Michael A Nader

Summary

Publications

  1. pmc Environmental modulation of drug taking: Nonhuman primate models of cocaine abuse and PET neuroimaging
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, 546 NRC, Winston Salem, NC 27157 1083, USA Electronic address
    Neuropharmacology 76:510-7. 2014
  2. pmc Nonhuman primate models of social behavior and cocaine abuse
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, 546 NRC, Medical Center Blvd, Winston Salem, NC 27157 1084, USA
    Psychopharmacology (Berl) 224:57-67. 2012
  3. pmc Social dominance in female monkeys: dopamine receptor function and cocaine reinforcement
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Biol Psychiatry 72:414-21. 2012
  4. pmc Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neuropsychopharmacology 34:1162-71. 2009
  5. ncbi request reprint Chronic cocaine self-administration is associated with altered functional activity in the temporal lobes of non human primates
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Eur J Neurosci 23:3109-18. 2006
  6. ncbi request reprint Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains
    Linda J Porrino
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    J Neurosci 24:3554-62. 2004
  7. pmc Effects of nicotinic acetylcholine receptor agonists on cognition in rhesus monkeys with a chronic cocaine self-administration history
    Robert W Gould
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neuropharmacology 64:479-88. 2013
  8. ncbi request reprint Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine
    Paul W Czoty
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 174:381-8. 2004
  9. doi request reprint Effect of menstrual cycle phase on dopamine D2 receptor availability in female cynomolgus monkeys
    Paul W Czoty
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neuropsychopharmacology 34:548-54. 2009
  10. ncbi request reprint PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 9:1050-6. 2006

Collaborators

Detail Information

Publications61

  1. pmc Environmental modulation of drug taking: Nonhuman primate models of cocaine abuse and PET neuroimaging
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, 546 NRC, Winston Salem, NC 27157 1083, USA Electronic address
    Neuropharmacology 76:510-7. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  2. pmc Nonhuman primate models of social behavior and cocaine abuse
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, 546 NRC, Medical Center Blvd, Winston Salem, NC 27157 1084, USA
    Psychopharmacology (Berl) 224:57-67. 2012
    ..Although cocaine is often abused in social situations, very few animal studies examine the effects of cocaine in the context of social behavior...
  3. pmc Social dominance in female monkeys: dopamine receptor function and cocaine reinforcement
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Biol Psychiatry 72:414-21. 2012
    ..For example, male monkeys that become dominant in a social group have significant elevations in D2/D3 receptor availability and are less vulnerable to cocaine reinforcement...
  4. pmc Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neuropsychopharmacology 34:1162-71. 2009
    ....
  5. ncbi request reprint Chronic cocaine self-administration is associated with altered functional activity in the temporal lobes of non human primates
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Eur J Neurosci 23:3109-18. 2006
    ....
  6. ncbi request reprint Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains
    Linda J Porrino
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    J Neurosci 24:3554-62. 2004
    ....
  7. pmc Effects of nicotinic acetylcholine receptor agonists on cognition in rhesus monkeys with a chronic cocaine self-administration history
    Robert W Gould
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neuropharmacology 64:479-88. 2013
    ..The cognitive enhancing effects of nAChR agonists may be beneficial in combination with behavioral treatments for cocaine addiction. This article is part of a Special Issue entitled 'Cognitive Enhancers'...
  8. ncbi request reprint Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine
    Paul W Czoty
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 174:381-8. 2004
    ..The present studies were designed to extend these findings to maintenance of cocaine reinforcement and to DA D(1) receptors...
  9. doi request reprint Effect of menstrual cycle phase on dopamine D2 receptor availability in female cynomolgus monkeys
    Paul W Czoty
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neuropsychopharmacology 34:548-54. 2009
    ....
  10. ncbi request reprint PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 9:1050-6. 2006
    ..Individual differences in the rate of recovery of D2 receptor function during abstinence were noted...
  11. ncbi request reprint Effects of chronic cocaine self-administration on norepinephrine transporters in the nonhuman primate brain
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 180:781-8. 2005
    ..To date, no studies have made a systematic investigation of the effects of chronic cocaine on primate NET density...
