David M Mutch

Summary

Publications

  1. pmc The limit fold change model: a practical approach for selecting differentially expressed genes from microarray data
    David M Mutch
    Metabolic and Genomic Regulation, Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    BMC Bioinformatics 3:17. 2002
  2. ncbi request reprint Nutrigenomics and nutrigenetics: the emerging faces of nutrition
    David M Mutch
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    FASEB J 19:1602-16. 2005
  3. pmc Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice
    David M Mutch
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, CA 92037, USA
    Genome Biol 8:R38. 2007
  4. doi request reprint Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles
    David M Mutch
    INSERM, Nutriomique U872 Team 7, Paris, France
    Am J Clin Nutr 89:51-7. 2009
  5. ncbi request reprint The disruption of hepatic cytochrome p450 reductase alters mouse lipid metabolism
    David M Mutch
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    J Proteome Res 6:3976-84. 2007
  6. ncbi request reprint An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet
    David M Mutch
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    FASEB J 19:599-601. 2005
  7. doi request reprint A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects
    David M Mutch
    INSERM, U, Nutriomique, Paris, France
    Am J Clin Nutr 94:1399-409. 2011
  8. pmc Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery
    David M Mutch
    Nutriomique U872 Team 7, Institut National de la Sante et de la Recherche Medicale, Paris, France
    PLoS ONE 4:e7905. 2009
  9. ncbi request reprint Unraveling lipid metabolism with microarrays: effects of arachidonate and docosahexaenoate acid on murine hepatic and hippocampal gene expression
    Alvin Berger
    Metabolic and Genomic Regulation, Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Genome Biol 3:PREPRINT0004. 2002
  10. pmc Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders
    David M Mutch
    INSERM, Nutriomique U872, Paris, France
    PLoS ONE 2:e1344. 2007

Detail Information

Publications18

  1. pmc The limit fold change model: a practical approach for selecting differentially expressed genes from microarray data
    David M Mutch
    Metabolic and Genomic Regulation, Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    BMC Bioinformatics 3:17. 2002
    ..Systematic and global mathematical approaches that can be readily applied to a large number of experimental designs become fundamental to correctly handle the otherwise overwhelming data sets...
  2. ncbi request reprint Nutrigenomics and nutrigenetics: the emerging faces of nutrition
    David M Mutch
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    FASEB J 19:1602-16. 2005
    ....
  3. pmc Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice
    David M Mutch
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, CA 92037, USA
    Genome Biol 8:R38. 2007
    ..Using an untargeted comprehensive metabolite profiling approach coupled with targeted gene expression analyses, the perturbed biochemistry and functional redundancy of PLSCR proteins was assessed...
  4. doi request reprint Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles
    David M Mutch
    INSERM, Nutriomique U872 Team 7, Paris, France
    Am J Clin Nutr 89:51-7. 2009
    ....
  5. ncbi request reprint The disruption of hepatic cytochrome p450 reductase alters mouse lipid metabolism
    David M Mutch
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    J Proteome Res 6:3976-84. 2007
    ....
  6. ncbi request reprint An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet
    David M Mutch
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    FASEB J 19:599-601. 2005
    ....
  7. doi request reprint A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects
    David M Mutch
    INSERM, U, Nutriomique, Paris, France
    Am J Clin Nutr 94:1399-409. 2011
    ..Weight loss has been shown to reduce risk factors associated with cardiovascular disease and diabetes; however, successful maintenance of weight loss continues to pose a challenge...
  8. pmc Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery
    David M Mutch
    Nutriomique U872 Team 7, Institut National de la Sante et de la Recherche Medicale, Paris, France
    PLoS ONE 4:e7905. 2009
    ..To generate further insight into the numerous metabolic adaptations associated with RYGB surgery, we profiled serum metabolites before and after gastric bypass surgery and integrated metabolite changes with clinical data...
  9. ncbi request reprint Unraveling lipid metabolism with microarrays: effects of arachidonate and docosahexaenoate acid on murine hepatic and hippocampal gene expression
    Alvin Berger
    Metabolic and Genomic Regulation, Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Genome Biol 3:PREPRINT0004. 2002
    ..Novel hippocampal PUFA-molecular targets suggest that PUFA transcriptionally regulated genes with roles in appetite and learning...
  10. pmc Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders
    David M Mutch
    INSERM, Nutriomique U872, Paris, France
    PLoS ONE 2:e1344. 2007
    ..Therefore, we asked whether it is possible to identify subjects who will lose weight during dietary intervention using only a single gene expression snapshot...
  11. pmc Unraveling the genetics of human obesity
    David M Mutch
    French National Institute of Health and Medical Research INSERM U755 Nutriomique, Paris, France
    PLoS Genet 2:e188. 2006
    ....
  12. ncbi request reprint Regional variations in ABC transporter expression along the mouse intestinal tract
    David M Mutch
    Nestle Research Center, CH 1000 Lausanne 26, Switzerland
    Physiol Genomics 17:11-20. 2004
    ....
  13. ncbi request reprint Genetics of human obesity
    David M Mutch
    INSERM, U755 Nutriomique, 75004 Paris, France
    Best Pract Res Clin Endocrinol Metab 20:647-64. 2006
    ..It is now necessary to integrate data of various origins (environment, genotype, expression) to clarify this field...
  14. ncbi request reprint Impact of commensal microbiota on murine gastrointestinal tract gene ontologies
    David M Mutch
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Physiol Genomics 19:22-31. 2004
    ....
  15. ncbi request reprint The Global Error Assessment (GEA) model for the selection of differentially expressed genes in microarray data
    Robert Mansourian
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Bioinformatics 20:2726-37. 2004
    ..The present work outlines a method that achieves sufficient statistical power for selecting differentially expressed genes under conditions of low k, while remaining as an intuitive and computationally efficient procedure...
  16. ncbi request reprint Putting the 'Ome' in lipid metabolism
    David M Mutch
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Biotechnol Annu Rev 12:67-84. 2006
    ....
  17. ncbi request reprint Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver
    David M Mutch
    Nutrient Bioavailability, Nestlé Research Center Vers Chez Les Blanc, Lausanne 26, Switzerland
    Am J Physiol Gastrointest Liver Physiol 291:G63-72. 2006
    ....
  18. pmc Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes
    Pascale Anderle
    ISREC, Swiss Institute for Experimental Cancer Research, 1066 Epalinges s Lausanne, Switzerland
    BMC Genomics 6:69. 2005
    ....