Buddha Basnyat

Summary

Affiliation: Kathmandu Medical College
Country: Nepal

Publications

  1. doi request reprint Acetazolamide fails to decrease pulmonary artery pressure at high altitude in partially acclimatized humans
    Buddha Basnyat
    Nepal International Clinic, Kathmandu, Nepal, Himalayan Rescue Association, Kathmandu, Nepal
    High Alt Med Biol 9:209-16. 2008
  2. pmc An open randomized comparison of gatifloxacin versus cefixime for the treatment of uncomplicated enteric fever
    Anil Pandit
    Patan Hospital, Lagankhel, Lalitpur, Nepal
    PLoS ONE 2:e542. 2007
  3. pmc Gatifloxacin versus chloramphenicol for uncomplicated enteric fever: an open-label, randomised, controlled trial
    Amit Arjyal
    Oxford University Clinical Research Unit Patan Academy of Health Sciences, Kathmandu, Nepal
    Lancet Infect Dis 11:445-54. 2011
  4. pmc Aetiologies of central nervous system infections in adults in Kathmandu, Nepal: a prospective hospital-based study
    Abhishek Giri
    Oxford University Clinical Research Unit Patan Hospital, Nepal
    Sci Rep 3:2382. 2013
  5. pmc The sensitivity of real-time PCR amplification targeting invasive Salmonella serovars in biological specimens
    Tran Vu Thieu Nga
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    BMC Infect Dis 10:125. 2010
  6. pmc High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    BMC Infect Dis 10:144. 2010
  7. ncbi request reprint High-altitude illness
    Buddha Basnyat
    Nepal International Clinic, Kathmandu, Nepal Himalayan Rescue Association, Kathmandu, Nepal
    Lancet 361:1967-74. 2003
  8. ncbi request reprint Everest or bust: a cross sectional, epidemiological study of acute mountain sickness at 4243 meters in the Himalayas
    B Basnyat
    Himalayan Rescue Association Nepal International Clinic Patan Hospital, Nepal
    Aviat Space Environ Med 70:867-73. 1999
  9. ncbi request reprint Pleural tuberculosis in a Nepali trekker
    Buddha Basnyat
    Nepal International Clinic, Lal Durbar, Kathmandu
    Wilderness Environ Med 13:129-30. 2002
  10. ncbi request reprint Disoriented and ataxic pilgrims: an epidemiological study of acute mountain sickness and high-altitude cerebral edema at a sacred lake at 4300 m in the Nepal Himalayas
    B Basnyat
    Nepal International Clinic, Patan Hospital
    Wilderness Environ Med 11:89-93. 2000

Collaborators

Detail Information

Publications63

  1. doi request reprint Acetazolamide fails to decrease pulmonary artery pressure at high altitude in partially acclimatized humans
    Buddha Basnyat
    Nepal International Clinic, Kathmandu, Nepal, Himalayan Rescue Association, Kathmandu, Nepal
    High Alt Med Biol 9:209-16. 2008
    ....
  2. pmc An open randomized comparison of gatifloxacin versus cefixime for the treatment of uncomplicated enteric fever
    Anil Pandit
    Patan Hospital, Lagankhel, Lalitpur, Nepal
    PLoS ONE 2:e542. 2007
    ..To assess the efficacy of gatifloxacin versus cefixime in the treatment of uncomplicated culture positive enteric fever...
  3. pmc Gatifloxacin versus chloramphenicol for uncomplicated enteric fever: an open-label, randomised, controlled trial
    Amit Arjyal
    Oxford University Clinical Research Unit Patan Academy of Health Sciences, Kathmandu, Nepal
    Lancet Infect Dis 11:445-54. 2011
    ..We aimed to investigate whether gatifloxacin, a new generation and affordable fluoroquinolone, is better than chloramphenicol for the treatment of uncomplicated enteric fever in children and adults...
