A N Nafziger

Summary

Publications

  1. ncbi request reprint Design issues in the combination of international data from two rural community cardiovascular intervention programs
    A N Nafziger
    Clinical Pharmacology Research Center and Department of Medicine and The Research Institute, Bassett Healthcare, Cooperstown, New York 13326 1394, USA
    Scand J Public Health Suppl 56:33-9. 2001
  2. ncbi request reprint The Otsego-Schoharie healthy heart program: prevention of cardiovascular disease in the rural US
    A N Nafziger
    Clinical Pharmacology Research Center and Department of Medicine, Bassett Healthcare, Cooperstown, New York 13326 1394, USA
    Scand J Public Health Suppl 56:21-32. 2001
  3. ncbi request reprint Incidence of sexual dysfunction in healthy volunteers on fluvoxamine therapy
    A N Nafziger
    Clinical Pharmacology Research Center and Department of Medicine, Bassett Healthcare, Cooperstown, NY 13326 1394, USA
    J Clin Psychiatry 60:187-90. 1999
  4. ncbi request reprint The Norsjö-Cooperstown healthy heart project: a case study combining data from different studies without the use of meta-analysis
    P L Jenkins
    The Mary Imogene Bassett Research Institute, Cooperstown, New York 13326 1394, USA
    Scand J Public Health Suppl 56:40-5. 2001
  5. ncbi request reprint Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity
    A D Kashuba
    Clinical Pharmacology Research Centre, Bassett Healthcare, Cooperstown, New York, USA
    Pharmacogenetics 9:453-62. 1999
  6. ncbi request reprint Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping
    A D Kashuba
    Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, New York, USA
    Pharmacogenetics 8:403-10. 1998
  7. ncbi request reprint Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail"
    D S Streetman
    Clinical Pharmacology Research Center, Department of Medicine, Bassett Healthcare, Cooperstown, NY, USA
    Clin Pharmacol Ther 68:375-83. 2000
  8. pmc Oral cimetidine prolongs clarithromycin absorption
    G W Amsden
    Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, New York 13326, USA
    Antimicrob Agents Chemother 42:1578-80. 1998
  9. ncbi request reprint Use of midazolam urinary metabolic ratios for cytochrome P450 3A (CYP3A) phenotyping
    D S Streetman
    Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, NY, USA
    Pharmacogenetics 11:349-55. 2001
  10. ncbi request reprint Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes
    D S Streetman
    Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, New York, USA
    Pharmacogenetics 10:187-216. 2000