  12. pmc Effects of chronic d-amphetamine administration on the reinforcing strength of cocaine in rhesus monkeys
    Paul W Czoty
    Department of Physiology and Pharmacology, Center for the Neurobiology of Addiction Treatments CNAT, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157 1083, USA
    Psychopharmacology (Berl) 209:375-82. 2010
    ..In preclinical studies, chronic d-amphetamine treatment decreased ongoing cocaine self-administration...
  13. ncbi request reprint Long-term cocaine self-administration under fixed-ratio and second-order schedules in monkeys
    Paul W Czoty
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, 546 NRC, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 191:287-95. 2007
    ..Studies in rodents have demonstrated that increased access to cocaine can result in increases in drug intake per unit time...
  14. pmc Characterization of the dopamine receptor system in adult rhesus monkeys exposed to cocaine throughout gestation
    Lindsey R Hamilton
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, 546 NRC, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 210:481-8. 2010
    ..Cocaine use during pregnancy is associated with alterations in the dopamine (DA) system in the fetal brain. However, little is known about the effects of prenatal cocaine exposure on the postnatal dopaminergic system...
  15. pmc Effects of chronic methylphenidate on cocaine self-administration under a progressive-ratio schedule of reinforcement in rhesus monkeys
    Paul W Czoty
    Department of Physiology and Pharmacology, Center for the Neurobiology of Addiction Treatments, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    J Pharmacol Exp Ther 345:374-82. 2013
    ..In contrast to the positive effects with the monoamine releaser d-amphetamine under identical conditions, these results do not support use of monoamine uptake inhibitors like MPD as a medication for cocaine dependence...
  16. pmc Relationship between response rates and measures of reinforcing strength using a choice procedure in monkeys
    Matthew L Banks
    Department of Physiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Behav Pharmacol 19:365-9. 2008
    ....
  17. ncbi request reprint Effects of the dopamine reuptake inhibitor PTT on reinstatement and on food- and cocaine-maintained responding in rhesus monkeys
    Joshua A Lile
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 174:246-53. 2004
    ....
  18. pmc Effect of time-out duration on the reinforcing strength of cocaine assessed under a progressive-ratio schedule in rhesus monkeys
    Jennifer L Martelle
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Behav Pharmacol 19:743-6. 2008
    ..However, the reinforcing strength of higher cocaine doses was unaffected by manipulating TO, suggesting that the BP value is a useful measure of reinforcing strength...
  19. ncbi request reprint PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation
    Michael A Nader
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Psychiatry 162:1473-82. 2005
    ....
  20. pmc Review. Positron emission tomography imaging studies of dopamine receptors in primate models of addiction
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, 546 NRC, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Philos Trans R Soc Lond B Biol Sci 363:3223-32. 2008
    ..These findings highlight a pervasive influence of the environment in modifying the reinforcing effects of cocaine and strongly implicate brain D2 receptors...
  21. pmc Lower reinforcing strength of the phenyltropane cocaine analogs RTI-336 and RTI-177 compared to cocaine in nonhuman primates
    Paul W Czoty
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Pharmacol Biochem Behav 96:274-8. 2010
    ..In addition, the present findings suggest that changes in PR session length can influence potency comparisons between drugs, but not measures of reinforcing strength...
  22. pmc Effects of cocaine and MDMA self-administration on serotonin transporter availability in monkeys
    Matthew L Banks
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neuropsychopharmacology 33:219-25. 2008
    ..The higher level of SERT availability in cocaine-experienced monkeys may lead to a reduced inhibitory tone of 5-HT on the DA system, which may explain, in part, differences in the abuse liability between cocaine and MDMA...
  23. pmc The influence of reinforcing effects of cocaine on cocaine-induced increases in extinguished responding in cynomolgus monkeys
    Matthew L Banks
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 192:449-56. 2007
    ..e., unconditioned, discriminative or reinforcing) mediate the increases in responding after extinction...
