Kenneth A Myers
Braun A, Dang K, Buslig F, Baird M, Davidson M, Waterman C, et al
. Rac1 and Aurora A regulate MCAK to polarize microtubule growth in migrating endothelial cells. J Cell Biol. 2014;206:97-112 pubmed publisher
..Thus, a Rac1-Aurora A-MCAK signaling pathway mediates EC polarization and directional migration by promoting regional differences in MT dynamics in the leading and trailing cell edges. ..
Pillarisetti P, Myers K. Identification and characterization of agnuside, a natural proangiogenic small molecule. Eur J Med Chem. 2018;160:193-206 pubmed publisher
..Our research supports that agnuside may be a lead molecule for therapeutic angiogenesis. ..
Dang K, Myers K. The role of hypoxia-induced miR-210 in cancer progression. Int J Mol Sci. 2015;16:6353-72 pubmed publisher
..Here we discuss hypoxia-induced dysregulation of miR-210 and the resultant changes in miR-210 protein targets that regulate cancer progression. Potential methods of targeting miR-210 as a therapeutic tool are also explored. ..
Braun A, Farber M, Klase Z, Berget P, Myers K. A cell surface display fluorescent biosensor for measuring MMP14 activity in real-time. Sci Rep. 2018;8:5916 pubmed publisher
..This MMP14 biosensor promises to serve as a tool for the advancement of a broad range of investigations targeting MMP14 activity during cell migration in health and disease. ..
Braun A, Caesar N, Dang K, Myers K. High-resolution Time-lapse Imaging and Automated Analysis of Microtubule Dynamics in Living Human Umbilical Vein Endothelial Cells. J Vis Exp. 2016;: pubmed publisher
..This methodology allows for the study of MT dynamics and the identification of how localized regulation of MT dynamics within sub-cellular regions contributes to the angiogenic processes of EC branching and migration. ..
D Angelo L, Myer N, Myers K. MCAK-mediated regulation of endothelial cell microtubule dynamics is mechanosensitive to myosin-II contractility. Mol Biol Cell. 2017;28:1223-1237 pubmed publisher
..Furthermore, we find that 3D ECM engagement uncouples MCAK-mediated regulation of MT growth persistence from myosin-II-mediated regulation of growth persistence specifically within EC branched protrusions. ..
Myer N, Myers K. CLASP1 regulates endothelial cell branching morphology and directed migration. Biol Open. 2017;6:1502-1515 pubmed publisher