  4. pmc Aetiologies of central nervous system infections in adults in Kathmandu, Nepal: a prospective hospital-based study
    Abhishek Giri
    Oxford University Clinical Research Unit Patan Hospital, Nepal
    Sci Rep 3:2382. 2013
    ..This is the first prospective molecular and serology based CSF analysis in adults with CNS infections in Kathmandu, Nepal. JEV and enteroviruses were the most commonly detected pathogens in this setting. ..
  5. pmc The sensitivity of real-time PCR amplification targeting invasive Salmonella serovars in biological specimens
    Tran Vu Thieu Nga
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    BMC Infect Dis 10:125. 2010
    ..Invasive Salmonella serovars, which cause enteric fever, can be commonly cultured from the blood of infected patients. Yet, the isolation of invasive Salmonella serovars from blood is protracted and potentially insensitive...
  6. pmc High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    BMC Infect Dis 10:144. 2010
    ..Kathmandu, the capital of Nepal, is an area of high incidence and the pediatric population appears to be at high risk of exposure and infection...
  7. ncbi request reprint High-altitude illness
    Buddha Basnyat
    Nepal International Clinic, Kathmandu, Nepal Himalayan Rescue Association, Kathmandu, Nepal
    Lancet 361:1967-74. 2003
    ..Despite investigation of other agents, acetazolamide remains the preferred drug for preventing AMS. The next few years are likely to see many advances in the understanding of the causes and management of high-altitude illness...
  8. ncbi request reprint Everest or bust: a cross sectional, epidemiological study of acute mountain sickness at 4243 meters in the Himalayas
    B Basnyat
    Himalayan Rescue Association Nepal International Clinic Patan Hospital, Nepal
    Aviat Space Environ Med 70:867-73. 1999
    ....
  9. ncbi request reprint Pleural tuberculosis in a Nepali trekker
    Buddha Basnyat
    Nepal International Clinic, Lal Durbar, Kathmandu
    Wilderness Environ Med 13:129-30. 2002
  10. ncbi request reprint Disoriented and ataxic pilgrims: an epidemiological study of acute mountain sickness and high-altitude cerebral edema at a sacred lake at 4300 m in the Nepal Himalayas
    B Basnyat
    Nepal International Clinic, Patan Hospital
    Wilderness Environ Med 11:89-93. 2000
    ..Although it is well known that western trekkers suffer from acute mountain sickness (AMS) in the Himalayas, not much is documented about the incidence of AMS in the local population of Nepal that go to high altitude...
  11. ncbi request reprint Delirium at high altitude
    Buddha Basnyat
    Nepal International Clinic, Himalayan Rescue Association, Patan Hosptial, Institute of Medicine, Kathmandu, Nepal
    High Alt Med Biol 3:69-71. 2002
    ..Finally, the importance of travelling with a reliable partner and using proper insurance is emphasized in treks to the Himalayas...
  12. ncbi request reprint Isolated facial and hypoglossal nerve palsies at high altitude
    B Basnyat
    Nepal International Clinic, Himalaya Rescue Association, Institute of Medicine, Tribhuvan University, and Patan Hospital, Kathmandu, Nepal
    High Alt Med Biol 2:301-3. 2001
    ..This report documents isolated facial and hypoglossal nerve palsies that occurred in two travellers at high altitude in the Nepal Himalaya. The possible pathophysiological mechanisms of these neurological deficits are discussed...
  13. pmc Gatifloxacin versus ofloxacin for the treatment of uncomplicated enteric fever in Nepal: an open-label, randomized, controlled trial
    Samir Koirala
    Oxford University Clinical Research Unit Nepal, Patan Academy of Health Sciences, Patan Hospital, Patan, Nepal
    PLoS Negl Trop Dis 7:e2523. 2013
    ....
  14. pmc Highly resistant Salmonella enterica serovar Typhi with a novel gyrA mutation raises questions about the long-term efficacy of older fluoroquinolones for treating typhoid fever
    Kanika Deshpande Koirala
    Oxford University Clinical Research Unit Patan Academy of Health Sciences, Kathmandu, Nepal
    Antimicrob Agents Chemother 56:2761-2. 2012
    ..The isolation of this organism has serious implications for the long-term efficacy of ciprofloxacin and ofloxacin for typhoid treatment...