  24. ncbi request reprint Effects of two novel D3-selective compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the reinforcing and discrimin
    Jennifer L Martelle
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, NRC 546, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    J Pharmacol Exp Ther 321:573-82. 2007
    ..The present findings support the continued examination of D3 compounds as pharmacological tools for better understanding the role of this receptor subtype in cocaine addiction and as potential lead compounds for novel therapeutic agents...
  25. pmc Prolonged attenuation of the reinforcing strength of cocaine by chronic d-amphetamine in rhesus monkeys
    Paul W Czoty
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neuropsychopharmacology 36:539-47. 2011
    ....
  26. pmc Differential effects of cocaine and MDMA self-administration on cortical serotonin transporter availability in monkeys
    Robert W Gould
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States
    Neuropharmacology 61:245-51. 2011
    ..These data extend our previous findings indicating that cocaine and MDMA self-administration differentially alter SERT availability in subcortical and cortical regions, which may have implications for development of treatment drugs...
  27. pmc Influence of thyroid hormones on 3,4-methylenedioxymethamphetamine-induced thermogenesis and reinforcing strength in monkeys
    Matthew L Banks
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Behav Pharmacol 19:167-70. 2008
    ..These results suggest that changes in thyroxine levels do not parallel the changes in ambient temperature in altering the reinforcing strength of MDMA...
  28. pmc Differences in D2 dopamine receptor availability and reaction to novelty in socially housed male monkeys during abstinence from cocaine
    Paul W Czoty
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, 546 NRC, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 208:585-92. 2010
    ....
  29. ncbi request reprint The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamics
    Joshua A Lile
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Center for the Neurobiological Investigation of Drug Abuse, Winston Salem, NC 27157 1083, USA
    J Pharmacol Exp Ther 307:356-66. 2003
    ..These data question the dogma regarding the role of pharmacokinetic factors and the relative influence of DAT and 5-HTT in stimulant reinforcement...
  30. ncbi request reprint PET imaging of striatal dopamine D2 receptors in nonhuman primates: increases in availability produced by chronic raclopride treatment
    Paul W Czoty
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Synapse 58:215-9. 2005
    ..Individual differences in rates of recovery were observed, such that the increases in DVR persisted in two of three subjects...
  31. ncbi request reprint The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys
    Renee Claytor
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Pharmacol Biochem Behav 83:456-64. 2006
    ..Future studies with more selective D3 antagonists are needed to better address the role of this receptor subtype in cocaine addiction...
  32. pmc Effects of ambient temperature on the relative reinforcing strength of MDMA using a choice procedure in monkeys
    Matthew L Banks
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 196:63-70. 2008
    ..3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is frequently used in hot environments, such as rave parties. Studies in laboratory animals have shown that ambient temperature can alter the behavioral and neurochemical effects of MDMA...
  33. pmc Effects of varenicline on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys
    Robert W Gould
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, 546 NRC, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    J Pharmacol Exp Ther 339:678-86. 2011
    ..1 mg/kg i.v.), potentiated the discriminative stimulus effects of cocaine. These results suggest that varenicline has low abuse liability in monkey models of cocaine abuse, but would not be an effective medication for cocaine addiction...
  34. ncbi request reprint Metabolic mapping of the effects of cocaine during the initial phases of self-administration in the nonhuman primate
    Linda J Porrino
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 22:7687-94. 2002
    ..The assessment of the effects of cocaine at a time not readily evaluated in humans provides a baseline from which the effects of chronic cocaine exposure can be investigated...
  35. pmc Effects of dopamine D2/D3 receptor ligands on food-cocaine choice in socially housed male cynomolgus monkeys
    Paul W Czoty
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    J Pharmacol Exp Ther 344:329-38. 2013
    ..Moreover, these results suggest that exposure to cocaine during treatment can counteract treatment-induced reductions in the reinforcing effects of cocaine...
  36. ncbi request reprint The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration
    Linda J Porrino
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neurosci Biobehav Rev 27:813-20. 2004
    ....
  37. pmc Behavioral characterization of adult male and female rhesus monkeys exposed to cocaine throughout gestation
    Lindsey R Hamilton
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, 546 NRC, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 213:799-808. 2011
    ..In utero cocaine exposure has been associated with alterations in the dopamine (DA) system in monkeys. However, the behavioral outcomes of prenatal cocaine exposure in adulthood are poorly understood...
