California 92780, USA
    J Int Med Res 33:620-31. 2005
    ..Both regimens were well tolerated, with no significant differences in terms of adverse event profile observed. Irbesartan 150 mg/HCTZ 12.5 mg resulted in greater reductions in ambulatory BP than losartan 50 mg/HCTZ 12.5 mg...
  26. ncbi request reprint Improving patient compliance: a major goal in the management of hypertension
    Joel M Neutel
    Orange County Heart Institute and Research Center, Orange, CA 92828, USA
    J Clin Hypertens (Greenwich) 5:127-32. 2003
    ..Achieving goal BP in hypertensive patients is one of the most important clinical dilemmas facing physicians. There is little doubt that an improvement in control rates will result in substantial reductions in cardiovascular disease...
  27. ncbi request reprint Evaluation of angiotensin II receptor blockers for 24-hour blood pressure control: meta-analysis of a clinical database
    Joel Neutel
    Division of Clinical Pharmacology and Hypertension, Veterans Affairs Medical Center, Long Beach, CA, USA
    J Clin Hypertens (Greenwich) 5:58-63. 2003
    ..Furthermore, telmisartan 80 mg was comparable to amlodipine 5 mg for controlling the early morning surge in blood pressure...
  28. ncbi request reprint Long-term efficacy and tolerability of telmisartan as monotherapy and in combination with other antihypertensive medications
    Joel M Neutel
    Orange County Heart Institute and Research Center, Orange, California, USA
    Blood Press 11:302-9. 2002
    ..Thus, telmisartan 80 mg administered alone or with HCTZ (12.5 or 25 mg) and/or other antihypertensives maintains a clinically significant therapeutic effect over the long term in patients with mild-to-moderate hypertension...
  29. ncbi request reprint Antihypertensive efficacy of olmesartan medoxomil, a new angiotensin II receptor antagonist, as assessed by ambulatory blood pressure measurements
    Joel M Neutel
    Orange County Heart Institute and Research Center, Orange, CA 92868, USA
    J Clin Hypertens (Greenwich) 4:325-31. 2002
    ..The safety profile of olmesartan medoxomil was similar to that of placebo. Olmesartan medoxomil appears to be a safe and effective once-a-day treatment for hypertension...
  30. ncbi request reprint Telmisartan vs losartan plus hydrochlorothiazide in the treatment of mild-to-moderate essential hypertension--a randomised ABPM study
    J M Neutel
    Orange County Heart Institute and Research Center, Orange, CA 92868, USA
    J Hum Hypertens 17:569-75. 2003
    ..3/-9.6 and -18.5/-11.1 mmHg in the patients treated with losartan/HCTZ (difference -2.4/-1.2 mmHg). There were no differences between the side-effect profiles of the two treatments...
  31. ncbi request reprint Why lowering blood pressure is not enough: the hypertension syndrome and the clinical context of cardiovascular risk reduction
    J M Neutel
    Department of Clinical Pharmacology, Orange County Heart Institute, 505 S Main Street 1025, Orange, CA 92868, USA
    Heart Dis 2:370-4. 2000
    ....
  32. ncbi request reprint Beyond the sphygmomanometric numbers: hypertension as a syndrome
    J M Neutel
    Department of Clinical Pharmacology, VA Medical Center, Long Beach, California 90806, USA
    Am J Hypertens 14:250S-257S. 2001
    ....
  33. ncbi request reprint Clinical studies of CS-866, the newest angiotensin II receptor antagonist
    J M Neutel
    Orange County Heart Institute and Research Center, Orange, California 92868, USA
    Am J Cardiol 87:37C-43C. 2001
    ..Dizziness was the only treatment-emergent adverse event with which CS-866 was associated...
  34. ncbi request reprint Use of ambulatory blood pressure monitoring to evaluate the selective angiotensin II receptor antagonist, telmisartan, and other antihypertensive drugs
    J M Neutel
    Orange County Heart Institute and Research Center, Orange, California, USA
    Blood Press Monit 5:S35-40. 2000
    ..These results demonstrate that telmisartan maintains a normal circadian blood pressure pattern and provides full 24 h blood pressure control with once-daily dosing...
  35. ncbi request reprint Clinical experience with perindopril in elderly hypertensive patients: a subgroup analysis of a large community trial
    Joel M Neutel
    Orange County Research Center, Tustin, California 92780, USA
    Am J Cardiovasc Drugs 4:335-41. 2004
    ..To evaluate the effectiveness and safety of perindopril in a subgroup of 3010 elderly (> or =65 years) hypertensive patients, who participated in a large US general practice-based community trial...
  36. ncbi request reprint Use of an olmesartan medoxomil-based treatment algorithm for hypertension control
    Joel M Neutel
    Orange County Research Center, 14351 Myford Road, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 6:168-74. 2004
    ....
