Astrid Nehlig

Summary

Publications

  1. pmc The neuroprotective effects of cocoa flavanol and its influence on cognitive performance
    Astrid Nehlig
    Faculty of Medicine, INSERM U 666, Strasbourg, France
    Br J Clin Pharmacol 75:716-27. 2013
  2. doi request reprint Hippocampal MRI and other structural biomarkers: experimental approach to epileptogenesis
    Astrid Nehlig
    INSERM U 666, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Biomark Med 5:585-97. 2011
  3. doi request reprint Is caffeine a cognitive enhancer?
    Astrid Nehlig
    INSERM U 666, Faculty of Medicine, UDS, Strasbourg Cedex, France
    J Alzheimers Dis 20:S85-94. 2010
  4. ncbi request reprint Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model
    Véronique André
    INSERM U 398, 405 and 666, Strasbourg, France
    Epilepsia 48:41-7. 2007
  5. ncbi request reprint The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats
    Ryosuke Hanaya
    INSERM U666, Strasbourg, France
    Neurobiol Dis 31:451-8. 2008
  6. ncbi request reprint Long-term pregabalin treatment protects basal cortices and delays the occurrence of spontaneous seizures in the lithium-pilocarpine model in the rat
    Véronique André
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Epilepsia 44:893-903. 2003
  7. ncbi request reprint Attention and executive functions in a rat model of chronic epilepsy
    Jean Baptiste Faure
    Laboratory of Cognitive and Adaptive Neuroscience LNCA, Faculty of Psychology, UMR 7364 University of Strasbourg CNRS, Strasbourg, France Faculty of Medicine, INSERM U 666, Strasbourg, France
    Epilepsia 55:644-53. 2014
  8. doi request reprint Neurobehavioral maturation of offspring from epileptic dams: study in the rat lithium-pilocarpine model
    Emmanuel Raffo
    INSERM U 398, Faculty of Medicine, Strasbourg, France
    Exp Neurol 219:414-23. 2009
  9. ncbi request reprint Prolonged low-dose caffeine exposure protects against hippocampal damage but not against the occurrence of epilepsy in the lithium-pilocarpine model in the rat
    Marie Aude Rigoulot
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Epilepsia 44:529-35. 2003
  10. ncbi request reprint Time course and mapping of cerebral perfusion during amygdala secondarily generalized seizures
    Serge Chassagnon
    INSERM U 398, Faculty of Medicine, Strasbourg, France
    Epilepsia 46:1178-87. 2005

Collaborators

Detail Information

Publications47

  1. pmc The neuroprotective effects of cocoa flavanol and its influence on cognitive performance
    Astrid Nehlig
    Faculty of Medicine, INSERM U 666, Strasbourg, France
    Br J Clin Pharmacol 75:716-27. 2013
    ..The present review intends to review the data available on the effects of cocoa and chocolate on brain health and cognitive abilities...
  2. doi request reprint Hippocampal MRI and other structural biomarkers: experimental approach to epileptogenesis
    Astrid Nehlig
    INSERM U 666, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Biomark Med 5:585-97. 2011
    ....
  3. doi request reprint Is caffeine a cognitive enhancer?
    Astrid Nehlig
    INSERM U 666, Faculty of Medicine, UDS, Strasbourg Cedex, France
    J Alzheimers Dis 20:S85-94. 2010
    ..In conclusion, it appears that caffeine cannot be considered a ;pure' cognitive enhancer. Its indirect action on arousal, mood and concentration contributes in large part to its cognitive enhancing properties...
  4. ncbi request reprint Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model
    Véronique André
    INSERM U 398, 405 and 666, Strasbourg, France
    Epilepsia 48:41-7. 2007
    ..Pharmacological protection of the basal cortices is necessary for a beneficial disease-modifying effect but this must be combined with protection of the hippocampus to prevent epileptogenesis in this model of TLE...
  5. ncbi request reprint The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats
    Ryosuke Hanaya
    INSERM U666, Strasbourg, France
    Neurobiol Dis 31:451-8. 2008
    ..The genetic background underlying the expression of audiogenic seizures sensitizes strongly the rats to a further insult and compromises their survival...
