Rajesh Nair

Summary

Publications

  1. ncbi request reprint Inferring sub-cellular localization through automated lexical analysis
    Rajesh Nair
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street BB217, New York, NY 10032, USA
    Bioinformatics 18:S78-86. 2002
  2. pmc LOCnet and LOCtarget: sub-cellular localization for structural genomics targets
    Rajesh Nair
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street BB217, New York, NY 10032, USA
    Nucleic Acids Res 32:W517-21. 2004
  3. doi request reprint Protein subcellular localization prediction using artificial intelligence technology
    Rajesh Nair
    CUBIC Department of Biochemistry and Molecular Biophysics and Center for Computational Biology and Bioinformatics, Columbia University, New York, NY, USA
    Methods Mol Biol 484:435-63. 2008
  4. ncbi request reprint Better prediction of sub-cellular localization by combining evolutionary and structural information
    Rajesh Nair
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Proteins 53:917-30. 2003
  5. ncbi request reprint Create and assess protein networks through molecular characteristics of individual proteins
    Yanay Ofran
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    Bioinformatics 22:e402-7. 2006
  6. pmc Structural genomics is the largest contributor of novel structural leverage
    Rajesh Nair
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    J Struct Funct Genomics 10:181-91. 2009
  7. pmc LOC3D: annotate sub-cellular localization for protein structures
    Rajesh Nair
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street BB217, New York, NY 10032, USA
    Nucleic Acids Res 31:3337-40. 2003
  8. pmc Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data
    W Nicholson Price
    Northeast Structural Genomics Consortium, Columbia University, New York, New York 10027, USA
    Nat Biotechnol 27:51-7. 2009
  9. ncbi request reprint Mimicking cellular sorting improves prediction of subcellular localization
    Rajesh Nair
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street BB217, New York, NY 10032, USA
    J Mol Biol 348:85-100. 2005
  10. pmc NLSdb: database of nuclear localization signals
    Rajesh Nair
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, BB217, 650 West 168th Street, New York, NY 10032, USA
    Nucleic Acids Res 31:397-9. 2003

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Inferring sub-cellular localization through automated lexical analysis
    Rajesh Nair
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street BB217, New York, NY 10032, USA
    Bioinformatics 18:S78-86. 2002
    ..With the rapid growth in sequence data, the biochemical characterisation of sequences has been falling behind. Our method may be a useful tool for supplementing functional information already automatically available...
  2. pmc LOCnet and LOCtarget: sub-cellular localization for structural genomics targets
    Rajesh Nair
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street BB217, New York, NY 10032, USA
    Nucleic Acids Res 32:W517-21. 2004
    ..The LOCtarget database currently contains localization predictions for all eukaryotic proteins from TargetDB and is updated every week. The server is available at http://www.rostlab.org/services/LOCtarget/...
  3. doi request reprint Protein subcellular localization prediction using artificial intelligence technology
    Rajesh Nair
    CUBIC Department of Biochemistry and Molecular Biophysics and Center for Computational Biology and Bioinformatics, Columbia University, New York, NY, USA
    Methods Mol Biol 484:435-63. 2008
    ..In this chapter, we review some of the most important methods for the prediction of subcellular localization...
  4. ncbi request reprint Better prediction of sub-cellular localization by combining evolutionary and structural information
    Rajesh Nair
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Proteins 53:917-30. 2003
    ..bioc.columbia.edu/db/LOC3D). We imagine that this pilot method-certainly in combination with similar tools-may be valuable target selection in structural genomics...
  5. ncbi request reprint Create and assess protein networks through molecular characteristics of individual proteins
    Yanay Ofran
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    Bioinformatics 22:e402-7. 2006
    ..Integrating molecular data and insights about the qualities of individual proteins into the analysis may enhance our ability to decipher biological pathways and processes...
  6. pmc Structural genomics is the largest contributor of novel structural leverage
    Rajesh Nair
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    J Struct Funct Genomics 10:181-91. 2009
    ..If the success of the PSI continues, it may just take another approximately15 years to cover most sequences in the current UniProt database...
  7. pmc LOC3D: annotate sub-cellular localization for protein structures
    Rajesh Nair
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street BB217, New York, NY 10032, USA
    Nucleic Acids Res 31:3337-40. 2003
    ..The web server can be used to predict sub-cellular localization for proteins for which only a predicted structure is available from threading servers. This makes the resource of particular interest to structural genomics initiatives...
  8. pmc Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data
    W Nicholson Price
    Northeast Structural Genomics Consortium, Columbia University, New York, New York 10027, USA
    Nat Biotechnol 27:51-7. 2009
    ..Our thermodynamic measurements do not generally support previous claims regarding correlations between sequence properties and protein stability...
  9. ncbi request reprint Mimicking cellular sorting improves prediction of subcellular localization
    Rajesh Nair
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street BB217, New York, NY 10032, USA
    J Mol Biol 348:85-100. 2005
    ....
  10. pmc NLSdb: database of nuclear localization signals
    Rajesh Nair
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, BB217, 650 West 168th Street, New York, NY 10032, USA
    Nucleic Acids Res 31:397-9. 2003
    ..NLS motifs often co-localize with DNA-binding regions. This observation was used to also annotate over 1500 DNA-binding proteins. NLSdb can be accessed via the web site: http://cubic.bioc.columbia.edu/db/NLSdb/...
  11. pmc Sequence conserved for subcellular localization
    Rajesh Nair
    Columbia University Bioinformatics Center CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Protein Sci 11:2836-47. 2002
    ..We succeeded in slightly improving the accuracy of inferring localization through homology by fine tuning the thresholds. Finally, we applied our results to the entire SWISS-PROT database and five entirely sequenced eukaryotes...