  15. pmc The burden and characteristics of enteric fever at a healthcare facility in a densely populated area of Kathmandu
    Abhilasha Karkey
    Oxford University Clinical Research Unit, Patan Academy of Health Sciences, Lagankhel, Kathmandu, Nepal
    PLoS ONE 5:e13988. 2010
    ..These findings are important for initiating a vaccination scheme and improvements in sanitation. We suggest any such intervention should be implemented throughout the LSMC area...
  16. ncbi request reprint Emerging trends in enteric fever in Nepal: 9124 cases confirmed by blood culture 1993-2003
    Ashish P Maskey
    Patan Hospital, GPO Box 252, Kathmandu, Nepal
    Trans R Soc Trop Med Hyg 102:91-5. 2008
    ..Salmonella paratyphi A contributes an increasingly large proportion of cases, and ciprofloxacin resistance is also emerging more rapidly in S. paratyphi A...
  17. ncbi request reprint Acetazolamide 125 mg BD is not significantly different from 375 mg BD in the prevention of acute mountain sickness: the prophylactic acetazolamide dosage comparison for efficacy (PACE) trial
    Buddha Basnyat
    Himalayan Rescue Association and Nepal International Clinic, Kathmandu, Nepal
    High Alt Med Biol 7:17-27. 2006
    ..02). We conclude that 125 mg bd of acetazolamide is not significantly different from 375 mg bd in the prevention of AMS; 125 mg bd should be considered the preferred dosage when indicated for persons ascending to altitudes above 2500 m...
  18. doi request reprint A patient with paratyphoid A fever: an emerging problem in Asia and not always a benign disease
    Anil Pandit
    Clinical Research, Patan Hospital, Lalitpur, Nepal
    J Travel Med 15:364-5. 2008
    ..Salmonella paratyphoid A, for which there is no commercial vaccine, may not be a benign disease as perceived, and cefixime that is recommended for enteric fever may be an ineffective choice...
  19. pmc Differential epidemiology of Salmonella Typhi and Paratyphi A in Kathmandu, Nepal: a matched case control investigation in a highly endemic enteric fever setting
    Abhilasha Karkey
    Oxford University Clinical Research Unit, Patan Academy of Health Sciences, Kathmandu, Nepal
    PLoS Negl Trop Dis 7:e2391. 2013
    ..Here, we sought to examine individual-level risk factors related to hygiene and sanitation to improve our understanding of the epidemiology of enteric fever in this setting...
  20. ncbi request reprint Another typhoid patient from Japan
    Rachana Thapa
    Nepal International Clinic Travel and Mountain Medicine, Kathmandu, Nepal
    J Travel Med 17:199-200. 2010
    ..Subsequently, his blood culture grew out Salmonella typhi...
  21. pmc The microbiological and clinical characteristics of invasive salmonella in gallbladders from cholecystectomy patients in kathmandu, Nepal
    Sabina Dongol
    Oxford University Clinical Research Unit, Patan Academy of Health Sciences, Kathmandu, Nepal
    PLoS ONE 7:e47342. 2012
    ..We predict that such individuals will become increasingly important if current transmission mechanisms are disturbed; prospectively identifying these individuals is, therefore, paramount for rapid local and regional elimination...
  22. ncbi request reprint Salmonella enterica serovar Paratyphi A and S. enterica serovar Typhi cause indistinguishable clinical syndromes in Kathmandu, Nepal
    Ashish P Maskey
    Patan Hospital, Lagankhel, Lalitpur, Bagmati, Kathmandu, Nepal
    Clin Infect Dis 42:1247-53. 2006
    ..enterica serovar Typhi. There are few data on which to base this assumption, little is known of the serovar's antibacterial susceptibilities, and there is no readily available tolerable vaccination...
