The effect of ascorbic acid on the pharmacokinetics of levodopa in elderly patients with Parkinson diseaseHiroshi Nagayama
Second Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
Clin Neuropharmacol 27:270-3. 2004
..hour/mL. In conclusion, AsA can improve LD absorption in elderly PD patients with poor LD bioavailability. LD therapy in combination with AsA may be one of the strategies for PD treatment...
Reliability of MIBG myocardial scintigraphy in the diagnosis of Parkinson's diseaseH Nagayama
Department of Neurology, Tokyo Metropolitan Tama Geriatric Hospital, Tokyo 189 8511, Japan
J Neurol Neurosurg Psychiatry 76:249-51. 2005
..To evaluate the reliability of [(123)I]meta-iodobenzylguanidine (MIBG) myocardial scintigraphy for diagnosing Parkinson's disease (PD)...
Abnormal cardiac [(123)I]-meta-iodobenzylguanidine uptake in multiple system atrophyHiroshi Nagayama
Divisions of Neurology, Nephrology, and Rheumatology, Department of Internal Medicine, Nippon Medical School, Sendagi Bunkyo ku, Tokyo, Japan
Mov Disord 25:1744-7. 2010
..This data clearly showed that cardiac MIBG uptake cannot necessarily be preserved in patients with MSA and that approximately 30% of patients with MSA showed decreased MIBG uptake without any correlation to disease duration or severity...
- Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients
Yasuhiro Nishiyama
Division of Neurology, Nephrology and Rheumatology, Department of Internal Medicine, Nippon Medical School, Bunkyo ku, Tokyo, Japan
J Atheroscler Thromb 18:131-7. 2011
..A prospective, controlled study was conducted to examine whether statin treatment affects serum ADMA concentrations in ischemic stroke patients...
- Influence of ageing on the pharmacokinetics of levodopa in elderly patients with Parkinson's disease
Hiroshi Nagayama
Department of Internal Medicine, Division of Neurology, Nephrology and Rheumatology, Nippon Medical School, Tokyo, Japan
Parkinsonism Relat Disord 17:150-2. 2011
..The difference in oral LD bioavailability between the groups may result from a difference in excretion ability. Physicians should consider LD pharmacokinetics when treating elderly PD patients...
- Correlation between insulin resistance and white matter lesions among non-diabetic patients with ischemic stroke
Toshiya Katsumata
Department of Internal Medicine, Division of Neurology, Nephrology, and Rheumatology, Nippon Medical School, Bunkyo ku, Tokyo, Japan
Neurol Res 32:743-7. 2010
..We investigated whether a correlation exists between insulin resistance and the severity of cerebral white matter lesions among non-diabetic patients with ischemic stroke...
- Early depressive symptoms after ischemic stroke are associated with a left lenticulocapsular area lesion
Yasuhiro Nishiyama
Divisions of Neurology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
J Stroke Cerebrovasc Dis 19:184-9. 2010
..We examined the relation between lesion location and presence of depressive symptoms 1 month after ischemic stroke, with a view toward early management of depressive symptoms...
- Asymmetric dimethylarginine (ADMA) as a possible risk marker for ischemic stroke
Yasuhiro Nishiyama
Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
J Neurol Sci 290:12-5. 2010
..Asymmetric dimethylarginine (ADMA) affects vascular function by blocking nitric oxide synthesis. We examined the relationship of ADMA concentration to vascular risk factors in subjects who have undergone annual medical check-up...
- [A case of infarction in brainstem and cerebellum as a initial symptom with bilateral hearing loss]
Eiko Sunami
The Second Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
No To Shinkei 58:791-5. 2006
..Involvements of the cochlear nerve and pontine auditory pathway were suggested from the ABR abnormalities in this case...
- Factors influencing outcome in Guillain-Barré Syndrome: comparison of plasma adsorption against other treatments
Takehiro Seta
The Second Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
Clin Neurol Neurosurg 107:491-6. 2005
..Since PA does not result in a risk of unknown infection, choosing a PA treatment may be justified, especially for patients (or doctors) who may be anxious about a possibility of unknown infection...
- Cerebral blood flow index: dynamic perfusion MRI delivers a simple and good predictor for the outcome of acute-stage ischemic lesion
Hironaka Igarashi
The Second Internal Medicine, Nippon Medical School, Tokyo, Japan
J Comput Assist Tomogr 27:874-81. 2003
....
- Low myocardial MIBG uptake in multiple system atrophy with incidental Lewy body pathology: an autopsy case report
Hiroshi Nagayama
Mov Disord 23:1055-7. 2008
