KarpaviÄienÄ— I, ValiulienÄ— G, RaÅ¡keviÄius V, LebedytÄ— I, BrukÅ¡tus A, Kairys V, et al
. Synthesis and antiproliferative activity of Î±-branched Î±,Î²-unsaturated ketones in human hematological and solid cancer cell lines. Eur J Med Chem. 2015;98:30-48 pubmed publisher
..6Â Î¼M against the hematological cell line and did not cause apoptosis, but blocked cell cycle in G0/G1. Moreover, it was demonstrated that this compound enhances and accelerates retinoic acid induced granulocytic differentiation. ..
Savickiene J, Treigyte G, Stirblyte I, Valiuliene G, Navakauskiene R. Euchromatic histone methyltransferase 2 inhibitor, BIX-01294, sensitizes human promyelocytic leukemia HL-60 and NB4 cells to growth inhibition and differentiation. Leuk Res. 2014;38:822-9 pubmed publisher
..Our results suggest that targeting EHMT2 may be of therapeutical benefits in myeloid leukemia. ..
Vitkeviciene A, Baksiene S, Borutinskaite V, Navakauskiene R. Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. Eur J Pharmacol. 2018;838:32-40 pubmed publisher
BorutinskaitÄ— V, NavakauskienÄ— R. The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming. Int J Mol Sci. 2015;16:18252-69 pubmed publisher
..Based on these and other findings from our group, we suggest that HDACIs, like BML-210, can be promising anticancer agents in promyelocytic leukemia treatment. ..
Navakauskiene R, Treigyte G, Borutinskaite V, Matuzevičius D, Navakauskas D, Magnusson K. Alpha-Dystrobrevin and its associated proteins in human promyelocytic leukemia cells induced to apoptosis. J Proteomics. 2012;75:3291-303 pubmed publisher
Navakauskiene R, Borutinskaite V, Treigyte G, Savickiene J, Matuzevičius D, Navakauskas D, et al
. Epigenetic changes during hematopoietic cell granulocytic differentiation--comparative analysis of primary CD34+ cells, KG1 myeloid cells and mature neutrophils. BMC Cell Biol. 2014;15:4 pubmed publisher
..These findings also suggest them as potentially important biomarkers of hematopoietic cell granulocytic differentiation and could be valuable for leukemia induced differentiation therapy. ..
Valiuliene G, Treigyte G, Savickiene J, Matuzevičius D, Alksnė M, Jarasiene Burinskaja R, et al
. Histone modifications patterns in tissues and tumours from acute promyelocytic leukemia xenograft model in response to combined epigenetic therapy. Biomed Pharmacother. 2016;79:62-70 pubmed publisher
..In summary, the effects of epigenetic agents used in this study were positive for leukemia prevention and linked to a modulation of the chromatin epigenetic environment in adult tissues of malignant organism. ..
Valiuliene G, Stirblyte I, Jasnauskaitė M, Borutinskaite V, Navakauskiene R. Anti-leukemic effects of HDACi Belinostat and HMTi 3-Deazaneplanocin A on human acute promyelocytic leukemia cells. Eur J Pharmacol. 2017;799:143-153 pubmed publisher
..Summarizing, these findings indicate that combined treatment with RA, Belinostat and 3-Deazaneplanocin A is an effective epigenetic inducer for leukemia cell differentiation. ..