  23. pmc Murine typhus and febrile illness, Nepal
    Mark D Zimmerman
    Patan Hospital, Kathmandu, Nepal
    Emerg Infect Dis 14:1656-9. 2008
    ..Of patients with murine typhus, 64% were women, 86% were residents of Kathmandu, and 90% were unwell during the winter. No characteristics clearly distinguished typhus patients from those with blood culture-positive enteric fever...
  24. doi request reprint Spironolactone does not prevent acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial by SPACE Trial Group (spironolactone and acetazolamide trial in the prevention of acute mountain sickness group)
    Buddha Basnyat
    Nepal International Clinic, Kathmandu, Nepal
    Wilderness Environ Med 22:15-22. 2011
    ..Hence, a prospective, double-blind, randomized, placebo-controlled trial was conducted to evaluate the efficacy of spironolactone in the prevention of AMS...
  25. doi request reprint Complications of steroid use on Mt. Everest
    Bishnu Hari Subedi
    Nepal International Clinic, Laldurbar, Kathmandu, Nepal
    Wilderness Environ Med 21:345-8. 2010
    ..High-altitude cerebral edema (HACE), steroid toxicity, and acute adrenal crisis can have similar clinical presentations. Differentiating between these life-threatening conditions at high altitude is essential for successful treatment...
  26. ncbi request reprint Kathmandu, Nepal: still an enteric fever capital of the world
    Abhilasha Karkey
    Oxford University Clinical Research Unit, Patan Hospital, Lagankhel, Lalitpur, Bagmati, Kathmandu, Nepal
    J Infect Dev Ctries 2:461-5. 2008
    ..Our findings highlight the requirement for better understanding of the disease within the city; in turn, this will aid development of a targeted control strategy...
  27. ncbi request reprint Enteric (typhoid) fever in travelers
    Buddha Basnyat
    Nepal International Clinic, Kathmandu, Nepal
    Clin Infect Dis 41:1467-72. 2005
    ..Because of the nonspecific clinical presentation of enteric fever, a high index of suspicion is important in febrile travelers who have traveled to areas of endemicity...
  28. doi request reprint Frostbite in a Sherpa
    Bishnu Hari Subedi
    Nepal International Clinic, Travel and Mountain Medicine Center, Kathmandu, Nepal
    Wilderness Environ Med 21:127-9. 2010
    ..Though there is no evidence whether Sherpas are more or less prone to frostbite, simple techniques for adequate prevention of hypoxia, hypothermia and dehydration will benefit any climber to the high altitudes...
  29. doi request reprint A diplomatic disease
    Ruthanne R Taylor
    Foreign Embassy, Kathmandu, Nepal
    J Travel Med 15:200-1. 2008
    ..However, on return to her post in Nepal, she was actually found to have hepatitis E. The differential diagnosis, importance, and prevention of hepatitis E are highlighted...
  30. ncbi request reprint Efficacy of low-dose acetazolamide (125 mg BID) for the prophylaxis of acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial
    Buddha Basnyat
    Nepal International Clinic, Himalayan Rescue Association
    High Alt Med Biol 4:45-52. 2003
    ..We concluded that acetazolamide 125 mg twice daily was effective in decreasing the incidence of AMS in this Himalayan trekking population...
  31. doi request reprint Cerebral venous sinus thrombosis at high altitude
    Promish Shrestha
    Nepal International Clinic, Travel and Mountain Medicine, Kathmandu, Nepal
    High Alt Med Biol 13:60-2. 2012
    ..Besides, such neurological conditions can occur independent of altitude illness and need to be recognized as their management differs...
