Helder Nakaya

Summary

Affiliation: Emory University
Location: Atlanta, United States

Publications

  1. ncbi request reprint RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors
    Rodrigo Louro
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Biochem Biophys Res Commun 316:618-27. 2004
  2. pmc Programming the magnitude and persistence of antibody responses with innate immunity
    Sudhir Pai Kasturi
    Emory Vaccine Center, Emory University, Atlanta, Georgia 30329, USA
    Nature 470:543-7. 2011
  3. pmc Systems vaccinology
    Bali Pulendran
    Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Immunity 33:516-29. 2010
  4. pmc The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling
    Hua Tang
    Emory Vaccine Center, Atlanta, Georgia, USA
    Nat Immunol 11:608-17. 2010
  5. pmc Origins of the Xylella fastidiosa prophage-like regions and their impact in genome differentiation
    Alessandro de Mello Varani
    Genome and Transposable Elements Laboratory GaTE Lab, Departamento de Botanica, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    PLoS ONE 3:e4059. 2008
  6. pmc Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
    Troy D Querec
    Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Nat Immunol 10:116-25. 2009
  7. ncbi request reprint Conserved tissue expression signatures of intronic noncoding RNAs transcribed from human and mouse loci
    Rodrigo Louro
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, Brasil
    Genomics 92:18-25. 2008
  8. doi request reprint Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors
    Helder I Nakaya
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Pau lo, SP, Brazil
    Biochem Biophys Res Commun 364:918-23. 2007
  9. pmc The iron stimulon of Xylella fastidiosa includes genes for type IV pilus and colicin V-like bacteriocins
    Paulo A Zaini
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes 748, 05508 000, Sao Paulo, SP, Brazil
    J Bacteriol 190:2368-78. 2008
  10. pmc Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription
    Helder I Nakaya
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Genome Biol 8:R43. 2007

Collaborators

Detail Information

Publications14

  1. ncbi request reprint RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors
    Rodrigo Louro
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Biochem Biophys Res Commun 316:618-27. 2004
    ..These results highlight a previously uncharacterized subfamily of Ras-related genes that may have a tumor suppressor role in prostate cancer...
  2. pmc Programming the magnitude and persistence of antibody responses with innate immunity
    Sudhir Pai Kasturi
    Emory Vaccine Center, Emory University, Atlanta, Georgia 30329, USA
    Nature 470:543-7. 2011
    ..Immunization protected completely against lethal avian and swine influenza virus strains in mice, and induced robust immunity against pandemic H1N1 influenza in rhesus macaques...
  3. pmc Systems vaccinology
    Bali Pulendran
    Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Immunity 33:516-29. 2010
    ..Here, we review these advances and critically examine the potential opportunities and challenges posed by systems biology in vaccine development...
  4. pmc The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling
    Hua Tang
    Emory Vaccine Center, Atlanta, Georgia, USA
    Nat Immunol 11:608-17. 2010
    ..Thus, the T(H)2 response to cysteine proteases requires DC-basophil cooperation via ROS-mediated signaling...
  5. pmc Origins of the Xylella fastidiosa prophage-like regions and their impact in genome differentiation
    Alessandro de Mello Varani
    Genome and Transposable Elements Laboratory GaTE Lab, Departamento de Botanica, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    PLoS ONE 3:e4059. 2008
    ..Integration sites and tRNA association is also evidenced. In summary, we present comparative and experimental evidence supporting the association and contribution of phage activity on the differentiation of Xylella genomes...
  6. pmc Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
    Troy D Querec
    Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Nat Immunol 10:116-25. 2009
    ..A distinct signature, including B cell growth factor TNFRS17, predicted the neutralizing antibody response with up to 100% accuracy. These data highlight the utility of systems biology approaches in predicting vaccine efficacy...
  7. ncbi request reprint Conserved tissue expression signatures of intronic noncoding RNAs transcribed from human and mouse loci
    Rodrigo Louro
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, Brasil
    Genomics 92:18-25. 2008
    ..Altogether, these results support an evolutionarily conserved role of intronic ncRNAs in human and mouse, which are likely to be involved in the fine tuning of gene expression regulation in different mammalian tissues...
  8. doi request reprint Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors
    Helder I Nakaya
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Pau lo, SP, Brazil
    Biochem Biophys Res Commun 364:918-23. 2007
    ..These results demonstrate that different isoforms of TLE genes are commonly transcribed in human tissues and suggest that TLE3 could be involved in prostate cancer development...
  9. pmc The iron stimulon of Xylella fastidiosa includes genes for type IV pilus and colicin V-like bacteriocins
    Paulo A Zaini
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes 748, 05508 000, Sao Paulo, SP, Brazil
    J Bacteriol 190:2368-78. 2008
    ..Taken together, our data support the hypothesis that Fur is not solely responsible for the modulation of the iron stimulon of X. fastidiosa, and they present novel evidence for iron regulation of pathogenicity determinants...
  10. pmc Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription
    Helder I Nakaya
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Genome Biol 8:R43. 2007
    ..However, the complement of human genes in which introns are transcribed, and the number of intronic transcriptional units and their tissue expression patterns are not known...
  11. pmc Androgen responsive intronic non-coding RNAs
    Rodrigo Louro
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, Brazil
    BMC Biol 5:4. 2007
    ....
  12. ncbi request reprint As antisense RNA gets intronic
    Eduardo M Reis
    Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, Sao Paulo, Brazil
    OMICS 9:2-12. 2005
    ....
  13. ncbi request reprint Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancer
    Eduardo M Reis
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brasil
    Oncogene 23:6684-92. 2004
    ..024) between the low/high degrees of tumor differentiation and antisense intronic RASSF1 transcript levels. The need to use intron arrays to reveal the transcriptome profile of antisense intronic RNA in cancer has clearly emerged...
  14. pmc Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults
    Jaikumar Duraiswamy
    Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA
    J Immunol 186:4200-12. 2011
    ..In conclusion, our study shows that most PD-1(hi) CD8 T cells in healthy adult humans are effector memory cells rather than exhausted cells...