Stanley Nattel

Summary

Publications

  1. doi request reprint Model systems for the discovery and development of antiarrhythmic drugs
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, Quebec, H1T 1C8 Canada
    Prog Biophys Mol Biol 98:328-39. 2008
  2. doi request reprint Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome
    Yung Hsin Yeh
    Department of Medicine, Montreal Heart Institute Research Center and Université de Montréal, Montreal, Quebec, Canada
    Circulation 119:1576-85. 2009
  3. ncbi request reprint Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atrium
    Peter Melnyk
    Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 65:104-16. 2005
  4. doi request reprint Mechanisms of atrial fibrillation termination by rapidly unbinding Na+ channel blockers: insights from mathematical models and experimental correlates
    Philippe Comtois
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    Am J Physiol Heart Circ Physiol 295:H1489-504. 2008
  5. doi request reprint The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome
    Xiaoyan Qi
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 2:295-304. 2009
  6. doi request reprint Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure
    Yung Hsin Yeh
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    Circ Arrhythm Electrophysiol 1:93-102. 2008
  7. doi request reprint Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure
    Brett Burstein
    Department of Medicine and Physiology Institute of Biomedical Engineering, Research Center Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada
    Circ Res 105:1213-22. 2009
  8. ncbi request reprint Atrial ionic remodeling induced by atrial tachycardia in the presence of congestive heart failure
    Tae Joon Cha
    Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circulation 110:1520-6. 2004
  9. doi request reprint Marked differences between atrial and ventricular gene-expression remodeling in dogs with experimental heart failure
    Sophie Cardin
    Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Mol Cell Cardiol 45:821-31. 2008
  10. doi request reprint Ion channel subunit expression changes in cardiac Purkinje fibers: a potential role in conduction abnormalities associated with congestive heart failure
    Ange Maguy
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Circ Res 104:1113-22. 2009

Collaborators

Detail Information

Publications71

  1. doi request reprint Model systems for the discovery and development of antiarrhythmic drugs
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, Quebec, H1T 1C8 Canada
    Prog Biophys Mol Biol 98:328-39. 2008
    ..It is hoped that the new technologies now available and the recently-developed models for arrhythmia-response assessment will permit the introduction of newer and more effective antiarrhythmic therapies in the near future...
  2. doi request reprint Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome
    Yung Hsin Yeh
    Department of Medicine, Montreal Heart Institute Research Center and Université de Montréal, Montreal, Quebec, Canada
    Circulation 119:1576-85. 2009
    ..This study examined the hypothesis that ATs impair SAN function by altering ion channel expression...
  3. ncbi request reprint Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atrium
    Peter Melnyk
    Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 65:104-16. 2005
    ..Pulmonary veins have different ionic current properties compared to left atrium, with pulmonary vein inward-rectifier currents being smaller and delayed-rectifier currents larger than in left atrium...
  4. doi request reprint Mechanisms of atrial fibrillation termination by rapidly unbinding Na+ channel blockers: insights from mathematical models and experimental correlates
    Philippe Comtois
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    Am J Physiol Heart Circ Physiol 295:H1489-504. 2008
    ..These results provide new insights into the mechanisms by which rapidly unbinding class I antiarrhythmic agents, a class including several novel compounds of considerable promise, terminate AF...
  5. doi request reprint The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome
    Xiaoyan Qi
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 2:295-304. 2009
    ..We addressed the importance of altered Ca(2+) handling, studying underlying mechanisms and consequences...
  6. doi request reprint Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure
    Yung Hsin Yeh
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    Circ Arrhythm Electrophysiol 1:93-102. 2008
    ..Focal sources of unknown mechanism have been described in CHF-related atrial fibrillation. The authors hypothesized that abnormal calcium (Ca(2+)) handling contributes to the CHF-related atrial arrhythmogenic substrate...
  7. doi request reprint Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure
    Brett Burstein
    Department of Medicine and Physiology Institute of Biomedical Engineering, Research Center Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada
    Circ Res 105:1213-22. 2009
    ..Although connexin changes are important for the ventricular arrhythmic substrate in congestive heart failure (CHF), connexin alterations during CHF-related atrial arrhythmogenic remodeling have received limited attention...
