Harold S Nelson

Summary

Publications

  1. ncbi request reprint Hydrofluoroalkane-134A beclomethasone or chlorofluorocarbon fluticasone: effect on small airways in poorly controlled asthma
    Torpong Thongngarm
    Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, 1400 Jackson St, Denver, CO 80206, USA
    J Asthma 42:257-63. 2005
  2. doi request reprint Subcutaneous immunotherapy versus sublingual immunotherapy: which is more effective?
    Harold S Nelson
    Department of Medicine, National Jewish Health and University of Colorado Denver School of Medicine, National Jewish Health, Denver, Colo Electronic address
    J Allergy Clin Immunol Pract 2:144-9. 2014
  3. doi request reprint Treatment of seasonal allergic rhinoconjunctivitis with a once-daily SQ-standardized grass allergy immunotherapy tablet
    Harold Nelson
    Department of Medicine, Division of Allergy and Immunology, National Jewish Health Center, Denver, CO 80206, USA
    Curr Med Res Opin 28:1043-51. 2012
  4. doi request reprint Subcutaneous injection immunotherapy for optimal effectiveness
    Harold S Nelson
    Department of Medicine, National Jewish Health and University of Colorado School of Medicine, 1400 Jackson Street, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 31:211-26, viii. 2011
  5. doi request reprint Efficacy and safety of timothy grass allergy immunotherapy tablet treatment in North American adults
    Harold S Nelson
    Department of Medicine, Division of Allergy and Immunology, National Jewish Health, Denver, Colo, USA
    J Allergy Clin Immunol 127:72-80, 80.e1-2. 2011
  6. doi request reprint Effect of the inhaled corticosteroid mometasone on small airway patency in patients with asthma
    Harold S Nelson
    Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
    Allergy Asthma Proc 30:284-92. 2009
  7. doi request reprint Safety of formoterol in patients with asthma: combined analysis of data from double-blind, randomized controlled trials
    Harold Nelson
    National Jewish Health, Denver, CO80206, USA
    J Allergy Clin Immunol 125:390-396.e8. 2010
  8. doi request reprint Short-term safety of somatropin inhalation powder in adults with mild to moderate asthma
    Harold S Nelson
    Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
    Allergy Asthma Proc 30:325-32. 2009
  9. doi request reprint Specific immunotherapy with allergen mixes: what is the evidence?
    Harold S Nelson
    National Jewish Health, Denver, Colorado 80206, USA
    Curr Opin Allergy Clin Immunol 9:549-53. 2009
  10. ncbi request reprint Immunologic response to administration of standardized dog allergen extract at differing doses
    Anne M Lent
    Division of Allergy and Clinical Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 118:1249-56. 2006

Detail Information

Publications44

  1. ncbi request reprint Hydrofluoroalkane-134A beclomethasone or chlorofluorocarbon fluticasone: effect on small airways in poorly controlled asthma
    Torpong Thongngarm
    Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, 1400 Jackson St, Denver, CO 80206, USA
    J Asthma 42:257-63. 2005
    ....
  2. doi request reprint Subcutaneous immunotherapy versus sublingual immunotherapy: which is more effective?
    Harold S Nelson
    Department of Medicine, National Jewish Health and University of Colorado Denver School of Medicine, National Jewish Health, Denver, Colo Electronic address
    J Allergy Clin Immunol Pract 2:144-9. 2014
    ..In the limited number of randomized, head-to-head studies, SCIT has more often provided greater clinical and immunologic responses. However, head-to-head studies with well-defined effective doses by the 2 routes are urgently needed. ..
  3. doi request reprint Treatment of seasonal allergic rhinoconjunctivitis with a once-daily SQ-standardized grass allergy immunotherapy tablet
    Harold Nelson
    Department of Medicine, Division of Allergy and Immunology, National Jewish Health Center, Denver, CO 80206, USA
    Curr Med Res Opin 28:1043-51. 2012
    ..This review compares results from these trials...
  4. doi request reprint Subcutaneous injection immunotherapy for optimal effectiveness
    Harold S Nelson
    Department of Medicine, National Jewish Health and University of Colorado School of Medicine, 1400 Jackson Street, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 31:211-26, viii. 2011
    ....
