Sarah C Mutka

Summary

Publications

  1. pmc Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation
    Joan P Blonder
    N30 Pharmaceuticals, Inc, 3122 Sterling Circle, Suite 200, Boulder, CO 80301, USA
    BMC Pulm Med 14:3. 2014
  2. pmc ADH IB expression, but not ADH III, is decreased in human lung cancer
    Sarah C Mutka
    N30 Pharmaceuticals, Inc, Boulder, Colorado, United States of America
    PLoS ONE 7:e52995. 2012
  3. pmc Identification of nuclear export inhibitors with potent anticancer activity in vivo
    Sarah C Mutka
    Kosan Biosciences, Inc, Hayward, California 92121, USA
    Cancer Res 69:510-7. 2009
  4. ncbi request reprint Discovery of potent and novel S-nitrosoglutathione reductase inhibitors devoid of cytochrome P450 activities
    Xicheng Sun
    N30 Pharmaceuticals LLC, 3122 Sterling Circle, Suite 200, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 21:5849-53. 2011
  5. ncbi request reprint Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: carboxamide modification
    Xicheng Sun
    N30 Pharmaceuticals LLC, 3122 Sterling Circle, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 22:2338-42. 2012
  6. ncbi request reprint Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement
    Xicheng Sun
    N30 Pharmaceuticals LLC, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 21:3671-5. 2011

Collaborators

  • Jian Qiu
  • Xicheng Sun
  • Joan P Blonder
  • Chris Delany
  • CHARLES SCOGGIN
  • Navdeep K Mehra
  • Lucia H Green
  • Doug Looker
  • Michael Suniga
  • Kirsten Look
  • Ramakrishna Boyanapalli
  • Gary J Rosenthal
  • Jane P Richards

Detail Information

Publications6

  1. pmc Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation
    Joan P Blonder
    N30 Pharmaceuticals, Inc, 3122 Sterling Circle, Suite 200, Boulder, CO 80301, USA
    BMC Pulm Med 14:3. 2014
    ..GSNOR inhibition with the novel small molecule, N6022, was explored as a therapeutic approach in an experimental model of asthma...
  2. pmc ADH IB expression, but not ADH III, is decreased in human lung cancer
    Sarah C Mutka
    N30 Pharmaceuticals, Inc, Boulder, Colorado, United States of America
    PLoS ONE 7:e52995. 2012
    ..We conclude that the previously reported results showed an incorrect association of GSNOR and human lung cancer risk, and a decrease in ADH IB, rather than GSNOR, correlates with human lung cancer...
  3. pmc Identification of nuclear export inhibitors with potent anticancer activity in vivo
    Sarah C Mutka
    Kosan Biosciences, Inc, Hayward, California 92121, USA
    Cancer Res 69:510-7. 2009
    ..These NEIs show the potential of CRM1 inhibitors as novel and potent anticancer agents...
  4. ncbi request reprint Discovery of potent and novel S-nitrosoglutathione reductase inhibitors devoid of cytochrome P450 activities
    Xicheng Sun
    N30 Pharmaceuticals LLC, 3122 Sterling Circle, Suite 200, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 21:5849-53. 2011
    ..We identified potent and novel GSNOR inhibitors having reduced CYP inhibition activities and demonstrated efficacy in a mouse ovalbumin (OVA) model of asthma...
  5. ncbi request reprint Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: carboxamide modification
    Xicheng Sun
    N30 Pharmaceuticals LLC, 3122 Sterling Circle, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 22:2338-42. 2012
    ..We have identified potent and novel GSNOR inhibitors that demonstrate efficacy in an ovalbumin (OVA) induced asthma model in mice...
  6. ncbi request reprint Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement
    Xicheng Sun
    N30 Pharmaceuticals LLC, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 21:3671-5. 2011
    ..We identified equally potent and novel GSNOR inhibitors having pyrrole regioisomers as scaffolds using a structure based approach...