  8. ncbi request reprint Atrial ionic remodeling induced by atrial tachycardia in the presence of congestive heart failure
    Tae Joon Cha
    Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circulation 110:1520-6. 2004
    ..The in vivo effects of atrial tachycardia (AT) remodeling are altered by CHF. This study evaluated underlying mechanisms at the level of ionic remodeling...
  9. doi request reprint Marked differences between atrial and ventricular gene-expression remodeling in dogs with experimental heart failure
    Sophie Cardin
    Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Mol Cell Cardiol 45:821-31. 2008
    ..VTP-induced CHF causes dramatically more gene-expression changes in LA than LV, dynamically altering the LA-LV differential gene-expression pattern. These results are relevant to understanding chamber-specific remodeling in CHF...
  10. doi request reprint Ion channel subunit expression changes in cardiac Purkinje fibers: a potential role in conduction abnormalities associated with congestive heart failure
    Ange Maguy
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Circ Res 104:1113-22. 2009
    ....
  11. ncbi request reprint Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling
    Brett Burstein
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    Cardiovasc Res 76:442-52. 2007
    ..This study investigated the hypothesis that rapid atrial cardiomyocyte activation produces factors that influence atrial fibroblast proliferation and secretory functions...
  12. ncbi request reprint Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure
    Akiko Shiroshita-Takeshita
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Canada
    Cardiovasc Res 74:75-84. 2007
    ..We evaluated the effects of simvastatin (antioxidant, anti-inflammatory) and fenofibrate (PPAR-alpha activator) on CHF-related atrial remodeling...
  13. ncbi request reprint Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure
    Tae Joon Cha
    5000 Belanger St East, Montreal, Quebec, H1T 1C8, Canada
    Circulation 109:412-8. 2004
    ..The relative importance of ionic versus structural remodeling in CHF-related atrial fibrillation (AF) is controversial...
  14. doi request reprint Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia
    Masao Sakabe
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger St E, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 78:63-70. 2008
    ..This study addressed the effects of geranylgeranylacetone (GGA), an orally active HSP inducer, on the atrial fibrillation (AF) substrate associated with acute atrial ischaemia (AI)...
  15. doi request reprint Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes
    Ling Xiao
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Res 103:733-42. 2008
    ..We conclude that tachycardia downregulates I to expression, with the Ca2+/calmodulin-dependent CaMKII and calcineurin/NFAT systems playing key Ca2+-sensing and signal-transducing roles in rate-dependent I to control...
  16. ncbi request reprint Comparison of Ca2+-handling properties of canine pulmonary vein and left atrial cardiomyocytes
    Pierre Coutu
    Research Center, Montreal Heart Institute, 5000 Belanger St East, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 291:H2290-300. 2006
    ....
  17. ncbi request reprint Contrasting gene expression profiles in two canine models of atrial fibrillation
    Sophie Cardin
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Res 100:425-33. 2007
    ....
  18. ncbi request reprint Omega-3 polyunsaturated fatty acids prevent atrial fibrillation associated with heart failure but not atrial tachycardia remodeling
    Masao Sakabe
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circulation 116:2101-9. 2007
    ..There is epidemiological evidence that omega-3 polyunsaturated fatty acids (PUFAs) reduce the risk of atrial fibrillation (AF), but clinical data are conflicting. The present study assessed the effects of PUFA on AF in experimental models...
  19. ncbi request reprint Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes
    Yung Hsin Yeh
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada, and First Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University, Tao Yuan, Taiwan
    Cardiovasc Res 74:406-15. 2007
    ..Adrenergic stimulation favors atrial arrhythmogenesis but its effects on IKH are poorly understood...
  20. doi request reprint Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs
    Reza Wakili
    Department of Medicine and Research Center, Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 3:530-41. 2010
    ..Action potential (AP)-prolonging drugs are reported to normalize atrial hypocontractility caused by atrial tachycardia remodeling (ATR). Here, we addressed the role of AP duration (APD) changes in ATR-induced hypocontractility...
  21. doi request reprint Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling
    Samy Makary
    Department of Medicine and Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    Circ Res 109:1031-43. 2011
    ..The underlying mechanisms are unknown...
