Cherupally Krishnan Krishnan Nair

Summary

Publications

  1. ncbi request reprint Radiation protection by Terminalia chebula: some mechanistic aspects
    Nitin Motilal Gandhi
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India
    Mol Cell Biochem 277:43-8. 2005
  2. doi request reprint Synthesis of nanosilver using a vitamin C derivative and studies on radiation protection
    Dhanya K Chandrasekharan
    Amala Cancer Research Centre, Thrissur, Kerala, India
    Cancer Biother Radiopharm 26:249-57. 2011
  3. ncbi request reprint Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract
    Jisha Joy
    Department of Radiation Biology, Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, Kerala, India
    J Cancer Res Ther 4:111-5. 2008
  4. ncbi request reprint Protection of DNA from gamma-radiation induced strand breaks by Epicatechin
    Cherupally Krishnan Krishnan Nair
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, India
    Mutat Res 650:48-54. 2008
  5. doi request reprint Protection of DNA and membranes from gamma-radiation induced damages by Centella asiatica
    Jisha Joy
    Amala Cancer Research Centre, Kerala, India
    J Pharm Pharmacol 61:941-7. 2009
  6. doi request reprint Protection from lethal and sub-lethal whole body exposures of mice to γ-radiation by Acorus calamus L.: studies on tissue antioxidant status and cellular DNA damage
    Divyasree Sandeep
    Amala Cancer Research Centre, Amala Nagar, Trichur 680555, Kerala, India
    Exp Toxicol Pathol 64:57-64. 2012
  7. pmc Radioprotective effects of gallic acid in mice
    Gopakumar Gopinathan Nair
    Department of Radiation Biology, Amala Cancer Research Centre, Thrissur, Kerala 680555, India
    Biomed Res Int 2013:953079. 2013
  8. doi request reprint Prevention of γ-radiation induced cellular genotoxicity by tempol: protection of hematopoietic system
    Lakshmy Ramachandran
    Amala Cancer Research Centre, Thrissur 680555, Kerala, India
    Environ Toxicol Pharmacol 34:253-62. 2012
  9. doi request reprint Protection of cellular DNA and membrane from γ-radiation-induced damages and enhancement in DNA repair by sesamol
    Gopakumar Gopinathan Nair
    Department of Radiation Biology, Amala Cancer Research Centre, Thrissur, Kerala, India
    Cancer Biother Radiopharm 25:629-35. 2010
  10. ncbi request reprint Radiation protection of DNA by ferulic acid under in vitro and in vivo conditions
    Dharmendra Kumar Maurya
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India
    Mol Cell Biochem 280:209-17. 2005

Collaborators

  • Dharmendra Kumar Maurya
  • Nitin Motilal Gandhi
  • Dhanya K Chandrasekharan
  • Lakshmy Ramachandran
  • Divyasree Sandeep
  • Gopakumar Gopinathan Nair
  • Jisha Joy
  • Tsutomu V Kagiya
  • Pawan K Khanna
  • R Nagalekshmi
  • Dani Mathew Maliakel
  • Rema Rajagopalan
  • Aditya Menon
  • Chirakkal V Krishnan

