Shaik Mohammad Naushad



  1. Kadali S, Madalasa T, Reddy G, Naushad S. Utility of amniotic fluid chitotriosidase in the prenatal diagnosis of lysosomal storage disorders. Clin Biochem. 2018;: pubmed publisher
    ..33?±?21.59?nmol/h/ml) showed very high levels of chitotriosidase. Amniotic fluid chitotriosidase has the potential to serve as a diagnostic marker for lysosomal storage disorders, more specifically for Gaucher and Niemann-Pick A/B. ..
  2. Naushad S, Vijayalakshmi S, Rupasree Y, Kumudini N, Sowganthika S, Naidu J, et al. Multifactor dimensionality reduction analysis to elucidate the cross-talk between one-carbon and xenobiotic metabolic pathways in multi-disease models. Mol Biol Rep. 2015;42:1211-24 pubmed publisher
    ..63). Cross-talk between one-carbon and xenobiotic pathways was observed in diseases with female preponderance. Gene-gene interactions within one-carbon metabolic pathway were observed in diseases with male preponderance. ..
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    Hussain T, Alrokayan S, Upasna U, Pavithrakumari M, Jayapriya J, Kutala V, et al. Meta-analysis of genetic polymorphisms in xenobiotic metabolizing enzymes and their association with breast cancer risk. J Genet. 2018;97:523-537 pubmed
    ..Cochrane Q-test and I² statistics revealed heterogeneity in association with these polymorphisms (P< 0.0001) with no evidence of publication bias. Thus, GSTT1 and GSTM1 null polymorphisms are risk factors for breast cancer. ..
  4. Naushad S, Shree Divyya P, Janaki Ramaiah M, Alex Stanley B, Prasanna Lakshmi S, Vishnupriya J, et al. Clinical utility of genetic variants of glutamate carboxypeptidase II in predicting breast cancer and prostate cancer risk. Cancer Genet. 2015;208:552-8 pubmed publisher
    ..7% of the variability, respectively. Thus, GCPII variants are potential contributors of risk toward breast cancer and prostate cancer. Risk modulation appeared to be mediated through changes in the expression of FOLH1 and PSMA. ..
  5. Naushad S, Ramaiah M, Pavithrakumari M, Jayapriya J, Hussain T, Alrokayan S, et al. Artificial neural network-based exploration of gene-nutrient interactions in folate and xenobiotic metabolic pathways that modulate susceptibility to breast cancer. Gene. 2016;580:159-68 pubmed publisher
    ..Dietary intake of folate appears to confer protection against breast cancer through its modulating effects on ER and PR expression and methylation of EC-SOD and BRCA1. ..
  6. Naushad S, Janaki Ramaiah M, Stanley B, Prasanna Lakshmi S, Vishnu Priya J, Hussain T, et al. In silico approaches to identify the potential inhibitors of glutamate carboxypeptidase II (GCPII) for neuroprotection. J Theor Biol. 2016;406:137-42 pubmed publisher
    ..Being a NAAG-analogue, this molecule might confer neuroprotection by inhibiting glutamatergic neurotransmission mediated by N-acetylated alpha-linked acidic dipeptidase (NAALADase), a splice variant of GCPII. ..
  7. Naushad S, Divya C, Janaki Ramaiah M, Hussain T, Alrokayan S, Kutala V. Population-level diversity in the association of genetic polymorphisms of one-carbon metabolism with breast cancer risk. J Community Genet. 2016;7:279-290 pubmed
    ..Dietary patterns and altitudinal variations are the likely risk modulators that are contributing toward ethnic- and population-level variations in genetic associations. ..
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    Naushad S, Rama Devi A, Nivetha S, Lakshmitha G, Stanley A, Hussain T, et al. Neuro-fuzzy model of homocysteine metabolism. J Genet. 2017;96:919-926 pubmed
    ..The restoration of one-carbon homeostasis by SHMT1 C1420T or increased flux of folate towards remethylation due to TYMS 5'-UTR 28 bp tandem repeat or nonvegetarian diet can lower homocysteine levels. ..
  9. Mohammad N, Jain J, Chintakindi K, Singh R, Naik U, Akella R. Aberrations in folate metabolic pathway and altered susceptibility to autism. Psychiatr Genet. 2009;19:171-6 pubmed publisher
    ..MTHFR C677T is a risk factor, whereas MTRR A66G and SHMT C1420T polymorphisms reduce risk for autism. MTHFR A1298C acts additively in increasing the risk for autism. ..

More Information


  1. Naushad S, Devi A. Role of parental folate pathway single nucleotide polymorphisms in altering the susceptibility to neural tube defects in South India. J Perinat Med. 2010;38:63-9 pubmed publisher
    ..26, 95% CI: 2.01-9.09, P<0.001). Maternal MTHFR C677T and parental GCP II C1561T polymorphisms are associated with increased risk for NTDs. Apart from individual genetic effects, epistatic interactions were also observed. ..