  22. ncbi request reprint Atrial tachycardia remodeling of pulmonary vein cardiomyocytes: comparison with left atrium and potential relation to arrhythmogenesis
    Tae Joon Cha
    Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circulation 111:728-35. 2005
    ..The relative importance of AT remodeling in PVs versus other atrial sites is unknown. The present study assessed AT-induced cellular changes in PVs versus left atrium (LA) and their relationship to arrhythmogenesis...
  23. doi request reprint Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome
    Thomas G Diness
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 79:61-9. 2008
    ..This study sought to evaluate the antiarrhythmic effect of a novel compound (NS1643) that activates the rapid delayed-rectifier K+ current, I(Kr), in two rabbit models of acquired LQTS...
  24. doi request reprint Atrial fibrillation-associated remodeling does not promote atrial thrombus formation in canine models
    Kunihiro Nishida
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 5:1168-75. 2012
    ..This study assessed effects of AF-related remodeling on the atrial thrombogenic milieu by using radiofrequency ablation (RFA) to create a quantifiable prothrombotic nidus...
  25. doi request reprint MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation
    Kristin Dawson
    Montreal Heart Institute Research Center, 5000 Belanger St E, Montreal, Quebec, H1T 1C8, Canada
    Circulation 127:1466-75, 1475e1-28. 2013
    ..In the present study, we examined miR29b changes in patients with AF and/or CHF and in a CHF-related AF animal model and assessed its potential role in controlling atrial fibrous tissue production...
  26. doi request reprint Feedback remodeling of cardiac potassium current expression: a novel potential mechanism for control of repolarization reserve
    Ling Xiao
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Circulation 118:983-92. 2008
    ..Accordingly, we assessed the effects of sustained inhibition of one K(+) current on various other cardiac ionic currents...
  27. doi request reprint A high-fat diet increases risk of ventricular arrhythmia in female rats: enhanced arrhythmic risk in the absence of obesity or hyperlipidemia
    Marie Claude Aubin
    Department of Pharmacology, Universite de Montreal, Montreal, Quebec, Canada
    J Appl Physiol 108:933-40. 2010
    ....
  28. doi request reprint Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice
    Khai Le Quang
    Research Center and Departments of Medicine, Université de Montréal and Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec, Canada
    Cardiovasc Res 91:420-8. 2011
    ..To clarify the role of I(CaT) in cardiac remodelling, we studied mice with either of the principal cardiac I(CaT)-subunits (Cav3.1 or Cav3.2) knocked out...
  29. pmc Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium
    Joachim R Ehrlich
    Department of Medicine, University of Montral, Montreal, Quebec, Canada
    J Physiol 557:583-97. 2004
    ..8 +/- 0.3 to -4.5 +/- 0.5 pA pF(-1), P < 0.01). We conclude that I(KH) is a time-dependent, hyperpolarization-activated K(+) current that likely involves Kir3 subunits and appears to play a significant role in atrial physiology...
  30. ncbi request reprint Sex-based transmural differences in cardiac repolarization and ionic-current properties in canine left ventricles
    Ling Xiao
    Department of Pharmacology and Therapeutics, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 291:H570-80. 2006
    ..3 +/- 0.3 pA/pF; endocarium: -4.5 +/- 0.4 vs. -3.2 +/- 0.3 pA/pF; P < 0.05 for each). We conclude that there are sex-based transmural differences in ionic currents that may underlie sex differences in transmural cardiac repolarization...
  31. doi request reprint Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation
    Ling Xiao
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, QC, Canada
    Circ Res 112:1310-22. 2013
    ..We hypothesized that DPP6 contributes to PF I(to) and that its overexpression might specifically alter PF I(to) properties and repolarization...
  32. pmc Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation
    Masahide Harada
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montre al, Montreal, Quebec, Canada
    Circulation 126:2051-64. 2012
    ..Fibroblast proliferation and differentiation are central in atrial fibrillation (AF)-promoting remodeling. Here, we investigated fibroblast regulation by Ca(2+)-permeable transient receptor potential canonical-3 (TRPC3) channels...
