Yoshimitsu Nakano

Summary

Publications

  1. pmc A novel antibiotic based long-term model of ovine smoke inhalation injury and septic shock
    Yoshimitsu Nakano
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, Shriners Burns Hospital for Children, 601 Harborside Drive, Galveston, TX 77555 1102, USA
    Burns 36:1050-8. 2010
  2. doi request reprint Pulmonary microvascular hyperpermeability and expression of vascular endothelial growth factor in smoke inhalation- and pneumonia-induced acute lung injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, Galveston, TX 77550, USA
    Burns 38:1072-8. 2012
  3. doi request reprint Time profile of oxidative stress and neutrophil activation in ovine acute lung injury and sepsis
    Matthias Lange
    Investigational Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 37:468-72. 2012
  4. pmc Beneficial pulmonary effects of a metalloporphyrinic peroxynitrite decomposition catalyst in burn and smoke inhalation injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The Univ of Texas Medical Branch, Shriners Hospitals for Children, Galveston, 77550, USA
    Am J Physiol Lung Cell Mol Physiol 300:L167-75. 2011
  5. pmc Beneficial effects of concomitant neuronal and inducible nitric oxide synthase inhibition in ovine burn and inhalation injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Shock 35:626-31. 2011
  6. doi request reprint Role of neuronal nitric oxide synthase in ovine sepsis model
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Shock 32:253-7. 2009
  7. pmc Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity
    Dirk M Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children at Galveston, 301 University Blvd, Galveston, TX 77555 0833, USA
    Biochem Biophys Res Commun 377:786-91. 2008
  8. doi request reprint Assessment of vascular permeability in an ovine model of acute lung injury and pneumonia-induced Pseudomonas aeruginosa sepsis
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX, USA
    Crit Care Med 36:1284-9. 2008
  9. doi request reprint Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, USA
    Biochem Biophys Res Commun 399:286-91. 2010
  10. pmc Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, 301 University Boulevard, Galveston, Texas 77550, USA
    Crit Care 14:R129. 2010

