Rikke Nørregaard



  1. Carlsen I, Frøkiær J, Nørregaard R. Quercetin attenuates cyclooxygenase-2 expression in response to acute ureteral obstruction. Am J Physiol Renal Physiol. 2015;308:F1297-305 pubmed publisher
  2. Cheema M, Irsik D, Wang Y, Miller Little W, Hyndman K, Marks E, et al. Estradiol regulates AQP2 expression in the collecting duct: a novel inhibitory role for estrogen receptor α. Am J Physiol Renal Physiol. 2015;309:F305-17 pubmed publisher
    ..These findings suggest that changes in estradiol levels, such as during menopause or following reproductive surgeries, may contribute to dysregulation of water homeostasis in women. ..
  3. Nilsson L, Madsen K, Krag S, Frøkiær J, Jensen B, Nørregaard R. Disruption of cyclooxygenase type 2 exacerbates apoptosis and renal damage during obstructive nephropathy. Am J Physiol Renal Physiol. 2015;309:F1035-48 pubmed publisher
    ..COX-2 is not likely to directly regulate antioxidant enzymes heme oxygenase-1 and SOD in the kidney. ..
  4. Kristensen M, Kierulf Lassen C, Nielsen P, Krag S, Birn H, Nejsum L, et al. Remote ischemic perconditioning attenuates ischemia/reperfusion-induced downregulation of AQP2 in rat kidney. Physiol Rep. 2016;4: pubmed publisher
    ..In conclusion, our data suggest that rIPeC might prevent dysregulation of renal water and salt handling via regulation of AQP2 expression and phosphorylation as well as via regulation of Na-K-ATPase expression in I/R rat kidneys. ..
  5. Yang C, Vu Quang H, Husum D, Tingskov S, Vinding M, Nielsen T, et al. Theranostic poly(lactic-co-glycolic acid) nanoparticle for magnetic resonance/infrared fluorescence bimodal imaging and efficient siRNA delivery to macrophages and its evaluation in a kidney injury model. Nanomedicine. 2017;13:2451-2462 pubmed publisher
    ..In addition, in vivo silencing of COX-2 was achieved by NP/PEI/siCOX-2, which further attenuated kidney injury. Our theranostic platform represents a promising approach for simultaneous diagnosis and treatment of inflammatory diseases. ..