  33. doi request reprint Differential effectiveness of pharmacological strategies to reveal dormant pulmonary vein conduction: a clinical-experimental correlation
    Tomas Datino
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Heart Rhythm 8:1426-33. 2011
    ..Adenosine or isoproterenol are used clinically to reveal dormant PV conduction and guide additional ablation...
  34. ncbi request reprint Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs
    Akiko Shiroshita-Takeshita
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Cardiovasc Res 69:865-75. 2006
    ..This study evaluated the efficacy of anti-inflammatory and calcineurin-inhibitory drugs on promotion of atrial fibrillation by atrial tachycardia-induced remodeling in dogs...
  35. pmc Post-transcriptional alterations in the expression of cardiac Na+ channel subunits in chronic heart failure
    Stephen Zicha
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Quebec, Canada
    J Mol Cell Cardiol 37:91-100. 2004
    ..5 protein expression was reduced about 30% in HF, while NaCh beta 1 and NaCh beta 2 protein were unchanged. We conclude that experimental HF in dogs results in post-transcriptional changes in cardiac NaCh alpha-subunit expression...
  36. doi request reprint Rate-dependence of atrial tachycardia effects on atrial refractoriness and atrial fibrillation maintenance
    Akiko Shiroshita-Takeshita
    Department of Medicine and Research Center, Montreal Heart Institute, Universite de Montreal, 5000 Belanger Street, Montreal, Quebec, Canada
    Cardiovasc Res 81:90-7. 2009
    ..This study assessed the effects of atrial tachypacing (ATP) over a range of clinically relevant rates on atrial electrophysiology and AF...
  37. ncbi request reprint Canine ventricular KCNE2 expression resides predominantly in Purkinje fibers
    Marc Pourrier
    Department of Medicine, University of Montreal, Montreal, Quebec, Canada
    Circ Res 93:189-91. 2003
    ..Thus, the cardiac Purkinje system is a strong candidate to play a role in arrhythmic syndromes due to MiRP1 abnormalities...
  38. doi request reprint Differences in atrial fibrillation properties under vagal nerve stimulation versus atrial tachycardia remodeling
    Grigorios Katsouras
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Heart Rhythm 6:1465-72. 2009
    ....
  39. ncbi request reprint Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model
    Stephen Zicha
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Quebec, Canada
    Cardiovasc Res 66:472-81. 2005
    ....
  40. ncbi request reprint Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization
    Joachim R Ehrlich
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, 5000 Belanger Street East, Montreal, Quebec, Canada, H1T 1C8
    Cardiovasc Res 67:520-8. 2005
    ....
  41. ncbi request reprint Mechanisms of atrial fibrillation: lessons from animal models
    Stanley Nattel
    Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Prog Cardiovasc Dis 48:9-28. 2005
    ..The complementary nature of animal research and clinical investigation is emphasized and the clinical relevance of findings in experimental models is highlighted...
  42. ncbi request reprint Model-dependent effects of the gap junction conduction-enhancing antiarrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs
    Akiko Shiroshita-Takeshita
    Department of Medicine and Research Center, Montreal Heart Institute Research Center, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada
    Circulation 115:310-8. 2007
    ....
  43. doi request reprint Association of neonatal hypoxia with lasting changes in left ventricular gene expression: an animal model
    Danny Del Duca
    Division of Cardiovascular Surgery, Montreal Children s Hospital McGill University Health Centre, Montreal, Quebec, Canada
    J Thorac Cardiovasc Surg 138:538-46, 546.e1. 2009
    ..We hypothesized that hypoxemia in early life causes lasting changes in gene expression in the developing heart and that such changes may persist into later life, affecting the physiology of the adult myocardium...
  44. doi request reprint Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis
    Georghia Michael
    Department of Medicine, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 81:491-9. 2009
    ..The present article reviews ionic remodelling of cardiac repolarization, and focuses on how potentially adaptive repolarization changes with congestive heart failure and AF can have arrhythmogenic consequences...
  45. doi request reprint Animal models for atrial fibrillation: clinical insights and scientific opportunities
    Kunihiro Nishida
    Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, Montreal, Quebec, Canada
    Europace 12:160-72. 2010
    ....