  38. ncbi request reprint Functional effects of cocaine self-administration in primate brain regions regulating cardiovascular function
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neurosci Lett 370:201-5. 2004
    ..These alterations progress with prolonged cocaine exposure, and therefore may be involved in mediating changes in central autonomic control and the neuroadaptations reported to result from chronic drug abuse...
  39. pmc The relationship between cocaine self-administration and actigraphy-based measures of sleep in adult rhesus monkeys
    Robert E Brutcher
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, 546 NRC, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 229:267-74. 2013
    ..Clinical trials show that chronic cocaine users suffer from sleep disturbances and preclinical research has shown that acute sleep deprivation increases the rate of cocaine self-administration in rats...
  40. doi request reprint Effects of chronic methylphenidate in adolescence on later methylphenidate self-administration in rhesus monkeys
    Susan E Martelle
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Behav Pharmacol 24:478-81. 2013
    ..These findings extend earlier research with cocaine reinforcement showing that MPH treatment in adolescent monkeys does not increase future reinforcing effects of stimulant drugs. ..
  41. pmc Chronic treatment with extended release methylphenidate does not alter dopamine systems or increase vulnerability for cocaine self-administration: a study in nonhuman primates
    Kathryn E Gill
    Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC, USA
    Neuropsychopharmacology 37:2555-65. 2012
    ..Furthermore, this treatment regimen and subsequent drug washout did not have an impact on vulnerability to cocaine abuse...
  42. ncbi request reprint Cocaine- and food-maintained responding under a multiple schedule in rhesus monkeys: environmental context and the effects of a dopamine antagonist
    Michael A Nader
    Department of Physiology and Pharmacology, The Center for Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, 5th Floor NRC, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 163:292-301. 2002
    ..The hypothesis was that changes in the magnitude of food reinforcement would affect cocaine-maintained response rates and influence the behavioral potency of a dopamine antagonist to decrease cocaine self-administration...
  43. pmc The relative reinforcing strength of methamphetamine and D-amphetamine in monkeys self-administering cocaine
    Joshua A Lile
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Behav Pharmacol 24:482-5. 2013
    ....
  44. pmc Effects of chronic cocaine self-administration on cognition and cerebral glucose utilization in Rhesus monkeys
    Robert W Gould
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Biol Psychiatry 72:856-63. 2012
    ..The effects of current cocaine use and abstinence on neurobiology and cognition are not well characterized...
  45. pmc Individual differences in the effects of environmental stimuli on cocaine choice in socially housed male cynomolgus monkeys
    Paul W Czoty
    Department of Physiology and Pharmacology, School of Medicine, Wake Forest University, Medical Center Blvd, 546 NRC, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 224:69-79. 2012
    ..Studies in laboratory animals have demonstrated an influence of environmentally derived stress and enrichment on the reinforcing effects of stimulants...
  46. ncbi request reprint Influence of abstinence and conditions of cocaine access on the reinforcing strength of cocaine in nonhuman primates
    Paul W Czoty
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Drug Alcohol Depend 85:213-20. 2006
    ..These results fail to support the views that increasing access to cocaine or abstinence enhances the reinforcing strength of cocaine...
  47. ncbi request reprint Chronic cocaine self-administration upregulates the norepinephrine transporter and alters functional activity in the bed nucleus of the stria terminalis of the rhesus monkey
    Darrel J Macey
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Neurosci 23:12-6. 2003
    ..Furthermore, given the role of the BNST in cocaine withdrawal and stress-related reinstatement of self-administration, the changes reported here may provide a substrate for these phenomena...
  48. ncbi request reprint Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration
    Drake Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 5:169-74. 2002
    ..These data demonstrate that alterations in an organism's environment can produce profound biological changes that have important behavioral associations, including vulnerability to cocaine addiction...
  49. ncbi request reprint The reinforcing efficacy of the dopamine reuptake inhibitor 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) as measured by a progressive-ratio schedule and a choice procedure in rhesus monkeys
    Joshua A Lile
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    J Pharmacol Exp Ther 303:640-8. 2002
    ....