  6. ncbi request reprint Long-term pregabalin treatment protects basal cortices and delays the occurrence of spontaneous seizures in the lithium-pilocarpine model in the rat
    Véronique André
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Epilepsia 44:893-903. 2003
    ....
  7. ncbi request reprint Attention and executive functions in a rat model of chronic epilepsy
    Jean Baptiste Faure
    Laboratory of Cognitive and Adaptive Neuroscience LNCA, Faculty of Psychology, UMR 7364 University of Strasbourg CNRS, Strasbourg, France Faculty of Medicine, INSERM U 666, Strasbourg, France
    Epilepsia 55:644-53. 2014
    ..In the rat lithium-pilocarpine temporal lobe epilepsy model, memory impairment and anxiety disorder are classically reported. Here we evaluated sustained visual attention in this model of epilepsy, a function not frequently explored...
  8. doi request reprint Neurobehavioral maturation of offspring from epileptic dams: study in the rat lithium-pilocarpine model
    Emmanuel Raffo
    INSERM U 398, Faculty of Medicine, Strasbourg, France
    Exp Neurol 219:414-23. 2009
    ..This indicates that the exposure to seizures during pregnancy is not harmful for the development of the fetus...
  9. ncbi request reprint Prolonged low-dose caffeine exposure protects against hippocampal damage but not against the occurrence of epilepsy in the lithium-pilocarpine model in the rat
    Marie Aude Rigoulot
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Epilepsia 44:529-35. 2003
    ..We explored whether the exposure to a low long-term dose of caffeine could protect the brain from neuronal damage and epileptogenesis in the lithium-pilocarpine model of temporal lobe epilepsy...
  10. ncbi request reprint Time course and mapping of cerebral perfusion during amygdala secondarily generalized seizures
    Serge Chassagnon
    INSERM U 398, Faculty of Medicine, Strasbourg, France
    Epilepsia 46:1178-87. 2005
    ....
  11. ncbi request reprint The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy
    Jennifer Francois
    INSERM U666, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Epilepsy Res 72:147-63. 2006
    ..In conclusion, although DZP-TPM treatment was able to partially protect two areas critical for epileptogenesis, the hippocampus and ventral entorhinal cortex, it was not sufficient to prevent epileptogenesis...
  12. ncbi request reprint Effects of carisbamate (RWJ-333369) in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS
    Jennifer Francois
    INSERM U 398 and 666, Strasbourg, France
    Epilepsia 49:393-9. 2008
    ....
  13. doi request reprint A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus
    Jean Baptiste Faure
    Faculty of Medicine, INSERM U 666, Strasbourg, France
    Epilepsia 54:1203-13. 2013
    ..To assess whether these carisbamate-induced changes affected comorbidity, we used a large battery of behavioral tests in rats that had developed temporal lobe or absence-like seizures...
  14. ncbi request reprint In the lithium-pilocarpine model of epilepsy, brain lesions are not linked to changes in blood-brain barrier permeability: an autoradiographic study in adult and developing rats
    Claire Leroy
    INSERM U 398, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg, Cedex, France
    Exp Neurol 182:361-72. 2003
    ....
  15. ncbi request reprint A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats
    Julien Detour
    INSERM U398, Faculty of Medicine, Strasbourg, France
    Epilepsia 46:499-508. 2005
    ..In temporal lobe epilepsy (TLE), interictal behavioral disorders affect patients' quality of life. Therefore we studied long-term behavioral impairments in the lithium-pilocarpine (li-pilo) model of TLE...
  16. pmc Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat
    Claire Leroy
    INSERM U398, Strasbourg, France
    Neurobiol Dis 43:588-97. 2011
    ..The changes in nutrient transporter expression reported here further support previous findings in other experimental models demonstrating rapid transcriptional responses to marked changes in cerebral energetic/glucose demand...
  17. doi request reprint Selective reorganization of GABAergic transmission in neonatal ventral hippocampal-lesioned rats
    Jennifer Francois
    INSERM U666, University Louis Pasteur, Strasbourg, France
    Int J Neuropsychopharmacol 12:1097-110. 2009
    ....