  46. pmc Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties
    Joachim R Ehrlich
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    J Physiol 551:801-13. 2003
    ....
  47. pmc Recent advances in the molecular pathophysiology of atrial fibrillation
    Reza Wakili
    Research Center, Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Clin Invest 121:2955-68. 2011
    ..We conclude with a discussion of the potential therapeutic implications that might arise from an improved mechanistic understanding...
  48. ncbi request reprint Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Physiol Rev 87:425-56. 2007
    ..We highlight areas of future investigation, as well as important opportunities for improved therapeutic approaches that are being opened by an improved understanding of the mechanisms of arrhythmogenic remodeling...
  49. ncbi request reprint Induction of heat shock response protects the heart against atrial fibrillation
    Bianca J J M Brundel
    Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger St E, Montreal, Quebec H1T 1C8, Canada
    Circ Res 99:1394-402. 2006
    ..These findings advance our understanding of the biochemical determinants of AF and suggest the possibility that HSP induction may be an interesting novel approach to preventing clinical AF...
  50. pmc MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation
    Xiaobin Luo
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    J Clin Invest 123:1939-51. 2013
    ..Our results demonstrate that miR-26 controls the expression of KCNJ2 and suggest that this downregulation may promote AF...
  51. pmc Congestive heart failure effects on atrial fibroblast phenotype: differences between freshly-isolated and cultured cells
    Kristin Dawson
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    PLoS ONE 7:e52032. 2012
    ..This study assessed CHF-induced changes in the phenotype of fibroblasts freshly isolated from control versus CHF dogs, and examined effects of cell culture on these differences...
  52. pmc In silico optimization of atrial fibrillation-selective sodium channel blocker pharmacodynamics
    Martin Aguilar-Shardonofsky
    Department of Medicine, University of Montreal, Montreal, Canada
    Biophys J 102:951-60. 2012
    ....
  53. doi request reprint Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model
    Kunihiro Nishida
    Research Center, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street E, Montreal, Quebec, Canada
    Circulation 123:137-46. 2011
    ..Coronary artery disease predisposes to atrial fibrillation (AF), but the effects of chronic atrial ischemia/infarction on AF-related substrates are unknown...
  54. ncbi request reprint Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure
    Nessrine Hanna
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Cardiovasc Res 63:236-44. 2004
    ..Congestive heart failure (CHF) causes arrhythmogenic remodeling in both atria and ventricles, but differences between atrial and ventricular remodeling in CHF have not been well characterized...
  55. ncbi request reprint Differential alterations of receptor densities of three muscarinic acetylcholine receptor subtypes and current densities of the corresponding K+ channels in canine atria with atrial fibrillation induced by experimental congestive heart failure
    Hong Shi
    Research Center, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
    Cell Physiol Biochem 14:31-40. 2004
    ....
  56. ncbi request reprint Barium block of Kir2 and human cardiac inward rectifier currents: evidence for subunit-heteromeric contribution to native currents
    Gernot Schram
    Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 59:328-38. 2003
    ..Kir2 subunits are believed to underlie the cardiac inwardly rectifying current I(K1). The subunit composition of native I(K1) currents is uncertain, and it has been suggested that heteromultimer formation may play a role...
  57. doi request reprint Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia
    Kristina Lemola
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
    Circulation 117:470-7. 2008
    ..However, PV ablation procedures also can affect intracardiac autonomic ganglia. The present study examined the relative role of PVs versus peri-PV autonomic ganglia in an experimental vagal AF model...
  58. ncbi request reprint Characterization of the cardiac KCNE1 gene promoter
    Zenab Mustapha
    Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Cardiovasc Res 73:82-91. 2007
    ..Varying minK expression is important in disease-related remodeling and species-dependent expression. This study addressed 5'-regulatory elements that potentially control KCNE1 transcription...
  59. ncbi request reprint Substrate size as a determinant of fibrillatory activity maintenance in a mathematical model of canine atrium
    Renqiang Zou
    Research Center, Montreal Heart Institute, 5000 Belanger St, Montreal, Quebec, Canada H1T 1C8
    Am J Physiol Heart Circ Physiol 289:H1002-12. 2005
    ....