  50. ncbi request reprint Assessment of the relative reinforcing strength of cocaine in socially housed monkeys using a choice procedure
    Paul W Czoty
    Center for the Neurobiogical Investigation of Drug Abuse, Department of Physiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Pharmacol Exp Ther 312:96-102. 2005
    ..053). These data indicate that despite an extensive history of cocaine self-administration, most subordinate monkeys were more sensitive to the relative reinforcing strength of cocaine than dominant monkeys...
  51. pmc The effects of cocaine: a shifting target over the course of addiction
    Linda J Porrino
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:1593-600. 2007
    ....
  52. pmc A within-subject assessment of the discriminative stimulus and reinforcing effects of self-administered cocaine in rhesus monkeys
    Jennifer L Martelle
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, 546 NRC, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 203:343-53. 2009
    ..All preclinical studies with cocaine have examined the discriminative stimulus (S(D)) and reinforcing (S(R)) effects in separate groups of subjects...
  53. ncbi request reprint PET Imaging of Dopamine D2 Receptor and Transporter Availability During Acquisition of Cocaine Self-administration in Rhesus Monkeys
    Paul W Czoty
    From the Department of Physiology and Pharmacology PWC, SHN, Man, Department of Radiology HDG, MB, Man, and Department of Biostatistical Sciences BAR, Wake Forest University School of Medicine, Winston Salem, NC
    J Addict Med 1:33-9. 2007
    ..These results demonstrate lateralization of D2R and DAT availability in brain areas that mediate cocaine self-administration, even under conditions in which cocaine does not affect overall receptor availability...
  54. ncbi request reprint Brain imaging in nonhuman primates: insights into drug addiction
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    ILAR J 49:89-102. 2008
    ..These techniques will provide the foundation for future studies aimed at developing behavioral and pharmacological treatments for many human diseases...
  55. ncbi request reprint A comparison of the reinforcing efficacy of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") with cocaine in rhesus monkeys
    Joshua A Lile
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Drug Alcohol Depend 78:135-40. 2005
    ..These data demonstrate that MDMA functions as a reinforcer, although its reinforcing efficacy appears to be less than that of cocaine...
  56. pmc A review of the discovery, pharmacological characterization, and behavioral effects of the dopamine D2-like receptor antagonist eticlopride
    Jennifer L Martelle
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    CNS Neurosci Ther 14:248-62. 2008
    ..While eticlopride is not used clinically, it remains a viable research tool for understanding DA receptor function and behavior...
  57. ncbi request reprint Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuropsychopharmacology 27:35-46. 2002
    ..These findings demonstrate that chronic cocaine self-administration produces neuroadaptations in dopamine systems, but that these changes do not occur in a parallel fashion...
  58. pmc A MEG investigation of somatosensory processing in the rhesus monkey
    Tony W Wilson
    Department of Neurology, Wake Forest University School of Medicine, USA
    Neuroimage 46:998-1003. 2009
    ....
  59. ncbi request reprint Ambient temperature effects on 3,4-methylenedioxymethamphetamine-induced thermodysregulation and pharmacokinetics in male monkeys
    Matthew L Banks
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Drug Metab Dispos 35:1840-5. 2007
    ..Overall, induction of hypothermia in a cool environment by MDMA may alter its disposition. These results could have implications for MDMA-induced serotonergic consequences...
  60. pmc Regionally-specific alterations in myelin proteins in nonhuman primate white matter following prolonged cocaine self-administration
    Hilary R Smith
    Department of Physiology and Pharmacology, Center for the Neurobiology of Addiction Treatment CNAT, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Drug Alcohol Depend 137:143-7. 2014
    ..The aim of the present studies was to investigate the influence of prolonged cocaine self-administration on the levels of myelin-associated proteins and mRNAs in nonhuman primate white matter...
  61. pmc Nonhuman Primate Models of Addiction and PET Imaging: Dopamine System Dysregulation
    Robert W Gould
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, 27157 1083, USA
    Curr Top Behav Neurosci 11:25-44. 2012
    ....