  32. ncbi request reprint A developing country perspective
    Buddha Basnyat
    Institute of Medicine, Tribhuvan University, Lal Durbar, GPO Box 3596, Kathmandu, Nepal
    Lancet 359:2026. 2002
  33. ncbi request reprint Neck irradiation or surgery may predispose to severe acute mountain sickness
    Buddha Basnyat
    J Travel Med 9:105. 2002
  34. ncbi request reprint The physiologic basis of high-altitude diseases
    Buddha Basnyat
    Ann Intern Med 142:591; author reply 592. 2005
  35. ncbi request reprint Steadfast to the summit: living and climbing at altitude
    Buddha Basnyat
    Natl Med J India 16:276-7. 2003
  36. ncbi request reprint Pulmonary extravascular fluid accumulation in climbers
    Buddha Basnyat
    Lancet 360:570; author reply 571-2. 2002
  37. doi request reprint Adaptation to high altitude in Sherpas: association with the insertion/deletion polymorphism in the Angiotensin-converting enzyme gene
    Yunden Droma
    First Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Wilderness Environ Med 19:22-9. 2008
    ..The objective of this study was to elucidate the genetic background underlying this characteristic among Sherpas with respect to the angiotension-converting enzyme (ACE) gene...
  38. ncbi request reprint Clinical images. A mystery
    Buddha Basnyat
    Wilderness Environ Med 15:53-5. 2004
  39. pmc Randomised, double blind, placebo controlled comparison of ginkgo biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: the prevention of high altitude illness trial (PHAIT)
    Jeffrey H Gertsch
    Department of Internal Medicine, Maricopa Medical Center, 2601 E Roosevelt Avenue number O D 10, Phoenix, AZ 85008, USA
    BMJ 328:797. 2004
    ..To evaluate the efficacy of ginkgo biloba, acetazolamide, and their combination as prophylaxis against acute mountain sickness...
  40. ncbi request reprint Role of the altitude level on cerebral autoregulation in residents at high altitude
    Gerard F A Jansen
    Dept of Anesthesiology, H1 Z, Academic Medical Centre, Univ of Amsterdam, The Netherlands
    J Appl Physiol (1985) 103:518-23. 2007
    ..This study showed that the altitude region between 3,440 and 4,243 m, marked by Sa(O(2)) in the high-altitude dwellers of 93% and 88%, is a transitional zone, above which cerebral autoregulation becomes critically impaired...
  41. ncbi request reprint The Khumbu cure
    Buddha Basnyat
    High Alt Med Biol 6:342-5. 2005
  42. ncbi request reprint Symptoms of acute mountain sickness in Sherpas exposed to extremely high altitude
    Yunden Droma
    High Alt Med Biol 7:312-4. 2006
    Droma, Yunden, Masayuki Hanaoka, Buddha Basnyat, Amit Arjyal, Pritam Neupane, Anil Pandit, Dependra Sharma, and Keishi Kubo. Symptoms of acute mountain sickness in Sherpas exposed to extremely high altitude. High Alt. Med. Biol...
  43. ncbi request reprint Higher venous bicarbonate concentration associated with hypoxemia, not acute mountain sickness, after ascent to moderate altitude
    Thomas A Cumbo
    The Johns Hopkins University Sinai Hospital Program in Internal Medicine, Baltimore, MD, USA
    J Travel Med 12:184-9. 2005
    ..To further characterize these findings, we returned to our original testing site to examine the hypothesis that subjects with lower levels of oxygen saturation and/or AMS would possess higher levels of venous bicarbonate...
  44. ncbi request reprint Genetic contribution of the endothelial nitric oxide synthase gene to high altitude adaptation in sherpas
    Yunden Droma
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    High Alt Med Biol 7:209-20. 2006
    ..The nitric oxide metabolites (NO( x )) in serum vary individually, thus it is not a reliable indicator for endogenous nitric oxide production...
  45. ncbi request reprint The pilgrim at high altitude
    Buddha Basnyat
    High Alt Med Biol 7:183-4. 2006
  46. pmc South Asian health: what is to be done? Better understanding is achievable
    Buddha Basnyat
    BMJ 328:839. 2004
  47. ncbi request reprint The etiology of febrile illness in adults presenting to Patan hospital in Kathmandu, Nepal
    David R Murdoch
    Department of Pathology, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand
    Am J Trop Med Hyg 70:670-5. 2004
    ..Given the lack of reliable clinical predictors, the development of cheap and accurate diagnostic tests are likely to be of great clinical utility in this setting...