Detail Information

Publications25

  1. ncbi request reprint Radiation protection by Terminalia chebula: some mechanistic aspects
    Nitin Motilal Gandhi
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India
    Mol Cell Biochem 277:43-8. 2005
    ..TCE also protected the human lymphocytes from undergoing the gamma radiation-induced damage to DNA exposed in vitro to 2 Gy gamma-radiation. These results suggest the radioprotective ability of TCE...
  2. doi request reprint Synthesis of nanosilver using a vitamin C derivative and studies on radiation protection
    Dhanya K Chandrasekharan
    Amala Cancer Research Centre, Thrissur, Kerala, India
    Cancer Biother Radiopharm 26:249-57. 2011
    ..The studies, under in vitro, ex vivo, and in vivo radiation exposure conditions, showed effective radiation protection...
  3. ncbi request reprint Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract
    Jisha Joy
    Department of Radiation Biology, Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, Kerala, India
    J Cancer Res Ther 4:111-5. 2008
    ..The purpose of the present study is to investigate whether the hydro-alcoholic extract of Rubia cordifolia could decrease the intensity of toxicity in Swiss albino mice...
  4. ncbi request reprint Protection of DNA from gamma-radiation induced strand breaks by Epicatechin
    Cherupally Krishnan Krishnan Nair
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, India
    Mutat Res 650:48-54. 2008
    ..Thus, EC was found to protect DNA from gamma-radiation indiced strand breaks under in vitro as well as in vivo conditions of radiation exposure...
  5. doi request reprint Protection of DNA and membranes from gamma-radiation induced damages by Centella asiatica
    Jisha Joy
    Amala Cancer Research Centre, Kerala, India
    J Pharm Pharmacol 61:941-7. 2009
    ..The objective of the present study was to examine the ability of Centella asiatica extract to offer protection to DNA and membranes against the deleterious effects of ionizing radiation exposure...
  6. doi request reprint Protection from lethal and sub-lethal whole body exposures of mice to γ-radiation by Acorus calamus L.: studies on tissue antioxidant status and cellular DNA damage
    Divyasree Sandeep
    Amala Cancer Research Centre, Amala Nagar, Trichur 680555, Kerala, India
    Exp Toxicol Pathol 64:57-64. 2012
    ..The survival rate was found to be increased up to 5%. These studies highlight the role of A. calamus extract as good source of natural radioprotecting agent and its therapeutic implications for radiation-induced injuries...
  7. pmc Radioprotective effects of gallic acid in mice
    Gopakumar Gopinathan Nair
    Department of Radiation Biology, Amala Cancer Research Centre, Thrissur, Kerala 680555, India
    Biomed Res Int 2013:953079. 2013
    ....
  8. doi request reprint Prevention of γ-radiation induced cellular genotoxicity by tempol: protection of hematopoietic system
    Lakshmy Ramachandran
    Amala Cancer Research Centre, Thrissur 680555, Kerala, India
    Environ Toxicol Pharmacol 34:253-62. 2012
    ..The studies thus provided compelling evidence to reveal the effectiveness of TPL to protect hematopoietic system from radiation injury...
  9. doi request reprint Protection of cellular DNA and membrane from γ-radiation-induced damages and enhancement in DNA repair by sesamol
    Gopakumar Gopinathan Nair
    Department of Radiation Biology, Amala Cancer Research Centre, Thrissur, Kerala, India
    Cancer Biother Radiopharm 25:629-35. 2010
    ..SM protected the biomembranes from radiation-induced lipid peroxidation. Thus, SM could act as a radioprotector for the biomembranes and cellular DNA against the deleterious effects of ionizing radiation...
  10. ncbi request reprint Radiation protection of DNA by ferulic acid under in vitro and in vivo conditions
    Dharmendra Kumar Maurya
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India
    Mol Cell Biochem 280:209-17. 2005
    ....
  11. ncbi request reprint Preferential radioprotection to DNA of normal tissues by ferulic acid under ex vivo and in vivo conditions in tumor bearing mice
    Dharmendra Kumar Maurya
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, 400 085, Maharashtra, India
    Mol Cell Biochem 285:181-90. 2006
    ..It was found that under ex vivo condition also only bone marrow cells were protected by FA. Thus the studies revealed that FA showed preferential protection to normal cells under both in vivo and ex vivo conditions...
  12. ncbi request reprint Protection against genotoxic damages following whole body gamma radiation exposure in mice by lipoic acid
    Lakshmy Ramachandran
    Amala Cancer Research Centre, Thrissur 680555, Kerala, India
    Mutat Res 724:52-8. 2011
    ..Thus taken together, LA a normal cellular constituent could be used as a radioprotector against whole body radiation exposure scenarios...
  13. ncbi request reprint Protection of cellular DNA from gamma-radiation-induced damages and enhancement in DNA repair by troxerutin
    Dharmendra Kumar Maurya
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, 400085, India
    Mol Cell Biochem 280:57-68. 2005
    ....