  5. doi request reprint Efficacy and safety of timothy grass allergy immunotherapy tablet treatment in North American adults
    Harold S Nelson
    Department of Medicine, Division of Allergy and Immunology, National Jewish Health, Denver, Colo, USA
    J Allergy Clin Immunol 127:72-80, 80.e1-2. 2011
    ..Trials of sublingual formulations in North America are needed to confirm European efficacy and safety data...
  6. doi request reprint Effect of the inhaled corticosteroid mometasone on small airway patency in patients with asthma
    Harold S Nelson
    Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
    Allergy Asthma Proc 30:284-92. 2009
    ..M. and P.M. peak expiratory flows, and albuterol use. Mometasone delivered by a dry powder inhaler improved asthma control and pulmonary function in tests reflecting both large and small airways...
  7. doi request reprint Safety of formoterol in patients with asthma: combined analysis of data from double-blind, randomized controlled trials
    Harold Nelson
    National Jewish Health, Denver, CO80206, USA
    J Allergy Clin Immunol 125:390-396.e8. 2010
    ..Concerns exist that regular long-acting beta(2)-adrenergic agonist (LABA) therapy may increase the risk of serious asthma-related events...
  8. doi request reprint Short-term safety of somatropin inhalation powder in adults with mild to moderate asthma
    Harold S Nelson
    Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
    Allergy Asthma Proc 30:325-32. 2009
    ..Future studies of SIP may enroll subjects with mild to moderate asthma for longer-term evaluation of safety and efficacy...
  9. doi request reprint Specific immunotherapy with allergen mixes: what is the evidence?
    Harold S Nelson
    National Jewish Health, Denver, Colorado 80206, USA
    Curr Opin Allergy Clin Immunol 9:549-53. 2009
    ..The purpose is to review the published evidence for the use of multiallergen mixes in subcutaneous and sublingual immunotherapy...
  10. ncbi request reprint Immunologic response to administration of standardized dog allergen extract at differing doses
    Anne M Lent
    Division of Allergy and Clinical Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 118:1249-56. 2006
    ..The immunologic response to immunotherapy with dog extract is not well characterized...
  11. pmc Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study
    John M Brehm
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    J Allergy Clin Immunol 126:52-8.e5. 2010
    ..Vitamin D status might play a role in preventing asthma exacerbations...
  12. ncbi request reprint Long-acting beta-agonists in adult asthma: Evidence that these drugs are safe
    Harold S Nelson
    National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Prim Care Respir J 15:271-7. 2006
    ..Studies in subjects receiving combination therapy with LABAs plus ICSs suggest that, if anything, there is an enhanced anti-inflammatory action with the LABA/ICS combination superior to that achieved with ICS alone at the same dose...
  13. ncbi request reprint Dose dependence and time course of the immunologic response to administration of standardized cat allergen extract
    Anil Nanda
    Department of Medicine, National Jewish Medical Center, University of Colorado, Denver, CO 80206, USA
    J Allergy Clin Immunol 114:1339-44. 2004
    ..The highest dose containing 15 mug of Fel d 1 produced the most consistent and favorable response. It is unknown whether the comparative response on reaching a maintenance dose is maintained with long-term maintenance therapy...
  14. doi request reprint Response to sublingual immunotherapy with grass pollen extract: monotherapy versus combination in a multiallergen extract
    Sheila M Amar
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 124:150-156.e1-5. 2009
    ..To date, there have been no randomized, double-blind studies showing the effectiveness of sublingual immunotherapy with multiple allergens...
  15. ncbi request reprint Budesonide Turbuhaler delivered once daily improves health-related quality of life and maintains improvements with a stepped-down dose in adults with mild to moderate asthma
    Thomas B Casale
    Department of Medicine, Creighton University, Omaha, Nebraska 68131, USA
    Ann Allergy Asthma Immunol 90:323-30. 2003
    ..Budesonide inhalation powder administered via Turbuhaler (budesonide Turbuhaler, AstraZeneca LP, Wilmington, DE) is proven efficacious and safe in the treatment of mild to severe asthma...