  48. ncbi request reprint It's OK, it's TB
    Buddha Basnyat
    Wilderness Environ Med 13:218-20. 2002
  49. ncbi request reprint A different kind of medicine
    Buddha Basnyat
    Natl Med J India 18:321. 2005
  50. ncbi request reprint Reducing the incidence of high-altitude pulmonary edema
    Buddha Basnyat
    Ann Intern Med 146:613; author reply 613-4. 2007
  51. ncbi request reprint Typhoid and paratyphoid fever
    Buddha Basnyat
    Lancet 366:1603. 2005
  52. ncbi request reprint Scientific English for non-English speakers
    Buddha Basnyat
    Lancet 359:896. 2002
  53. ncbi request reprint Basilar artery blood flow velocity and the ventilatory response to acute hypoxia in mountaineers
    Gerard F A Jansen
    Department of Anesthesiology, Academic Medical Centre, University of Amsterdam, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Respir Physiol Neurobiol 133:65-74. 2002
    ..The conflicting effects of hypoxia and hypocapnia on both medullary blood flow and ventilatory drive thus balance out, giving climbers a greater drive and higher Sa(O(2)), despite lower PET(CO(2)) and lower brain stem blood flow...
  54. ncbi request reprint Allele frequencies for 15 STR loci in Tibetan populations from Nepal
    Masao Ota
    Department of Legal Medicine, Shinshu University School of Medicine, Asahi 3 1 1, 390 8621 Matsumoto, Japan
    Forensic Sci Int 169:234-8. 2007
    ..Genetic parameters of forensic interest were calculated and genetic differentiation between the two populations tested...
  55. pmc Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones
    Tran Thuy Chau
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam
    Antimicrob Agents Chemother 51:4315-23. 2007
    ..The 8-methoxy fluoroquinolone gatifloxacin showed rapid killing of serovar Typhi harboring both the single- and double-amino-acid substitutions...
  56. ncbi request reprint Changes in metabolic and hematologic laboratory values with ascent to altitude and the development of acute mountain sickness in Nepalese pilgrims
    Mark B Shah
    Department of Emergency Medicine, MSC 10 5560, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
    Wilderness Environ Med 17:171-7. 2006
    ....
  57. pmc Pilgrimage medicine
    Buddha Basnyat
    BMJ 324:745. 2002
  58. pmc Second generation Tibetan lowlanders acclimatize to high altitude more quickly than Caucasians
    Claudio Marconi
    I B F M Consiglio Nazionale delle Ricerche, L I T A, Via Fratelli Cervi 93, I 20090 Segrate Milan, Italy
    J Physiol 556:661-71. 2004
    ..The above findings and the time course of adjustment of the investigated variables suggest that Tibetan lowlanders acclimatize to chronic hypoxia more quickly than Caucasians, independent of the degree of fitness of the latter...
  59. ncbi request reprint Emergence of Salmonella enterica serotype Paratyphi A as a major cause of enteric fever in Kathmandu, Nepal
    Christopher W Woods
    Duke University Medical Center, Durham, NC, USA
    Trans R Soc Trop Med Hyg 100:1063-7. 2006
    ..In contrast, only 21 (36%) of the 58 S. Typhi isolates exhibited a common genotype, which is consistent with endemic disease from multiple sources...
  60. ncbi request reprint Minimum pesticide list for the developing world
    Buddha Basnyat
    Lancet 361:259-60. 2003
  61. ncbi request reprint Mountain sickness
    Buddha Basnyat
    Natl Med J India 15:294-5. 2002
  62. ncbi request reprint Salmeterol for the prevention of high-altitude pulmonary edema
    Buddha Basnyat
    N Engl J Med 347:1282-5; author reply 1282-5. 2002
  63. ncbi request reprint Neurological conditions at altitude that fall outside the usual definition of altitude sickness
    Buddha Basnyat
    Nepal International Clinic and Himalayan Rescue Association, Department of Physiology, Institute of Medicine and Patan Hospital, Kathmandi, NEPA
    High Alt Med Biol 5:171-9. 2004
    ....