Model systems for the discovery and development of antiarrhythmic drugsStanley Nattel
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, Quebec, H1T 1C8 Canada
Prog Biophys Mol Biol 98:328-39. 2008
..It is hoped that the new technologies now available and the recently-developed models for arrhythmia-response assessment will permit the introduction of newer and more effective antiarrhythmic therapies in the near future...
Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atriumPeter Melnyk
Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
Cardiovasc Res 65:104-16. 2005
..3 in pulmonary veins and differential pulmonary vein subcellular distribution of Kir2.3, ERG and KvLQT1 subunits may contribute to ionic current differences between pulmonary vein and left atrial cardiomyocytes...
- Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome
Yung Hsin Yeh
Department of Medicine, Montreal Heart Institute Research Center and Université de Montréal, Montreal, Quebec, Canada
Circulation 119:1576-85. 2009
..This study examined the hypothesis that ATs impair SAN function by altering ion channel expression...
- The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome
Xiaoyan Qi
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
Circ Arrhythm Electrophysiol 2:295-304. 2009
..We addressed the importance of altered Ca(2+) handling, studying underlying mechanisms and consequences...
- Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure
Yung Hsin Yeh
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
Circ Arrhythm Electrophysiol 1:93-102. 2008
..Focal sources of unknown mechanism have been described in CHF-related atrial fibrillation. The authors hypothesized that abnormal calcium (Ca(2+)) handling contributes to the CHF-related atrial arrhythmogenic substrate...
- Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure
Brett Burstein
Department of Medicine and Physiology Institute of Biomedical Engineering, Research Center Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada
Circ Res 105:1213-22. 2009
..Although connexin changes are important for the ventricular arrhythmic substrate in congestive heart failure (CHF), connexin alterations during CHF-related atrial arrhythmogenic remodeling have received limited attention...
- Mechanisms of atrial fibrillation termination by rapidly unbinding Na+ channel blockers: insights from mathematical models and experimental correlates
Philippe Comtois
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
Am J Physiol Heart Circ Physiol 295:H1489-504. 2008
..These results provide new insights into the mechanisms by which rapidly unbinding class I antiarrhythmic agents, a class including several novel compounds of considerable promise, terminate AF...
- Atrial ionic remodeling induced by atrial tachycardia in the presence of congestive heart failure
Tae-Joon Cha
Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
Circulation 110:1520-6. 2004
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- Marked differences between atrial and ventricular gene-expression remodeling in dogs with experimental heart failure
Sophie Cardin
Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
J Mol Cell Cardiol 45:821-31. 2008
..VTP-induced CHF causes dramatically more gene-expression changes in LA than LV, dynamically altering the LA-LV differential gene-expression pattern. These results are relevant to understanding chamber-specific remodeling in CHF...
- Ion channel subunit expression changes in cardiac Purkinje fibers: a potential role in conduction abnormalities associated with congestive heart failure
Ange Maguy
Department of Medicine, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
Circ Res 104:1113-22. 2009
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- Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia
Masao Sakabe
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger St E, Montreal, Quebec, Canada H1T 1C8
Cardiovasc Res 78:63-70. 2008
..This study addressed the effects of geranylgeranylacetone (GGA), an orally active HSP inducer, on the atrial fibrillation (AF) substrate associated with acute atrial ischaemia (AI)...
- Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure
Akiko Shiroshita Takeshita
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Canada
Cardiovasc Res 74:75-84. 2007
..We evaluated the effects of simvastatin (antioxidant, anti-inflammatory) and fenofibrate (PPAR-alpha activator) on CHF-related atrial remodeling...
- Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling
Brett Burstein
Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
Cardiovasc Res 76:442-52. 2007
..This study investigated the hypothesis that rapid atrial cardiomyocyte activation produces factors that influence atrial fibroblast proliferation and secretory functions...
- Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes
Ling Xiao
Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
Circ Res 103:733-42. 2008
..We conclude that tachycardia downregulates I to expression, with the Ca2+/calmodulin-dependent CaMKII and calcineurin/NFAT systems playing key Ca2+-sensing and signal-transducing roles in rate-dependent I to control...
- Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure
Tae Joon Cha
5000 Belanger St East, Montreal, Quebec, H1T 1C8, Canada
Circulation 109:412-8. 2004
..The relative importance of ionic versus structural remodeling in CHF-related atrial fibrillation (AF) is controversial...
- Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome
Thomas G Diness
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
Cardiovasc Res 79:61-9. 2008
..This study sought to evaluate the antiarrhythmic effect of a novel compound (NS1643) that activates the rapid delayed-rectifier K+ current, I(Kr), in two rabbit models of acquired LQTS...
- Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling
Samy Makary
Department of Medicine and Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
Circ Res 109:1031-43. 2011
..The underlying mechanisms are unknown...
- Omega-3 polyunsaturated fatty acids prevent atrial fibrillation associated with heart failure but not atrial tachycardia remodeling
Masao Sakabe
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
Circulation 116:2101-9. 2007
..There is epidemiological evidence that omega-3 polyunsaturated fatty acids (PUFAs) reduce the risk of atrial fibrillation (AF), but clinical data are conflicting. The present study assessed the effects of PUFA on AF in experimental models...
- Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes
Yung Hsin Yeh
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada, and First Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University, Tao Yuan, Taiwan
Cardiovasc Res 74:406-15. 2007
..Adrenergic stimulation favors atrial arrhythmogenesis but its effects on IKH are poorly understood...
- Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs
Reza Wakili
Department of Medicine and Research Center, Universite de Montreal, Montreal, Quebec, Canada
Circ Arrhythm Electrophysiol 3:530-41. 2010
..Action potential (AP)-prolonging drugs are reported to normalize atrial hypocontractility caused by atrial tachycardia remodeling (ATR). Here, we addressed the role of AP duration (APD) changes in ATR-induced hypocontractility...
- Contrasting gene expression profiles in two canine models of atrial fibrillation
Sophie Cardin
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
Circ Res 100:425-33. 2007
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- Comparison of Ca2+-handling properties of canine pulmonary vein and left atrial cardiomyocytes
Pierre Coutu
Research Center, Montreal Heart Institute, 5000 Belanger St. East, Montreal, Quebec, Canada
Am J Physiol Heart Circ Physiol 291:H2290-300. 2006
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- Atrial tachycardia remodeling of pulmonary vein cardiomyocytes: comparison with left atrium and potential relation to arrhythmogenesis
Tae-Joon Cha
Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
Circulation 111:728-35. 2005
..PVs are not essential for AT-induced atrial tachyarrhythmia promotion in this model, which may relate to the failure of PV isolation to prevent AF in some patient populations...
- Sex-based transmural differences in cardiac repolarization and ionic-current properties in canine left ventricles
Ling Xiao
Department of Pharmacology and Therapeutics, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
Am J Physiol Heart Circ Physiol 291:H570-80. 2006
..3 +/- 0.3 pA/pF; endocarium: -4.5 +/- 0.4 vs. -3.2 +/- 0.3 pA/pF; P < 0.05 for each). We conclude that there are sex-based transmural differences in ionic currents that may underlie sex differences in transmural cardiac repolarization...
- A high-fat diet increases risk of ventricular arrhythmia in female rats: enhanced arrhythmic risk in the absence of obesity or hyperlipidemia
Marie Claude Aubin
Department of Pharmacology, Universite de Montreal, Montreal, Quebec, Canada
J Appl Physiol 108:933-40. 2010
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- Feedback remodeling of cardiac potassium current expression: a novel potential mechanism for control of repolarization reserve
Ling Xiao
Department of Medicine, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
Circulation 118:983-92. 2008
..Accordingly, we assessed the effects of sustained inhibition of one K(+) current on various other cardiac ionic currents...
Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atriumJoachim R Ehrlich
Department of Medicine, University of Montral, Montreal, Quebec, Canada
J Physiol 557:583-97. 2004
..8 +/- 0.3 to -4.5 +/- 0.5 pA pF(-1), P < 0.01). We conclude that I(KH) is a time-dependent, hyperpolarization-activated K(+) current that likely involves Kir3 subunits and appears to play a significant role in atrial physiology...
- Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice
Khai Le Quang
Research Center and Departments of Medicine, Université de Montréal and Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec, Canada
Cardiovasc Res 91:420-8. 2011
..To clarify the role of I(CaT) in cardiac remodelling, we studied mice with either of the principal cardiac I(CaT)-subunits (Cav3.1 or Cav3.2) knocked out...
- Differential effectiveness of pharmacological strategies to reveal dormant pulmonary vein conduction: a clinical-experimental correlation
Tomas Datino
Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
Heart Rhythm 8:1426-33. 2011
..Adenosine or isoproterenol are used clinically to reveal dormant PV conduction and guide additional ablation...
- Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation
Masahide Harada
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montre al, Montreal, Quebec, Canada
Circulation 126:2051-64. 2012
..Fibroblast proliferation and differentiation are central in atrial fibrillation (AF)-promoting remodeling. Here, we investigated fibroblast regulation by Ca(2+)-permeable transient receptor potential canonical-3 (TRPC3) channels...
- Differences in atrial fibrillation properties under vagal nerve stimulation versus atrial tachycardia remodeling
Grigorios Katsouras
Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
Heart Rhythm 6:1465-72. 2009
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- Rate-dependence of atrial tachycardia effects on atrial refractoriness and atrial fibrillation maintenance
Akiko Shiroshita-Takeshita
Department of Medicine and Research Center, Montreal Heart Institute, Universite de Montreal, 5000 Belanger Street, Montreal, Quebec, Canada
Cardiovasc Res 81:90-7. 2009
..This study assessed the effects of atrial tachypacing (ATP) over a range of clinically relevant rates on atrial electrophysiology and AF...
- Canine ventricular KCNE2 expression resides predominantly in Purkinje fibers
Marc Pourrier
Department of Medicine, University of Montreal, Montreal, Quebec, Canada
Circ Res 93:189-91. 2003
..Thus, the cardiac Purkinje system is a strong candidate to play a role in arrhythmic syndromes due to MiRP1 abnormalities...
- Post-transcriptional alterations in the expression of cardiac Na+ channel subunits in chronic heart failure
Stephen Zicha
Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Quebec, Canada
J Mol Cell Cardiol 37:91-100. 2004
..5 protein expression was reduced about 30% in HF, while NaCh beta 1 and NaCh beta 2 protein were unchanged. We conclude that experimental HF in dogs results in post-transcriptional changes in cardiac NaCh alpha-subunit expression...
- Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs
Akiko Shiroshita-Takeshita
Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
Cardiovasc Res 69:865-75. 2006
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- Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model
Stephen Zicha
Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Quebec, Canada
Cardiovasc Res 66:472-81. 2005
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- Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization
Joachim R Ehrlich
Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, 5000 Belanger Street East, Montreal, Quebec, Canada, H1T 1C8
Cardiovasc Res 67:520-8. 2005
..This study reveals a novel amino acid determinant of the minK-KvLQT1 interaction, and if the role of minK38G in AF is confirmed, would suggest mechanistic heterogeneity in genetic determinants of AF...
- Model-dependent effects of the gap junction conduction-enhancing antiarrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs
Akiko Shiroshita Takeshita
Department of Medicine and Research Center, Montreal Heart Institute Research Center, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada
Circulation 115:310-8. 2007
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- Mechanisms of atrial fibrillation: lessons from animal models
Stanley Nattel
Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
Prog Cardiovasc Dis 48:9-28. 2005
..The complementary nature of animal research and clinical investigation is emphasized and the clinical relevance of findings in experimental models is highlighted...