  16. ncbi request reprint Cardiac safety profile of nebulized formoterol in adults with COPD: a 12-week, multicenter, randomized, double- blind, double-dummy, placebo- and active-controlled trial
    Harold S Nelson
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Clin Ther 29:2167-78. 2007
    ....
  17. pmc Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program
    Sunita Sharma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 122:921-928.e4. 2008
    ..Among asthmatic subjects, bronchodilator response (BDR) to inhaled beta(2)-adrenergic agonists is variable, and the significance of a consistent response over time is unknown...
  18. pmc In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma
    Robyn T Cohen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachussetts, USA
    J Allergy Clin Immunol 126:491-7. 2010
    ..Few studies have examined the effects of in utero smoke exposure (IUS) on lung function in children with asthma, and there are no published data on the impact of IUS on treatment outcomes in children with asthma...
  19. doi request reprint Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial
    William W Busse
    Department of Medicine, Section of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Am J Respir Crit Care Med 178:1002-8. 2008
    ..The mechanism of action likely involves inhibition of proinflammatory cytokine generation by IL-2R blockade in activated T cells. Clinical trial registered with www.clinicaltrials.gov (NCT00028288)...
  20. ncbi request reprint Is there a problem with inhaled long-acting beta-adrenergic agonists?
    Harold S Nelson
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 117:3-16; quiz 17. 2006
    ..This suggests that these outcomes were not a direct toxic effect of the drugs and increases the possibility that they resulted from an interaction between relief of symptoms by beta(2)-agonists and delay in seeking medical care...
  21. ncbi request reprint Efficacy and safety of fluticasone propionate 44 microg/salmeterol 21 microg administered in a hydrofluoroalkane metered-dose inhaler as an initial asthma maintenance treatment
    Harold S Nelson
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Ann Allergy Asthma Immunol 91:263-9. 2003
    ....
  22. ncbi request reprint The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol
    Harold S Nelson
    National Jewish Medical and Research Center, Denver, CO, USA
    Chest 129:15-26. 2006
    ..To compare the safety of salmeterol xinafoate or placebo added to usual asthma care...
  23. ncbi request reprint Advances in upper airway diseases and allergen immunotherapy
    Harold S Nelson
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 113:635-42. 2004
    ....
  24. ncbi request reprint Advances in upper airway diseases and allergen immunotherapy
    Harold S Nelson
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:676-84. 2005
    ..No symptom improvement was seen the first year, but symptoms were reduced the second year without further treatment...
  25. ncbi request reprint Advances in upper airway diseases and allergen immunotherapy
    Harold S Nelson
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 111:S793-8. 2003
    ..The latter, because of cross-reacting profilins, is often clinically irrelevant...
  26. doi request reprint Update on the safety of long-acting beta-agonists in combination with inhaled corticosteroids for the treatment of asthma
    Harold S Nelson
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Ann Allergy Asthma Immunol 102:11-5. 2009
    ....
  27. ncbi request reprint Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalers
    Harold S Nelson
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 112:29-36. 2003
    ..The coadministration of long-acting inhaled beta(2)-agonists and inhaled corticosteroids is the most effective treatment for persistent asthma...
  28. doi request reprint Multiallergen immunotherapy for allergic rhinitis and asthma
    Harold S Nelson
    Department of Medicine, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 123:763-9. 2009
    ..It is concluded that simultaneous administration of more than 1 allergen extract is clinically effective. However, more studies are needed, particularly with more than 2 allergen extracts and with sublingual administration...
  29. doi request reprint Mediator measurements after daily instillation of allergen: Increased IL-5 and decreased IFN-gamma
    Robert A McDermott
    Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Allergy Asthma Proc 29:146-51. 2008
    ..01) and a decrease in IFN-gamma (p = 0.02) at day 9. Daily instillation of moderate doses of allergen intranasally is characterized by persistent symptoms, elevation of IL-5, and reduced levels of IFN-gamma...
  30. ncbi request reprint Advances in upper airway diseases and allergen immunotherapy
    Harold S Nelson
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:872-80. 2007
    ....