  18. ncbi request reprint Optimal window for ictal blood flow mapping. Insight from the study of discrete temporo-limbic seizures in rats
    Serge Chassagnon
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Epilepsy Res 69:100-18. 2006
    ....
  19. ncbi request reprint EAAC1 glutamate transporter expression in the rat lithium-pilocarpine model of temporal lobe epilepsy
    Brigitte Voutsinos-Porche
    INSERM U 666, Faculty of Medicine, Strasbourg, France
    J Cereb Blood Flow Metab 26:1419-30. 2006
    ..It is, however, not clear to what extent the overexpression of EAAC1 contributes to epileptogenesis and in which area it may represent a preventive or compensatory or response to injury...
  20. ncbi request reprint Role of nitric oxide in cerebral blood flow changes during kainate seizures in mice: genetic and pharmacological approaches
    Anne Pereira de Vasconcelos
    INSERM U 398, Faculte de Medecine, 67085 Strasbourg Cedex, France
    Neurobiol Dis 18:270-81. 2005
    ..Neuronal NO appears to be not involved in the cerebrovascular response within the epileptic focus, but may rather have a role in the maintenance of distant LCBF regulation during seizures...
  21. ncbi request reprint Developmental characteristics of picrotoxin-induced convulsions in rats with genetic absence epilepsy
    Marguerite Vergnes
    INSERM U 398, Faculty of Medicine, 11 rue Humann, 67085, Strasbourg Cedex, France
    Exp Neurol 184:549-51. 2003
    ..After 40 days of age, GAERS appeared definitely more prone than NERs to convulse in response to picrotoxin injection. A developmental imbalance in excitation/inhibition may parallel the occurrence of SWDs...
  22. doi request reprint Metabolic activity in the brain of juvenile and adult rats with a neonatal ventral hippocampal lesion
    Jennifer Francois
    INSERM U 666, University Louis Pasteur, Strasbourg, France
    Hippocampus 20:841-51. 2010
    ....
  23. pmc The ketogenic diet has no effect on the expression of spike-and-wave discharges and nutrient transporters in genetic absence epilepsy rats from Strasbourg
    Astrid Nehlig
    INSERM U398, Strasbourg, France
    J Neurochem 109:207-13. 2009
    ..This report extends the observation in humans that the KD does not appear to show effectiveness in intractable atypical absence epilepsy to this model of typical childhood absence epilepsy which responds to specific antiepileptic drugs...
  24. ncbi request reprint Calorie-restricted ketogenic diet increases thresholds to all patterns of pentylenetetrazol-induced seizures: critical importance of electroclinical assessment
    Emmanuel Raffo
    INSERM U 666, 67085 Strasbourg, France
    Epilepsia 49:320-8. 2008
    ..Thresholds to pentylenetetrazol (PTZ) seizures were usually based only on clinical symptoms. Our purpose was to use electroclinical patterns to assess the efficacy of a ketogenic and/or calorie-restricted diet on PTZ-induced seizures...
  25. ncbi request reprint Ictal and interictal perfusion variations measured by SISCOM analysis in typical childhood absence seizures
    Astrid Nehlig
    INSERM U398, Strasbourg, France
    Epileptic Disord 6:247-53. 2004
    ..Our data are concordant with the hypothesis that neuronal activity underlying the occurrence of spike-and-wave discharges does not seem to require an increase in metabolic demand and blood flow rates. [Published with videosequences]...
  26. ncbi request reprint Role of endothelial nitric oxide synthase in cerebral blood flow changes during kainate seizures: a genetic approach using knockout mice
    Anne Pereira de Vasconcelos
    INSERM U 398, Faculte de Medecine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Neurobiol Dis 23:219-27. 2006
    ..Thus, endothelial NO is the mediator of the cerebrovascular response within the epileptic focus and participates in the maintenance of LCBF in distant areas...
  27. ncbi request reprint Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model
    Catherine Roch
    UMR 7004 ULP CNRS IFR37, Institut de Physique Biologique, Faculte de Medecine, and INSERM U398, Faculte de Medecine, Strasbourg, France
    Epilepsia 43:1129-36. 2002
    ..Thus with magnetic resonance imaging (MRI), we explored the differences in the evolution of lesions in these two populations of rats...