  14. doi request reprint Hepatoprotective activity of Andrographis paniculata and Swertia chirayita
    R Nagalekshmi
    Amrita School of Pharmacy, Kochi 682041, Kerala, India
    Food Chem Toxicol 49:3367-73. 2011
    ..Thus the present study revealed that the extracts of A. paniculata or S. chirayita offered protection against hepatotoxicity induced by paracetamol...
  15. ncbi request reprint Radiation protection by 6-palmitoyl ascorbic acid-2-glucoside: studies on DNA damage in vitro, ex vivo, in vivo and oxidative stress in vivo
    Dhanya K Chandrasekharan
    Amala Cancer Research Centre, Thrissur, Kerala, India
    J Radiat Res 50:203-12. 2009
    ..PAsAG administration improved the per cent survival of mice following exposure to 10 Gy whole body gamma-radiation. Thus PAsAG could act as a radioprotector under in vitro, ex vivo and in vivo conditions of ionizing-radiation exposure...
  16. doi request reprint Prevention of cisplatin-induced nephrotoxicity by glucosides of ascorbic acid and alpha-tocopherol
    Dani Mathew Maliakel
    Amala Cancer Research Centre, Trichur 680555, Kerala, India
    Exp Toxicol Pathol 60:521-7. 2008
    ..This drug, at effective higher doses, causes many physiological adverse effects such as nephrotoxicity and genotoxicity. The toxicity of the drug has been attributed to the induction of oxidative free radicals...
  17. doi request reprint Cellular radioprotecting potential of glyzyrrhizic acid, silver nanoparticle and their complex
    Dhanya K Chandrasekharan
    Amala Cancer Research Centre, Thrissur 680555, Kerala, India
    Mutat Res 723:51-7. 2011
    ..In SN-GLY treated mice the cellular DNA was found protected to a greater extent compared to GLY or SN treated mice. The studies, under in vivo radiation exposure conditions, showed effective radiation protection...
  18. ncbi request reprint Protection of DNA and membrane from gamma radiation induced damage by gallic acid
    Nitin Motilal Gandhi
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India
    Mol Cell Biochem 278:111-7. 2005
    ..Administration of GA to mice prior to whole body radiation exposure reduced the peroxidation of lipids and the damage to the cellular DNA indicating in vivo radiation protection of membranes and DNA by GA...
  19. doi request reprint Radioprotection by α-asarone: prevention of genotoxicity and hematopoietic injury in mammalian organism
    Divyasree Sandeep
    Amala Cancer Research Centre, Trichur 680555, Kerala, India
    Mutat Res 722:62-8. 2011
    ..These studies highlight the role of α-asarone as a good natural radioprotecting agent with therapeutic implications in case of radiation-exposure scenarios...
  20. doi request reprint Studies on silver nanoparticle-glycyrrhizic acid complex as a radioprotector and an adjuvant in radiotherapy under in vivo conditions
    Dhanya K Chandrasekharan
    Amala Cancer Research Centre, Thrissur, India
    Cancer Biother Radiopharm 27:642-51. 2012
    ..It was also found that the oral administration of the complex to tumor-bearing mice before 4 Gy gamma irradiation resulted in a faster tumor regression...
  21. doi request reprint A novel microplate-based assay for screening radioprotectors and its validation based on DNA and membrane system
    Dharmendra Kumar Maurya
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
    Mutat Res 749:93-6. 2012
    ..In conclusion, the crocin bleaching assay developed here is a simple, fast and economical screening assay and it will have great value in radioprotection programme for screening many potential compounds for radioprotection...
  22. doi request reprint Radioprotection by alpha-lipoic acid palladium complex formulation (POLY-MVA) in mice
    Lakshmy Ramachandran
    Amala Cancer Research Centre, Thrissur, India
    Cancer Biother Radiopharm 25:395-9. 2010
    ..These results suggest the potential use of POLY-MVA as a radioprotector in cases of planned radiation exposures...
  23. ncbi request reprint Radiation protection by diethyldithiocarbamate: protection of membrane and DNA in vitro and in vivo against gamma-radiation
    Nitin Motilal Gandhi
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India
    J Radiat Res 45:175-80. 2004
    ..The present study has implication for the potential use of DDTC as a radioprotector...
  24. ncbi request reprint Protection of DNA and membrane from γ-radiation induced damage by the extract of Acorus calamus Linn.: An in vitro study
    Divyasree Sandeep
    Amala Cancer Research Centre, Trichur 680555, Kerala, India
    Environ Toxicol Pharmacol 29:302-7. 2010
    ..Also the A. calamus extract effectively protected DNA from radiation induced strand breaks and enhanced the DNA repair process. Hence A. calamus extract can be used as a good source of natural radioprotecting agent...
  25. ncbi request reprint Radiosensitizer sanazole (AK-2123) enhances gamma-radiation-induced apoptosis in murine fibrosarcoma
    Rema Rajagopalan
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
    J Radiat Res 44:359-65. 2003
    ..p. administration of AK-2123 and irradiation alone; it was higher during the first few days followed by the treatment...