  37. ncbi request reprint Effect of the renin--angiotensin system on the vessel wall: using ACE inhibition to improve endothelial function
    J M Neutel
    Orange County Heart Institute, Orange, CA 92868, USA
    J Hum Hypertens 18:599-606. 2004
    ....
  38. ncbi request reprint Efficacy of combination therapy for systolic blood pressure in patients with severe systolic hypertension: the Systolic Evaluation of Lotrel Efficacy and Comparative Therapies (SELECT) study
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 7:641-6; quiz 647-8. 2005
    ..This data supports the recommendation of the JNC 7 for the use of combination therapy in patients with stage 2 hypertension...
  39. ncbi request reprint The efficacy and safety of low- and high-dose fixed combinations of irbesartan/hydrochlorothiazide in patients with uncontrolled systolic blood pressure on monotherapy: the INCLUSIVE trial
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 7:578-86. 2005
    ..Treatments were well tolerated. This irbesartan/HCTZ treatment regimen achieved SBP goals in more than 75% of patients uncontrolled on monotherapy...
  40. ncbi request reprint Comparison of a chronotherapeutically administered beta blocker vs. a traditionally administered beta blocker in patients with hypertension
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 7:395-400; quiz 401-2. 2005
    ..m. and noon in beta-blocker sensitive patients than does traditionally dosed propranolol...
  41. ncbi request reprint Telmisartan/Hydrochlorothiazide in comparison with losartan/hydrochlorothiazide in managing patients with mild-to-moderate hypertension
    Joel M Neutel
    Orange County Research Center, Tustin, USA
    Hypertens Res 28:555-63. 2005
    ..5 during the last 6 h of the 24-h dosing interval, which corresponds to the high-risk early-morning hours, and that T80/H12.5 provided additional blood pressure reductions...
  42. ncbi request reprint Hypertension control: still not there-how to select the right add-on therapy to reach goal blood pressures
    Joel M Neutel
    Orange County Research Center, Tustin, CA, USA
    J Clin Hypertens (Greenwich) 9:889-96. 2007
    ..The authors maintained full control of the discussion and the resulting content of this article...
  43. ncbi request reprint Effect of antihypertensive monotherapy and combination therapy on arterial distensibility and left ventricular mass
    Joel M Neutel
    Orange County Heart Institute and Research Center, Orange, California, USA
    Am J Hypertens 17:37-42. 2004
    ..This study examined whether combined therapy has greater arterial and cardiac effects than doubled doses of the individual drugs...
  44. doi request reprint Efficacy of amlodipine and olmesartan medoxomil in patients with hypertension: the AZOR Trial Evaluating Blood Pressure Reductions and Control (AZTEC) study
    Henry Punzi
    Trinity Hypertension Research Institute and Metabolic Research Institute, Punzi Medical Center, 1932 Walnut Plaza, Carrollton, TX 75006, USA
    Ther Adv Cardiovasc Dis 4:209-21. 2010
    ..The study drug was well tolerated with few adverse events (peripheral edema, 2.2%; dizziness, 1.1%). An AML/OM-based titration regimen effectively reduces BP in patients with hypertension...
  45. ncbi request reprint Efficacy and safety of coadministered amlodipine and atorvastatin in patients with hypertension and dyslipidemia: results of the AVALON trial
    Franz H Messerli
    St Luke s Roosevelt Hospital Center, New York, NY 10019, USA
    J Clin Hypertens (Greenwich) 8:571-81; quiz 582-3. 2006
    ..Concomitant administration of amlodipine and atorvastatin is an effective and well tolerated treatment for coexisting hypertension and dyslipidemia...
  46. ncbi request reprint Combination therapy of amlodipine/benazepril versus monotherapy of amlodipine in a practice-based setting
    Franz H Messerli
    Division of Research, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Hypertens 15:550-6. 2002
    ..This large practice-based clinical trial assessed the efficacy and tolerability of fixed-dose combination therapy with amlodipine/benazepril, compared with amlodipine monotherapy, in patients with mild-to-moderate hypertension...
  47. ncbi request reprint Prospective, randomized, open-label, blinded-endpoint (PROBE) designed trials yield the same results as double-blind, placebo-controlled trials with respect to ABPM measurements
    David H Smith
    Integrium, Orange, California 92868, USA
    J Hypertens 21:1291-8. 2003
    ....
  48. ncbi request reprint The use of combination drug therapy in the treatment of hypertension
    Joel M Neutel
    Orange County Heart Institute and Research Center, 505 S Main Street, Orange, CA 92868, USA
    Prog Cardiovasc Nurs 17:81-8. 2002
    ....
  49. ncbi request reprint Combination therapy as initial treatment for hypertension
    Joel M Neutel
    Orange County Research Center, Tustin, Calif, USA
    Manag Care 13:5-11; discussion 12-6. 2004