  28. pmc Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy
    Claire Leroy
    Psychopathologie et Pharmacologie de la Cognition, INSERM U405, Strasbourg, France
    J Physiol 557:473-87. 2004
    ..The failure of benzodiazepine and neurosteroid to potentiate inhibition early after SE may be a critical factor in the development of epileptogenesis and occurrence of seizures...
  29. ncbi request reprint Dissociation of the immunoreactivity of synaptophysin and GAP-43 during the acute and latent phases of the lithium-pilocarpine model in the immature and adult rat
    Ryosuke Hanaya
    INSERM U405, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Exp Neurol 204:720-32. 2007
    ..The process of reorganization in regions with neuronal damage is not fully clarified...
  30. ncbi request reprint Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy
    Brigitte Voutsinos-Porche
    INSERM U405, Faculty of Medicine, Strasbourg, France
    Neurobiol Dis 17:385-402. 2004
    ..These data suggest that seizure-related IL1-beta, NF-kappaB, and COX-2 expression may contribute to the pathophysiology of epilepsy by inducing neuronal death and astrocytic activation...
  31. ncbi request reprint What is animal experimentation telling us about new drug treatments of status epilepticus?
    Astrid Nehlig
    INSERM U 666, Faculty of Medicine, Strasbourg, France
    Epilepsia 48:78-81. 2007
    ..At this point, many data are still missing, namely which drugs could efficiently stop SE or which mechanisms of action should be searched for to prevent the harmful consequences of SE...
  32. pmc Deletion of the STOP gene, a microtubule stabilizing factor, leads only to discrete cerebral metabolic changes in mice
    Ryosuke Hanaya
    INSERM U 666, Strasbourg, France
    J Neurosci Res 86:813-20. 2008
    ..These data might reflect hyperdopaminergic activity, olfactory deficits, and sleep disturbances in STOP-KO mice that have also been reported in schizophrenic patients...
  33. ncbi request reprint Pentylenetetrazol-induced status epilepticus up-regulates the expression of glucose transporter mRNAs but not proteins in the immature rat brain
    Astrid Nehlig
    INSERM U 666, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Brain Res 1082:32-42. 2006
    ..These data show that acute pentylenetetrazol seizures induce a rapid up-regulation of the GLUT1 and GLUT3 mRNAs, but do not result in measurable increases in protein levels, suggesting translational regulation...
  34. ncbi request reprint Selective uptake of [14C]2-deoxyglucose by neurons and astrocytes: high-resolution microautoradiographic imaging by cellular 14C-trajectography combined with immunohistochemistry
    Astrid Nehlig
    INSERM U 398, University Louis Pasteur, Faculty of Medicine, Strasbourg, France
    J Cereb Blood Flow Metab 24:1004-14. 2004
    ..0% were localized in astrocytes on GFAP-labeled sections and 60.1% in neurons on MAP2-labeled sections. These data represent the first in vivo evidence of the compartmentation of uptake and metabolism of glucose in neurons and astrocytes...
  35. ncbi request reprint Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures
    Astrid Nehlig
    Faculte de Medecine, INSERM U 398, University Louis Pasteur, 11 rue Humann, 67085 Strasbourg Cedex, France
    Epilepsy Res 51:189-97. 2002
    ..Thus, SE induced by lithium and pilocarpine early in life does not change the sensitivity to limbic seizures or seizures induced by GABA(A) antagonists during adulthood...
  36. ncbi request reprint Effects of topiramate in two models of genetically determined generalized epilepsy, the GAERS and the Audiogenic Wistar AS
    Marie Aude Rigoulot
    INSERM U 398, Faculty of Medicine, Strasbourg, France
    Epilepsia 44:14-9. 2003
    ....
  37. doi request reprint Carisbamate has powerful disease-modifying effects in the lithium-pilocarpine model of temporal lobe epilepsy
    Jennifer Francois
    InsermU666, University Louis Pasteur Faculty of Medicine, 11 rue Humann, 67085 Strasbourg Cedex, France
    Neuropharmacology 61:313-28. 2011
    ..In conclusion, carisbamate is able to induce strong neuroprotection and affect the nature of epileptogenic events occurring during and after lithium-pilocarpine status epilepticus, reflecting marked insult- and disease-modifying effects...
