Leon J Nesti

Summary

Publications

  1. ncbi Differentiation potential of multipotent progenitor cells derived from war-traumatized muscle tissue
    Leon J Nesti
    J Bone Joint Surg Am 90:2390-8. 2008
  2. ncbi In vitro adipose tissue engineering using an electrospun nanofibrous scaffold
    Rabie M Shanti
    Department of Health and Human Services, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Ann Plast Surg 61:566-71. 2008
  3. ncbi Human marrow-derived mesenchymal progenitor cells: isolation, culture expansion, and analysis of differentiation
    Edward J Caterson
    Cartilage Biology and Orthopedics Branch, National Institute of Arthritis, and Musculoskeletal Skin Diseases, National Institutes of Health, Bethesda, MD 20992-5755, USA
    Mol Biotechnol 20:245-56. 2002
  4. ncbi TGF-beta1-stimulated osteoblasts require intracellular calcium signaling for enhanced alpha5 integrin expression
    Leon J Nesti
    Department of Orthopaedic Surgery, 501 Curtis Building, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA
    Ann N Y Acad Sci 961:178-82. 2002
  5. ncbi TGF-beta1 calcium signaling increases alpha5 integrin expression in osteoblasts
    Leon J Nesti
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Orthop Res 20:1042-9. 2002
  6. ncbi Titanium particles suppress expression of osteoblastic phenotype in human mesenchymal stem cells
    Mark L Wang
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Orthop Res 20:1175-84. 2002
  7. ncbi Myeloperoxidase and chlorinated peptides in osteoarthritis: potential biomarkers of the disease
    Marla J Steinbeck
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Orthop Res 25:1128-35. 2007
  8. ncbi Adult mesenchymal stem cells: biological properties, characteristics, and applications in maxillofacial surgery
    Rabie M Shanti
    Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Oral Maxillofac Surg 65:1640-7. 2007

Collaborators

  • Rocky S Tuan
  • Rabie M Shanti
  • Marla J Steinbeck
  • Peter F Sharkey
  • Keith G Danielson
  • Mark L Wang
  • Edward J Caterson
  • Javad Parvizi
  • Richard Tuli
  • Jovin Lazatin

Detail Information

Publications8

  1. ncbi Differentiation potential of multipotent progenitor cells derived from war-traumatized muscle tissue
    Leon J Nesti
    J Bone Joint Surg Am 90:2390-8. 2008
    ..The site of injury is also the site of healing, and we propose that débrided muscle tissue contains cells with robust reparative and regenerative potential...
  2. ncbi In vitro adipose tissue engineering using an electrospun nanofibrous scaffold
    Rabie M Shanti
    Department of Health and Human Services, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Ann Plast Surg 61:566-71. 2008
    ..These results suggest that the poly L-lactic acid-based nanofibrous scaffold is a promising candidate for adult stem cell-based engineering of adipose tissue...
  3. ncbi Human marrow-derived mesenchymal progenitor cells: isolation, culture expansion, and analysis of differentiation
    Edward J Caterson
    Cartilage Biology and Orthopedics Branch, National Institute of Arthritis, and Musculoskeletal Skin Diseases, National Institutes of Health, Bethesda, MD 20992-5755, USA
    Mol Biotechnol 20:245-56. 2002
    ....
  4. ncbi TGF-beta1-stimulated osteoblasts require intracellular calcium signaling for enhanced alpha5 integrin expression
    Leon J Nesti
    Department of Orthopaedic Surgery, 501 Curtis Building, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA
    Ann N Y Acad Sci 961:178-82. 2002
    ..These early events are necessary for osteoblast adhesion; thus they determine the fate of the cell and ultimately affect bone function...
  5. ncbi TGF-beta1 calcium signaling increases alpha5 integrin expression in osteoblasts
    Leon J Nesti
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Orthop Res 20:1042-9. 2002
    ..The TGF-beta1 induced intracellular Ca2+ signal in human osteoblasts is thus an important mechanistic step in the regulation of alpha5 integrin expression, later contributing to enhanced cell adhesion...
  6. ncbi Titanium particles suppress expression of osteoblastic phenotype in human mesenchymal stem cells
    Mark L Wang
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Orthop Res 20:1175-84. 2002
    ..Understanding the nature of hMSC bioreactivity to orthopaedic wear debris should provide additional insights into mechanisms underlying aseptic loosening...
  7. ncbi Myeloperoxidase and chlorinated peptides in osteoarthritis: potential biomarkers of the disease
    Marla J Steinbeck
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Orthop Res 25:1128-35. 2007
    ..Patients in the control and advanced OA groups demonstrated little elevation in MPO levels and Cl-peptides were undetectable. These results indicate that MPO and Cl-peptides may serve as diagnostic markers for the detection of early OA...
  8. ncbi Adult mesenchymal stem cells: biological properties, characteristics, and applications in maxillofacial surgery
    Rabie M Shanti
    Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Oral Maxillofac Surg 65:1640-7. 2007