Genomes and Genes
Affiliation: Emory University
Location: Atlanta, United States
- RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumorsRodrigo Louro
Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
Biochem Biophys Res Commun 316:618-27. 2004..These results highlight a previously uncharacterized subfamily of Ras-related genes that may have a tumor suppressor role in prostate cancer...
- Programming the magnitude and persistence of antibody responses with innate immunitySudhir Pai Kasturi
Emory Vaccine Center, Emory University, Atlanta, Georgia 30329, USA
Nature 470:543-7. 2011..Immunization protected completely against lethal avian and swine influenza virus strains in mice, and induced robust immunity against pandemic H1N1 influenza in rhesus macaques...
- Systems vaccinologyBali Pulendran
Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA
Immunity 33:516-29. 2010..Here, we review these advances and critically examine the potential opportunities and challenges posed by systems biology in vaccine development...
- The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signalingHua Tang
Emory Vaccine Center, Atlanta, Georgia, USA
Nat Immunol 11:608-17. 2010..Thus, the T(H)2 response to cysteine proteases requires DC-basophil cooperation via ROS-mediated signaling...
- Origins of the Xylella fastidiosa prophage-like regions and their impact in genome differentiationAlessandro de Mello Varani
Genome and Transposable Elements Laboratory GaTE Lab, Departamento de Botanica, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
PLoS ONE 3:e4059. 2008..Integration sites and tRNA association is also evidenced. In summary, we present comparative and experimental evidence supporting the association and contribution of phage activity on the differentiation of Xylella genomes...
- Systems biology approach predicts immunogenicity of the yellow fever vaccine in humansTroy D Querec
Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
Nat Immunol 10:116-25. 2009..A distinct signature, including B cell growth factor TNFRS17, predicted the neutralizing antibody response with up to 100% accuracy. These data highlight the utility of systems biology approaches in predicting vaccine efficacy...
- Conserved tissue expression signatures of intronic noncoding RNAs transcribed from human and mouse lociRodrigo Louro
Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, Brasil
Genomics 92:18-25. 2008..Altogether, these results support an evolutionarily conserved role of intronic ncRNAs in human and mouse, which are likely to be involved in the fine tuning of gene expression regulation in different mammalian tissues...
- Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumorsHelder I Nakaya
Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Pau lo, SP, Brazil
Biochem Biophys Res Commun 364:918-23. 2007..These results demonstrate that different isoforms of TLE genes are commonly transcribed in human tissues and suggest that TLE3 could be involved in prostate cancer development...
- The iron stimulon of Xylella fastidiosa includes genes for type IV pilus and colicin V-like bacteriocinsPaulo A Zaini
Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes 748, 05508 000, Sao Paulo, SP, Brazil
J Bacteriol 190:2368-78. 2008..Taken together, our data support the hypothesis that Fur is not solely responsible for the modulation of the iron stimulon of X. fastidiosa, and they present novel evidence for iron regulation of pathogenicity determinants...
- Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcriptionHelder I Nakaya
Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
Genome Biol 8:R43. 2007..However, the complement of human genes in which introns are transcribed, and the number of intronic transcriptional units and their tissue expression patterns are not known...
- Androgen responsive intronic non-coding RNAsRodrigo Louro
Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, Brazil
BMC Biol 5:4. 2007....
- As antisense RNA gets intronicEduardo M Reis
Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, Sao Paulo, Brazil
OMICS 9:2-12. 2005....
- Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancerEduardo M Reis
Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brasil
Oncogene 23:6684-92. 2004..024) between the low/high degrees of tumor differentiation and antisense intronic RASSF1 transcript levels. The need to use intron arrays to reveal the transcriptome profile of antisense intronic RNA in cancer has clearly emerged...
- Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adultsJaikumar Duraiswamy
Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA
J Immunol 186:4200-12. 2011..In conclusion, our study shows that most PD-1(hi) CD8 T cells in healthy adult humans are effector memory cells rather than exhausted cells...