Detail Information

Publications14

  1. ncbi request reprint Design issues in the combination of international data from two rural community cardiovascular intervention programs
    A N Nafziger
    Clinical Pharmacology Research Center and Department of Medicine and The Research Institute, Bassett Healthcare, Cooperstown, New York 13326 1394, USA
    Scand J Public Health Suppl 56:33-9. 2001
    ....
  2. ncbi request reprint The Otsego-Schoharie healthy heart program: prevention of cardiovascular disease in the rural US
    A N Nafziger
    Clinical Pharmacology Research Center and Department of Medicine, Bassett Healthcare, Cooperstown, New York 13326 1394, USA
    Scand J Public Health Suppl 56:21-32. 2001
    ..To describe a rural, hospital-based public health intervention program and to evaluate its effectiveness in cardiovascular disease (CVD) risk reduction using cross-sectional studies and a panel study...
  3. ncbi request reprint Incidence of sexual dysfunction in healthy volunteers on fluvoxamine therapy
    A N Nafziger
    Clinical Pharmacology Research Center and Department of Medicine, Bassett Healthcare, Cooperstown, NY 13326 1394, USA
    J Clin Psychiatry 60:187-90. 1999
    ..The objective of this study was to determine the incidence of sexual dysfunction secondary to fluvoxamine in healthy volunteers...
  4. ncbi request reprint The Norsjö-Cooperstown healthy heart project: a case study combining data from different studies without the use of meta-analysis
    P L Jenkins
    The Mary Imogene Bassett Research Institute, Cooperstown, New York 13326 1394, USA
    Scand J Public Health Suppl 56:40-5. 2001
    ..comparing, and maximizing the statistical power of two longitudinal studies of risk factors for cardiovascular disease that did not have identical data collection methodologies...
  5. ncbi request reprint Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity
    A D Kashuba
    Clinical Pharmacology Research Centre, Bassett Healthcare, Cooperstown, New York, USA
    Pharmacogenetics 9:453-62. 1999
    ..41, P = 0.1). The large intraindividual variability of the 3MM/DM urinary ratio, as well as the inability to discriminate moderate CYP3A inhibition, makes this a suboptimal method for accurately assessing CYP3A activity...
  6. ncbi request reprint Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping
    A D Kashuba
    Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, New York, USA
    Pharmacogenetics 8:403-10. 1998
    ....
  7. ncbi request reprint Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail"
    D S Streetman
    Clinical Pharmacology Research Center, Department of Medicine, Bassett Healthcare, Cooperstown, NY, USA
    Clin Pharmacol Ther 68:375-83. 2000
    ..Simultaneous administration of several probes enhances the utility of phenotyping, but poor specificity, side effects, and use of drugs not approved by the Food and Drug Administration limit the usefulness of prior phenotyping cocktails...
  8. pmc Oral cimetidine prolongs clarithromycin absorption
    G W Amsden
    Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, New York 13326, USA
    Antimicrob Agents Chemother 42:1578-80. 1998
    ..No mechanism for this interaction has been identified...
  9. ncbi request reprint Use of midazolam urinary metabolic ratios for cytochrome P450 3A (CYP3A) phenotyping
    D S Streetman
    Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, NY, USA
    Pharmacogenetics 11:349-55. 2001
    ..3% versus 23.1%; P= 0.0004). Based on these results, although this midazolam urinary ratio was not very reflective of baseline CYP3A activity, it may be a useful indicator of CYP3A inhibition...
  10. ncbi request reprint Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes
    D S Streetman
    Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, New York, USA
    Pharmacogenetics 10:187-216. 2000
    ..Despite the limitations of many currently available probes, with continued research, phenotyping will become an even more valuable research and clinical resource...
  11. pmc Pharmacokinetics in serum and leukocyte exposures of oral azithromycin, 1,500 milligrams, given over a 3- or 5-day period in healthy subjects
    G W Amsden
    Clinical Pharmacology Research Center, Departments of Pharmacy and Medicine, and Research Institute, Bassett Healthcare, Cooperstown, New York 13326, USA
    Antimicrob Agents Chemother 43:163-5. 1999
    ..These results indicate that the standard 1,500-mg dose of oral azithromycin can be administered over either 5 or 3 days...
  12. pmc Optimizing aminoglycoside therapy for nosocomial pneumonia caused by gram-negative bacteria
    A D Kashuba
    Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, New York 13326, USA
    Antimicrob Agents Chemother 43:623-9. 1999
    ....
  13. pmc Pharmacokinetics of oral fleroxacin in male and premenopausal female volunteers
    J S Bertino
    Department of Pharmacy Services, Bassett Healthcare, Cooperstown, New York 13326 1394, USA
    Antimicrob Agents Chemother 40:789-91. 1996
    ..No difference in other pharmacokinetic parameters was noted. Since adverse events appear to occur in women more commonly than in men, dose-response studies of fleroxacin in women may be appropriate...
  14. ncbi request reprint Effect of intravenous flumazenil on oral midazolam pharmacokinetics and pharmacodynamics for use as a cytochrome P450 3A probe
    J D Ma
    Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, NY, USA
    Int J Clin Pharmacol Ther 47:111-9. 2009
    ..Determining methods to minimize CNS side effects optimizes use of midazolam as a CYP3A probe...