- Recent advances in the molecular pathophysiology of atrial fibrillation
Reza Wakili
Research Center, Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
J Clin Invest 121:2955-68. 2011
..We conclude with a discussion of the potential therapeutic implications that might arise from an improved mechanistic understanding...
- Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis
Georghia Michael
Department of Medicine, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
Cardiovasc Res 81:491-9. 2009
..The present article reviews ionic remodelling of cardiac repolarization, and focuses on how potentially adaptive repolarization changes with congestive heart failure and AF can have arrhythmogenic consequences...
- Animal models for atrial fibrillation: clinical insights and scientific opportunities
Kunihiro Nishida
Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, Montreal, Quebec, Canada
Europace 12:160-72. 2010
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- Association of neonatal hypoxia with lasting changes in left ventricular gene expression: an animal model
Danny Del Duca
Division of Cardiovascular Surgery, Montreal Children s Hospital McGill University Health Centre, Montreal, Quebec, Canada
J Thorac Cardiovasc Surg 138:538-46, 546.e1. 2009
..We hypothesized that hypoxemia in early life causes lasting changes in gene expression in the developing heart and that such changes may persist into later life, affecting the physiology of the adult myocardium...
- Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties
Joachim R Ehrlich
Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
J Physiol 551:801-13. 2003
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- Induction of heat shock response protects the heart against atrial fibrillation
Bianca J J M Brundel
Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger St E, Montreal, Quebec H1T 1C8, Canada
Circ Res 99:1394-402. 2006
..These findings advance our understanding of the biochemical determinants of AF and suggest the possibility that HSP induction may be an interesting novel approach to preventing clinical AF...
- Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation
Stanley Nattel
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
Physiol Rev 87:425-56. 2007
..We highlight areas of future investigation, as well as important opportunities for improved therapeutic approaches that are being opened by an improved understanding of the mechanisms of arrhythmogenic remodeling...
- In silico optimization of atrial fibrillation-selective sodium channel blocker pharmacodynamics
Martin Aguilar-Shardonofsky
Department of Medicine, University of Montreal, Montreal, Canada
Biophys J 102:951-60. 2012
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- Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model
Kunihiro Nishida
Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street E, Montreal, Quebec, Canada
Circulation 123:137-46. 2011
..Coronary artery disease predisposes to atrial fibrillation (AF), but the effects of chronic atrial ischemia/infarction on AF-related substrates are unknown...
- Differential alterations of receptor densities of three muscarinic acetylcholine receptor subtypes and current densities of the corresponding K+ channels in canine atria with atrial fibrillation induced by experimental congestive heart failure
Hong Shi
Research Center, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
Cell Physiol Biochem 14:31-40. 2004
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- Substrate size as a determinant of fibrillatory activity maintenance in a mathematical model of canine atrium
Renqiang Zou
Research Center, Montreal Heart Institute, 5000 Belanger St, Montreal, Quebec, Canada H1T 1C8
Am J Physiol Heart Circ Physiol 289:H1002-12. 2005
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- Barium block of Kir2 and human cardiac inward rectifier currents: evidence for subunit-heteromeric contribution to native currents
Gernot Schram
Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
Cardiovasc Res 59:328-38. 2003
..These observations suggest that a substantial proportion of native I(K1) may result from heteromultimer formation among diverse Kir2 family subunits...
- Characterization of the cardiac KCNE1 gene promoter
Zenab Mustapha
Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
Cardiovasc Res 73:82-91. 2007
..Varying minK expression is important in disease-related remodeling and species-dependent expression. This study addressed 5'-regulatory elements that potentially control KCNE1 transcription...
- Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia
Kristina Lemola
Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
Circulation 117:470-7. 2008
..However, PV ablation procedures also can affect intracardiac autonomic ganglia. The present study examined the relative role of PVs versus peri-PV autonomic ganglia in an experimental vagal AF model...
- Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure
Nessrine Hanna
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
Cardiovasc Res 63:236-44. 2004
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- Roles of the left atrial roof and pulmonary veins in the anatomic substrate for persistent atrial fibrillation and ablation in a canine model
Kunihiro Nishida
Research Center, Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
J Am Coll Cardiol 56:1728-36. 2010
..the aim of this study was to establish the electrophysiological consequences of pulmonary vein encircling ablation (PVEA) and linear left atrial roof ablation (LARA) for the atrial fibrillation (AF) substrate in an experimental model...
- Pharmacological prevention of atrial tachycardia induced atrial remodeling as a potential therapeutic strategy
Kaori Shinagawa
Montreal Heart Institute, Research Center, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
Pacing Clin Electrophysiol 26:752-64. 2003
..Despite great potential value, the development of pharmacological interventions to prevent atrial electrical remodeling is still in its infancy...
- In vivo electrophysiological effects of a selective slow delayed-rectifier potassium channel blocker in anesthetized dogs: potential insights into class III actions
Hideko Nakashima
Research Center, Department of Medicine, Montreal Heart Institute and University of Montreal, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
Cardiovasc Res 61:705-14. 2004
..The slow delayed-rectifier current is particularly important when rapid delayed-rectifier current is suppressed, illustrating the importance of repolarization reserve...
- The role of pulmonary veins vs. autonomic ganglia in different experimental substrates of canine atrial fibrillation
Kunihiro Nishida
Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, QC, Canada H1T 1C8
Cardiovasc Res 89:825-33. 2011
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- The Kv4.2 N-terminal restores fast inactivation and confers KChlP2 modulatory effects on N-terminal-deleted Kv1.4 channels
Marc Pourrier
Research Center, Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec HIT 1C8, Canada
Pflugers Arch 449:235-47. 2004
..4, indicating the ability of Kvl.4 subunits to display these properties and the sufficiency of the Kv4.2 N-terminal to convey them...
- Mechanisms of atrial remodeling and clinical relevance
Stanley Nattel
Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Quebec, Canada
Curr Opin Cardiol 20:21-5. 2005
..This paper reviews recent progress in understanding atrial remodeling, as well as the consequent clinical insights into atrial fibrillation pathophysiology and treatment...
- Mechanisms of atrial fibrillation termination by pure sodium channel blockade in an ionically-realistic mathematical model
James Kneller
Research Center and Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
Circ Res 96:e35-47. 2005
..These results provide insights into previously enigmatic mechanisms of class I antiarrhythmic drug-induced AF termination. The full text of this article is available online at http://circres.ahajournals.org..
- Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences
Brett Burstein
Department of Medicine, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
Circulation 117:1630-41. 2008
..In various heart disease paradigms, atria show stronger fibrotic responses than ventricles. The possibility that atrial and ventricular fibroblasts respond differentially to pathological stimuli has not been examined...
- Atrial structural remodeling as an antiarrhythmic target
Brett Burstein
Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
J Cardiovasc Pharmacol 52:4-10. 2008
..This review will highlight pharmacologic approaches that have shown promise for attenuating structural remodeling to achieve antiarrhythmic efficacy in AF...
- Prognostic significance of ventricular arrhythmias post-myocardial infarction
Paul Khairy
Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
Can J Cardiol 19:1393-404. 2003
..Inhospital mortality is higher when ventricular fibrillation presents in the acute phase but long term prognosis is not adversely affected...
- Atrial fibrillation: basic mechanisms, remodeling and triggers
Akiko Shiroshita-Takeshita
Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
J Interv Card Electrophysiol 13:181-93. 2005
- Effects of resveratrol (trans-3,5,4'-trihydroxystilbene) treatment on cardiac remodeling following myocardial infarction
Brett Burstein
Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
J Pharmacol Exp Ther 323:916-23. 2007
..Resveratrol treatment does not improve cardiac remodeling and global hemodynamic function post-MI but does preserve contractile reserve and attenuate ANF and CTGF up-regulation...
