Tomohiro Nakamura

Summary

Publications

  1. pmc Aberrant protein s-nitrosylation in neurodegenerative diseases
    Tomohiro Nakamura
    Del E Web Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 78:596-614. 2013
  2. pmc Emerging role of protein-protein transnitrosylation in cell signaling pathways
    Tomohiro Nakamura
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Antioxid Redox Signal 18:239-49. 2013
  3. pmc S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration
    Tomohiro Nakamura
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mitochondrion 10:573-8. 2010
  4. ncbi request reprint S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
    Takashi Uehara
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 441:513-7. 2006
  5. pmc Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases
    Tomohiro Nakamura
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Exp Neurol 238:12-21. 2012
  6. pmc S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury
    Dong Hyung Cho
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 324:102-5. 2009
  7. pmc Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies
    Tomohiro Nakamura
    Center for Neuroscience, Aging and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Calcium 47:190-7. 2010
  8. ncbi request reprint Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases
    Tomohiro Nakamura
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, La Jolla, California 92039, USA
    Antioxid Redox Signal 10:87-101. 2008
  9. ncbi request reprint Inflammatory mediators leading to protein misfolding and uncompetitive/fast off-rate drug therapy for neurodegenerative disorders
    Stuart A Lipton
    Neuroscience and Aging Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Int Rev Neurobiol 82:1-27. 2007
  10. pmc S-nitrosylation of Cdk5: potential implications in amyloid-β-related neurotoxicity in Alzheimer disease
    Jing Qu
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Prion 6:364-70. 2012

