From dinosaurs to DNA: a history of colorectal cancerHugh E Mulcahy
Centre for Colorectal Diseases, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
Int J Colorectal Dis 18:210-5. 2003
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- Changing patterns of sedation use for routine out-patient diagnostic gastroscopy between 1989 and 1998
H E Mulcahy
Digestive Diseases Research Centre, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
Aliment Pharmacol Ther 15:217-20. 2001
..However, no data are available on sedation trends in Britain over the past 10 years...
- A prospective controlled trial of an ultrathin versus a conventional endoscope in unsedated upper gastrointestinal endoscopy
H E Mulcahy
Digestive Diseases Research Centre, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
Endoscopy 33:311-6. 2001
..We assessed the effect of endoscope diameter on patient discomfort during unsedated transoral gastroscopy...
- Factors associated with tolerance to, and discomfort with, unsedated diagnostic gastroscopy
H E Mulcahy
Dept of Gastroenterology, Homerton Hospital, London, UK
Scand J Gastroenterol 36:1352-7. 2001
..We prospectively assessed patient and endoscopic variables in subjects attending for endoscopy in order to identify factors associated with patients' experience of the unsedated examination...
Tumour tissue microenvironment can inhibit dendritic cell maturation in colorectal cancerAdriana J Michielsen
Centre for Colorectal Disease, St Vincent s University Hospital, Elm Park, Dublin, Ireland
PLoS ONE 6:e27944. 2011
..In conclusion, tumour conditioned media strongly influences dendritic cell maturation and function...
Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosisAlan Coss
Centre for Colorectal Disease, St Vincent s University Hospital, Dublin, Ireland
Cancer Lett 276:228-38. 2009
..Our results suggest that gene amplification may represent an important mechanism underlying these changes...
- Surgery, Crohn's disease, and the biological era: has there been an impact?
Eoin Slattery
Centre for Colorectal Disease, St Vincent s University Hospital, Dublin, Ireland
J Clin Gastroenterol 45:691-3. 2011
..The management of Crohn's disease (CD) has changed considerably over the last 20 years. Immunomodulators and biological therapies now play a role in treating patients with CD, but little is known of their influence on surgical rates...
- Impact of magnetic resonance enterography in the management of small bowel Crohn's disease
Danny G Cheriyan
Department of Gastroenterology Hospital, St Vincent s University Hospital, Centre for Colorectal Disease, Dublin, Ireland
Eur J Gastroenterol Hepatol 25:550-5. 2013
..Magnetic resonance enterography (MRE) is a relatively new imaging modality that involves small bowel distension with orally administered fluid. Few studies have assessed its impact on patient management...
- Stage II colonic adenocarcinoma: a detailed study of pT4N0 with emphasis on peritoneal involvement and the role of tumour budding
Aoife L Canney
Centre for Colorectal Disease, St Vincent s University Hospital, Dublin, Ireland
Histopathology 61:488-96. 2012
..Evaluation of peritoneal involvement in colonic cancer (CC) can be difficult. We studied pT4N0 cancers and their association with pathological prognostic markers, including tumour budding...
- A comparative study of short- and medium-term outcomes comparing emergent surgery and stenting as a bridge to surgery in patients with acute malignant colonic obstruction
Dara O Kavanagh
Center for Colorectal Disease, St Vincent University Hospital, Elm Park, and School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
Dis Colon Rectum 56:433-40. 2013
..However, concerns about the safety of stenting have been raised following recent randomized studies...
- Development, validation and clinical assessment of a short questionnaire to assess disease-related knowledge in inflammatory bowel disease patients
Denise Keegan
Department of Gastroenterology, Centre for Colorectal Disease, St Vincent s University Hospital University College Dublin, Elm Park, Dublin, Ireland
Scand J Gastroenterol 48:183-8. 2013
..The aim of this study was to develop and validate a short knowledge questionnaire for clinical and academic research purposes...
- Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer
Edward J Fox
Department of Pathology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
J Mol Diagn 8:68-75. 2006
..01). We demonstrated an inverse relationship between hMLH1 promoter hypermethylation and MGMT promoter hypermethylation (P = 0.041), suggesting that a number of distinct hypermethylation-associated pathways may exist in colorectal cancer...
- A 5-year prospective observational study of the outcomes of international treatment guidelines for Crohn's disease
Garret Cullen
Centre for Colorectal Disease, St Vincent s University Hospital, Dublin, Ireland
Clin Gastroenterol Hepatol 7:323-8; quiz 252. 2009
..We reviewed outcomes and corticosteroid-dependency rates of patients with moderate-to-severe disease who were treated according to the international guidelines...