  60. doi request reprint The role of pulmonary veins vs. autonomic ganglia in different experimental substrates of canine atrial fibrillation
    Kunihiro Nishida
    Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, QC, Canada H1T 1C8
    Cardiovasc Res 89:825-33. 2011
    ....
  61. doi request reprint Atrial structural remodeling as an antiarrhythmic target
    Brett Burstein
    Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    J Cardiovasc Pharmacol 52:4-10. 2008
    ..This review will highlight pharmacologic approaches that have shown promise for attenuating structural remodeling to achieve antiarrhythmic efficacy in AF...
  62. doi request reprint Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences
    Brett Burstein
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Circulation 117:1630-41. 2008
    ..In various heart disease paradigms, atria show stronger fibrotic responses than ventricles. The possibility that atrial and ventricular fibroblasts respond differentially to pathological stimuli has not been examined...
  63. doi request reprint Roles of the left atrial roof and pulmonary veins in the anatomic substrate for persistent atrial fibrillation and ablation in a canine model
    Kunihiro Nishida
    Research Center, Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Am Coll Cardiol 56:1728-36. 2010
    ..the aim of this study was to establish the electrophysiological consequences of pulmonary vein encircling ablation (PVEA) and linear left atrial roof ablation (LARA) for the atrial fibrillation (AF) substrate in an experimental model...
  64. ncbi request reprint In vivo electrophysiological effects of a selective slow delayed-rectifier potassium channel blocker in anesthetized dogs: potential insights into class III actions
    Hideko Nakashima
    Research Center, Department of Medicine, Montreal Heart Institute and University of Montreal, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
    Cardiovasc Res 61:705-14. 2004
    ....
  65. ncbi request reprint Pharmacological prevention of atrial tachycardia induced atrial remodeling as a potential therapeutic strategy
    Kaori Shinagawa
    Montreal Heart Institute, Research Center, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8
    Pacing Clin Electrophysiol 26:752-64. 2003
    ..Despite great potential value, the development of pharmacological interventions to prevent atrial electrical remodeling is still in its infancy...
  66. ncbi request reprint The Kv4.2 N-terminal restores fast inactivation and confers KChlP2 modulatory effects on N-terminal-deleted Kv1.4 channels
    Marc Pourrier
    Research Center, Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec HIT 1C8, Canada
    Pflugers Arch 449:235-47. 2004
    ..4, indicating the ability of Kvl.4 subunits to display these properties and the sufficiency of the Kv4.2 N-terminal to convey them...
  67. ncbi request reprint Mechanisms of atrial fibrillation termination by pure sodium channel blockade in an ionically-realistic mathematical model
    James Kneller
    Research Center and Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circ Res 96:e35-47. 2005
    ..These results provide insights into previously enigmatic mechanisms of class I antiarrhythmic drug-induced AF termination. The full text of this article is available online at http://circres.ahajournals.org..
  68. ncbi request reprint Mechanisms of atrial remodeling and clinical relevance
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Quebec, Canada
    Curr Opin Cardiol 20:21-5. 2005
    ..This paper reviews recent progress in understanding atrial remodeling, as well as the consequent clinical insights into atrial fibrillation pathophysiology and treatment...
  69. ncbi request reprint Prognostic significance of ventricular arrhythmias post-myocardial infarction
    Paul Khairy
    Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
    Can J Cardiol 19:1393-404. 2003
    ..Inhospital mortality is higher when ventricular fibrillation presents in the acute phase but long term prognosis is not adversely affected...
  70. ncbi request reprint Effects of resveratrol (trans-3,5,4'-trihydroxystilbene) treatment on cardiac remodeling following myocardial infarction
    Brett Burstein
    Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Pharmacol Exp Ther 323:916-23. 2007
    ..Resveratrol treatment does not improve cardiac remodeling and global hemodynamic function post-MI but does preserve contractile reserve and attenuate ANF and CTGF up-regulation...
  71. ncbi request reprint Atrial fibrillation: basic mechanisms, remodeling and triggers
    Akiko Shiroshita-Takeshita
    Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    J Interv Card Electrophysiol 13:181-93. 2005