  38. doi request reprint NIRS-measured oxy- and deoxyhemoglobin changes associated with EEG spike-and-wave discharges in a genetic model of absence epilepsy: the GAERS
    Nadege Roche-Labarbe
    GRAMFC, EA 4293, Faculty of Medicine, University of Picardy, Amiens, France
    Epilepsia 51:1374-84. 2010
    ..We hypothesized that conflicting results from other techniques might be due to the averaging of a biphasic response such as the one we described in children...
  39. ncbi request reprint Cellular pathways of energy metabolism in the brain: is glucose used by neurons or astrocytes?
    Astrid Nehlig
    INSERM U 666, Faculty of Medicine, Strasbourg, France
    Glia 55:1238-50. 2007
    ..Finally, the sequence of metabolic changes occurring during a transient increase of electrical activity in specific regions of the brain remains to be clarified...
  40. ncbi request reprint Magnetic resonance imaging in the study of the lithium-pilocarpine model of temporal lobe epilepsy in adult rats
    Catherine Roch
    Institut de Physique Biologique UMR 7004 ULP CNRS IFR37, Faculte de Medecine, 4 rue Kirschleger, 67085 Strasbourg Cedex, France
    Epilepsia 43:325-35. 2002
    ....
  41. ncbi request reprint Effects of remacemide in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS
    Astrid Nehlig
    INSERM U 398, Faculty of Medicine, 11 rue Humann, 67085 Cedex, Strasbourg, France
    Epilepsy Res 52:253-61. 2003
    ..The present results support the effects of remacemide in tonic/clonic seizure, which was the first target of the drug, and confirm the effect of the anticonvulsant on absence seizures...
  42. pmc SPECT assessment of brain activation induced by caffeine: no effect on areas involved in dependence
    Astrid Nehlig
    INSERM U666, Strasbourg, France
    Dialogues Clin Neurosci 12:255-63. 2010
    ....
  43. ncbi request reprint Basal levels of metabolic activity are elevated in Genetic Absence Epilepsy Rats from Strasbourg (GAERS): measurement of regional activity of cytochrome oxidase and lactate dehydrogenase by histochemistry
    Franck Dufour
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Exp Neurol 182:346-52. 2003
    ..However, they still do not allow us to understand why the ubiquitous mutation(s) generates spike-and-wave discharges only in the thalamocortical circuit...
  44. pmc Loss of STOP protein impairs peripheral olfactory neurogenesis
    Karelle Benardais
    INSERM U666, Strasbourg, France
    PLoS ONE 5:e12753. 2010
    ..Experimentally-induced loss of olfactory neurons leads to epithelial regeneration within two months, providing a useful model to evaluate the role played by STOP protein in adult olfactory neurogenesis...
  45. ncbi request reprint Brain uptake and metabolism of ketone bodies in animal models
    Astrid Nehlig
    INSERM U 405, Faculty of Medicine, 11, rue Humann, 67085 Strasbourg Cedex, France
    Prostaglandins Leukot Essent Fatty Acids 70:265-75. 2004
    ....
  46. ncbi request reprint Dynamic variations of local cerebral blood flow in maximal electroshock seizures in the rat
    Véronique André
    INSERM U398, Universite Louis Pasteur, Strasbourg, France
    Epilepsia 43:1120-8. 2002
    ....
  47. ncbi request reprint Local cerebral blood flow during lithium-pilocarpine seizures in the developing and adult rat: role of coupling between blood flow and metabolism in the genesis of neuronal damage
    Anne Pereira de Vasconcelos
    Faculty of Medicine, Institut National de la Sante et de la Recherche Medicale, Strasbourg, France
    J Cereb Blood Flow Metab 22:196-205. 2002
    ..Thus, the level of coupling between blood flow supply and metabolism is not involved in seizure-related brain damage in the developing brain, which appears to be resistant to the consequences of such a mismatch...