Detail Information

Publications28

  1. pmc A novel antibiotic based long-term model of ovine smoke inhalation injury and septic shock
    Yoshimitsu Nakano
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, Shriners Burns Hospital for Children, 601 Harborside Drive, Galveston, TX 77555 1102, USA
    Burns 36:1050-8. 2010
    ..80.5 h in AB6h, and 65 h in AB12h animals. Combined ciprofloxacin and piperacillin therapy was effective, reduced nitric oxide production and mortality, and will allow future long-term studies in this model...
  2. doi request reprint Pulmonary microvascular hyperpermeability and expression of vascular endothelial growth factor in smoke inhalation- and pneumonia-induced acute lung injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, Galveston, TX 77550, USA
    Burns 38:1072-8. 2012
    ..The current study was designed further evaluate the mechanism of pulmonary vascular hyperpermeability in sheep with these injuries...
  3. doi request reprint Time profile of oxidative stress and neutrophil activation in ovine acute lung injury and sepsis
    Matthias Lange
    Investigational Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 37:468-72. 2012
    ....
  4. pmc Beneficial pulmonary effects of a metalloporphyrinic peroxynitrite decomposition catalyst in burn and smoke inhalation injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The Univ of Texas Medical Branch, Shriners Hospitals for Children, Galveston, 77550, USA
    Am J Physiol Lung Cell Mol Physiol 300:L167-75. 2011
    ..Administration of an ONOO(-) decomposition catalyst may represent a potential treatment option for this injury...
  5. pmc Beneficial effects of concomitant neuronal and inducible nitric oxide synthase inhibition in ovine burn and inhalation injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Shock 35:626-31. 2011
    ..This novel treatment strategy may represent a useful therapeutic adjunct for patients with these injuries...
  6. doi request reprint Role of neuronal nitric oxide synthase in ovine sepsis model
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Shock 32:253-7. 2009
    ..The above results suggest that the nNOS-derived NO may be involved in the pathophysiology of sepsis-related multiorgan dysfunction...
  7. pmc Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity
    Dirk M Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children at Galveston, 301 University Blvd, Galveston, TX 77555 0833, USA
    Biochem Biophys Res Commun 377:786-91. 2008
    ..These findings suggest that ONOO(-) plays a pivotal role in the pathology of IL-2-induced pulmonary VLS, and that WW-85 may become a useful treatment option...
  8. doi request reprint Assessment of vascular permeability in an ovine model of acute lung injury and pneumonia-induced Pseudomonas aeruginosa sepsis
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX, USA
    Crit Care Med 36:1284-9. 2008
    ..To assess the time changes and mechanism of pulmonary and peripheral vascular permeability in sheep with acute lung injury and sepsis...
  9. doi request reprint Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, USA
    Biochem Biophys Res Commun 399:286-91. 2010
    ..Future studies should investigate the effects of specific pharmacological inhibition of nNOS and iNOS at different time points during the disease process...
  10. pmc Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, 301 University Boulevard, Galveston, Texas 77550, USA
    Crit Care 14:R129. 2010
    ..However, the time changes of these pathogenic factors are largely undetermined...
  11. doi request reprint Time course of early histopathological lung changes in an ovine model of acute lung injury and pulmonary infection
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas 77555, USA
    Exp Lung Res 39:201-6. 2013
    ....
  12. doi request reprint Muscarinic receptor antagonist therapy improves acute pulmonary dysfunction after smoke inhalation injury in sheep
    Collette Jonkam
    Shriners Hospitals for Children and The University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 38:2339-44. 2010
    ....
  13. pmc Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury
    Fiona D Saunders
    Investigational Intensive Care Unit, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Am J Physiol Lung Cell Mol Physiol 298:L427-36. 2010
    ....
  14. doi request reprint A murine model of sepsis following smoke inhalation injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, USA
    Biochem Biophys Res Commun 391:1555-60. 2010
    ..In conclusion, bacterial pneumonia is predominantly responsible for mortality and morbidity in this novel murine model of smoke inhalation and pulmonary sepsis. Reactive oxygen and nitrogen species mediate the severity of lung injury...
  15. doi request reprint Predictive role of arterial carboxyhemoglobin concentrations in ovine burn and smoke inhalation-induced lung injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas 77550, USA
    Exp Lung Res 37:239-45. 2011
    ..Arterial carboxyhemoglobin in sheep with combined burn and inhalation injury are correlated with the degree of pulmonary failure and edema formation, but not with certain histological alterations including airway obstruction scores...
  16. doi request reprint Effects of early neuronal and delayed inducible nitric oxide synthase blockade on cardiovascular, renal, and hepatic function in ovine sepsis
    Matthias Lange
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas, USA
    Anesthesiology 113:1376-84. 2010
    ..We hypothesized that early neuronal and delayed inducible nitric oxide synthase blockade attenuates multiple organ dysfunctions during sepsis...
  17. pmc Preclinical evaluation of epinephrine nebulization to reduce airway hyperemia and improve oxygenation after smoke inhalation injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX, USA
    Crit Care Med 39:718-24. 2011
    ....
  18. pmc Inhibition of neuronal nitric oxide synthase in ovine model of acute lung injury
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 37:208-14. 2009
    ..In this study, we have tested the hypothesis that inhibition of neuronal nitric oxide synthase could ameliorate the severity of acute lung injury using our well-established ovine model of cutaneous burn and smoke inhalation...
  19. doi request reprint Time course of the inflammatory and oxidative stress response to pulmonary infection in mice
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Exp Lung Res 38:157-63. 2012
    ..In addition, the identification of the time changes of the described pathogenetic factors may enhance the timing of innovate therapeutic approaches in future experiments...
  20. pmc Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock
    Marc O Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, 301 University Blvd, Galveston, TX 77555 0591, USA
    Crit Care 14:R217. 2010
    ....
  21. ncbi request reprint Combined anticoagulants ameliorate acute lung injury in sheep after burn and smoke inhalation
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Clin Sci (Lond) 114:321-9. 2008
    ..In conclusion, the results provide definitive evidence that anticoagulant therapy may be a novel and effective treatment tool in the management of burn patients with concomitant smoke inhalation injury...
  22. pmc Combined neuronal and inducible nitric oxide synthase inhibition in ovine acute lung injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX, USA
    Crit Care Med 37:223-9. 2009
    ....
  23. doi request reprint Specific inhibition of nitric oxide synthases at different time points in a murine model of pulmonary sepsis
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, USA
    Biochem Biophys Res Commun 404:877-81. 2011
    ..Future investigations should identify the time changes of the expression and activation of NOS isoforms...
  24. ncbi request reprint Role of nitric oxide in shock: the large animal perspective
    Matthias Lange
    Investigational Intensive Care Unit, University of Texas Medical Branch, 610 Texas Avenue, Galveston, Texas 77550, USA
    Front Biosci (Landmark Ed) 14:1979-89. 2009
    ..Further investigation in large animal models is warranted to clarify the time course of increased expression and/or activity of different NOS isoenzymes and the effects of specific inhibition of the NOS isoforms at different time points...
  25. doi request reprint Heterogeneity of the effects of combined nitric oxide synthase inhibition on organ perfusion in ovine sepsis
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX, USA Department of Anesthesiology, Intensive Care and Pain Medicine, University of Muenster, Muenster, Germany Electronic address
    Burns 39:1565-70. 2013
    ..However, the effects of NOS inhibition on regional blood flow remained undetermined. The current study was conducted to assess the effects of combined NOS inhibition on blood flow to various organs in an ovine sepsis model...
  26. doi request reprint Multiple versus single injections of fluorescent microspheres for the determination of regional organ blood flow in septic sheep
    Matthias Lange
    Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas 77555, USA
    Lab Anim 47:203-9. 2013
    ..015). In conclusion, the results indicate that multiple versus single microsphere injections induced no or negligible alterations during ovine sepsis. This finding may help reduce the quantity of animals needed in future experiments...
  27. ncbi request reprint Novel ovine model of methicillin-resistant Staphylococcus aureus-induced pneumonia and sepsis
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, and Shriners Hospital for Children, Galveston, TX 77551, USA
    Shock 29:642-9. 2008
    ..The smoke inhalation alone had a little or no effect on these variables. This model closely mimics hyperdynamic human sepsis. The excessive production of NO may be extensively involved in the pathogenic process...
  28. ncbi request reprint Effects of the bradykinin B2 receptor antagonist icatibant on microvascular permeability after thermal injury in sheep
    Collette C Jonkam
    Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospital for Children, 610 Texas Avenue, Galveston, TX 77551, USA
    Shock 28:704-9. 2007
    ....