Richard M Myers

Summary

Publications

  1. pmc Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation
    Jason Gertz
    HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America
    PLoS Genet 7:e1002228. 2011
  2. pmc Functional analysis of transcription factor binding sites in human promoters
    Troy W Whitfield
    Program in Bioinformatics and Integrative Biology and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Genome Biol 13:R50. 2012
  3. pmc Characterization of X-linked SNP genotypic variation in globally distributed human populations
    Amanda M Casto
    Department of Genetics, Stanford University, Mail Stop 5120, Stanford, California 94305, USA
    Genome Biol 11:R10. 2010
  4. pmc Characterizing the admixed African ancestry of African Americans
    Fouad Zakharia
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Genome Biol 10:R141. 2009
  5. pmc Distinct properties of cell-type-specific and shared transcription factor binding sites
    Jason Gertz
    HudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL 35806, USA
    Mol Cell 52:25-36. 2013
  6. pmc Dynamic DNA methylation across diverse human cell lines and tissues
    Katherine E Varley
    HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA
    Genome Res 23:555-67. 2013
  7. pmc Effects of sequence variation on differential allelic transcription factor occupancy and gene expression
    Timothy E Reddy
    HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA
    Genome Res 22:860-9. 2012
  8. pmc The hypersensitive glucocorticoid response specifically regulates period 1 and expression of circadian genes
    Timothy E Reddy
    HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA
    Mol Cell Biol 32:3756-67. 2012
  9. pmc Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner
    Jason Gertz
    HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA
    Genome Res 22:2153-62. 2012
  10. ncbi request reprint Recurrent read-through fusion transcripts in breast cancer
    Katherine E Varley
    HudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL, 35806, USA
    Breast Cancer Res Treat 146:287-97. 2014

Detail Information

Publications13

  1. pmc Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation
    Jason Gertz
    HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America
    PLoS Genet 7:e1002228. 2011
    ..Overall, our results demonstrate that the influence of genotype on patterns of DNA methylation is widespread in the genome and greatly exceeds the influence of imprinting on genome-wide methylation patterns...
  2. pmc Functional analysis of transcription factor binding sites in human promoters
    Troy W Whitfield
    Program in Bioinformatics and Integrative Biology and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Genome Biol 13:R50. 2012
    ..We carried out functional tests on these sites in four different immortalized human cell lines using transient transfections with a luciferase reporter assay, primarily for the transcription factors CTCF, GABP, GATA2, E2F, STAT, and YY1...
  3. pmc Characterization of X-linked SNP genotypic variation in globally distributed human populations
    Amanda M Casto
    Department of Genetics, Stanford University, Mail Stop 5120, Stanford, California 94305, USA
    Genome Biol 11:R10. 2010
    ..Here we characterize the genomic variation represented by 16,297 X-linked SNPs genotyped in the CEPH human genome diversity project samples...
  4. pmc Characterizing the admixed African ancestry of African Americans
    Fouad Zakharia
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Genome Biol 10:R141. 2009
    ..To focus on African ancestry, we reduced the data to include only those genotypes in each African American determined statistically to be African in origin...
  5. pmc Distinct properties of cell-type-specific and shared transcription factor binding sites
    Jason Gertz
    HudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL 35806, USA
    Mol Cell 52:25-36. 2013
    ..The distinct properties of cell-specific binding were also observed with glucocorticoid receptor and for ER in primary mouse tissues, representing an elegant genomic encoding scheme for generating cell-type-specific gene regulation. ..
  6. pmc Dynamic DNA methylation across diverse human cell lines and tissues
    Katherine E Varley
    HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA
    Genome Res 23:555-67. 2013
    ..This study provides an atlas of DNA methylation across diverse and well-characterized samples and enables new discoveries about DNA methylation and its role in gene regulation and disease...
  7. pmc Effects of sequence variation on differential allelic transcription factor occupancy and gene expression
    Timothy E Reddy
    HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA
    Genome Res 22:860-9. 2012
    ..Our results have the potential to increase the power and interpretability of association studies by targeting functional intergenic variants in addition to protein coding sequences...
  8. pmc The hypersensitive glucocorticoid response specifically regulates period 1 and expression of circadian genes
    Timothy E Reddy
    HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA
    Mol Cell Biol 32:3756-67. 2012
    ..These findings show that hypersensitive GR binding occurs throughout the genome, drives targeted gene expression, and may be important to endocrine mediation of peripheral circadian rhythms...
  9. pmc Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner
    Jason Gertz
    HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA
    Genome Res 22:2153-62. 2012
    ....
  10. ncbi request reprint Recurrent read-through fusion transcripts in breast cancer
    Katherine E Varley
    HudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL, 35806, USA
    Breast Cancer Res Treat 146:287-97. 2014
    ..Both breast cancer associated fusion transcripts identified in this study involve membrane proteins (SCNN1A-TNFRSF1A and CTSD-IFITM10), which raises the possibility that they could be breast cancer-specific cell surface markers. ..
  11. pmc Transposase mediated construction of RNA-seq libraries
    Jason Gertz
    HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA
    Genome Res 22:134-41. 2012
    ..Our results show that high-quality RNA-seq libraries can be constructed efficiently and in an automatable fashion using transposition technology...
  12. pmc Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation
    Timothy E Reddy
    HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA
    Genome Res 19:2163-71. 2009
    ..Overall, the genome-wide determination and analysis of GR:DNA binding and transcriptional response to hormone reveals new insights into the complexities of gene regulatory activities managed by GR...