  31. ncbi request reprint Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis
    Brenda J Guyer
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Allergy Asthma Proc 27:208-13. 2006
    ..Single-dose R112 appears safe and significantly reduces PGD2 but not histamine or tryptase release in response to allergen challenge in subjects with AR...
  32. ncbi request reprint Unresponsive wheezing to asthma therapy in a 32-year-old female
    Peck Y Ong
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
    Ann Allergy Asthma Immunol 90:199-202. 2003
    ..This will prevent unnecessary side effects of asthma therapy and provide prompt treatment for other diseases that may require urgent attention...
  33. ncbi request reprint A 47-year-old woman with progressive dyspnea and cough
    Sitesh R Roy
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Ann Allergy Asthma Immunol 88:364-9. 2002
  34. ncbi request reprint Prospects for antihistamines in the treatment of asthma
    Harold S Nelson
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 112:S96-100. 2003
    ..If higher doses are sedative, the addition of decongestants or leukotriene-receptor antagonists might enhance the effects of lower doses of the antihistamines...
  35. ncbi request reprint Preparing and mixing allergen vaccines
    Harold S Nelson
    National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Clin Allergy Immunol 18:457-79. 2004
  36. ncbi request reprint Combination therapy of long-acting beta agonists and inhaled corticosteroids in the management of chronic asthma
    Harold S Nelson
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Allergy Asthma Rep 5:123-9. 2005
    ..Also, at least for combination therapies including formoterol, adjustable dosing and perhaps even use as a rescue as well as a maintenance therapy may be possible...
  37. ncbi request reprint Allergen immunotherapy: where is it now?
    Harold S Nelson
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:769-79. 2007
    ....
  38. ncbi request reprint Advances in upper airway diseases and allergen immunotherapy
    Harold S Nelson
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 117:1047-53. 2006
    ..In addition, an update of the "Practice parameters on sinusitis" was published. The major focus in allergen immunotherapy continues to be sublingual administration...
  39. ncbi request reprint Efficacy and safety of allergen immunotherapy in children
    Harold S Nelson
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Ann Allergy Asthma Immunol 96:S2-5. 2006
    ..To determine the efficacy and safety of immunotherapy in children with allergic rhinitis and allergic asthma...
  40. pmc Evaluation of cytokines in nasal secretions after nasal antigen challenge: lack of influence of antihistamines
    Greg W Bensch
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Ann Allergy Asthma Immunol 88:457-62. 2002
    ..For this study we used filter paper as a matrix to collect nasal secretions in patients undergoing nasal antigen challenge...
  41. ncbi request reprint Measurement of changes in mRNA for IL-5 in noninvasive scrapings of nasal epithelium taken from patients undergoing nasal allergen challenge
    Stephen C Dreskin
    Department of Medicine, Division of Allergy, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box B164, Denver 80262, USA
    J Immunol Methods 268:189-95. 2002
    ..Furthermore, these changes can be measured quantitatively in very small amounts of tissue...
  42. doi request reprint Pain perception and performance of three devices for single-site allergen skin testing
    Harold S Nelson
    National Jewish Health, Denver, Colorado, USA
    Allergy Asthma Proc 35:63-5. 2014
    ..Testing with histamine revealed differences in wheal size and reproducibility among the three devices and testing with saline revealed differing likelihood of inducing a significantly sized wheal. ..
  43. ncbi request reprint A double-blind, placebo-controlled immunotherapy dose-response study with standardized cat extract
    Penelope A Ewbank
    National Jewish Medical and Research Center, Denver, Colo 80206, USA
    J Allergy Clin Immunol 111:155-61. 2003
    ..However, the maintenance doses used in allergy practice in the United States are often considerably less than this proven dose...
  44. ncbi request reprint A comparison of methods for assessing hypothalamic-pituitary-adrenal (HPA) axis activity in asthma patients treated with inhaled corticosteroids
    Harold S Nelson
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Clin Pharmacol 42:319-26. 2002
    ..Because it is noninvasive, salivary cortisol measurement offers distinct advantages as a screening method for detecting pronounced HPA axis suppression in asthma patients receiving corticosteroid therapy...