Collaborators

Detail Information

Publications25

  1. pmc Aberrant protein s-nitrosylation in neurodegenerative diseases
    Tomohiro Nakamura
    Del E Web Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 78:596-614. 2013
    ..Insight into the pathophysiological role of aberrant S-nitrosylation pathways will enhance our understanding of molecular mechanisms leading to neurodegenerative diseases and point to potential therapeutic interventions...
  2. pmc Emerging role of protein-protein transnitrosylation in cell signaling pathways
    Tomohiro Nakamura
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Antioxid Redox Signal 18:239-49. 2013
    ..For example, S-nitrosylation of critical cysteine thiols in protein-disulfide isomerase and in parkin alters their activity, thus contributing to protein misfolding in Parkinson's disease...
  3. pmc S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration
    Tomohiro Nakamura
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mitochondrion 10:573-8. 2010
    ..Here, we provide an extended commentary on our findings of nitric oxide-mediated abnormal mitochondrial dynamics...
  4. ncbi request reprint S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
    Takashi Uehara
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 441:513-7. 2006
    ..Thus, PDI prevents neurotoxicity associated with ER stress and protein misfolding, but NO blocks this protective effect in neurodegenerative disorders through the S-nitrosylation of PDI...
  5. pmc Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases
    Tomohiro Nakamura
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Exp Neurol 238:12-21. 2012
    ..Additionally, high levels of NO can S-nitrosylate a number of aberrant targets involved in neuronal survival pathways, including the antiapoptotic protein XIAP, inhibiting its ability to prevent apoptosis...
  6. pmc S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury
    Dong Hyung Cho
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 324:102-5. 2009
    ..Preventing nitrosylation of Drp1 by cysteine mutation abrogated these neurotoxic events. SNO-Drp1 is increased in brains of human Alzheimer's disease patients and may thus contribute to the pathogenesis of neurodegeneration...
  7. pmc Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies
    Tomohiro Nakamura
    Center for Neuroscience, Aging and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Calcium 47:190-7. 2010
    ..Secondly, therapeutic pro-electrophiles are activated in the face of oxidative insult, thus protecting cells from calcium-induced oxidative stress via the Keap1/Nrf2 transcriptional pathway...
  8. ncbi request reprint Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases
    Tomohiro Nakamura
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, La Jolla, California 92039, USA
    Antioxid Redox Signal 10:87-101. 2008
    ....
  9. ncbi request reprint Inflammatory mediators leading to protein misfolding and uncompetitive/fast off-rate drug therapy for neurodegenerative disorders
    Stuart A Lipton
    Neuroscience and Aging Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Int Rev Neurobiol 82:1-27. 2007
    ..Targeted S-nitrosylation of the NMDA receptor can be achieved by coupling NO to memantine, yielding second-generation "UFO drugs" known as NitroMemantines...
  10. pmc S-nitrosylation of Cdk5: potential implications in amyloid-β-related neurotoxicity in Alzheimer disease
    Jing Qu
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Prion 6:364-70. 2012
    ..Thus, together with our previous report, these findings delineate an S-nitrosylation pathway wherein Cdk5/NOS1 interaction enhances SNO-Cdk5 formation, mediating mitochondrial dysfunction and synaptic loss during the etiology of AD...
  11. doi request reprint Cell death: protein misfolding and neurodegenerative diseases
    Tomohiro Nakamura
    Center for Neuroscience, Aging and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Apoptosis 14:455-68. 2009
    ..We discuss how memantine/NitroMemantine can inhibit excessive NMDA receptor activity to ameliorate NO production, protein misfolding, and neurodegeneration...
  12. pmc Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer's and Parkinson's diseases
    Tomohiro Nakamura
    Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Apoptosis 15:1354-63. 2010
    ..For example, S-nitrosylation of parkin disrupts its E3 ubiquitin ligase activity, and thereby affects Lewy body formation and neuronal cell death...
  13. pmc S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide
    Jing Qu
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:14330-5. 2011
    ..These findings suggest that S-nitrosylation of Cdk5 is an aberrant regulatory mechanism of enzyme activity that may contribute to the pathogenesis of AD...
  14. pmc S-nitrosylation of critical protein thiols mediates protein misfolding and mitochondrial dysfunction in neurodegenerative diseases
    Tomohiro Nakamura
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Antioxid Redox Signal 14:1479-92. 2011
    ....
  15. pmc S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease
    Jianguo Fang
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:18742-7. 2007
    ..Dopaminergic neurons, which are lost in PD, become particularly vulnerable. Thus, our data provide a direct link between nitrosative/oxidative stress and neurodegenerative disorders such as PD...
  16. ncbi request reprint Contribution of glutamatergic signaling to nitrosative stress-induced protein misfolding in normal brain aging and neurodegenerative diseases
    Tomohiro Nakamura
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Aging Cell 6:351-9. 2007
    ..Here, we present evidence for the hypothesis that NO contributes to normal brain aging and degenerative conditions by S-nitrosylating specific chaperones that would otherwise prevent accumulation of misfolded proteins...
  17. pmc Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death
    Tomohiro Nakamura
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 39:184-95. 2010
    ..These findings provide insights into the regulation of caspase activation in neurodegenerative disorders mediated, at least in part, by nitrosative stress...
  18. pmc S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke
    Zhong Qing Shi
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:3137-42. 2013
    ..These findings suggest that formation of SNO-SHP-2 represents a key chemical reaction contributing to excitotoxic damage in stroke and potentially other neurological disorders...
  19. pmc Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif
    Hiroto Takahashi
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 53:53-64. 2007
    ..These thiols may be nitrosylated preferentially during increasing hypoxia or stroke conditions, thus preventing excessive activity associated with cytotoxicity while avoiding blockade of physiologically active NMDARs...
  20. doi request reprint Mitochondrial dynamics in cell death and neurodegeneration
    Dong Hyung Cho
    Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Mol Life Sci 67:3435-47. 2010
    ....
  21. pmc Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
    Maria Talantova
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:E2518-27. 2013
    ..Importantly, the improved NMDAR antagonist NitroMemantine, which selectively inhibits extrasynaptic over physiological synaptic NMDAR activity, protects synapses from Aβ-induced damage both in vitro and in vivo. ..
  22. pmc Isobaric tagging-based quantification by mass spectrometry of differentially regulated proteins in synaptosomes of HIV/gp120 transgenic mice: implications for HIV-associated neurodegeneration
    Sugato Banerjee
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Exp Neurol 236:298-306. 2012
    ....
  23. pmc Redox Regulation of Protein Function via Cysteine S-Nitrosylation and Its Relevance to Neurodegenerative Diseases
    Mohd Waseem Akhtar
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Int J Cell Biol 2012:463756. 2012
    ....
  24. doi request reprint According to GOSPEL: filling in the GAP(DH) of NO-mediated neurotoxicity
    Tomohiro Nakamura
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Neuron 63:3-6. 2009
    ..In this issue of Neuron, Sen et al. identify a novel, negative regulator of this GAPDH neurotoxic pathway termed GOSPEL, which, like GAPDH itself, is regulated by S-nitrosylation...
  25. ncbi request reprint Comment on "S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function"
    Stuart A Lipton
    Center for Neuroscience and Aging, Burnham Institute, La Jolla, CA 92037, USA
    Science 308:1870; author reply 1870. 2005